Details for: PTPRR

Gene ID: 5801

Symbol: PTPRR

Ensembl ID: ENSG00000153233

Description: protein tyrosine phosphatase receptor type R

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.2868
    Cell Significance Index: 71.9700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.1653
    Cell Significance Index: 140.0100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.0129
    Cell Significance Index: 37.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.9625
    Cell Significance Index: 594.2800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.6223
    Cell Significance Index: 99.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.3730
    Cell Significance Index: 123.2700
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 2.2403
    Cell Significance Index: 29.8900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.9413
    Cell Significance Index: 55.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.8047
    Cell Significance Index: 210.3200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.5579
    Cell Significance Index: 1077.5300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.4826
    Cell Significance Index: 99.6900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.4769
    Cell Significance Index: 25.3100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.3960
    Cell Significance Index: 10.7600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3671
    Cell Significance Index: 260.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.9571
    Cell Significance Index: 58.8300
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.7973
    Cell Significance Index: 10.3400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7720
    Cell Significance Index: 276.8900
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.7151
    Cell Significance Index: 7.8900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6893
    Cell Significance Index: 622.3800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6489
    Cell Significance Index: 64.1900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5986
    Cell Significance Index: 97.3600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.5462
    Cell Significance Index: 8.1900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5016
    Cell Significance Index: 12.0300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.3154
    Cell Significance Index: 7.6400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.3118
    Cell Significance Index: 3.7800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3072
    Cell Significance Index: 33.4100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2454
    Cell Significance Index: 44.2400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1989
    Cell Significance Index: 11.9400
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.1527
    Cell Significance Index: 2.1500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1376
    Cell Significance Index: 3.9700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1257
    Cell Significance Index: 8.7000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1003
    Cell Significance Index: 54.7500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0886
    Cell Significance Index: 1.9200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.0846
    Cell Significance Index: 2.7700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0488
    Cell Significance Index: 2.2100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0481
    Cell Significance Index: 5.9100
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.0462
    Cell Significance Index: 0.4400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0456
    Cell Significance Index: 1.1400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0285
    Cell Significance Index: 0.3100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0199
    Cell Significance Index: 0.7000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0029
    Cell Significance Index: 0.1800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0071
    Cell Significance Index: -0.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0083
    Cell Significance Index: -15.2800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0087
    Cell Significance Index: -0.3800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0090
    Cell Significance Index: -13.8600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0093
    Cell Significance Index: -17.4500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0105
    Cell Significance Index: -14.3000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0108
    Cell Significance Index: -0.2300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0216
    Cell Significance Index: -0.5400
  • Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
    Fold Change: -0.0218
    Cell Significance Index: -0.2200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0219
    Cell Significance Index: -0.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0245
    Cell Significance Index: -15.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0288
    Cell Significance Index: -13.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0289
    Cell Significance Index: -21.3800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0316
    Cell Significance Index: -23.9400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0321
    Cell Significance Index: -0.4600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0397
    Cell Significance Index: -24.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0399
    Cell Significance Index: -22.5200
  • Cell Name: diffuse bipolar 1 cell (CL4033027)
    Fold Change: -0.0405
    Cell Significance Index: -0.4900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0489
    Cell Significance Index: -21.6000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0493
    Cell Significance Index: -1.5700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0625
    Cell Significance Index: -17.9900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0812
    Cell Significance Index: -16.1200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0832
    Cell Significance Index: -4.6700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1067
    Cell Significance Index: -22.4800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1121
    Cell Significance Index: -19.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1349
    Cell Significance Index: -19.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1393
    Cell Significance Index: -19.1300
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.1448
    Cell Significance Index: -1.8000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1541
    Cell Significance Index: -3.3300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1545
    Cell Significance Index: -1.9500
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1603
    Cell Significance Index: -1.8700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1609
    Cell Significance Index: -16.4400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1684
    Cell Significance Index: -8.8400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1691
    Cell Significance Index: -19.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1735
    Cell Significance Index: -8.0900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1805
    Cell Significance Index: -23.3200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1831
    Cell Significance Index: -2.1900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1952
    Cell Significance Index: -1.8500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2056
    Cell Significance Index: -5.7500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2135
    Cell Significance Index: -27.3700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2236
    Cell Significance Index: -23.2800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2306
    Cell Significance Index: -8.0800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2471
    Cell Significance Index: -18.9600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2722
    Cell Significance Index: -21.5600
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.3044
    Cell Significance Index: -2.3400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3050
    Cell Significance Index: -6.5000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3054
    Cell Significance Index: -9.7800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3128
    Cell Significance Index: -23.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3264
    Cell Significance Index: -21.0600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3500
    Cell Significance Index: -18.2300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3627
    Cell Significance Index: -3.3400
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.3853
    Cell Significance Index: -5.4000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3995
    Cell Significance Index: -6.0200
  • Cell Name: diffuse bipolar 2 cell (CL4033028)
    Fold Change: -0.4111
    Cell Significance Index: -5.0500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.4299
    Cell Significance Index: -5.7300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.4578
    Cell Significance Index: -9.0100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4825
    Cell Significance Index: -10.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4847
    Cell Significance Index: -22.7800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5089
    Cell Significance Index: -18.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PTPRR is a transmembrane receptor, with a characteristic structure comprising an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain contains immunoglobulin-like domains, which are involved in ligand binding and receptor activation. The intracellular domain possesses a phosphatase domain, which is responsible for dephosphorylating tyrosine residues on target proteins. PTPRR is a negative regulator of various signaling pathways, including the ErbB2 cascade and the Erk1/2 pathway, and it plays a crucial role in regulating cell adhesion and migration. **Pathways and Functions:** PTPRR is involved in several key signaling pathways, including: 1. **ErbB2 signaling pathway**: PTPRR negatively regulates the ErbB2 cascade, which is involved in cell proliferation, differentiation, and survival. 2. **Negative regulation of epithelial cell migration**: PTPRR plays a crucial role in regulating epithelial cell migration, a process that is essential for tissue development and repair. 3. **Regulation of homophilic cell adhesion**: PTPRR interacts with its ligand, promoting homophilic cell adhesion, which is essential for maintaining tissue structure and function. 4. **Protein binding and dephosphorylation**: PTPRR dephosphorylates tyrosine residues on target proteins, modulating their activity and influencing various cellular processes. **Clinical Significance:** Dysregulation of PTPRR has been implicated in various diseases, including: 1. **Cancer**: Alterations in PTPRR expression and function have been observed in several types of cancer, including breast, lung, and colon cancer. 2. **Neurological disorders**: PTPRR has been implicated in neurological disorders, such as Alzheimer's disease, Parkinson's disease, and schizophrenia. 3. **Immune system dysregulation**: PTPRR plays a crucial role in regulating immune responses, and dysregulation of PTPRR has been observed in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. In conclusion, PTPRR is a critical receptor-type tyrosine-protein phosphatase that plays a pivotal role in regulating various cellular processes, including signal transduction, cell adhesion, and immune responses. Further research is necessary to fully elucidate the mechanisms by which PTPRR regulates cellular processes and to explore its therapeutic potential in various diseases.

Genular Protein ID: 1201292037

Symbol: PTPRR_HUMAN

Name: Receptor-type tyrosine-protein phosphatase R

UniProtKB Accession Codes:

Q15256 B2R5Z7 B7Z3J1 F5GXR7 O00342 Q92682 Q9UE65

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DEPOD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 ELM 1 EMBL 26 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIRSF 1 PRINTS 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 RefSeq 4 Rhea 3 SABIO-RK 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7557444

Title: Cloning and expression of PCPTP1 encoding protein tyrosine phosphatase.

PubMed ID: 7557444

DOI: 10.1016/0378-1119(95)00306-q

PubMed ID: 10705342

Title: Protein tyrosine phosphatase (PC12, Br7,Sl) family: expression characterization in the adult human and mouse.

PubMed ID: 10705342

DOI: 10.1002/(sici)1097-0185(20000301)258:3<221::aid-ar1>3.0.co;2-w

PubMed ID: 11147789

Title: Type 2 diabetes locus on 12q15: further mapping and mutation screening of two candidate genes.

PubMed ID: 11147789

DOI: 10.2337/diabetes.50.1.204

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 25326458

Title: Identification of chondroitin sulfate linkage region glycopeptides reveals prohormones as a novel class of proteoglycans.

PubMed ID: 25326458

DOI: 10.1074/mcp.m114.043703

PubMed ID: 16441242

Title: Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases.

PubMed ID: 16441242

DOI: 10.1042/bj20051931

Sequence Information:

  • Length: 657
  • Mass: 73834
  • Checksum: 42CD98F37AC5B638
  • Sequence:
    • MRRAVCFPAL CLLLNLHAAG CFSGNNDHFL AINQKKSGKP VFIYKHSQDI EKSLDIAPQK 
IYRHSYHSSS EAQVSKRHQI VNSAFPRPAY DPSLNLLAMD GQDLEVENLP IPAANVIVVT 
LQMDVNKLNI TLLRIFRQGV AAALGLLPQQ VHINRLIGKK NSIELFVSPI NRKTGISDAL 
PSEEVLRSLN INVLHQSLSQ FGITEVSPEK NVLQGQHEAD KIWSKEGFYA VVIFLSIFVI 
IVTCLMILYR LKERFQLSLR QDKEKNQEIH LSPITLQPAL SEAKTVHSMV QPEQAPKVLN 
VVVDPQGRGA PEIKATTATS VCPSPFKMKP IGLQERRGSN VSLTLDMSSL GNIEPFVSIP 
TPREKVAMEY LQSASRILTR SQLRDVVASS HLLQSEFMEI PMNFVDPKEI DIPRHGTKNR 
YKTILPNPLS RVCLRPKNVT DSLSTYINAN YIRGYSGKEK AFIATQGPMI NTVDDFWQMV 
WQEDSPVIVM ITKLKEKNEK CVLYWPEKRG IYGKVEVLVI SVNECDNYTI RNLVLKQGSH 
TQHVKHYWYT SWPDHKTPDS AQPLLQLMLD VEEDRLASQG RGPVVVHCSA GIGRTGCFIA 
TSIGCQQLKE EGVVDALSIV CQLRMDRGGM VQTSEQYEFV HHALCLYESR LSAETVQ

Genular Protein ID: 2413212265

Symbol: Q7Z2V8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7Z2V8

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 1 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 2 PRINTS 2 PROSITE 5 PeptideAtlas 1 Pfam 1 RefSeq 1 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 412
  • Mass: 46551
  • Checksum: BC8F13B2CDA7113D
  • Sequence:
    • MILYRLKERF QLSLRQDKEK NQEIHLSPIT LQPALSEAKT VHSMVQPEQA PKVLNVVVDP 
QGRGAPEIRA TTATSVCPSP FKMKPIGLQE RRGSNVSLTL DMSSLGNIEP FVSIPTPREK 
VAMEYLQSAS RILTRSQLRD VVASSHLLQS EFMEIPMNFV DPKEIDIPRH GTKNRYKTIL 
PNPLSRVCLR PKNVTDSLST YINANYIRGY SGKEKAFIAT QGPMINTVDD FWQMVWQEDS 
PVIVMITKLK EKNEKCVLYW PEKRGIYGKV EVLVISVNEC DNYTIRNLVL KQGSHTQHVK 
HYWYTSWPDH KTPDSAQPLL QLMLDVEEGR LASQGRGPVV VHCSAGIGRT GCFIATSIGC 
QQLKEEGVVD ALSIVCQLRM DRGGMVQTSE QYEFVHHALC LYESRLSAET VQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.