Details for: PROS1

Gene ID: 5627

Symbol: PROS1

Ensembl ID: ENSG00000184500

Description: protein S

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 184.8980
    Cell Significance Index: -28.7600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 113.5058
    Cell Significance Index: -28.7900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 71.2469
    Cell Significance Index: -29.3500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 63.3835
    Cell Significance Index: -25.7500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 61.5306
    Cell Significance Index: -29.0500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 57.3111
    Cell Significance Index: -29.4800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 43.4561
    Cell Significance Index: -29.1600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 26.8973
    Cell Significance Index: -25.6800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.3504
    Cell Significance Index: -28.7900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.2976
    Cell Significance Index: -18.1600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.2807
    Cell Significance Index: -28.7300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 5.4791
    Cell Significance Index: 92.3000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 4.9344
    Cell Significance Index: 79.1700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 3.5986
    Cell Significance Index: 59.3000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 2.9118
    Cell Significance Index: 42.2800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.5901
    Cell Significance Index: 55.3700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.9011
    Cell Significance Index: 188.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.8231
    Cell Significance Index: 361.8100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.7594
    Cell Significance Index: 286.1500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1746
    Cell Significance Index: 127.7600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.1633
    Cell Significance Index: 16.6700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1340
    Cell Significance Index: 68.0800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.9048
    Cell Significance Index: 17.6600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.8687
    Cell Significance Index: 45.2500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.7497
    Cell Significance Index: 42.0700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6424
    Cell Significance Index: 49.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6406
    Cell Significance Index: 128.5000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.5983
    Cell Significance Index: 8.6100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.5339
    Cell Significance Index: 8.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5095
    Cell Significance Index: 69.9700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5039
    Cell Significance Index: 180.7300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4129
    Cell Significance Index: 372.8000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3645
    Cell Significance Index: 25.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2934
    Cell Significance Index: 13.3000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2711
    Cell Significance Index: 3.0800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2442
    Cell Significance Index: 12.3400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.1892
    Cell Significance Index: 2.7200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1507
    Cell Significance Index: 4.3200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1457
    Cell Significance Index: 274.2500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1400
    Cell Significance Index: 3.5000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1239
    Cell Significance Index: 3.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1230
    Cell Significance Index: 7.5600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1181
    Cell Significance Index: 22.4800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1175
    Cell Significance Index: 74.6000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1091
    Cell Significance Index: 1.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1006
    Cell Significance Index: 2.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0916
    Cell Significance Index: 41.5600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0901
    Cell Significance Index: 62.3100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0756
    Cell Significance Index: 9.7000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0478
    Cell Significance Index: 0.3900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0440
    Cell Significance Index: 1.9500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0363
    Cell Significance Index: 2.2900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0214
    Cell Significance Index: 9.4500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0206
    Cell Significance Index: 31.7900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0134
    Cell Significance Index: 0.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0003
    Cell Significance Index: -0.2300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0009
    Cell Significance Index: -1.2900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0035
    Cell Significance Index: -1.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0052
    Cell Significance Index: -0.9400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0077
    Cell Significance Index: -4.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0102
    Cell Significance Index: -18.7700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0170
    Cell Significance Index: -12.6200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0206
    Cell Significance Index: -11.6300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0352
    Cell Significance Index: -0.7500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0377
    Cell Significance Index: -27.6500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0694
    Cell Significance Index: -19.9600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0739
    Cell Significance Index: -4.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0746
    Cell Significance Index: -10.8500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0812
    Cell Significance Index: -17.1000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0894
    Cell Significance Index: -2.5500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0968
    Cell Significance Index: -16.5300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1057
    Cell Significance Index: -12.3200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1311
    Cell Significance Index: -16.1200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1320
    Cell Significance Index: -5.0000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1486
    Cell Significance Index: -15.1800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1509
    Cell Significance Index: -3.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1828
    Cell Significance Index: -20.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2190
    Cell Significance Index: -28.2900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2227
    Cell Significance Index: -3.1700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2338
    Cell Significance Index: -26.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2385
    Cell Significance Index: -24.8300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2420
    Cell Significance Index: -4.0700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2474
    Cell Significance Index: -4.1400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2545
    Cell Significance Index: -30.0100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2660
    Cell Significance Index: -8.5200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2784
    Cell Significance Index: -19.6900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3505
    Cell Significance Index: -27.7600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3515
    Cell Significance Index: -5.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3528
    Cell Significance Index: -16.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3781
    Cell Significance Index: -28.1800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3959
    Cell Significance Index: -9.5000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4129
    Cell Significance Index: -11.5400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4207
    Cell Significance Index: -6.3400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4347
    Cell Significance Index: -11.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4638
    Cell Significance Index: -29.9200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4669
    Cell Significance Index: -8.2500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4872
    Cell Significance Index: -29.8700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4982
    Cell Significance Index: -3.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5203
    Cell Significance Index: -27.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5261
    Cell Significance Index: -27.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Vitamin K-dependent**: Protein S requires vitamin K for its post-translational modification, specifically gamma-carboxylation, which is essential for its function. 2. **Serine proteinase inhibitor**: Protein S inhibits the activity of serine proteases, such as thrombin, factor Xa, and factor IXa, thereby regulating blood coagulation. 3. **Anticoagulant pathway**: Protein S works in conjunction with protein C to prevent excessive thrombin formation and maintain normal blood clotting. 4. **Complement cascade regulation**: Protein S also regulates the complement cascade, a part of the innate immune system that helps eliminate pathogens. **Pathways and Functions** 1. **Blood coagulation**: Protein S inhibits the activity of serine proteases, such as thrombin, factor Xa, and factor IXa, thereby regulating blood coagulation. 2. **Complement cascade**: Protein S regulates the complement cascade, a part of the innate immune system that helps eliminate pathogens. 3. **Endopeptidase inhibition**: Protein S inhibits the activity of endopeptidases, such as factor Xa, thereby regulating blood coagulation. 4. **Cell surface interactions**: Protein S interacts with cell surface receptors, such as the protease-activated receptor 1 (PAR1), to regulate cell signaling and aggregation. 5. **Gamma-carboxylation and hypusinylation**: Protein S undergoes gamma-carboxylation and hypusinylation, post-translational modifications that are essential for its function. **Clinical Significance** 1. **Thrombophilia**: Mutations in the PROS1 gene can lead to thrombophilia, a condition characterized by an increased risk of blood clots. 2. **Anticoagulant deficiency**: Protein S deficiency can lead to an increased risk of blood clots, particularly in patients with cancer or inflammatory disorders. 3. **Cancer**: Protein S has been implicated in cancer progression and metastasis, as it can regulate cell signaling and aggregation. 4. **Cardiovascular disease**: Protein S has been linked to cardiovascular disease, as it can regulate blood coagulation and inflammation. 5. **Neurological disorders**: Protein S has been implicated in neurological disorders, such as Alzheimer's disease and stroke, as it can regulate blood coagulation and inflammation. In conclusion, the PROS1 gene encodes a critical protein that plays a central role in regulating blood coagulation and the complement cascade. Mutations in this gene can lead to thrombophilia and an increased risk of blood clots, highlighting the importance of protein S in maintaining normal cardiovascular and immune function.

Genular Protein ID: 764541020

Symbol: PROS_HUMAN

Name: Vitamin K-dependent protein S

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2820795

Title: Human protein S cDNA encodes Phe-16 and Tyr 222 in consensus sequences for the post-translational processing.

PubMed ID: 2820795

DOI: 10.1016/0014-5793(87)80217-x

PubMed ID: 3467362

Title: Cloning and characterization of human liver cDNA encoding a protein S precursor.

PubMed ID: 3467362

DOI: 10.1073/pnas.84.2.349

PubMed ID: 2148110

Title: Organization of the human protein S genes.

PubMed ID: 2148110

DOI: 10.1021/bi00486a010

PubMed ID: 2148111

Title: Intron-exon organization of the active human protein S gene PS alpha and its pseudogene PS beta: duplication and silencing during primate evolution.

PubMed ID: 2148111

DOI: 10.1021/bi00486a011

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2944113

Title: Isolation and sequence of the cDNA for human protein S, a regulator of blood coagulation.

PubMed ID: 2944113

DOI: 10.1073/pnas.83.18.6716

PubMed ID: 7482398

Title: Identification of eight point mutations in protein S deficiency type I -- analysis of 15 pedigrees.

PubMed ID: 7482398

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 15952784

Title: Solution structure of the Ca2+-binding EGF3-4 pair from vitamin K-dependent protein S: identification of an unusual fold in EGF3.

PubMed ID: 15952784

DOI: 10.1021/bi050101f

PubMed ID: 2143091

Title: Heerlen polymorphism of protein S, an immunologic polymorphism due to dimorphism of residue 460.

PubMed ID: 2143091

PubMed ID: 8298131

Title: Protein S Tokushima: abnormal molecule with a substitution of Glu for Lys-155 in the second epidermal growth factor-like domain of protein S.

PubMed ID: 8298131

PubMed ID: 7803790

Title: Identification of 15 different candidate causal point mutations and three polymorphisms in 19 patients with protein S deficiency using a scanning method for the analysis of the protein S active gene.

PubMed ID: 7803790

PubMed ID: 7545463

Title: Detection and characterization of seven novel protein S (PROS) gene lesions: evaluation of reverse transcript-polymerase chain reaction as a mutation screening strategy.

PubMed ID: 7545463

PubMed ID: 7579449

Title: Protein S deficiency type I: identification of point mutations in 9 of 10 families.

PubMed ID: 7579449

PubMed ID: 8977443

Title: Identification of two novel point mutations in the human protein S gene associated with familial protein S deficiency and thrombosis.

PubMed ID: 8977443

DOI: 10.1161/01.atv.16.12.1407

PubMed ID: 8639833

Title: Molecular basis of a hereditary type I protein S deficiency caused by a substitution of Cys for Arg474.

PubMed ID: 8639833

PubMed ID: 8781426

Title: Molecular basis of protein S deficiency in three families also showing independent inheritance of factor V Leiden.

PubMed ID: 8781426

PubMed ID: 8943854

Title: Identification of 19 protein S gene mutations in patients with phenotypic protein S deficiency and thrombosis.

PubMed ID: 8943854

PubMed ID: 8765219

Title: Molecular basis for protein S hereditary deficiency: genetic defects observed in 118 patients with type I and type IIa deficiencies.

PubMed ID: 8765219

DOI: 10.1016/s0022-2143(96)90015-3

PubMed ID: 8701404

Title: Five novel mutations of the protein S active gene (PROS 1) in 8 Norman families.

PubMed ID: 8701404

PubMed ID: 9031443

Title: Identification of three novel mutations in hereditary protein S deficiency.

PubMed ID: 9031443

PubMed ID: 9241758

Title: Protein S deficiency: a database of mutations.

PubMed ID: 9241758

PubMed ID: 10447256

Title: Protein S gene analysis reveals the presence of a cosegregating mutation in most pedigrees with type I but not type III PS deficiency.

PubMed ID: 10447256

DOI: 10.1002/(sici)1098-1004(1999)14:1<30::aid-humu4>3.0.co;2-x

PubMed ID: 10613647

Title: Poor relationship between phenotypes of protein S deficiency and mutations in the protein S alpha gene.

PubMed ID: 10613647

PubMed ID: 10706858

Title: Genetic analysis, phenotypic diagnosis, and risk of venous thrombosis in families with inherited deficiencies of protein S.

PubMed ID: 10706858

PubMed ID: 10790208

Title: Optimization of a simple and rapid single-strand conformation analysis for detection of mutations in the PROS1 gene: identification of seven novel mutations and three novel, apparently neutral, variants.

PubMed ID: 10790208

DOI: 10.1002/(sici)1098-1004(200005)15:5<463::aid-humu8>3.0.co;2-e

PubMed ID: 11372770

Title: DNA sequence analysis of protein S deficiency -- identification of four point mutations in twelve Japanese subjects.

PubMed ID: 11372770

DOI: 10.1055/s-2001-14075

PubMed ID: 11776305

Title: Characterization and structural impact of five novel PROS1 mutations in eleven protein S-deficient families.

PubMed ID: 11776305

PubMed ID: 12351389

Title: Protein S Gla-domain mutations causing impaired Ca(2+)-induced phospholipid binding and severe functional protein S deficiency.

PubMed ID: 12351389

DOI: 10.1182/blood-2002-03-0909

PubMed ID: 11858485

Title: Genetic and phenotypic variability between families with hereditary protein S deficiency.

PubMed ID: 11858485

DOI: 10.1055/s-0037-1612982

PubMed ID: 11927129

Title: Four missense mutations identified in the protein S gene of thrombosis patients with protein S deficiency: effects on secretion and anticoagulant activity of protein S.

PubMed ID: 11927129

DOI: 10.1016/s0049-3848(02)00015-4

PubMed ID: 12632031

Title: Familial thrombophilia is an oligogenetic disease: involvement of the prothrombin G20210A, PROC and PROS gene mutations.

PubMed ID: 12632031

DOI: 10.1097/01.mbc.0000046180.72384.39

PubMed ID: 15238143

Title: Identification of protein Salpha gene mutations including four novel mutations in eight unrelated patients with protein S deficiency.

PubMed ID: 15238143

DOI: 10.1111/j.1365-2141.2004.05026.x

PubMed ID: 15712227

Title: Molecular diversity and thrombotic risk in protein S deficiency: the PROSIT study.

PubMed ID: 15712227

DOI: 10.1002/humu.20136

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 18322254

Title: Functional characterization of twelve natural PROS1 mutations associated with anticoagulant protein S deficiency.

PubMed ID: 18322254

DOI: 10.3324/haematol.12090

PubMed ID: 20484936

Title: Intracerebral mass bleeding in a term neonate: manifestation of hereditary protein S deficiency with a new mutation in the PROS1 gene.

PubMed ID: 20484936

DOI: 10.1159/000298282

PubMed ID: 27535533

Title: Analysis of protein-coding genetic variation in 60,706 humans.

PubMed ID: 27535533

DOI: 10.1038/nature19057

Sequence Information:

  • Length: 676
  • Mass: 75123
  • Checksum: 2B88A04F85403F25
  • Sequence:
  • MRVLGGRCGA LLACLLLVLP VSEANFLSKQ QASQVLVRKR RANSLLEETK QGNLERECIE 
    ELCNKEEARE VFENDPETDY FYPKYLVCLR SFQTGLFTAA RQSTNAYPDL RSCVNAIPDQ 
    CSPLPCNEDG YMSCKDGKAS FTCTCKPGWQ GEKCEFDINE CKDPSNINGG CSQICDNTPG 
    SYHCSCKNGF VMLSNKKDCK DVDECSLKPS ICGTAVCKNI PGDFECECPE GYRYNLKSKS 
    CEDIDECSEN MCAQLCVNYP GGYTCYCDGK KGFKLAQDQK SCEVVSVCLP LNLDTKYELL 
    YLAEQFAGVV LYLKFRLPEI SRFSAEFDFR TYDSEGVILY AESIDHSAWL LIALRGGKIE 
    VQLKNEHTSK ITTGGDVINN GLWNMVSVEE LEHSISIKIA KEAVMDINKP GPLFKPENGL 
    LETKVYFAGF PRKVESELIK PINPRLDGCI RSWNLMKQGA SGIKEIIQEK QNKHCLVTVE 
    KGSYYPGSGI AQFHIDYNNV SSAEGWHVNV TLNIRPSTGT GVMLALVSGN NTVPFAVSLV 
    DSTSEKSQDI LLSVENTVIY RIQALSLCSD QQSHLEFRVN RNNLELSTPL KIETISHEDL 
    QRQLAVLDKA MKAKVATYLG GLPDVPFSAT PVNAFYNGCM EVNINGVQLD LDEAISKHND 
    IRAHSCPSVW KKTKNS

Genular Protein ID: 3927980759

Symbol: A0A0S2Z4L3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 708
  • Mass: 78854
  • Checksum: 7019A63DD3043AB2
  • Sequence:
  • MRVLGGRCGA LLACLLLVLP VSEANFCLYF RNDFIYNRAC ISVLVGLSGC NFFYSICFLS 
    KQQASQVLVR KRRANSLLEE TKQGNLEREC IEELCNKEEA REVFENDPET DYFYPKYLVC 
    LRSFQTGLFT AARQSTNAYP DLRSCVNAIP DQCSPLPCNE DGYMSCKDGK ASFTCTCKPG 
    WQGEKCEFDI NECKDPSNIN GGCSQICDNT PGSYHCSCKN GFVMLSNKKD CKDVDECSLK 
    PSICGTAVCK NIPGDFECEC PEGYRYNLKS KSCEDIDECS ENMCAQLCVN YPGGYTCYCD 
    GKKGFKLAQD QKSCEVVSVC LPLNLDTKYE LLYLAEQFAG VVLYLKFRLP EISRFSAEFD 
    FRTYDSEGVI LYAESIDHSA WLLIALRGGK IEVQLKNEHT SKITTGGDVI NNGLWNMVSV 
    EELEHSISIK IAKEAVMDIN KPGPLFKPEN GLLETKVYFA GFPRKVESEL IKPINPRLDG 
    CIRSWNLMKQ GASGIKEIIQ EKQNKHCLVT VEKGSYYPGS GIAQFHIDYN NVSSAEGWHV 
    NVTLNIRPST GTGVMLALVS GNNTVPFAVS LVDSTSEKSQ DILLSVENTV IYRIQALSLC 
    SDQQSHLEFR VNRNNLELST PLKIETISHE DLQRQLAVLD KAMKAKVATY LGGLPDVPFS 
    ATPVNAFYNG CMEVNINGVQ LDLDEAISKH NDIRAHSCPS VWKKTKNS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.