Details for: PRTN3

Gene ID: 5657

Symbol: PRTN3

Ensembl ID: ENSG00000196415

Description: proteinase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 6.6912
    Cell Significance Index: 44.3900
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 6.0514
    Cell Significance Index: 38.6300
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 5.3039
    Cell Significance Index: -0.8300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.8791
    Cell Significance Index: 21.3000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.5833
    Cell Significance Index: 10.0600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 0.4131
    Cell Significance Index: -1.6300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.2036
    Cell Significance Index: 3.2300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 0.1183
    Cell Significance Index: -0.0300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.1031
    Cell Significance Index: 1.0200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.0741
    Cell Significance Index: 0.6300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 0.0730
    Cell Significance Index: -0.0900
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.0464
    Cell Significance Index: 0.5300
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0340
    Cell Significance Index: 0.4300
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.0216
    Cell Significance Index: 0.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0191
    Cell Significance Index: 3.8300
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: 0.0184
    Cell Significance Index: 0.1000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0123
    Cell Significance Index: 0.3100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0117
    Cell Significance Index: 1.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0041
    Cell Significance Index: 0.7400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0026
    Cell Significance Index: 1.4000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0010
    Cell Significance Index: 0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0005
    Cell Significance Index: -0.8500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0006
    Cell Significance Index: -1.0000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0009
    Cell Significance Index: -1.2100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0014
    Cell Significance Index: -0.0300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0017
    Cell Significance Index: -0.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0021
    Cell Significance Index: -1.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0022
    Cell Significance Index: -0.9900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0023
    Cell Significance Index: -1.4900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0023
    Cell Significance Index: -1.7300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0029
    Cell Significance Index: -1.0300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0030
    Cell Significance Index: -0.4100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0034
    Cell Significance Index: -0.1400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0035
    Cell Significance Index: -0.0500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0040
    Cell Significance Index: -1.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0053
    Cell Significance Index: -0.9100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0057
    Cell Significance Index: -1.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0067
    Cell Significance Index: -0.1900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0067
    Cell Significance Index: -0.1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0079
    Cell Significance Index: -1.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0079
    Cell Significance Index: -0.9000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0085
    Cell Significance Index: -0.3700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0087
    Cell Significance Index: -1.8300
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0093
    Cell Significance Index: -0.1100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0096
    Cell Significance Index: -0.1400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0105
    Cell Significance Index: -0.5500
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0116
    Cell Significance Index: -0.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0123
    Cell Significance Index: -1.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0123
    Cell Significance Index: -0.6400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0126
    Cell Significance Index: -1.2900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0126
    Cell Significance Index: -0.9400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0126
    Cell Significance Index: -0.5900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0127
    Cell Significance Index: -1.6400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0133
    Cell Significance Index: -1.3900
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: -0.0154
    Cell Significance Index: -0.1300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0167
    Cell Significance Index: -0.7400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0195
    Cell Significance Index: -0.5300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0206
    Cell Significance Index: -0.3300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0207
    Cell Significance Index: -0.5600
  • Cell Name: immature neutrophil (CL0000776)
    Fold Change: -0.0223
    Cell Significance Index: -0.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0224
    Cell Significance Index: -0.8500
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0233
    Cell Significance Index: -0.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0234
    Cell Significance Index: -1.1000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0246
    Cell Significance Index: -0.3500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0247
    Cell Significance Index: -0.8100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0248
    Cell Significance Index: -1.3900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0255
    Cell Significance Index: -0.6500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0259
    Cell Significance Index: -1.6700
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: -0.0263
    Cell Significance Index: -0.2600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0268
    Cell Significance Index: -0.9400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0271
    Cell Significance Index: -0.5400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0277
    Cell Significance Index: -0.5400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0292
    Cell Significance Index: -0.6400
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.0294
    Cell Significance Index: -0.4000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0295
    Cell Significance Index: -0.9400
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.0299
    Cell Significance Index: -0.3300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0301
    Cell Significance Index: -0.6300
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0330
    Cell Significance Index: -0.4200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0338
    Cell Significance Index: -1.2400
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0338
    Cell Significance Index: -0.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0342
    Cell Significance Index: -1.2000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0345
    Cell Significance Index: -0.8600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0358
    Cell Significance Index: -0.3700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0363
    Cell Significance Index: -1.2600
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0394
    Cell Significance Index: -0.4300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0402
    Cell Significance Index: -0.3700
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0402
    Cell Significance Index: -0.5500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0409
    Cell Significance Index: -1.2100
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.0415
    Cell Significance Index: -0.4800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0432
    Cell Significance Index: -1.2500
  • Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
    Fold Change: -0.0438
    Cell Significance Index: -0.5200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0481
    Cell Significance Index: -1.3800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0485
    Cell Significance Index: -0.6800
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0489
    Cell Significance Index: -0.6200
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0493
    Cell Significance Index: -0.4400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0499
    Cell Significance Index: -1.0600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0511
    Cell Significance Index: -0.8600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0523
    Cell Significance Index: -1.1300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0524
    Cell Significance Index: -1.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Serine-type peptidase activity**: PRTN3 is a serine protease that catalyzes the hydrolysis of peptide bonds, releasing smaller peptides and amino acids from larger protein substrates. 2. **Intracellular localization**: PRTN3 is primarily found in intracellular compartments, such as azurophil granules in neutrophils and lysosomes in other cells. 3. **Cell-type specificity**: PRTN3 is expressed in various cell types, including immune cells (e.g., neutrophils, monocytes, dendritic cells), endothelial cells, and epithelial cells. 4. **Regulatory functions**: PRTN3 has been implicated in negative regulation of phagocytosis, neutrophil degranulation, and cell population proliferation. 5. **Antimicrobial properties**: PRTN3 has been shown to possess antimicrobial activity against certain bacteria and fungi, suggesting a potential role in innate immunity. **Pathways and Functions** 1. **Antimicrobial humoral response**: PRTN3 is involved in the innate immune response, where it contributes to the antimicrobial activity of neutrophils and other immune cells. 2. **Neutrophil degranulation**: PRTN3 regulates the degranulation process in neutrophils, controlling the release of antimicrobial peptides and other inflammatory mediators. 3. **Cell-cell junction maintenance**: PRTN3 has been implicated in the regulation of cell-cell junctions, particularly in endothelial cells, where it may contribute to the maintenance of tissue integrity. 4. **Cytokine signaling**: PRTN3 interacts with cytokine receptors, modulating the signaling pathways involved in immune responses and inflammation. 5. **Fibrin clot formation**: PRTN3 is involved in the common pathway of fibrin clot formation, contributing to the regulation of blood coagulation. **Clinical Significance** 1. **Inflammatory diseases**: PRTN3 has been implicated in various inflammatory diseases, including rheumatoid arthritis, atherosclerosis, and cancer. 2. **Neutropenia**: Abnormalities in PRTN3 expression or function have been linked to neutropenia, a condition characterized by an abnormally low count of neutrophils. 3. **Cancer**: PRTN3 has been identified as a potential biomarker for cancer, particularly in lung and breast cancers, where it may play a role in tumor progression and metastasis. 4. **Thrombosis**: PRTN3 has been implicated in the regulation of blood coagulation, and abnormalities in its expression or function may contribute to thrombotic events. In conclusion, PRTN3 is a multifunctional protein with significant implications for various physiological and pathological processes, including inflammation, immune response, and cell signaling. Further research is necessary to fully elucidate the mechanisms of PRTN3's functions and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 673592150

Symbol: PRTN3_HUMAN

Name: Myeloblastin

UniProtKB Accession Codes:

P24158 P15637 P18078 Q4VB08 Q4VB09 Q6LBM7 Q6LBN2 Q9UD25 Q9UQD8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 1 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 1 EMBL 16 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 1 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1681549

Title: Wegener autoantigen and myeloblastin are encoded by a single mRNA.

PubMed ID: 1681549

DOI: 10.1073/pnas.88.20.9253

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1518849

Title: Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter.

PubMed ID: 1518849

DOI: 10.1073/pnas.89.17.8215

PubMed ID: 1400430

Title: Structure, chromosomal assignment, and expression of the gene for proteinase-3. The Wegener's granulomatosis autoantigen.

PubMed ID: 1400430

DOI: 10.1016/s0021-9258(19)36816-4

PubMed ID: 9924693

Title: Donor-recipient polymorphism of the proteinase 3 gene: a potential target for T-cell alloresponses to myeloid leukemia.

PubMed ID: 9924693

DOI: 10.1097/00002371-199901000-00001

PubMed ID: 2001463

Title: Wegener's autoantigen and leukemia.

PubMed ID: 2001463

PubMed ID: 2258701

Title: Cloning of cDNA for proteinase 3: a serine protease, antibiotic, and autoantigen from human neutrophils.

PubMed ID: 2258701

DOI: 10.1084/jem.172.6.1709

PubMed ID: 2598267

Title: Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells.

PubMed ID: 2598267

DOI: 10.1016/0092-8674(89)90752-6

PubMed ID: 2377228

Title: Wegener's autoantigen decoded.

PubMed ID: 2377228

DOI: 10.1038/346520a0

PubMed ID: 2033050

Title: Characterization of proteinase-3 (PR-3), a neutrophil serine proteinase. Structural and functional properties.

PubMed ID: 2033050

DOI: 10.1016/s0021-9258(18)92854-1

PubMed ID: 2404977

Title: Characterization of two azurphil granule proteases with active-site homology to neutrophil elastase.

PubMed ID: 2404977

DOI: 10.1016/s0021-9258(19)39936-3

PubMed ID: 2121162

Title: Monoclonal antibodies specific for neutrophil proteinase 4. Production and use for isolation of the enzyme.

PubMed ID: 2121162

DOI: 10.1515/bchm3.1990.371.2.549

PubMed ID: 2285532

Title: The relation of 29 kD C-ANCA antigen to proteinase 3.

PubMed ID: 2285532

DOI: 10.1111/j.1600-0463.1990.tb05713.x

PubMed ID: 2679910

Title: Wegener's granulomatosis autoantigen is a novel neutrophil serine proteinase.

PubMed ID: 2679910

PubMed ID: 2501794

Title: Antibiotic proteins of human polymorphonuclear leukocytes.

PubMed ID: 2501794

DOI: 10.1073/pnas.86.14.5610

PubMed ID: 7897245

Title: Use of proteinase 3 purified by reverse phase HPLC to detect autoantibodies in systemic vasculitis.

PubMed ID: 7897245

DOI: 10.1016/0022-1759(94)00295-8

PubMed ID: 1688612

Title: Anti-neutrophil cytoplasm antibodies in Wegener's granulomatosis recognize an elastinolytic enzyme.

PubMed ID: 1688612

DOI: 10.1084/jem.171.1.357

PubMed ID: 7539799

Title: A novel form of dipeptidylpeptidase IV found in human serum. Isolation, characterization, and comparison with T lymphocyte membrane dipeptidylpeptidase IV (CD26).

PubMed ID: 7539799

DOI: 10.1074/jbc.270.23.14107

PubMed ID: 3198760

Title: Proteinase 3. A distinct human polymorphonuclear leukocyte proteinase that produces emphysema in hamsters.

PubMed ID: 3198760

DOI: 10.1172/jci113816

PubMed ID: 2242436

Title: Identity of Wegener's autoantigen (p29) with proteinase 3 and myeloblastin.

PubMed ID: 2242436

PubMed ID: 17244676

Title: NB1 mediates surface expression of the ANCA antigen proteinase 3 on human neutrophils.

PubMed ID: 17244676

DOI: 10.1182/blood-2006-10-055327

PubMed ID: 18462208

Title: Neutrophil surface presentation of the anti-neutrophil cytoplasmic antibody-antigen proteinase 3 depends on N-terminal processing.

PubMed ID: 18462208

DOI: 10.1111/j.1365-2249.2008.03663.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21193407

Title: Complement receptor Mac-1 is an adaptor for NB1 (CD177)-mediated PR3-ANCA neutrophil activation.

PubMed ID: 21193407

DOI: 10.1074/jbc.m110.171256

PubMed ID: 22266279

Title: Proteinase 3 contributes to transendothelial migration of NB1-positive neutrophils.

PubMed ID: 22266279

DOI: 10.4049/jimmunol.1102540

PubMed ID: 23202369

Title: Neutrophil proteinase 3 acts on protease-activated receptor-2 to enhance vascular endothelial cell barrier function.

PubMed ID: 23202369

DOI: 10.1161/atvbaha.112.300474

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28240246

Title: Characterization of the CD177 interaction with the ANCA antigen proteinase 3.

PubMed ID: 28240246

DOI: 10.1038/srep43328

PubMed ID: 30692621

Title: SERPINB1-mediated checkpoint of inflammatory caspase activation.

PubMed ID: 30692621

DOI: 10.1038/s41590-018-0303-z

PubMed ID: 8757293

Title: The crystal structure of PR3, a neutrophil serine proteinase antigen of Wegener's granulomatosis antibodies.

PubMed ID: 8757293

DOI: 10.1006/jmbi.1996.0458

Sequence Information:

  • Length: 256
  • Mass: 27807
  • Checksum: CBECA36D8C4B2A40
  • Sequence:
    • MAHRPPSPAL ASVLLALLLS GAARAAEIVG GHEAQPHSRP YMASLQMRGN PGSHFCGGTL 
IHPSFVLTAA HCLRDIPQRL VNVVLGAHNV RTQEPTQQHF SVAQVFLNNY DAENKLNDVL 
LIQLSSPANL SASVATVQLP QQDQPVPHGT QCLAMGWGRV GAHDPPAQVL QELNVTVVTF 
FCRPHNICTF VPRRKAGICF GDSGGPLICD GIIQGIDSFV IWGCATRLFP DFFTRVALYV 
DWIRSTLRRV EAKGRP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.