Details for: PSPH

Gene ID: 5723

Symbol: PSPH

Ensembl ID: ENSG00000146733

Description: phosphoserine phosphatase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 93.8634
    Cell Significance Index: -14.6000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 52.0416
    Cell Significance Index: -13.2000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 33.4025
    Cell Significance Index: -13.5700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 32.9364
    Cell Significance Index: -15.5500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.2237
    Cell Significance Index: -13.5800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.1578
    Cell Significance Index: -14.9900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.7263
    Cell Significance Index: -15.3400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.0795
    Cell Significance Index: -12.5300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.8570
    Cell Significance Index: -15.2200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.0516
    Cell Significance Index: -4.4900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0037
    Cell Significance Index: 99.2900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7925
    Cell Significance Index: 47.5800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7445
    Cell Significance Index: 147.7400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7073
    Cell Significance Index: 638.6700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6994
    Cell Significance Index: 18.7400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6822
    Cell Significance Index: 74.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6347
    Cell Significance Index: 127.3200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5742
    Cell Significance Index: 15.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5259
    Cell Significance Index: 85.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.4978
    Cell Significance Index: 143.2200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3955
    Cell Significance Index: 11.4000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3615
    Cell Significance Index: 68.8000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3481
    Cell Significance Index: 26.7200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3291
    Cell Significance Index: 4.4900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3123
    Cell Significance Index: 21.6000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2311
    Cell Significance Index: 82.8900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2248
    Cell Significance Index: 5.9100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2209
    Cell Significance Index: 120.6500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1911
    Cell Significance Index: 5.3400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1777
    Cell Significance Index: 8.0600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1640
    Cell Significance Index: 113.4200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1523
    Cell Significance Index: 17.9600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1268
    Cell Significance Index: 56.0500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1050
    Cell Significance Index: 3.6500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0967
    Cell Significance Index: 17.4400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0686
    Cell Significance Index: 2.4100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0667
    Cell Significance Index: 2.9500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0629
    Cell Significance Index: 1.3400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0620
    Cell Significance Index: 8.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0583
    Cell Significance Index: 3.0300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0471
    Cell Significance Index: 6.0400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0456
    Cell Significance Index: 2.9500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0434
    Cell Significance Index: 1.6500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0377
    Cell Significance Index: 4.6400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0308
    Cell Significance Index: 2.1800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0249
    Cell Significance Index: 1.4000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0242
    Cell Significance Index: 0.2500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0237
    Cell Significance Index: 0.7600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0211
    Cell Significance Index: 39.7600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0158
    Cell Significance Index: 21.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0145
    Cell Significance Index: 26.8000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0127
    Cell Significance Index: 19.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0120
    Cell Significance Index: 0.2600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0058
    Cell Significance Index: 0.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0022
    Cell Significance Index: -1.6600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0028
    Cell Significance Index: -1.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0041
    Cell Significance Index: -0.1100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0090
    Cell Significance Index: -0.1500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0092
    Cell Significance Index: -6.7200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0105
    Cell Significance Index: -1.7900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0150
    Cell Significance Index: -11.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0151
    Cell Significance Index: -6.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0240
    Cell Significance Index: -13.5500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0265
    Cell Significance Index: -1.6300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0266
    Cell Significance Index: -16.6000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0279
    Cell Significance Index: -1.3000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0465
    Cell Significance Index: -3.1300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0480
    Cell Significance Index: -5.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0505
    Cell Significance Index: -5.1600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0539
    Cell Significance Index: -1.2500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0647
    Cell Significance Index: -9.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0753
    Cell Significance Index: -9.7300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0777
    Cell Significance Index: -16.3700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0792
    Cell Significance Index: -4.1600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0827
    Cell Significance Index: -1.8100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0827
    Cell Significance Index: -5.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0860
    Cell Significance Index: -9.8500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1127
    Cell Significance Index: -2.8800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1223
    Cell Significance Index: -3.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1228
    Cell Significance Index: -12.7900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1272
    Cell Significance Index: -9.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1340
    Cell Significance Index: -6.3000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1429
    Cell Significance Index: -8.7600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1560
    Cell Significance Index: -3.9000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1606
    Cell Significance Index: -12.7200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1694
    Cell Significance Index: -2.1700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1865
    Cell Significance Index: -4.9900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1869
    Cell Significance Index: -4.8100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1955
    Cell Significance Index: -2.8000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1987
    Cell Significance Index: -10.3500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2391
    Cell Significance Index: -3.5300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2661
    Cell Significance Index: -4.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2901
    Cell Significance Index: -9.2400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2919
    Cell Significance Index: -6.1100
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.2927
    Cell Significance Index: -3.9500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2938
    Cell Significance Index: -9.6200
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.3139
    Cell Significance Index: -2.4200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3251
    Cell Significance Index: -6.9000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3269
    Cell Significance Index: -7.8400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3297
    Cell Significance Index: -11.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Serine Metabolism:** PSPH is a key enzyme in the serine biosynthetic pathway, responsible for converting phosphoserine to serine. This reaction is essential for the production of serine, a non-essential amino acid involved in various cellular processes. 2. **Dephosphorylation:** As a phosphatase, PSPH catalyzes the dephosphorylation of phosphoserine, which is a critical step in regulating serine metabolism. 3. **Cellular Expression:** PSPH is expressed in various cell types, including cardiac muscle myoblasts, kidney proximal straight tubule epithelial cells, and cerebral cortex GABAergic interneurons. 4. **Tissue-Specific Expression:** PSPH is also expressed in the gastrointestinal tract, where it plays a role in maintaining the integrity of the intestinal epithelium. **Pathways and Functions:** 1. **Serine Biosynthesis:** PSPH is involved in the biosynthesis of serine, which is essential for various cellular processes, including protein synthesis, nucleotide synthesis, and energy metabolism. 2. **L-serine Biosynthetic Process:** PSPH is a key enzyme in the L-serine biosynthetic pathway, which is responsible for converting pyruvate to L-serine. 3. **L-serine Metabolic Process:** PSPH is also involved in the metabolic process of L-serine, which is essential for maintaining cellular homeostasis. 4. **Dephosphorylation:** PSPH catalyzes the dephosphorylation of phosphoserine, which is a critical step in regulating serine metabolism. 5. **Response to Stimuli:** PSPH is involved in responding to various stimuli, including mechanical stress, nutrient levels, and testosterone. **Clinical Significance:** 1. **Neurological Disorders:** Alterations in PSPH expression have been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease. 2. **Gastrointestinal Disorders:** PSPH expression in the gastrointestinal tract is essential for maintaining the integrity of the intestinal epithelium, and alterations in PSPH expression have been linked to gastrointestinal disorders, such as inflammatory bowel disease. 3. **Cardiovascular Diseases:** PSPH expression in cardiac muscle myoblasts is essential for maintaining cardiac function, and alterations in PSPH expression have been linked to cardiovascular diseases, such as heart failure. 4. **Cancer:** PSPH expression has been linked to cancer, including colon cancer, where it plays a role in maintaining the integrity of the intestinal epithelium. In conclusion, phosphoserine phosphatase (PSPH) is a critical enzyme involved in serine metabolism and plays a pivotal role in various cellular processes, including development, differentiation, and response to stimuli. Its expression in different tissues and cell types highlights its importance in maintaining cellular homeostasis, and alterations in PSPH expression have been linked to various diseases, including neurological disorders, gastrointestinal disorders, cardiovascular diseases, and cancer. Further research is needed to elucidate the mechanisms by which PSPH regulates serine metabolism and to explore its therapeutic potential in disease prevention and treatment.

Genular Protein ID: 1139805925

Symbol: SERB_HUMAN

Name: O-phosphoserine phosphohydrolase

UniProtKB Accession Codes:

P78330 B2RCR5 Q7Z3S5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChEBI 21 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 5 EC 2 EMBL 5 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 2 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 9 Rhea 4 SFLD 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9188776

Title: Human L-3-phosphoserine phosphatase: sequence, expression and evidence for a phosphoenzyme intermediate.

PubMed ID: 9188776

DOI: 10.1016/s0014-5793(97)00438-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1965857

Title: Phosphoserine phosphatase of human brain: partial purification, characterization, regional distribution, and effect of certain modulators including psychoactive drugs.

PubMed ID: 1965857

DOI: 10.1007/bf01208581

PubMed ID: 15291819

Title: How calcium inhibits the magnesium-dependent enzyme human phosphoserine phosphatase.

PubMed ID: 15291819

DOI: 10.1111/j.0014-2956.2004.04277.x

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 12213811

Title: Molecular basis for the local conformational rearrangement of human phosphoserine phosphatase.

PubMed ID: 12213811

DOI: 10.1074/jbc.m204866200

PubMed ID: 12777757

Title: High-resolution structure of human phosphoserine phosphatase in open conformation.

PubMed ID: 12777757

DOI: 10.1107/s0907444903005407

PubMed ID: 31205021

Title: Crystal structures and snapshots along the reaction pathway of human phosphoserine phosphatase.

PubMed ID: 31205021

DOI: 10.1107/s2059798319006867

PubMed ID: 9222972

Title: Phosphoserine phosphatase deficiency in a patient with Williams syndrome.

PubMed ID: 9222972

DOI: 10.1136/jmg.34.7.594

PubMed ID: 14673469

Title: Mutations responsible for 3-phosphoserine phosphatase deficiency.

PubMed ID: 14673469

DOI: 10.1038/sj.ejhg.5201083

PubMed ID: 25080166

Title: Phosphoserine phosphatase (PSPH) gene mutation in an intellectual disability family from Pakistan.

PubMed ID: 25080166

DOI: 10.1111/cge.12445

Sequence Information:

  • Length: 225
  • Mass: 25008
  • Checksum: BD5D72697747FA30
  • Sequence:
    • MVSHSELRKL FYSADAVCFD VDSTVIREEG IDELAKICGV EDAVSEMTRR AMGGAVPFKA 
ALTERLALIQ PSREQVQRLI AEQPPHLTPG IRELVSRLQE RNVQVFLISG GFRSIVEHVA 
SKLNIPATNV FANRLKFYFN GEYAGFDETQ PTAESGGKGK VIKLLKEKFH FKKIIMIGDG 
ATDMEACPPA DAFIGFGGNV IRQQVKDNAK WYITDFVELL GELEE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.