Details for: MAPK8

Gene ID: 5599

Symbol: MAPK8

Ensembl ID: ENSG00000107643

Description: mitogen-activated protein kinase 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 393.4547
    Cell Significance Index: -61.2000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 238.0508
    Cell Significance Index: -60.3800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 113.9516
    Cell Significance Index: -58.6200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 50.5371
    Cell Significance Index: -62.3100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.1326
    Cell Significance Index: -59.2900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 15.9144
    Cell Significance Index: -34.8300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.9071
    Cell Significance Index: -62.7700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.3055
    Cell Significance Index: -47.0100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 5.8797
    Cell Significance Index: 96.8900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 5.4556
    Cell Significance Index: 306.1400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 3.7448
    Cell Significance Index: 89.8100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 3.2807
    Cell Significance Index: 201.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.7353
    Cell Significance Index: 548.7000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.2679
    Cell Significance Index: 813.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.0713
    Cell Significance Index: 411.0600
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 1.9920
    Cell Significance Index: 20.7500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.9884
    Cell Significance Index: 152.5900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.9179
    Cell Significance Index: 128.9600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.6481
    Cell Significance Index: 1139.8700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6128
    Cell Significance Index: 22.0100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.5281
    Cell Significance Index: 29.8300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.4856
    Cell Significance Index: 65.7100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.4627
    Cell Significance Index: 55.3900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.3809
    Cell Significance Index: 95.5000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.2834
    Cell Significance Index: 32.9900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.2442
    Cell Significance Index: 34.7700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.1354
    Cell Significance Index: 32.4000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.8829
    Cell Significance Index: 15.1300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8491
    Cell Significance Index: 24.4700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8187
    Cell Significance Index: 133.1500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6483
    Cell Significance Index: 70.5100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.6347
    Cell Significance Index: 1195.1600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.6044
    Cell Significance Index: 13.2400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5117
    Cell Significance Index: 13.7100
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.4484
    Cell Significance Index: 3.9800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3635
    Cell Significance Index: 27.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.3519
    Cell Significance Index: 223.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2985
    Cell Significance Index: 53.8100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2827
    Cell Significance Index: 255.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2796
    Cell Significance Index: 126.8800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2755
    Cell Significance Index: 424.0500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2636
    Cell Significance Index: 11.9500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2631
    Cell Significance Index: 32.3500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2406
    Cell Significance Index: 443.6900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2104
    Cell Significance Index: 114.9200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1459
    Cell Significance Index: 3.9700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1294
    Cell Significance Index: 17.7700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1234
    Cell Significance Index: 23.4800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1157
    Cell Significance Index: 51.1700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1099
    Cell Significance Index: 10.8700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0923
    Cell Significance Index: 125.5300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0916
    Cell Significance Index: 3.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0139
    Cell Significance Index: -0.6600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0263
    Cell Significance Index: -1.6600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.0276
    Cell Significance Index: -0.1700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0347
    Cell Significance Index: -1.6200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0551
    Cell Significance Index: -40.8000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0584
    Cell Significance Index: -42.8100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0752
    Cell Significance Index: -56.9500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0814
    Cell Significance Index: -1.7400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0963
    Cell Significance Index: -16.4400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1012
    Cell Significance Index: -57.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1098
    Cell Significance Index: -68.5900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1438
    Cell Significance Index: -3.8400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1648
    Cell Significance Index: -21.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1660
    Cell Significance Index: -24.1300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1824
    Cell Significance Index: -52.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1985
    Cell Significance Index: -25.6500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2349
    Cell Significance Index: -27.3700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2362
    Cell Significance Index: -12.2700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2469
    Cell Significance Index: -3.5500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2713
    Cell Significance Index: -31.9900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2785
    Cell Significance Index: -3.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3065
    Cell Significance Index: -31.3100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3108
    Cell Significance Index: -65.4600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3227
    Cell Significance Index: -33.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3862
    Cell Significance Index: -44.2500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3979
    Cell Significance Index: -25.6700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4148
    Cell Significance Index: -10.3700
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.4368
    Cell Significance Index: -2.7000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.4420
    Cell Significance Index: -7.4400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4648
    Cell Significance Index: -9.1900
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.4727
    Cell Significance Index: -6.6100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5492
    Cell Significance Index: -38.8400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5497
    Cell Significance Index: -11.9100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.5677
    Cell Significance Index: -8.1700
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.5745
    Cell Significance Index: -8.7400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5986
    Cell Significance Index: -31.4300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6123
    Cell Significance Index: -9.0400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6203
    Cell Significance Index: -20.3100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.6584
    Cell Significance Index: -8.2100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6784
    Cell Significance Index: -53.7300
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.6786
    Cell Significance Index: -8.8000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6887
    Cell Significance Index: -18.1100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6900
    Cell Significance Index: -14.7000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6904
    Cell Significance Index: -13.8600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7335
    Cell Significance Index: -23.3600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7496
    Cell Significance Index: -15.9100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7761
    Cell Significance Index: -47.5800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8069
    Cell Significance Index: -28.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MAPK8 is a member of the MAPK family, which consists of three main subfamilies: JNK (c-Jun N-terminal kinase), p38, and ERK (extracellular signal-regulated kinase). MAPK8 is specifically activated by stress signals, such as osmotic shock, heat shock, and oxidative stress, and is involved in the regulation of apoptosis, inflammation, and immune responses. MAPK8 is also known to interact with various other proteins, including the BH3-only proteins Bax and Bak, which are key regulators of mitochondrial apoptosis. **Pathways and Functions** MAPK8 is involved in a wide range of cellular processes, including: 1. **Apoptosis**: MAPK8 is activated by stress signals and phosphorylates and activates pro-apoptotic proteins, such as Bax and Bak, which promote mitochondrial outer membrane permeabilization and cell death. 2. **Immune responses**: MAPK8 is involved in the regulation of immune responses, including the activation of cytokines and the production of inflammatory mediators. 3. **Cell survival**: MAPK8 can also promote cell survival by phosphorylating and activating anti-apoptotic proteins, such as Bcl-2 and Bcl-xL. 4. **Stress responses**: MAPK8 is activated by stress signals, such as heat shock and oxidative stress, and regulates the expression of heat shock proteins and other stress response genes. 5. **Cytokine signaling**: MAPK8 is involved in the regulation of cytokine signaling, including the activation of NF-κB and the production of inflammatory mediators. **Clinical Significance** Dysregulation of MAPK8 has been implicated in various diseases, including: 1. **Cancer**: MAPK8 is overexpressed in many types of cancer, including breast, lung, and colon cancer, and is associated with poor prognosis. 2. **Autoimmune diseases**: MAPK8 is involved in the regulation of autoimmune responses, including rheumatoid arthritis and lupus. 3. **Neurological disorders**: MAPK8 is involved in the regulation of neuronal survival and death, and is implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 4. **Infectious diseases**: MAPK8 is involved in the regulation of immune responses to infections, including the activation of cytokines and the production of inflammatory mediators. In conclusion, MAPK8 is a critical regulator of cellular processes, including apoptosis, immune responses, and stress responses. Dysregulation of MAPK8 has been implicated in various diseases, and understanding its role in these processes is essential for the development of novel therapeutic strategies.

Genular Protein ID: 742610565

Symbol: MK08_HUMAN

Name: Mitogen-activated protein kinase 8

UniProtKB Accession Codes:

P45983 B5BTZ5 B7ZLV4 D3DX88 D3DX92 Q15709 Q15712 Q15713 Q308M2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 1 CPTAC 10 CPTC 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 10 DrugCentral 1 EC 2 ELM 1 EMBL 15 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 47 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 34 PDBsum 34 PIR 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 12 RefSeq 16 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8137421

Title: JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain.

PubMed ID: 8137421

DOI: 10.1016/0092-8674(94)90380-8

PubMed ID: 8654373

Title: Selective interaction of JNK protein kinase isoforms with transcription factors.

PubMed ID: 8654373

DOI: 10.1002/j.1460-2075.1996.tb00636.x

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7839144

Title: Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms.

PubMed ID: 7839144

DOI: 10.1126/science.7839144

PubMed ID: 11062067

Title: Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7.

PubMed ID: 11062067

DOI: 10.1042/bj3520145

PubMed ID: 10856240

Title: The evi-1 oncoprotein inhibits c-Jun N-terminal kinase and prevents stress-induced cell death.

PubMed ID: 10856240

DOI: 10.1093/emboj/19.12.2958

PubMed ID: 10747973

Title: c-Jun NH2-terminal kinase targeting and phosphorylation of heat shock factor-1 suppress its transcriptional activity.

PubMed ID: 10747973

DOI: 10.1074/jbc.m000958200

PubMed ID: 12514174

Title: JNK1 physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1-mediated apoptosis.

PubMed ID: 12514174

DOI: 10.1074/jbc.m208373200

PubMed ID: 15693750

Title: Characterization of a novel human sperm-associated antigen 9 (SPAG9) having structural homology with c-Jun N-terminal kinase-interacting protein.

PubMed ID: 15693750

DOI: 10.1042/bj20041577

PubMed ID: 16581800

Title: Association and regulation of heat shock transcription factor 4b with both extracellular signal-regulated kinase mitogen-activated protein kinase and dual-specificity tyrosine phosphatase DUSP26.

PubMed ID: 16581800

DOI: 10.1128/mcb.26.8.3282-3294.2006

PubMed ID: 17875713

Title: Nuclear factor of activated T3 is a negative regulator of Ras-JNK1/2-AP-1 induced cell transformation.

PubMed ID: 17875713

DOI: 10.1158/0008-5472.can-06-4788

PubMed ID: 17761173

Title: GRASP-1 is a neuronal scaffold protein for the JNK signaling pathway.

PubMed ID: 17761173

DOI: 10.1016/j.febslet.2007.08.008

PubMed ID: 17158878

Title: Prostate-derived sterile 20-like kinase 1-alpha induces apoptosis. JNK- and caspase-dependent nuclear localization is a requirement for membrane blebbing.

PubMed ID: 17158878

DOI: 10.1074/jbc.m608336200

PubMed ID: 17296730

Title: Rev7/MAD2B links c-Jun N-terminal protein kinase pathway signaling to activation of the transcription factor Elk-1.

PubMed ID: 17296730

DOI: 10.1128/mcb.02276-06

PubMed ID: 18307971

Title: Phosphorylation of two eukaryotic transcription factors, Jun dimerization protein 2 and activation transcription factor 2, in Escherichia coli by Jun N-terminal kinase 1.

PubMed ID: 18307971

DOI: 10.1016/j.ab.2008.01.038

PubMed ID: 18570871

Title: JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy.

PubMed ID: 18570871

DOI: 10.1016/j.molcel.2008.06.001

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19166818

Title: Crystal structure of SCCA1 and insight about the interaction with JNK1.

PubMed ID: 19166818

DOI: 10.1016/j.bbrc.2009.01.057

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20027304

Title: JNK1 phosphorylates SIRT1 and promotes its enzymatic activity.

PubMed ID: 20027304

DOI: 10.1371/journal.pone.0008414

PubMed ID: 21364637

Title: JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis.

PubMed ID: 21364637

DOI: 10.1038/cddis.2010.7

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21660049

Title: A critical step for JNK activation: isomerization by the prolyl isomerase Pin1.

PubMed ID: 21660049

DOI: 10.1038/cdd.2011.82

PubMed ID: 22441692

Title: JNK regulates the photic response of the mammalian circadian clock.

PubMed ID: 22441692

DOI: 10.1038/embor.2012.37

PubMed ID: 21095239

Title: Phosphorylation of Bcl-associated death protein (Bad) by erythropoietin-activated c-Jun N-terminal protein kinase 1 contributes to survival of erythropoietin-dependent cells.

PubMed ID: 21095239

DOI: 10.1016/j.biocel.2010.11.011

PubMed ID: 21148294

Title: Defective anchoring of JNK1 in the cytoplasm by MKK7 in Jurkat cells is associated with resistance to Fas-mediated apoptosis.

PubMed ID: 21148294

DOI: 10.1091/mbc.e10-06-0492

PubMed ID: 21856198

Title: JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress.

PubMed ID: 21856198

DOI: 10.1016/j.molcel.2011.06.021

PubMed ID: 22966201

Title: Phosphorylation of the eukaryotic translation initiation factor 4E-transporter (4E-T) by c-Jun N-terminal kinase promotes stress-dependent P-body assembly.

PubMed ID: 22966201

DOI: 10.1128/mcb.00544-12

PubMed ID: 22327296

Title: The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.

PubMed ID: 22327296

DOI: 10.1038/nature10806

PubMed ID: 27568560

Title: JNK phosphorylates SIRT6 to stimulate DNA double-strand break repair in response to oxidative stress by recruiting PARP1 to DNA Breaks.

PubMed ID: 27568560

DOI: 10.1016/j.celrep.2016.08.006

PubMed ID: 28943315

Title: NLRP3 phosphorylation is an essential priming event for inflammasome activation.

PubMed ID: 28943315

DOI: 10.1016/j.molcel.2017.08.017

PubMed ID: 30878395

Title: MicroRNA-143-3p promotes human cardiac fibrosis via targeting sprouty3 after myocardial infarction.

PubMed ID: 30878395

DOI: 10.1016/j.yjmcc.2019.03.005

PubMed ID: 34048572

Title: Post-translational modification of RNA m6A demethylase ALKBH5 regulates ROS-induced DNA damage response.

PubMed ID: 34048572

DOI: 10.1093/nar/gkab415

PubMed ID: 15141161

Title: Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125.

PubMed ID: 15141161

DOI: 10.1038/sj.emboj.7600212

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 427
  • Mass: 48296
  • Checksum: 94FB6BE0358B9B60
  • Sequence:
    • MSRSKRDNNF YSVEIGDSTF TVLKRYQNLK PIGSGAQGIV CAAYDAILER NVAIKKLSRP 
FQNQTHAKRA YRELVLMKCV NHKNIIGLLN VFTPQKSLEE FQDVYIVMEL MDANLCQVIQ 
MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTAGTSF 
MMTPYVVTRY YRAPEVILGM GYKENVDLWS VGCIMGEMVC HKILFPGRDY IDQWNKVIEQ 
LGTPCPEFMK KLQPTVRTYV ENRPKYAGYS FEKLFPDVLF PADSEHNKLK ASQARDLLSK 
MLVIDASKRI SVDEALQHPY INVWYDPSEA EAPPPKIPDK QLDEREHTIE EWKELIYKEV 
MDLEERTKNG VIRGQPSPLG AAVINGSQHP SSSSSVNDVS SMSTDPTLAS DTDSSLEAAA 
GPLGCCR

Genular Protein ID: 3942873268

Symbol: A1L4K2_HUMAN

Name: N/A

UniProtKB Accession Codes:

A1L4K2

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 11 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 10 ExpressionAtlas 1 GO 8 Gene3D 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 Pfam 1 PharmGKB 1 RefSeq 5 Rhea 6 RuleBase 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 427
  • Mass: 48088
  • Checksum: 3F5CC3F6A4F3EF2D
  • Sequence:
    • MSRSKRDNNF YSVEIGDSTF TVLKRYQNLK PIGSGAQGIV CAAYDAILER NVAIKKLSRP 
FQNQTHAKRA YRELVLMKCV NHKNIIGLLN VFTPQKSLEE FQDVYIVMEL MDANLCQVIQ 
MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTAGTSF 
MMTPYVVTRY YRAPEVILGM GYKENVDIWS VGCIMGEMIK GGVLFPGTDH IDQWNKVIEQ 
LGTPCPEFMK KLQPTVRTYV ENRPKYAGYS FEKLFPDVLF PADSEHNKLK ASQARDLLSK 
MLVIDASKRI SVDEALQHPY INVWYDPSEA EAPPPKIPDK QLDEREHTIE EWKELIYKEV 
MDLEERTKNG VIRGQPSPLG AAVINGSQHP SSSSSVNDVS SMSTDPTLAS DTDSSLEAAA 
GPLGCCR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.