Details for: PTGIS

Gene ID: 5740

Symbol: PTGIS

Ensembl ID: ENSG00000124212

Description: prostaglandin I2 synthase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 97.8494
    Cell Significance Index: -15.2200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 60.0055
    Cell Significance Index: -15.2200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.4699
    Cell Significance Index: -14.1600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.8520
    Cell Significance Index: -15.2000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.9717
    Cell Significance Index: 58.0000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 1.7573
    Cell Significance Index: 88.8100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.4053
    Cell Significance Index: 30.7700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.3758
    Cell Significance Index: 21.2900
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.2940
    Cell Significance Index: 7.6400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.2732
    Cell Significance Index: 16.3100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.0635
    Cell Significance Index: 15.2700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.9763
    Cell Significance Index: 31.2700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.6774
    Cell Significance Index: 4.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5692
    Cell Significance Index: 66.3300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2548
    Cell Significance Index: 32.6700
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.2281
    Cell Significance Index: 2.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1624
    Cell Significance Index: 32.5800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1428
    Cell Significance Index: 2.9900
  • Cell Name: fibroblast of the aortic adventitia (CL0002547)
    Fold Change: 0.1358
    Cell Significance Index: 1.3700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1305
    Cell Significance Index: 8.0200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1149
    Cell Significance Index: 1.6500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1147
    Cell Significance Index: 1.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1116
    Cell Significance Index: 40.0500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1006
    Cell Significance Index: 16.3700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0415
    Cell Significance Index: 2.4900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0248
    Cell Significance Index: 0.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0235
    Cell Significance Index: 4.6600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0011
    Cell Significance Index: -0.7500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0016
    Cell Significance Index: -2.9500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0095
    Cell Significance Index: -17.5800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0101
    Cell Significance Index: -1.2400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0117
    Cell Significance Index: -18.0800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0118
    Cell Significance Index: -2.1200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0136
    Cell Significance Index: -18.4900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0143
    Cell Significance Index: -6.4900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0174
    Cell Significance Index: -12.8700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0179
    Cell Significance Index: -11.4000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0180
    Cell Significance Index: -13.6600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0241
    Cell Significance Index: -15.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0271
    Cell Significance Index: -15.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0286
    Cell Significance Index: -8.2400
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0293
    Cell Significance Index: -0.3200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0302
    Cell Significance Index: -16.5200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0387
    Cell Significance Index: -5.3200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0413
    Cell Significance Index: -0.6800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0558
    Cell Significance Index: -2.4700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0665
    Cell Significance Index: -14.0000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0685
    Cell Significance Index: -5.2600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0707
    Cell Significance Index: -10.2800
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0747
    Cell Significance Index: -0.7200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0800
    Cell Significance Index: -13.6600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0829
    Cell Significance Index: -3.1400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0944
    Cell Significance Index: -6.5300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1072
    Cell Significance Index: -13.8500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1102
    Cell Significance Index: -1.8500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1153
    Cell Significance Index: -11.7800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1294
    Cell Significance Index: -14.8200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1342
    Cell Significance Index: -10.0000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1364
    Cell Significance Index: -2.8300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1392
    Cell Significance Index: -14.4900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1398
    Cell Significance Index: -1.5200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1459
    Cell Significance Index: -9.8100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1521
    Cell Significance Index: -3.3000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1790
    Cell Significance Index: -11.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1853
    Cell Significance Index: -5.3400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1866
    Cell Significance Index: -3.9800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2054
    Cell Significance Index: -5.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2081
    Cell Significance Index: -9.7800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2111
    Cell Significance Index: -9.1800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2211
    Cell Significance Index: -11.5200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2212
    Cell Significance Index: -14.2700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2238
    Cell Significance Index: -12.5600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2239
    Cell Significance Index: -5.3700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2266
    Cell Significance Index: -11.7700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2757
    Cell Significance Index: -7.2500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2774
    Cell Significance Index: -4.1800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2997
    Cell Significance Index: -7.2600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3128
    Cell Significance Index: -7.8000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3156
    Cell Significance Index: -16.5700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3226
    Cell Significance Index: -11.2100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3303
    Cell Significance Index: -15.4000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3396
    Cell Significance Index: -5.8200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3455
    Cell Significance Index: -12.1100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3888
    Cell Significance Index: -12.7300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3977
    Cell Significance Index: -9.9200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4043
    Cell Significance Index: -14.8400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4139
    Cell Significance Index: -12.1600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4248
    Cell Significance Index: -6.1100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4349
    Cell Significance Index: -13.8500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4376
    Cell Significance Index: -12.8900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4577
    Cell Significance Index: -9.0500
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -0.4586
    Cell Significance Index: -4.7500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4734
    Cell Significance Index: -13.5100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4776
    Cell Significance Index: -12.7800
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.4817
    Cell Significance Index: -4.4700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4988
    Cell Significance Index: -13.9400
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.5013
    Cell Significance Index: -7.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5056
    Cell Significance Index: -13.5000
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.5061
    Cell Significance Index: -3.1000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5122
    Cell Significance Index: -10.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Prostaglandin I2 Synthase**: PTGIS is responsible for converting prostaglandin H2 (PGH2) into prostaglandin I2 (PGI2) through a two-step reaction involving the enzyme cyclooxygenase (COX) and the addition of a hydroxyl group to PGH2. 2. **Vasodilatory and Anti-Thrombotic Effects**: PGI2 exerts its effects by activating guanylyl cyclase, leading to increased levels of cyclic guanosine monophosphate (cGMP), which in turn causes smooth muscle relaxation and inhibition of platelet aggregation. 3. **Inflammation Regulation**: PTGIS is involved in the regulation of inflammatory responses, particularly in the context of cardiovascular diseases, where it helps to counterbalance the pro-inflammatory effects of other prostaglandins. 4. **Tissue-Specific Expression**: PTGIS is expressed in various tissues, including the cardiovascular system, lungs, and gastrointestinal tract, highlighting its importance in maintaining tissue homeostasis. **Pathways and Functions** 1. **Prostaglandin Biosynthetic Pathway**: PTGIS is integral to the prostaglandin biosynthetic pathway, which involves the conversion of arachidonic acid into PGH2, followed by the conversion of PGH2 into PGI2. 2. **Cyclooxygenase Pathway**: PTGIS is upstream of the cyclooxygenase (COX) enzyme, which is responsible for converting arachidonic acid into PGH2. 3. **Nitric Oxide Biosynthetic Pathway**: PTGIS is involved in the regulation of nitric oxide (NO) biosynthesis, which is essential for maintaining vascular homeostasis and regulating blood pressure. 4. **Angiogenesis and Apoptosis**: PTGIS is involved in the regulation of angiogenesis and apoptosis, particularly in the context of cardiovascular diseases. **Clinical Significance** 1. **Cardiovascular Diseases**: PTGIS is involved in the regulation of cardiovascular diseases, such as hypertension, atherosclerosis, and heart failure, where dysregulation of PGI2 levels can contribute to disease progression. 2. **Inflammatory Disorders**: PTGIS is involved in the regulation of inflammatory responses, particularly in the context of inflammatory disorders such as arthritis, asthma, and allergies. 3. **Cancer**: PTGIS is involved in the regulation of cancer progression, particularly in the context of colon and lung cancer, where dysregulation of PGI2 levels can contribute to tumor growth and metastasis. 4. **Therapeutic Applications**: PTGIS is a potential therapeutic target for the treatment of cardiovascular diseases, inflammatory disorders, and cancer, where modulation of PGI2 levels can have beneficial effects. In conclusion, PTGIS is a crucial enzyme involved in the biosynthesis of prostaglandin I2, a potent vasodilator and inhibitor of platelet aggregation. Its dysregulation is implicated in various diseases, including cardiovascular diseases, inflammatory disorders, and cancer. Further research is needed to fully understand the role of PTGIS in human disease and to explore its therapeutic potential.

Genular Protein ID: 718661334

Symbol: PTGIS_HUMAN

Name: Prostacyclin synthase

UniProtKB Accession Codes:

Q16647 Q3MII8 Q9HAX2 Q9HAX3 Q9HAX4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 CarbonylDB 1 ChEBI 16 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 3 DrugCentral 1 EC 2 EMBL 9 Ensembl 1 EvolutionaryTrace 1 GO 25 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PIRSF 2 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 8 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8185632

Title: Molecular cloning and expression of human prostacyclin synthase.

PubMed ID: 8185632

DOI: 10.1006/bbrc.1994.1652

PubMed ID: 11281454

Title: Characterization of new mutations in the coding sequence and 5'-untranslated region of the human prostacyclin synthase gene (CYP8A1).

PubMed ID: 11281454

DOI: 10.1007/s004390000444

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12372404

Title: Splicing mutation of the prostacyclin synthase gene in a family associated with hypertension.

PubMed ID: 12372404

DOI: 10.1016/s0006-291x(02)02341-0

PubMed ID: 15115769

Title: Purification and characterization of recombinant human prostacyclin synthase.

PubMed ID: 15115769

DOI: 10.1093/jb/mvh059

PubMed ID: 17459323

Title: Reaction mechanisms of 15-hydroperoxyeicosatetraenoic acid catalyzed by human prostacyclin and thromboxane synthases.

PubMed ID: 17459323

DOI: 10.1016/j.abb.2007.03.012

PubMed ID: 25623425

Title: Analysis of genetic polymorphism and biochemical characterization of a functionally decreased variant in prostacyclin synthase gene (CYP8A1) in humans.

PubMed ID: 25623425

DOI: 10.1016/j.abb.2015.01.012

PubMed ID: 17020766

Title: Crystal structure of the human prostacyclin synthase.

PubMed ID: 17020766

DOI: 10.1016/j.jmb.2006.09.039

PubMed ID: 18032380

Title: Structures of prostacyclin synthase and its complexes with substrate analog and inhibitor reveal a ligand-specific heme conformation change.

PubMed ID: 18032380

DOI: 10.1074/jbc.m707470200

Sequence Information:

  • Length: 500
  • Mass: 57104
  • Checksum: 39595442BFC0B625
  • Sequence:
    • MAWAALLGLL AALLLLLLLS RRRTRRPGEP PLDLGSIPWL GYALDFGKDA ASFLTRMKEK 
HGDIFTILVG GRYVTVLLDP HSYDAVVWEP RTRLDFHAYA IFLMERIFDV QLPHYSPSDE 
KARMKLTLLH RELQALTEAM YTNLHAVLLG DATEAGSGWH EMGLLDFSYS FLLRAGYLTL 
YGIEALPRTH ESQAQDRVHS ADVFHTFRQL DRLLPKLARG SLSVGDKDHM CSVKSRLWKL 
LSPARLARRA HRSKWLESYL LHLEEMGVSE EMQARALVLQ LWATQGNMGP AAFWLLLFLL 
KNPEALAAVR GELESILWQA EQPVSQTTTL PQKVLDSTPV LDSVLSESLR LTAAPFITRE 
VVVDLAMPMA DGREFNLRRG DRLLLFPFLS PQRDPEIYTD PEVFKYNRFL NPDGSEKKDF 
YKDGKRLKNY NMPWGAGHNH CLGRSYAVNS IKQFVFLVLV HLDLELINAD VEIPEFDLSR 
YGFGLMQPEH DVPVRYRIRP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.