Details for: PSD

Gene ID: 5662

Symbol: PSD

Ensembl ID: ENSG00000059915

Description: pleckstrin and Sec7 domain containing

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 87.3701
    Cell Significance Index: -13.5900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 54.0128
    Cell Significance Index: -13.7000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 27.0641
    Cell Significance Index: -11.0000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.0791
    Cell Significance Index: -13.6600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.3823
    Cell Significance Index: -13.4600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 3.0151
    Cell Significance Index: 190.0300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.8296
    Cell Significance Index: 52.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7872
    Cell Significance Index: 358.5200
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.7617
    Cell Significance Index: 9.2700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.4669
    Cell Significance Index: 32.1200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.2922
    Cell Significance Index: 9.9600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.1419
    Cell Significance Index: 76.7800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.9379
    Cell Significance Index: 35.5200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.9219
    Cell Significance Index: 40.7800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.8820
    Cell Significance Index: 10.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6955
    Cell Significance Index: 249.4800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6149
    Cell Significance Index: 37.8000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5304
    Cell Significance Index: 52.4700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4621
    Cell Significance Index: 417.2600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.3607
    Cell Significance Index: 8.6500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.3543
    Cell Significance Index: 4.3000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3108
    Cell Significance Index: 42.6800
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.2907
    Cell Significance Index: 2.2300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2727
    Cell Significance Index: 44.3600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2538
    Cell Significance Index: 27.6100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2484
    Cell Significance Index: 13.0400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2161
    Cell Significance Index: 41.1300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1923
    Cell Significance Index: 4.1000
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.1735
    Cell Significance Index: 2.2500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1643
    Cell Significance Index: 9.8700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1474
    Cell Significance Index: 101.9500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0786
    Cell Significance Index: 5.4400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0629
    Cell Significance Index: 0.7500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0589
    Cell Significance Index: 2.6700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0569
    Cell Significance Index: 1.6400
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.0431
    Cell Significance Index: 0.4100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0286
    Cell Significance Index: 0.4900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0208
    Cell Significance Index: 0.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0193
    Cell Significance Index: 10.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0105
    Cell Significance Index: 1.9000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0023
    Cell Significance Index: 4.1800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0022
    Cell Significance Index: 0.0600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0018
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0018
    Cell Significance Index: -1.3000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0024
    Cell Significance Index: -3.6700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0026
    Cell Significance Index: -4.8400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0054
    Cell Significance Index: -7.4100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0111
    Cell Significance Index: -4.9000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0148
    Cell Significance Index: -1.9000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0149
    Cell Significance Index: -8.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0157
    Cell Significance Index: -9.9700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0160
    Cell Significance Index: -11.7000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0175
    Cell Significance Index: -13.2700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0180
    Cell Significance Index: -3.5700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0221
    Cell Significance Index: -13.7900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0252
    Cell Significance Index: -11.4600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0316
    Cell Significance Index: -0.6900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0377
    Cell Significance Index: -10.8400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0391
    Cell Significance Index: -0.5600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0457
    Cell Significance Index: -0.9700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0510
    Cell Significance Index: -10.7500
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0511
    Cell Significance Index: -0.4500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0531
    Cell Significance Index: -6.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0547
    Cell Significance Index: -7.9500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0567
    Cell Significance Index: -9.6800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0690
    Cell Significance Index: -8.0400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0735
    Cell Significance Index: -1.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0809
    Cell Significance Index: -4.5400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0830
    Cell Significance Index: -2.3200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0886
    Cell Significance Index: -2.5400
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0890
    Cell Significance Index: -0.7400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0900
    Cell Significance Index: -0.9800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0978
    Cell Significance Index: -12.6400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1041
    Cell Significance Index: -10.6300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1064
    Cell Significance Index: -12.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1079
    Cell Significance Index: -12.3600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1107
    Cell Significance Index: -3.6300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1141
    Cell Significance Index: -2.2900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1272
    Cell Significance Index: -4.0500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1291
    Cell Significance Index: -13.4400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1376
    Cell Significance Index: -2.7200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1412
    Cell Significance Index: -2.9300
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.1420
    Cell Significance Index: -2.0000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1452
    Cell Significance Index: -1.8600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1534
    Cell Significance Index: -12.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1586
    Cell Significance Index: -12.1700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1674
    Cell Significance Index: -11.8400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1688
    Cell Significance Index: -12.5800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1689
    Cell Significance Index: -5.4100
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1766
    Cell Significance Index: -2.0600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1833
    Cell Significance Index: -4.8200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1854
    Cell Significance Index: -4.0100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1872
    Cell Significance Index: -8.7300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1951
    Cell Significance Index: -12.5900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1968
    Cell Significance Index: -4.9200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2021
    Cell Significance Index: -2.5200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2055
    Cell Significance Index: -10.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2085
    Cell Significance Index: -10.8300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2121
    Cell Significance Index: -5.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2217
    Cell Significance Index: -10.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Domain structure:** The PSD gene encodes a protein with a pleckstrin homology domain and a Sec7 domain, which are essential for its interactions with phospholipids and guanyl-nucleotide exchange factors, respectively. 2. **Cellular localization:** PSD proteins are predominantly found in postsynaptic densities, dendritic spines, and ruffles, indicating their involvement in synaptic plasticity and neuronal development. 3. **Expression pattern:** PSD proteins are expressed in a wide range of cell types, including kidney proximal convoluted tubule epithelial cells, smooth muscle cells, endocrine cells, and various neurons, underscoring their pleiotropic functions. **Pathways and Functions:** 1. **Guanyl-nucleotide exchange factor activity:** PSD proteins interact with guanyl-nucleotide exchange factors (GEFs), facilitating the exchange of GDP for GTP in small GTPases, such as ARF6. This interaction regulates membrane trafficking, endocytosis, and exocytosis. 2. **Phospholipid binding:** PSD proteins bind to phospholipids, modulating membrane dynamics and influencing signaling pathways, including those involved in neuronal development and synaptic plasticity. 3. **Regulation of ARF protein signal transduction:** PSD proteins interact with ARF proteins, regulating their activity and influencing membrane trafficking, endocytosis, and exocytosis. 4. **Neuron projection development:** PSD proteins are essential for the development and maintenance of neuronal projections, including axons and dendrites. **Clinical Significance:** 1. **Immune regulation:** Alterations in PSD protein expression or function may contribute to immune-related disorders, such as autoimmune diseases or immunodeficiencies. 2. **Neurological disorders:** Dysregulation of PSD proteins has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. 3. **Cancer:** PSD proteins have been shown to play a role in cancer progression, particularly in the context of metastasis and tumor cell migration. 4. **Neurodevelopmental disorders:** PSD proteins are essential for normal neuronal development, and abnormalities in PSD protein expression or function may contribute to neurodevelopmental disorders, such as autism spectrum disorder. In conclusion, the PSD gene is a complex and multifaceted component of the human genome, influencing various cellular processes, including immune regulation, neuronal development, and signaling pathways. Further research is necessary to fully elucidate the mechanisms underlying PSD protein function and its clinical significance in human disease.

Genular Protein ID: 2388436014

Symbol: PSD1_HUMAN

Name: PH and SEC7 domain-containing protein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9417912

Title: Identification of a novel gene, PSD, adjacent to NFKB2/lyt-10, which contains Sec7 and pleckstrin-homology domains.

PubMed ID: 9417912

DOI: 10.1006/geno.1997.5022

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23603394

Title: EFA6 activates Arf6 and participates in its targeting to the Flemming body during cytokinesis.

PubMed ID: 23603394

DOI: 10.1016/j.febslet.2013.03.042

Sequence Information:

  • Length: 1024
  • Mass: 109543
  • Checksum: 74583FEAAB0E4E01
  • Sequence:
  • MAQGAMRFCS EGDCAISPPR CPRRWLPEGP VPQSPPASMY GSTGSLLRRV AGPGPRGREL 
    GRVTAPCTPL RGPPSPRVAP SPWAPSSPTG QPPPGAQSSV VIFRFVEKAS VRPLNGLPAP 
    GGLSRSWDLG GVSPPRPTPA LGPGSNRKLR LEASTSDPLP ARGGSALPGS RNLVHGPPAP 
    PQVGADGLYS SLPNGLGGPP ERLATLFGGP ADTGFLNQGD TWSSPREVSS HAQRIARAKW 
    EFFYGSLDPP SSGAKPPEQA PPSPPGVGSR QGSGVAVGRA AKYSETDLDT VPLRCYRETD 
    IDEVLAEREE ADSAIESQPS SEGPPGTAYP PAPRPGPLPG PHPSLGSGNE DEDDDEAGGE 
    EDVDDEVFEA SEGARPGSRM PLKSPVPFLP GTSPSADGPD SFSCVFEAIL ESHRAKGTSY 
    TSLASLEALA SPGPTQSPFF TFELPPQPPA PRPDPPAPAP LAPLEPDSGT SSAADGPWTQ 
    RGEEEEAEAR AKLAPGREPP SPCHSEDSLG LGAAPLGSEP PLSQLVSDSD SELDSTERLA 
    LGSTDTLSNG QKADLEAAQR LAKRLYRLDG FRKADVARHL GKNNDFSKLV AGEYLKFFVF 
    TGMTLDQALR VFLKELALMG ETQERERVLA HFSQRYFQCN PEALSSEDGA HTLTCALMLL 
    NTDLHGHNIG KRMTCGDFIG NLEGLNDGGD FPRELLKALY SSIKNEKLQW AIDEEELRRS 
    LSELADPNPK VIKRISGGSG SGSSPFLDLT PEPGAAVYKH GALVRKVHAD PDCRKTPRGK 
    RGWKSFHGIL KGMILYLQKE EYKPGKALSE TELKNAISIH HALATRASDY SKRPHVFYLR 
    TADWRVFLFQ APSLEQMQSW ITRINVVAAM FSAPPFPAAV SSQKKFSRPL LPSAATRLSQ 
    EEQVRTHEAK LKAMASELRE HRAAQLGKKG RGKEAEEQRQ KEAYLEFEKS RYSTYAALLR 
    VKLKAGSEEL DAVEAALAQA GSTEDGLPPS HSSPSLQPKP SSQPRAQRHS SEPRPGAGSG 
    RRKP

Genular Protein ID: 1822716364

Symbol: Q86YI3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 927
  • Mass: 99721
  • Checksum: F9E5543BAC3B5A7B
  • Sequence:
  • QIWRCPLQHH AESAPPLPAL SWAQPLLCLS SVSALGEQRP TPALGPGSNR KLRLEASTSD 
    PLPARGGSAL PGSRNLVHGP PAPPQVGADG LYSSLPNGLG GPPERLATLF GGPADTGFMN 
    QGDTWSSPRE VSSHAQRIAR AKWEFFYGSL DPPSSGAKPP EQAPPSPPGV GSRQGSGVAV 
    GRAAKYSETD LDTVPLRCYR ETDIDEVLAE REEADSAIES QPSSEGPPGT AYPPAPRPGP 
    LPGPHPSLGS GNEDEDDDEA GGEEDVDDEV FEASEGARPG SRMPLKSPVP FLPGTSPSAD 
    GPDSFSCVFE AILESHRAKG TSYTSLASLE ALASPGPTQS PFFTFELPPQ PPAPRPDPPA 
    PAPLAPLEPD SGTSSAADGP WTQRGEEEEA EARAKLAPGR EPPSPCHSED SLGLGAAPLG 
    SEPPLSQLVS DSDSELDSTE RLALGSTDTL SNGQKADLEA AQRLAKRLYR LDGFRKADVA 
    RHLGKNNDFS KLVAGEYLKF FVFTGMTLDQ ALRVFLKELA LMGETQERER VLAHFSQRYF 
    QCNPEALSSE DGAHTLTCAL MLLNTDLHGH NIGKRMTCGD FIGNLECLND GGDFPRELLK 
    ALYSSIKNEK LQWAIDEEEL RRSLSELADP NPKVIKRISG GSGSGSSPFL DLTPEPGAAV 
    YKHGALVRKV HADPDCRKTP RGKRGWKSFH GILKGMILYL QKEEYKPGKA LSETELKNAI 
    SIHNALATRA SDYSKRPHVF YLRTADWRVF LFLAPSLEQM QSWITRINVV AAMFSAPPFP 
    AAVSSQKKFS RPLLPSAATR LSQEEQVRTH EAKLKAMASE LREHRAAQLG KKGRGKEAEE 
    QRQKEAYLEF EKSRYSTYAA LLRVKLKAGS EELDAVEAAL AQAGSTEDGL PPSHSSPSLQ 
    PKPSSQPRAQ RHSSEPRPGA GSGRRKP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.