PRKCZ | ENSG00000067606 | NCBI 5590

Details for: PRKCZ

Gene ID: 5590

Symbol: PRKCZ

Ensembl ID: ENSG00000067606

Description: protein kinase C zeta

Associated with

Esr-mediated signaling
(R-HSA-8939211)
Estrogen-stimulated signaling through prkcz
(R-HSA-9634635)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Gpvi-mediated activation cascade
(R-HSA-114604)
Hemostasis
(R-HSA-109582)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate nadph oxidases
(R-HSA-5668599)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by tgf-beta receptor complex
(R-HSA-170834)
Signaling by tgfb family members
(R-HSA-9006936)
Signaling by vegf
(R-HSA-194138)
Tgf-beta receptor signaling in emt (epithelial to mesenchymal transition)
(R-HSA-2173791)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Vegfr2 mediated cell proliferation
(R-HSA-5218921)
14-3-3 protein binding
(GO:0071889)
Apical cortex
(GO:0045179)
Apical plasma membrane
(GO:0016324)
Atp binding
(GO:0005524)
Axon hillock
(GO:0043203)
Bicellular tight junction
(GO:0005923)
Cell-cell junction
(GO:0005911)
Cell junction
(GO:0030054)
Cell leading edge
(GO:0031252)
Cell migration
(GO:0016477)
Cell surface receptor signaling pathway
(GO:0007166)
Cellular response to insulin stimulus
(GO:0032869)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Diacylglycerol-dependent serine/threonine kinase activity
(GO:0004697)
Endosome
(GO:0005768)
Establishment of cell polarity
(GO:0030010)
Establishment or maintenance of epithelial cell apical/basal polarity
(GO:0045197)
Extracellular exosome
(GO:0070062)
Glutamatergic synapse
(GO:0098978)
Inflammatory response
(GO:0006954)
Insulin receptor substrate binding
(GO:0043560)
Intracellular signal transduction
(GO:0035556)
Long-term memory
(GO:0007616)
Long-term synaptic potentiation
(GO:0060291)
Membrane
(GO:0016020)
Membrane depolarization
(GO:0051899)
Membrane hyperpolarization
(GO:0060081)
Metal ion binding
(GO:0046872)
Microtubule cytoskeleton organization
(GO:0000226)
Microtubule organizing center
(GO:0005815)
Myelin sheath abaxonal region
(GO:0035748)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of insulin receptor signaling pathway
(GO:0046627)
Negative regulation of peptidyl-tyrosine phosphorylation
(GO:0050732)
Negative regulation of protein-containing complex assembly
(GO:0031333)
Neuron projection extension
(GO:1990138)
Nuclear envelope
(GO:0005635)
Nuclear matrix
(GO:0016363)
Par polarity complex
(GO:0120157)
Peptidyl-serine phosphorylation
(GO:0018105)
Perinuclear region of cytoplasm
(GO:0048471)
Phospholipase binding
(GO:0043274)
Plasma membrane
(GO:0005886)
Positive regulation of cell-matrix adhesion
(GO:0001954)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of excitatory postsynaptic potential
(GO:2000463)
Positive regulation of insulin receptor signaling pathway
(GO:0046628)
Positive regulation of interleukin-4 production
(GO:0032753)
Positive regulation of interleukin-5 production
(GO:0032754)
Positive regulation of interleukin-10 production
(GO:0032733)
Positive regulation of interleukin-13 production
(GO:0032736)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of protein transport
(GO:0051222)
Positive regulation of t-helper 2 cell cytokine production
(GO:2000553)
Positive regulation of t-helper 2 cell differentiation
(GO:0045630)
Postsynaptic density
(GO:0014069)
Potassium channel regulator activity
(GO:0015459)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein kinase binding
(GO:0019901)
Protein kinase c signaling
(GO:0070528)
Protein localization to plasma membrane
(GO:0072659)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
(GO:0098696)
Schaffer collateral - ca1 synapse
(GO:0098685)
Signal transduction
(GO:0007165)
Stress fiber
(GO:0001725)
Tight junction
(GO:0070160)
Vesicle
(GO:0031982)
Vesicle transport along microtubule
(GO:0047496)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 165.9003
Cell Significance Index: -25.8100
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 99.5886
Cell Significance Index: -25.2600
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 48.0238
Cell Significance Index: -19.5100
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 37.5360
Cell Significance Index: -25.1900
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 21.0227
Cell Significance Index: -25.9200
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 20.4348
Cell Significance Index: -19.5100
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 8.7092
Cell Significance Index: -26.7500
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 8.4700
Cell Significance Index: -22.6900
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 4.7327
Cell Significance Index: 126.3700
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 3.9889
Cell Significance Index: -8.7300
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.0233
Cell Significance Index: 405.8800
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 1.9756
Cell Significance Index: 87.3900
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 1.7757
Cell Significance Index: 67.2400
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.6673
Cell Significance Index: 271.1700
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.1786
Cell Significance Index: 61.8800
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.1632
Cell Significance Index: 15.8700
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.1177
Cell Significance Index: 50.6600
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.1138
Cell Significance Index: 399.4900
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 1.0844
Cell Significance Index: 30.9500
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.0539
Cell Significance Index: 209.1500
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.0486
Cell Significance Index: 62.9500
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.0019
Cell Significance Index: 28.0000
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.9679
Cell Significance Index: 12.0100
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.8414
Cell Significance Index: 98.0500
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.8366
Cell Significance Index: 56.2600
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.6732
Cell Significance Index: 19.4000
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.6464
Cell Significance Index: 447.1000
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.5796
Cell Significance Index: 40.0900
Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: 0.5622
Cell Significance Index: 7.5000
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.4973
Cell Significance Index: 12.4300
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.4822
Cell Significance Index: 70.0900
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.4481
Cell Significance Index: 27.5400
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4474
Cell Significance Index: 44.2600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.4289
Cell Significance Index: 22.2800
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3776
Cell Significance Index: 340.9500
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.3252
Cell Significance Index: 58.6300
Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.3219
Cell Significance Index: 7.7200
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2639
Cell Significance Index: 144.1300
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.2603
Cell Significance Index: 4.4600
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.2581
Cell Significance Index: 31.7300
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.2568
Cell Significance Index: 3.7900
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.2202
Cell Significance Index: 3.3000
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.1928
Cell Significance Index: 12.1500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1639
Cell Significance Index: 5.7600
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.1599
Cell Significance Index: 12.2700
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.1537
Cell Significance Index: 3.3700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1534
Cell Significance Index: 7.1500
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.1507
Cell Significance Index: 3.2100
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.1368
Cell Significance Index: 0.8500
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1242
Cell Significance Index: 233.8800
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1198
Cell Significance Index: 22.7900
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0953
Cell Significance Index: 42.1200
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0852
Cell Significance Index: 131.1700
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0764
Cell Significance Index: 140.9600
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.0401
Cell Significance Index: 0.4200
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.0386
Cell Significance Index: 0.3600
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0272
Cell Significance Index: 17.2500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0194
Cell Significance Index: 26.3800
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0050
Cell Significance Index: 0.8500
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0035
Cell Significance Index: 2.6300
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0006
Cell Significance Index: -0.0200
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0185
Cell Significance Index: -13.5700
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0292
Cell Significance Index: -21.6500
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.0327
Cell Significance Index: -0.3900
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0364
Cell Significance Index: -1.7100
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0407
Cell Significance Index: -18.4700
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0414
Cell Significance Index: -23.3500
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0452
Cell Significance Index: -28.2100
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0600
Cell Significance Index: -7.7600
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0615
Cell Significance Index: -8.4400
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0707
Cell Significance Index: -20.3400
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.1004
Cell Significance Index: -2.1300
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1052
Cell Significance Index: -3.6600
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1109
Cell Significance Index: -11.3300
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1207
Cell Significance Index: -14.2300
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1342
Cell Significance Index: -10.0000
Cell Name: odontoblast (CL0000060)
Fold Change: -0.1342
Cell Significance Index: -17.2100
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: -0.1358
Cell Significance Index: -1.2900
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1360
Cell Significance Index: -28.6400
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.1383
Cell Significance Index: -1.9800
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.1414
Cell Significance Index: -3.8500
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1416
Cell Significance Index: -16.2200
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.1917
Cell Significance Index: -3.7900
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2061
Cell Significance Index: -21.4600
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.2507
Cell Significance Index: -17.7300
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.2522
Cell Significance Index: -3.8000
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2564
Cell Significance Index: -20.3100
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2565
Cell Significance Index: -8.1700
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2582
Cell Significance Index: -6.7900
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2645
Cell Significance Index: -8.6600
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.2759
Cell Significance Index: -5.5400
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2813
Cell Significance Index: -15.7900
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.2884
Cell Significance Index: -6.2300
Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.3079
Cell Significance Index: -3.8400
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: -0.3206
Cell Significance Index: -3.0500
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.3249
Cell Significance Index: -3.5400
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.3280
Cell Significance Index: -8.7900
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.3333
Cell Significance Index: -7.2200
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3335
Cell Significance Index: -20.4500
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.3586
Cell Significance Index: -18.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** PRKCZ is a serine/threonine kinase that is predominantly expressed in cells of the immune system, including T cells, B cells, and dendritic cells. It is also found in various non-immune cells, such as neurons, epithelial cells, and muscle cells. PRKCZ has a distinct subcellular localization, with a significant presence at the plasma membrane, where it interacts with various signaling molecules to modulate cellular responses. **Pathways and Functions:** PRKCZ is involved in numerous signaling pathways, including: 1. **Cell-cell junctions**: PRKCZ regulates the formation and maintenance of tight junctions and adherens junctions, which are essential for maintaining the integrity of epithelial and endothelial barriers. 2. **Apoptosis**: PRKCZ negatively regulates apoptosis, a process of programmed cell death, which is critical for maintaining immune homeostasis. 3. **Inflammation**: PRKCZ modulates inflammatory responses by regulating the production of cytokines, chemokines, and other inflammatory mediators. 4. **Neurotransmission**: PRKCZ is involved in the regulation of neurotransmitter release and synaptic plasticity, which are essential for learning and memory. 5. **Immune cell development**: PRKCZ plays a crucial role in the development and differentiation of immune cells, including T cells, B cells, and dendritic cells. PRKCZ's functions are mediated through its interactions with various signaling molecules, including: 1. **14-3-3 proteins**: PRKCZ binds to 14-3-3 proteins, which regulate its activity and localization. 2. **Phospholipids**: PRKCZ is activated by diacylglycerol (DAG), a phospholipid that is generated by the activation of G-protein coupled receptors. 3. **Tyrosine kinases**: PRKCZ interacts with tyrosine kinases, which are involved in the regulation of immune cell signaling. **Clinical Significance:** PRKCZ's dysregulation has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases**: PRKCZ's role in regulating immune cell development and function has been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer**: PRKCZ's involvement in cell proliferation and survival has been implicated in cancer development and progression. 3. **Neurological disorders**: PRKCZ's role in neurotransmission and synaptic plasticity has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, PRKCZ is a multifunctional protein kinase that plays a critical role in regulating immune cell development, function, and regulation. Its dysregulation has been implicated in various immune-related disorders, highlighting the importance of understanding its functions and mechanisms of action in the context of immunology.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Protein kinase C zeta type

Genular Protein ID: 4107812178

Symbol: KPCZ_HUMAN

Name: Protein kinase C zeta type

UniProtKB Accession Codes:

Q05513 A8K4N0 A8MU64 B7Z2J7 E9PCW2 Q15207 Q5SYT5 Q969S4

Database IDs:

Citations:

PubMed ID: 8224878

Title: The cDNA sequence encoding human protein kinase C-zeta.

PubMed ID: 8224878

DOI: 10.1016/0378-1119(93)90213-m

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8375396

Title: Activation and substrate specificity of the human protein kinase C alpha and zeta isoenzymes.

PubMed ID: 8375396

DOI: 10.1111/j.1432-1033.1993.tb18179.x

PubMed ID: 7597083

Title: Regulated assembly of tight junctions by protein kinase C.

PubMed ID: 7597083

DOI: 10.1073/pnas.92.13.6072

PubMed ID: 9447975

Title: Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes.

PubMed ID: 9447975

DOI: 10.1128/mcb.18.2.790

PubMed ID: 9566925

Title: Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62.

PubMed ID: 9566925

DOI: 10.1128/mcb.18.5.3069

PubMed ID: 9768361

Title: Regulation of protein kinase C zeta by PI 3-kinase and PDK-1.

PubMed ID: 9768361

DOI: 10.1016/s0960-9822(98)70444-0

PubMed ID: 10356400

Title: The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation.

PubMed ID: 10356400

DOI: 10.1093/emboj/18.11.3044

PubMed ID: 11035106

Title: Protein kinase C zeta plays a central role in activation of the p42/44 mitogen-activated protein kinase by endotoxin in alveolar macrophages.

PubMed ID: 11035106

DOI: 10.4049/jimmunol.165.8.4632

PubMed ID: 11260256

Title: Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C.

PubMed ID: 11260256

DOI: 10.1046/j.1365-2443.2001.00404.x

PubMed ID: 11781095

Title: Regulation of both PDK1 and the phosphorylation of PKC-zeta and -delta by a C-terminal PRK2 fragment.

PubMed ID: 11781095

DOI: 10.1021/bi010719z

PubMed ID: 12162751

Title: Characterization of PDK2 activity against protein kinase B gamma.

PubMed ID: 12162751

DOI: 10.1021/bi026065r

PubMed ID: 11755531

Title: p62 forms a ternary complex with PKCzeta and PAR-4 and antagonizes PAR-4-induced PKCzeta inhibition.

PubMed ID: 11755531

DOI: 10.1016/s0014-5793(01)03224-0

PubMed ID: 12234671

Title: Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties.

PubMed ID: 12234671

DOI: 10.1016/s0378-1119(02)00681-9

PubMed ID: 12893243

Title: Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C.

PubMed ID: 12893243

DOI: 10.1016/s0006-291x(03)01187-2

PubMed ID: 12887891

Title: PB1 domain-mediated heterodimerization in NADPH oxidase and signaling complexes of atypical protein kinase C with Par6 and p62.

PubMed ID: 12887891

DOI: 10.1016/s1097-2765(03)00246-6

PubMed ID: 15084291

Title: Atypical PKC phosphorylates PAR-1 kinases to regulate localization and activity.

PubMed ID: 15084291

DOI: 10.1016/j.cub.2004.04.007

PubMed ID: 15324659

Title: aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity.

PubMed ID: 15324659

DOI: 10.1016/j.cub.2004.08.021

PubMed ID: 15314172

Title: Role of atypical protein kinase C in estradiol-triggered G1/S progression of MCF-7 cells.

PubMed ID: 15314172

DOI: 10.1128/mcb.24.17.7643-7653.2004

PubMed ID: 16792529

Title: A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda.

PubMed ID: 16792529

DOI: 10.1042/bj20060511

PubMed ID: 17313651

Title: WD-repeat-propeller-FYVE protein, ProF, binds VAMP2 and protein kinase Czeta.

PubMed ID: 17313651

DOI: 10.1111/j.1742-4658.2007.05702.x

PubMed ID: 18190796

Title: KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling.

PubMed ID: 18190796

DOI: 10.1016/j.bbamcr.2007.12.007

PubMed ID: 18321849

Title: Protein kinase Czeta-dependent LKB1 serine 428 phosphorylation increases LKB1 nucleus export and apoptosis in endothelial cells.

PubMed ID: 18321849

DOI: 10.1074/jbc.m708208200

PubMed ID: 31519760

Title: Withdrawal: Protein kinase Czeta-dependent LKB1 serine 428 phosphorylation increases LKB1 nucleus export and apoptosis in endothelial cells.

PubMed ID: 31519760

DOI: 10.1074/jbc.w119.010661

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20332120

Title: CCM1 regulates vascular-lumen organization by inducing endothelial polarity.

PubMed ID: 20332120

DOI: 10.1242/jcs.059329

PubMed ID: 12761192

Title: Protein kinase Czeta (PKCzeta): activation mechanisms and cellular functions.

PubMed ID: 12761192

DOI: 10.1093/jb/mvg017

PubMed ID: 16903823

Title: Protein kinase Czeta and glucose uptake.

PubMed ID: 16903823

DOI: 10.1134/s0006297906070017

PubMed ID: 16322752

Title: PKCzeta at the crossroad of NF-kappaB and Jak1/Stat6 signaling pathways.

PubMed ID: 16322752

DOI: 10.1038/sj.cdd.4401823

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24682284

Title: Evolutionary and Molecular Facts Link the WWC Protein Family to Hippo Signaling.

PubMed ID: 24682284

DOI: 10.1093/molbev/msu115

PubMed ID: 26583432

Title: APPL proteins promote TGFbeta-induced nuclear transport of the TGFbeta type I receptor intracellular domain.

PubMed ID: 26583432

DOI: 10.18632/oncotarget.6346

PubMed ID: 36040231

Title: PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain.

PubMed ID: 36040231

DOI: 10.1042/bcj20220308

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 592
Mass: 67660
Checksum: 88CCD0577E6A596C
Sequence:

MPSRTGPKME GSGGRVRLKA HYGGDIFITS VDAATTFEEL CEEVRDMCRL HQQHPLTLKW 
VDSEGDPCTV SSQMELEEAF RLARQCRDEG LIIHVFPSTP EQPGLPCPGE DKSIYRRGAR 
RWRKLYRANG HLFQAKRFNR RAYCGQCSER IWGLARQGYR CINCKLLVHK RCHGLVPLTC 
RKHMDSVMPS QEPPVDDKNE DADLPSEETD GIAYISSSRK HDSIKDDSED LKPVIDGMDG 
IKISQGLGLQ DFDLIRVIGR GSYAKVLLVR LKKNDQIYAM KVVKKELVHD DEDIDWVQTE 
KHVFEQASSN PFLVGLHSCF QTTSRLFLVI EYVNGGDLMF HMQRQRKLPE EHARFYAAEI 
CIALNFLHER GIIYRDLKLD NVLLDADGHI KLTDYGMCKE GLGPGDTTST FCGTPNYIAP 
EILRGEEYGF SVDWWALGVL MFEMMAGRSP FDIITDNPDM NTEDYLFQVI LEKPIRIPRF 
LSVKASHVLK GFLNKDPKER LGCRPQTGFS DIKSHAFFRS IDWDLLEKKQ ALPPFQPQIT 
DDYGLDNFDT QFTSEPVQLT PDDEDAIKRI DQSEFEGFEY INPLLLSTEE SV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PRKCZ

Associated with

Cells (max top 100)

Other Information

The cDNA sequence encoding human protein kinase C-zeta. PubMed ID: 8224878

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Activation and substrate specificity of the human protein kinase C alpha and zeta isoenzymes. PubMed ID: 8375396

Regulated assembly of tight junctions by protein kinase C. PubMed ID: 7597083

Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes. PubMed ID: 9447975

Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62. PubMed ID: 9566925

Regulation of protein kinase C zeta by PI 3-kinase and PDK-1. PubMed ID: 9768361

The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation. PubMed ID: 10356400

Protein kinase C zeta plays a central role in activation of the p42/44 mitogen-activated protein kinase by endotoxin in alveolar macrophages. PubMed ID: 11035106

Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C. PubMed ID: 11260256

Regulation of both PDK1 and the phosphorylation of PKC-zeta and -delta by a C-terminal PRK2 fragment. PubMed ID: 11781095

Characterization of PDK2 activity against protein kinase B gamma. PubMed ID: 12162751

p62 forms a ternary complex with PKCzeta and PAR-4 and antagonizes PAR-4-induced PKCzeta inhibition. PubMed ID: 11755531

Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties. PubMed ID: 12234671

Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C. PubMed ID: 12893243

PB1 domain-mediated heterodimerization in NADPH oxidase and signaling complexes of atypical protein kinase C with Par6 and p62. PubMed ID: 12887891

Atypical PKC phosphorylates PAR-1 kinases to regulate localization and activity. PubMed ID: 15084291

aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity. PubMed ID: 15324659

Role of atypical protein kinase C in estradiol-triggered G1/S progression of MCF-7 cells. PubMed ID: 15314172

A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda. PubMed ID: 16792529

WD-repeat-propeller-FYVE protein, ProF, binds VAMP2 and protein kinase Czeta. PubMed ID: 17313651

KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling. PubMed ID: 18190796

Protein kinase Czeta-dependent LKB1 serine 428 phosphorylation increases LKB1 nucleus export and apoptosis in endothelial cells. PubMed ID: 18321849

Withdrawal: Protein kinase Czeta-dependent LKB1 serine 428 phosphorylation increases LKB1 nucleus export and apoptosis in endothelial cells. PubMed ID: 31519760

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

CCM1 regulates vascular-lumen organization by inducing endothelial polarity. PubMed ID: 20332120

Protein kinase Czeta (PKCzeta): activation mechanisms and cellular functions. PubMed ID: 12761192

Protein kinase Czeta and glucose uptake. PubMed ID: 16903823

PKCzeta at the crossroad of NF-kappaB and Jak1/Stat6 signaling pathways. PubMed ID: 16322752

Initial characterization of the human central proteome. PubMed ID: 21269460

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Evolutionary and Molecular Facts Link the WWC Protein Family to Hippo Signaling. PubMed ID: 24682284

APPL proteins promote TGFbeta-induced nuclear transport of the TGFbeta type I receptor intracellular domain. PubMed ID: 26583432

PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain. PubMed ID: 36040231

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846