Details for: MAP2K3

Gene ID: 5606

Symbol: MAP2K3

Ensembl ID: ENSG00000034152

Description: mitogen-activated protein kinase kinase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 113.8212
    Cell Significance Index: -28.8700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 73.2787
    Cell Significance Index: -29.7700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 73.0742
    Cell Significance Index: -34.5000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 65.6706
    Cell Significance Index: -33.7800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 51.3247
    Cell Significance Index: -34.4400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 31.6316
    Cell Significance Index: -30.2000
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 26.0374
    Cell Significance Index: -4.0500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.9307
    Cell Significance Index: -14.7100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.1279
    Cell Significance Index: -29.8100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.2272
    Cell Significance Index: -32.4700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.1465
    Cell Significance Index: -21.9500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.6680
    Cell Significance Index: -12.4100
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 4.4485
    Cell Significance Index: 13.2300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.9819
    Cell Significance Index: 385.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.1703
    Cell Significance Index: 252.9200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.8193
    Cell Significance Index: 85.5100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.7795
    Cell Significance Index: 92.4400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.6848
    Cell Significance Index: 31.1400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.4920
    Cell Significance Index: 26.3700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3478
    Cell Significance Index: 80.9200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2825
    Cell Significance Index: 139.5000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.2195
    Cell Significance Index: 19.5700
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.1957
    Cell Significance Index: 7.4000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.1731
    Cell Significance Index: 31.3800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0797
    Cell Significance Index: 175.6000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.0435
    Cell Significance Index: 77.7700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9836
    Cell Significance Index: 21.3100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.9233
    Cell Significance Index: 15.5300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7700
    Cell Significance Index: 34.9000
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.7655
    Cell Significance Index: 5.5000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.6934
    Cell Significance Index: 20.3700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6873
    Cell Significance Index: 47.5300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6528
    Cell Significance Index: 17.7700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6393
    Cell Significance Index: 349.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6321
    Cell Significance Index: 29.4700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.6075
    Cell Significance Index: 17.4200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5686
    Cell Significance Index: 36.6900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5287
    Cell Significance Index: 233.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5147
    Cell Significance Index: 92.7900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5072
    Cell Significance Index: 35.8700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4953
    Cell Significance Index: 58.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4894
    Cell Significance Index: 48.4100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4484
    Cell Significance Index: 55.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3990
    Cell Significance Index: 79.1900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3290
    Cell Significance Index: 4.9300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3025
    Cell Significance Index: 60.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2878
    Cell Significance Index: 6.1300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2793
    Cell Significance Index: 53.1500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2017
    Cell Significance Index: 27.6900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1953
    Cell Significance Index: 176.3700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1934
    Cell Significance Index: 6.8000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1843
    Cell Significance Index: 14.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1325
    Cell Significance Index: 47.5300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1266
    Cell Significance Index: 21.6200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1115
    Cell Significance Index: 5.8100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0850
    Cell Significance Index: 58.7700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0771
    Cell Significance Index: 0.7100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0498
    Cell Significance Index: 5.6900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0487
    Cell Significance Index: 91.6500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0430
    Cell Significance Index: 5.5100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0328
    Cell Significance Index: 0.7600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0324
    Cell Significance Index: 20.5700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0240
    Cell Significance Index: 18.1400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0056
    Cell Significance Index: 0.1500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0001
    Cell Significance Index: -0.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0017
    Cell Significance Index: -2.5800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0041
    Cell Significance Index: -0.6000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0065
    Cell Significance Index: -0.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0080
    Cell Significance Index: -5.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0094
    Cell Significance Index: -4.2700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0116
    Cell Significance Index: -21.3600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0136
    Cell Significance Index: -8.5100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0137
    Cell Significance Index: -18.6900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0251
    Cell Significance Index: -14.1300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0358
    Cell Significance Index: -3.6600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0560
    Cell Significance Index: -1.5700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0828
    Cell Significance Index: -0.5000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0830
    Cell Significance Index: -17.4900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0899
    Cell Significance Index: -25.8800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0965
    Cell Significance Index: -2.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1003
    Cell Significance Index: -11.4900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1151
    Cell Significance Index: -1.5700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1490
    Cell Significance Index: -2.5100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1554
    Cell Significance Index: -8.1600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2529
    Cell Significance Index: -6.1700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2713
    Cell Significance Index: -8.6900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2724
    Cell Significance Index: -6.8100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2736
    Cell Significance Index: -6.9900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2872
    Cell Significance Index: -29.9000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3011
    Cell Significance Index: -23.8500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3521
    Cell Significance Index: -4.0000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.3541
    Cell Significance Index: -5.0400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3635
    Cell Significance Index: -12.6300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4076
    Cell Significance Index: -27.4100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4634
    Cell Significance Index: -6.8400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4748
    Cell Significance Index: -29.9300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4796
    Cell Significance Index: -29.4800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4846
    Cell Significance Index: -29.7100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4994
    Cell Significance Index: -22.0900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5009
    Cell Significance Index: -8.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Dual specificity:** MAP2K3 possesses dual specificity, allowing it to phosphorylate and activate both MAPK and MAPKK kinases. 2. **Widespread expression:** MAP2K3 is expressed in various cell types, including immune cells, epithelial cells, and stem cells. 3. **Signaling pathways:** MAP2K3 is involved in multiple signaling pathways, including the MAPK cascade, Toll-like receptor (TLR) signaling, and the NF-κB pathway. 4. **Cellular stress response:** MAP2K3 is activated in response to cellular stress, including oxidative stress, heat shock, and hypoxia. **Pathways and Functions:** MAP2K3 is a key player in the following pathways: 1. **MAPK cascade:** MAP2K3 activates downstream MAPK kinases, which in turn phosphorylate and activate transcription factors, leading to the regulation of gene expression. 2. **Toll-like receptor signaling:** MAP2K3 is involved in the activation of TLR signaling pathways, which are essential for the recognition of pathogens and the activation of the innate immune response. 3. **NF-κB pathway:** MAP2K3 activates the NF-κB transcription factor, which regulates the expression of genes involved in inflammation, immune response, and cellular survival. 4. **Cytokine production:** MAP2K3 regulates the production of cytokines and chemokines, which are essential for the coordination of the immune response. 5. **Cellular stress response:** MAP2K3 is activated in response to cellular stress, leading to the activation of stress-activated protein kinases (SAPKs) and the regulation of gene expression. **Clinical Significance:** 1. **Inflammatory disorders:** MAP2K3 is involved in the pathogenesis of various inflammatory disorders, including rheumatoid arthritis, asthma, and inflammatory bowel disease. 2. **Cancer:** MAP2K3 is overexpressed in several types of cancer, including lung, breast, and colon cancer, and is associated with tumor progression and metastasis. 3. **Neurological disorders:** MAP2K3 is involved in the pathogenesis of neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. 4. **Infectious diseases:** MAP2K3 is activated in response to bacterial and viral infections, and is involved in the regulation of the innate immune response. In conclusion, MAP2K3 is a complex gene that plays a crucial role in the regulation of various cellular processes, including immune response, inflammation, and cellular stress. Further research is needed to fully understand the mechanisms by which MAP2K3 influences disease pathology and to develop novel therapeutic strategies targeting this gene.

Genular Protein ID: 4201741963

Symbol: MP2K3_HUMAN

Name: Dual specificity mitogen-activated protein kinase kinase 3

UniProtKB Accession Codes:

P46734 B3KSK7 Q99441 Q9UE71 Q9UE72

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CPTAC 2 CTD 1 ChEBI 17 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 3 EMBL 6 Ensembl 3 ExpressionAtlas 1 GO 29 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 3 RefSeq 7 Rhea 9 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7839144

Title: Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms.

PubMed ID: 7839144

DOI: 10.1126/science.7839144

PubMed ID: 8900184

Title: Purification and identification of a major activator for p38 from osmotically shocked cells: activation of mitogen-activated protein kinase kinase 6 by osmotic shock, tumor necrosis factor-alpha, and H2O2.

PubMed ID: 8900184

DOI: 10.1074/jbc.271.43.26981

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8622669

Title: MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway.

PubMed ID: 8622669

DOI: 10.1128/mcb.16.3.1247

PubMed ID: 11279118

Title: Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2.

PubMed ID: 11279118

DOI: 10.1074/jbc.m100681200

PubMed ID: 11980910

Title: Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha.

PubMed ID: 11980910

DOI: 10.1074/jbc.m203257200

PubMed ID: 16709866

Title: Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation.

PubMed ID: 16709866

DOI: 10.4049/jimmunol.176.11.7039

PubMed ID: 16728640

Title: Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation.

PubMed ID: 16728640

DOI: 10.1126/science.1126867

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21224381

Title: A-kinase anchoring protein (AKAP)-Lbc anchors a PKN-based signaling complex involved in alpha1-adrenergic receptor-induced p38 activation.

PubMed ID: 21224381

DOI: 10.1074/jbc.m110.185645

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 11414763

Title: Mutation analyses of 268 candidate genes in human tumor cell lines.

PubMed ID: 11414763

DOI: 10.1006/geno.2001.6551

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 347
  • Mass: 39318
  • Checksum: A80BA4FDFF8F75A2
  • Sequence:
    • MESPASSQPA SMPQSKGKSK RKKDLRISCM SKPPAPNPTP PRNLDSRTFI TIGDRNFEVE 
ADDLVTISEL GRGAYGVVEK VRHAQSGTIM AVKRIRATVN SQEQKRLLMD LDINMRTVDC 
FYTVTFYGAL FREGDVWICM ELMDTSLDKF YRKVLDKNMT IPEDILGEIA VSIVRALEHL 
HSKLSVIHRD VKPSNVLINK EGHVKMCDFG ISGYLVDSVA KTMDAGCKPY MAPERINPEL 
NQKGYNVKSD VWSLGITMIE MAILRFPYES WGTPFQQLKQ VVEEPSPQLP ADRFSPEFVD 
FTAQCLRKNP AERMSYLELM EHPFFTLHKT KKTDIAAFVK EILGEDS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.