Details for: TAS2R38

Gene ID: 5726

Symbol: TAS2R38

Ensembl ID: ENSG00000257138

Description: taste 2 receptor member 38

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0476
    Cell Significance Index: 0.9500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0258
    Cell Significance Index: 0.3700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0180
    Cell Significance Index: 0.8400
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.0082
    Cell Significance Index: 0.1000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.0008
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.3300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0002
    Cell Significance Index: -0.3100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0003
    Cell Significance Index: -0.4400
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0003
    Cell Significance Index: 0.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0014
    Cell Significance Index: -0.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0034
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0093
    Cell Significance Index: -1.0700
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0104
    Cell Significance Index: -0.1400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0114
    Cell Significance Index: -0.4000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0119
    Cell Significance Index: -0.1300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0126
    Cell Significance Index: -0.4000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0139
    Cell Significance Index: -0.2800
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0141
    Cell Significance Index: -0.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0148
    Cell Significance Index: -0.3900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0151
    Cell Significance Index: -0.1900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0152
    Cell Significance Index: -0.1600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0160
    Cell Significance Index: -0.4000
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0176
    Cell Significance Index: -0.2200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0182
    Cell Significance Index: -0.2300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0189
    Cell Significance Index: -0.3700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0192
    Cell Significance Index: -0.2500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0196
    Cell Significance Index: -0.2300
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0199
    Cell Significance Index: -0.1800
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0207
    Cell Significance Index: -0.2900
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0208
    Cell Significance Index: -0.2500
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0211
    Cell Significance Index: -0.2200
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0212
    Cell Significance Index: -0.2500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0224
    Cell Significance Index: -0.2400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0232
    Cell Significance Index: -0.2200
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0235
    Cell Significance Index: -0.2400
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0252
    Cell Significance Index: -0.2900
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0268
    Cell Significance Index: -0.2900
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0271
    Cell Significance Index: -0.3100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0272
    Cell Significance Index: -0.2400
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0275
    Cell Significance Index: -0.2500
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0275
    Cell Significance Index: -0.2400
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0279
    Cell Significance Index: -0.3400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0288
    Cell Significance Index: -0.3300
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0288
    Cell Significance Index: -0.2000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0289
    Cell Significance Index: -0.5000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0322
    Cell Significance Index: -0.3800
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0330
    Cell Significance Index: -0.3500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0334
    Cell Significance Index: -0.4100
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0346
    Cell Significance Index: -0.3400
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0355
    Cell Significance Index: -0.2200
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0357
    Cell Significance Index: -0.3300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0359
    Cell Significance Index: -0.4200
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0361
    Cell Significance Index: -0.3800
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0381
    Cell Significance Index: -0.3600
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0384
    Cell Significance Index: -0.4300
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0389
    Cell Significance Index: -0.2700
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0399
    Cell Significance Index: -0.2900
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0404
    Cell Significance Index: -0.3600
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0410
    Cell Significance Index: -0.4400
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0438
    Cell Significance Index: -0.4200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0439
    Cell Significance Index: -0.2700
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0439
    Cell Significance Index: -0.4500
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.0448
    Cell Significance Index: -0.3700
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.0501
    Cell Significance Index: -0.5300
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.0514
    Cell Significance Index: -0.3700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0533
    Cell Significance Index: -0.4300
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.0560
    Cell Significance Index: -0.2700
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.0584
    Cell Significance Index: -0.5000
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0589
    Cell Significance Index: -0.3700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0622
    Cell Significance Index: -1.5900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0637
    Cell Significance Index: -0.7500
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0672
    Cell Significance Index: -0.4500
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0725
    Cell Significance Index: -0.4300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0733
    Cell Significance Index: -0.6900
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0915
    Cell Significance Index: -0.7700
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: -0.0991
    Cell Significance Index: -0.7600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1508
    Cell Significance Index: -2.9800
  • Cell Name: serotonergic neuron (CL0000850)
    Fold Change: -0.1673
    Cell Significance Index: -0.4000
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.2056
    Cell Significance Index: -1.3400
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.2128
    Cell Significance Index: -1.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Bitter Taste Receptor:** TAS2R38 is a bitter taste receptor that is activated by a wide range of bitter compounds, including quinine, caffeine, and tannins. 2. **GPCR Family:** TAS2R38 belongs to the GPCR family, which is a large family of receptors that respond to a variety of ligands, including hormones, neurotransmitters, and small molecules. 3. **Signaling Pathway:** The TAS2R38 receptor activates a signaling pathway that involves the Gαi protein, which regulates various cellular processes, including gene expression and cell proliferation. 4. **Tissue Expression:** TAS2R38 is expressed in a variety of tissues, including connective tissue cells, renal cells, and smooth muscle cells. 5. **Variability:** The TAS2R38 gene has significant variability among individuals, with some people having a more sensitive version of the gene (AVI haplotype) and others having a less sensitive version (AVI haplotype). **Pathways and Functions:** 1. **Bitter Taste Perception:** TAS2R38 plays a critical role in the perception of bitter taste, and its dysfunction has been associated with impaired taste perception. 2. **Sensory Perception:** TAS2R38 is also involved in the perception of other tastes, including sweet and umami (glutamate) taste. 3. **Signaling Pathway:** The TAS2R38 receptor activates a signaling pathway that regulates various cellular processes, including gene expression and cell proliferation. 4. **Immune Response:** TAS2R38 has been implicated in the immune response, with some studies suggesting that it plays a role in the regulation of immune cell function. **Clinical Significance:** 1. **Impaired Taste Perception:** Variations in the TAS2R38 gene have been associated with impaired taste perception, particularly in individuals with a less sensitive version of the gene. 2. **Disease Association:** TAS2R38 has been implicated in various diseases, including diabetes, obesity, and certain types of cancer. 3. **Food Allergy:** TAS2R38 has been implicated in food allergy, with some studies suggesting that it plays a role in the regulation of immune cell function. 4. **Pharmacological Applications:** TAS2R38 has potential therapeutic applications, particularly in the development of new treatments for taste disorders and certain types of cancer. In conclusion, the TAS2R38 gene plays a critical role in the perception of bitter taste and has significant implications for our understanding of taste perception, flavor perception, and disease susceptibility. Further research is needed to fully elucidate the functions and clinical significance of this gene.

Genular Protein ID: 2323788070

Symbol: T2R38_HUMAN

Name: Taste receptor type 2 member 38

UniProtKB Accession Codes:

P59533 A4D1U6 P59552 Q2M3E8 Q645W3 Q86UK3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 8 Ensembl 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 2 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 3 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 12379855

Title: The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides.

PubMed ID: 12379855

DOI: 10.1038/ng1014

PubMed ID: 12584440

Title: Identification and characterization of human taste receptor genes belonging to the TAS2R family.

PubMed ID: 12584440

DOI: 10.1159/000068546

PubMed ID: 12595690

Title: Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide.

PubMed ID: 12595690

DOI: 10.1126/science.1080190

PubMed ID: 15496549

Title: Evolution of bitter taste receptors in humans and apes.

PubMed ID: 15496549

DOI: 10.1093/molbev/msi027

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12139982

Title: Receptors for bitter and sweet taste.

PubMed ID: 12139982

DOI: 10.1016/s0959-4388(02)00345-8

PubMed ID: 11696554

Title: Molecular mechanisms of bitter and sweet taste transduction.

PubMed ID: 11696554

DOI: 10.1074/jbc.r100054200

PubMed ID: 12581520

Title: Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.

PubMed ID: 12581520

DOI: 10.1016/s0092-8674(03)00071-0

PubMed ID: 16720576

Title: Members of RTP and REEP gene families influence functional bitter taste receptor expression.

PubMed ID: 16720576

DOI: 10.1074/jbc.m513637200

Sequence Information:

  • Length: 333
  • Mass: 37892
  • Checksum: E3B5EDD5AB99994C
  • Sequence:
    • MLTLTRIRTV SYEVRSTFLF ISVLEFAVGF LTNAFVFLVN FWDVVKRQAL SNSDCVLLCL 
SISRLFLHGL LFLSAIQLTH FQKLSEPLNH SYQAIIMLWM IANQANLWLA ACLSLLYCSK 
LIRFSHTFLI CLASWVSRKI SQMLLGIILC SCICTVLCVW CFFSRPHFTV TTVLFMNNNT 
RLNWQIKDLN LFYSFLFCYL WSVPPFLLFL VSSGMLTVSL GRHMRTMKVY TRNSRDPSLE 
AHIKALKSLV SFFCFFVISS CAAFISVPLL ILWRDKIGVM VCVGIMAACP SGHAAILISG 
NAKLRRAVMT ILLWAQSSLK VRADHKADSR TLC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.