Details for: PTAFR

Gene ID: 5724

Symbol: PTAFR

Ensembl ID: ENSG00000169403

Description: platelet activating factor receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 75.8622
    Cell Significance Index: -11.8000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 46.7586
    Cell Significance Index: -11.8600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 27.3870
    Cell Significance Index: -12.9300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 26.9351
    Cell Significance Index: -13.8600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.6475
    Cell Significance Index: -11.9000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.3675
    Cell Significance Index: -7.3700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.0486
    Cell Significance Index: -12.0300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.6511
    Cell Significance Index: 49.0000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.2299
    Cell Significance Index: 75.4100
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.5426
    Cell Significance Index: 3.6000
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.5125
    Cell Significance Index: 6.3400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.4749
    Cell Significance Index: 6.7600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4221
    Cell Significance Index: 80.3300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.2676
    Cell Significance Index: 4.1400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2235
    Cell Significance Index: 3.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1914
    Cell Significance Index: 22.3000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1902
    Cell Significance Index: 18.8200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1882
    Cell Significance Index: 22.2000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1791
    Cell Significance Index: 161.7500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1514
    Cell Significance Index: 94.5200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1358
    Cell Significance Index: 16.7000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1122
    Cell Significance Index: 18.2600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1070
    Cell Significance Index: 2.2200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0876
    Cell Significance Index: 9.5300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0773
    Cell Significance Index: 42.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0546
    Cell Significance Index: 10.9600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0481
    Cell Significance Index: 2.8900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0476
    Cell Significance Index: 1.3300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0422
    Cell Significance Index: 0.9200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0380
    Cell Significance Index: 16.8100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0218
    Cell Significance Index: 4.3200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0196
    Cell Significance Index: 3.5400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0094
    Cell Significance Index: 17.7700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0066
    Cell Significance Index: 0.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0034
    Cell Significance Index: 6.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0033
    Cell Significance Index: 4.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0022
    Cell Significance Index: 3.4000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0046
    Cell Significance Index: -0.1600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0049
    Cell Significance Index: -0.7200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0055
    Cell Significance Index: -4.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0062
    Cell Significance Index: -2.2100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0066
    Cell Significance Index: -4.5900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0076
    Cell Significance Index: -0.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0083
    Cell Significance Index: -4.7000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0092
    Cell Significance Index: -0.2000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0098
    Cell Significance Index: -2.8200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0121
    Cell Significance Index: -0.3500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0130
    Cell Significance Index: -8.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0148
    Cell Significance Index: -11.2200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0152
    Cell Significance Index: -0.2600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0168
    Cell Significance Index: -12.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0203
    Cell Significance Index: -9.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0227
    Cell Significance Index: -4.7900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0299
    Cell Significance Index: -0.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0321
    Cell Significance Index: -5.4800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0340
    Cell Significance Index: -1.5400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0357
    Cell Significance Index: -3.6500
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0580
    Cell Significance Index: -0.4700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0616
    Cell Significance Index: -0.7000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0771
    Cell Significance Index: -2.4700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0794
    Cell Significance Index: -9.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0898
    Cell Significance Index: -12.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0913
    Cell Significance Index: -10.4600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1007
    Cell Significance Index: -13.0100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1019
    Cell Significance Index: -13.0600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1054
    Cell Significance Index: -10.9700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1068
    Cell Significance Index: -1.6100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1274
    Cell Significance Index: -2.1000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1372
    Cell Significance Index: -9.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1413
    Cell Significance Index: -10.5300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1435
    Cell Significance Index: -1.1700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1446
    Cell Significance Index: -11.1000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1543
    Cell Significance Index: -7.2500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1594
    Cell Significance Index: -8.2800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1611
    Cell Significance Index: -12.7600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1681
    Cell Significance Index: -11.3000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1945
    Cell Significance Index: -12.2600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1949
    Cell Significance Index: -2.8500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2014
    Cell Significance Index: -12.3800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2026
    Cell Significance Index: -13.0700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2093
    Cell Significance Index: -9.1000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2160
    Cell Significance Index: -2.8700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2175
    Cell Significance Index: -9.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2297
    Cell Significance Index: -12.8900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2392
    Cell Significance Index: -8.3800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2522
    Cell Significance Index: -9.5500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2600
    Cell Significance Index: -8.2800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2666
    Cell Significance Index: -14.0000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2706
    Cell Significance Index: -5.2900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2789
    Cell Significance Index: -9.1300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3081
    Cell Significance Index: -11.3100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3183
    Cell Significance Index: -16.0900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3404
    Cell Significance Index: -9.0900
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.3443
    Cell Significance Index: -3.0100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3481
    Cell Significance Index: -16.2300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3644
    Cell Significance Index: -9.0900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3714
    Cell Significance Index: -12.9100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.3785
    Cell Significance Index: -3.3400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3858
    Cell Significance Index: -9.6200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3912
    Cell Significance Index: -16.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** PTAFR is a seven-transmembrane GPCR, consisting of an extracellular N-terminus, a transmembrane domain, and an intracellular C-terminus. 2. **Binding:** PTAFR binds to platelet-activating factor (PAF), a potent phospholipid mediator that plays a key role in immune responses and inflammation. 3. **Signaling:** Upon binding to PAF, PTAFR activates G-proteins, leading to the activation of downstream signaling pathways. **Pathways and Functions:** 1. **Immune Response:** PTAFR is involved in the regulation of immune responses, including the activation of neutrophils, macrophages, and other immune cells. 2. **Inflammation:** PTAFR contributes to the development of inflammation by promoting the production of pro-inflammatory cytokines, such as TNF-α and IL-6. 3. **Cell Signaling:** PTAFR regulates various cell signaling pathways, including the mitogen-activated protein kinase (MAPK) pathway, the phospholipase C (PLC) pathway, and the inositol trisphosphate (IP3) pathway. 4. **Cellular Ex extravasation:** PTAFR promotes the transmigration of leukocytes across the endothelial barrier, contributing to the recruitment of immune cells to sites of inflammation. 5. **Regulation of Blood Pressure:** PTAFR is involved in the regulation of blood pressure, particularly in the context of hypertension. **Clinical Significance:** 1. **Inflammatory Disorders:** PTAFR has been implicated in various inflammatory disorders, including rheumatoid arthritis, asthma, and inflammatory bowel disease. 2. **Cardiovascular Disease:** PTAFR has been linked to cardiovascular disease, including hypertension, atherosclerosis, and cardiac arrhythmias. 3. **Cancer:** PTAFR has been identified as a potential target for cancer therapy, particularly in the context of leukemia and lymphoma. 4. **Neurological Disorders:** PTAFR has been implicated in neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. **Significantly Expressed Cells:** 1. **Monocytes:** PTAFR is highly expressed on classical monocytes, which are involved in the regulation of immune responses. 2. **Macrophages:** PTAFR is also expressed on macrophages, which play a key role in the clearance of pathogens and the regulation of inflammation. 3. **Neutrophils:** PTAFR is expressed on neutrophils, which are involved in the regulation of inflammation and the clearance of pathogens. **Conclusion:** In conclusion, PTAFR is a complex immunoreceptor that plays a crucial role in various cellular processes, including immune responses, inflammation, and cell signaling. Its dysregulation has been implicated in various diseases, including inflammatory disorders, cardiovascular disease, and cancer. Further research is needed to fully understand the mechanisms of PTAFR and its clinical significance. **References:** 1. [Insert references to relevant studies on PTAFR] 2. [Insert references to relevant reviews on PTAFR]

Genular Protein ID: 1185374764

Symbol: PTAFR_HUMAN

Name: Platelet-activating factor receptor

UniProtKB Accession Codes:

P25105 A3KMC8 A8K2H5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 13 Ensembl 3 GO 38 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 4 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1656963

Title: Characterization of a human cDNA that encodes a functional receptor for platelet activating factor.

PubMed ID: 1656963

DOI: 10.1016/s0006-291x(05)81261-6

PubMed ID: 1657923

Title: Molecular cloning and expression of platelet-activating factor receptor from human leukocytes.

PubMed ID: 1657923

DOI: 10.1016/s0021-9258(18)54936-x

PubMed ID: 1374385

Title: The human leukocyte platelet-activating factor receptor. cDNA cloning, cell surface expression, and construction of a novel epitope-bearing analog.

PubMed ID: 1374385

DOI: 10.1016/s0021-9258(19)50394-5

PubMed ID: 1322356

Title: The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1.

PubMed ID: 1322356

DOI: 10.1016/0888-7543(92)90162-l

PubMed ID: 1281995

Title: Molecular cloning and characterization of the platelet-activating factor receptor gene expressed in the human heart.

PubMed ID: 1281995

DOI: 10.1016/0006-291x(92)92245-s

PubMed ID: 8383507

Title: Cloning of a human platelet-activating factor receptor gene: evidence for an intron in the 5'-untranslated region.

PubMed ID: 8383507

DOI: 10.1165/ajrcmb/8.3.240

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16709866

Title: Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation.

PubMed ID: 16709866

DOI: 10.4049/jimmunol.176.11.7039

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

Sequence Information:

  • Length: 342
  • Mass: 39203
  • Checksum: 890073C9EBA79228
  • Sequence:
    • MEPHDSSHMD SEFRYTLFPI VYSIIFVLGV IANGYVLWVF ARLYPCKKFN EIKIFMVNLT 
MADMLFLITL PLWIVYYQNQ GNWILPKFLC NVAGCLFFIN TYCSVAFLGV ITYNRFQAVT 
RPIKTAQANT RKRGISLSLV IWVAIVGAAS YFLILDSTNT VPDSAGSGNV TRCFEHYEKG 
SVPVLIIHIF IVFSFFLVFL IILFCNLVII RTLLMQPVQQ QRNAEVKRRA LWMVCTVLAV 
FIICFVPHHV VQLPWTLAEL GFQDSKFHQA INDAHQVTLC LLSTNCVLDP VIYCFLTKKF 
RKHLTEKFYS MRSSRKCSRA TTDTVTEVVV PFNQIPGNSL KN

Genular Protein ID: 2843615260

Symbol: A8K7N8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K7N8

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 3 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 2 RuleBase 1 SAM 1 SUPFAM 1

Sequence Information:

  • Length: 342
  • Mass: 39176
  • Checksum: BB21AE2BCA7F4106
  • Sequence:
    • MEPHDSSHMD SEFRYTLFPI VYSIIFVLGV IANGYVLWVF ARLYPCKKFN EIKIFMVNLT 
MADMLFLITL PLWIVYYQNQ GNWILPKFLC NVAGCLFFIN TYCSVAFLGV ITYNRFQAVT 
RPIKTAQAST RKRGISLSLV IWVAIVGAAS YFLILDSTNT VPDSAGSGNV TRCFEHYEKG 
SVPVLIIHIF IVFSFFLVFL IILFCNLVII RTLLMQPVQQ QRNAEVKRRA LWMVCTVLAV 
FIICFVPHHV VQLPWTLAEL GFQDSKFHQA INDAHQVTLC LLSTNCVLDP VIYCFLTKKF 
RKHLTEKFYS MRSSRKCSRA TTDTVTEVVV PFNQIPGNSL KN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.