Details for: THAP12

Gene ID: 5612

Symbol: THAP12

Ensembl ID: ENSG00000137492

Description: THAP domain containing 12

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 60.8317
    Cell Significance Index: -28.7200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 58.2144
    Cell Significance Index: -23.6500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 52.7620
    Cell Significance Index: -27.1400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 24.8601
    Cell Significance Index: -23.7400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.8587
    Cell Significance Index: -26.4100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.2060
    Cell Significance Index: -15.9900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.0855
    Cell Significance Index: -11.1300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.7533
    Cell Significance Index: 190.7100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3206
    Cell Significance Index: 214.7900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0780
    Cell Significance Index: 973.3800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9046
    Cell Significance Index: 62.5600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.8181
    Cell Significance Index: 51.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6274
    Cell Significance Index: 125.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5676
    Cell Significance Index: 16.3600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5409
    Cell Significance Index: 97.5100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5022
    Cell Significance Index: 13.6700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4840
    Cell Significance Index: 59.5100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4625
    Cell Significance Index: 6.3100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4451
    Cell Significance Index: 61.1200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4303
    Cell Significance Index: 30.4400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4033
    Cell Significance Index: 178.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4015
    Cell Significance Index: 144.0000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2669
    Cell Significance Index: 52.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2592
    Cell Significance Index: 13.5000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2557
    Cell Significance Index: 11.5900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2537
    Cell Significance Index: 138.5600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2370
    Cell Significance Index: 13.3000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2352
    Cell Significance Index: 44.7600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2141
    Cell Significance Index: 13.8200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2114
    Cell Significance Index: 2.5200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2085
    Cell Significance Index: 9.7200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1850
    Cell Significance Index: 127.9600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1848
    Cell Significance Index: 23.6900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1302
    Cell Significance Index: 6.5800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1215
    Cell Significance Index: 20.7400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0964
    Cell Significance Index: 9.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0851
    Cell Significance Index: 9.7600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0686
    Cell Significance Index: 3.5700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0579
    Cell Significance Index: 4.4400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0112
    Cell Significance Index: 0.1700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0085
    Cell Significance Index: 0.2000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0064
    Cell Significance Index: 0.7600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0009
    Cell Significance Index: 1.6300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0005
    Cell Significance Index: -0.3400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0036
    Cell Significance Index: -0.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0129
    Cell Significance Index: -23.7400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0142
    Cell Significance Index: -0.8700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0151
    Cell Significance Index: -23.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0153
    Cell Significance Index: -9.7300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0154
    Cell Significance Index: -0.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0177
    Cell Significance Index: -13.4300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0181
    Cell Significance Index: -24.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0232
    Cell Significance Index: -1.7300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0255
    Cell Significance Index: -18.9000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0313
    Cell Significance Index: -14.2100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0322
    Cell Significance Index: -0.8600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0459
    Cell Significance Index: -25.8900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0487
    Cell Significance Index: -30.3900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0562
    Cell Significance Index: -7.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0651
    Cell Significance Index: -9.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0664
    Cell Significance Index: -3.1200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0759
    Cell Significance Index: -21.8500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0845
    Cell Significance Index: -0.7100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0890
    Cell Significance Index: -2.5500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0988
    Cell Significance Index: -10.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1425
    Cell Significance Index: -30.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1591
    Cell Significance Index: -18.5400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1595
    Cell Significance Index: -5.1100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1694
    Cell Significance Index: -11.3900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1916
    Cell Significance Index: -4.0100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1930
    Cell Significance Index: -6.7100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2060
    Cell Significance Index: -2.3400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2229
    Cell Significance Index: -6.2300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2246
    Cell Significance Index: -9.9400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2395
    Cell Significance Index: -18.9700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2473
    Cell Significance Index: -25.7500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2722
    Cell Significance Index: -10.3100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2916
    Cell Significance Index: -15.3100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2964
    Cell Significance Index: -7.6200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3005
    Cell Significance Index: -6.4000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3012
    Cell Significance Index: -7.5300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3193
    Cell Significance Index: -3.3100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3781
    Cell Significance Index: -23.1800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3816
    Cell Significance Index: -10.0400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4347
    Cell Significance Index: -8.4900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4433
    Cell Significance Index: -18.1600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4914
    Cell Significance Index: -10.7600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5095
    Cell Significance Index: -12.2200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5167
    Cell Significance Index: -13.2000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5427
    Cell Significance Index: -10.0300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.5582
    Cell Significance Index: -7.8400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5816
    Cell Significance Index: -19.0400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5847
    Cell Significance Index: -12.4100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5856
    Cell Significance Index: -15.6700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5864
    Cell Significance Index: -18.6800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5916
    Cell Significance Index: -17.3800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6102
    Cell Significance Index: -21.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6277
    Cell Significance Index: -13.6000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6477
    Cell Significance Index: -11.1000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6606
    Cell Significance Index: -24.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** THAP12 exhibits a unique combination of characteristics that distinguish it from other genes. Its THAP domain, a conserved motif found in various transcriptional regulators, enables it to interact with multiple proteins and modulate cellular processes. The gene is significantly expressed in a wide range of cell types, including pancreatic acinar cells, mural cells, extravillous trophoblasts, and T cells. This broad expression profile suggests that THAP12 plays a crucial role in maintaining cellular homeostasis and regulating immune responses. **Pathways and Functions:** THAP12 is involved in several key cellular pathways, including: 1. **DNA binding and metal ion binding:** THAP12's THAP domain enables it to bind to specific DNA sequences, modulating gene expression. Additionally, its metal ion-binding capabilities allow it to interact with various proteins, influencing signaling pathways. 2. **Negative regulation of cell population proliferation:** THAP12 has been shown to inhibit cell proliferation, suggesting its role in maintaining tissue homeostasis and preventing cancer. 3. **Protein binding and dimerization activity:** THAP12's ability to interact with multiple proteins and form dimers enables it to regulate complex cellular processes, including immune responses and cell signaling. 4. **Signal transduction:** THAP12's involvement in signal transduction pathways suggests its role in responding to environmental cues and modulating cellular responses. **Clinical Significance:** The clinical significance of THAP12 is an area of active research. Studies have implicated THAP12 in various diseases, including: 1. **Immunological disorders:** THAP12's role in regulating immune responses makes it a potential target for treating autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer:** THAP12's ability to inhibit cell proliferation suggests its potential as a tumor suppressor gene, with implications for cancer therapy. 3. **Neurological disorders:** THAP12's involvement in neuronal development and function suggests its potential role in neurodegenerative diseases, such as Alzheimer's and Parkinson's. In conclusion, THAP12 is a multifaceted gene with a wide range of cellular expression profiles and functional roles. Its involvement in various cellular pathways and its potential as a therapeutic target make it an area of increasing interest in the scientific community. Further research is necessary to fully elucidate the clinical significance of THAP12 and its potential applications in human disease.

Genular Protein ID: 3869746474

Symbol: P52K_HUMAN

Name: 52 kDa repressor of the inhibitor of the protein kinase

UniProtKB Accession Codes:

O43422 A8K728 Q17RY9 Q8WTW1 Q9Y3Z4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 6 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9447982

Title: Regulation of interferon-induced protein kinase PKR: modulation of P58IPK inhibitory function by a novel protein, P52rIPK.

PubMed ID: 9447982

DOI: 10.1128/mcb.18.2.859

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 761
  • Mass: 87704
  • Checksum: 88809CFE52399C13
  • Sequence:
    • MPNFCAAPNC TRKSTQSDLA FFRFPRDPAR CQKWVENCRR ADLEDKTPDQ LNKHYRLCAK 
HFETSMICRT SPYRTVLRDN AIPTIFDLTS HLNNPHSRHR KRIKELSEDE IRTLKQKKID 
ETSEQEQKHK ETNNSNAQNP SEEEGEGQDE DILPLTLEEK ENKEYLKSLF EILILMGKQN 
IPLDGHEADE IPEGLFTPDN FQALLECRIN SGEEVLRKRF ETTAVNTLFC SKTQQRQMLE 
ICESCIREET LREVRDSHFF SIITDDVVDI AGEEHLPVLV RFVDESHNLR EEFIGFLPYE 
ADAEILAVKF HTMITEKWGL NMEYCRGQAY IVSSGFSSKM KVVASRLLEK YPQAIYTLCS 
SCALNMWLAK SVPVMGVSVA LGTIEEVCSF FHRSPQLLLE LDNVISVLFQ NSKERGKELK 
EICHSQWTGR HDAFEILVEL LQALVLCLDG INSDTNIRWN NYIAGRAFVL CSAVSDFDFI 
VTIVVLKNVL SFTRAFGKNL QGQTSDVFFA AGSLTAVLHS LNEVMENIEV YHEFWFEEAT 
NLATKLDIQM KLPGKFRRAH QGNLESQLTS ESYYKETLSV PTVEHIIQEL KDIFSEQHLK 
ALKCLSLVPS VMGQLKFNTS EEHHADMYRS DLPNPDTLSA ELHCWRIKWK HRGKDIELPS 
TIYEALHLPD IKFFPNVYAL LKVLCILPVM KVENERYENG RKRLKAYLRN TLTDQRSSNL 
ALLNINFDIK HDLDLMVDTY IKLYTSKSEL PTDNSETVEN T

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.