Details for: RAB5B

Gene ID: 5869

Symbol: RAB5B

Ensembl ID: ENSG00000111540

Description: RAB5B, member RAS oncogene family

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 197.1131
    Cell Significance Index: -30.6600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 117.2709
    Cell Significance Index: -29.7500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 68.1391
    Cell Significance Index: -32.1700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 60.6355
    Cell Significance Index: -31.1900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 25.9377
    Cell Significance Index: -31.9800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.2772
    Cell Significance Index: -30.2100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.1439
    Cell Significance Index: -28.0900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.3096
    Cell Significance Index: -32.7900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.5235
    Cell Significance Index: 34.4300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4428
    Cell Significance Index: 86.6200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.1232
    Cell Significance Index: 29.9900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0726
    Cell Significance Index: 174.4400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9172
    Cell Significance Index: 183.9800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.8850
    Cell Significance Index: 8.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8032
    Cell Significance Index: 159.4000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7609
    Cell Significance Index: 137.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7581
    Cell Significance Index: 93.2200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7406
    Cell Significance Index: 38.4700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6720
    Cell Significance Index: 18.2900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5516
    Cell Significance Index: 11.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5411
    Cell Significance Index: 53.5300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.5291
    Cell Significance Index: 12.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4717
    Cell Significance Index: 257.6300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4644
    Cell Significance Index: 63.7700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4608
    Cell Significance Index: 165.3000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3876
    Cell Significance Index: 18.0700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3783
    Cell Significance Index: 167.2500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3647
    Cell Significance Index: 27.1800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.3415
    Cell Significance Index: 4.7900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3373
    Cell Significance Index: 17.7100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3141
    Cell Significance Index: 9.0500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3006
    Cell Significance Index: 14.1300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2922
    Cell Significance Index: 18.8500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2691
    Cell Significance Index: 7.5200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.2686
    Cell Significance Index: 3.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2635
    Cell Significance Index: 16.6100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2524
    Cell Significance Index: 32.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2398
    Cell Significance Index: 30.9800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2254
    Cell Significance Index: 203.5000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1900
    Cell Significance Index: 3.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1875
    Cell Significance Index: 32.0100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1761
    Cell Significance Index: 33.5200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1209
    Cell Significance Index: 3.1800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0877
    Cell Significance Index: 6.2000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0797
    Cell Significance Index: 2.8000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0745
    Cell Significance Index: 8.7900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0680
    Cell Significance Index: 5.2200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0199
    Cell Significance Index: 37.4800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0127
    Cell Significance Index: 9.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0096
    Cell Significance Index: 0.5400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0069
    Cell Significance Index: 0.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0004
    Cell Significance Index: 0.7300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0021
    Cell Significance Index: -1.3600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0023
    Cell Significance Index: -1.6900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0055
    Cell Significance Index: -8.4800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0099
    Cell Significance Index: -7.3200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0105
    Cell Significance Index: -6.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0119
    Cell Significance Index: -16.1700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0225
    Cell Significance Index: -1.3800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0238
    Cell Significance Index: -10.8200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0353
    Cell Significance Index: -19.9200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0360
    Cell Significance Index: -1.2500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0360
    Cell Significance Index: -3.6800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0602
    Cell Significance Index: -4.0500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0839
    Cell Significance Index: -17.6800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0932
    Cell Significance Index: -10.6400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0944
    Cell Significance Index: -27.1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1214
    Cell Significance Index: -17.6500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1318
    Cell Significance Index: -3.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1403
    Cell Significance Index: -16.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1555
    Cell Significance Index: -18.1200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1687
    Cell Significance Index: -3.5000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1854
    Cell Significance Index: -3.8800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1930
    Cell Significance Index: -4.1100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1962
    Cell Significance Index: -2.9800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2068
    Cell Significance Index: -5.1700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.2267
    Cell Significance Index: -1.4000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2672
    Cell Significance Index: -12.1100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2684
    Cell Significance Index: -8.6000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2836
    Cell Significance Index: -4.8600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2890
    Cell Significance Index: -4.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2915
    Cell Significance Index: -30.3500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2917
    Cell Significance Index: -8.3300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3062
    Cell Significance Index: -24.2500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3497
    Cell Significance Index: -15.4700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3569
    Cell Significance Index: -3.7000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3863
    Cell Significance Index: -3.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3890
    Cell Significance Index: -23.8500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3939
    Cell Significance Index: -7.2800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4127
    Cell Significance Index: -11.8300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4351
    Cell Significance Index: -16.4800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4470
    Cell Significance Index: -11.4200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4713
    Cell Significance Index: -12.1200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5528
    Cell Significance Index: -6.5900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5671
    Cell Significance Index: -13.6000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6556
    Cell Significance Index: -19.3100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6776
    Cell Significance Index: -21.5800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6917
    Cell Significance Index: -25.3900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6950
    Cell Significance Index: -14.7500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6961
    Cell Significance Index: -22.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RAB5B is a small GTPase that belongs to the RAS superfamily, characterized by its ability to bind and hydrolyze GTP. Its expression is widespread, with significant levels detected in germ cells, squamous epithelial cells, and various types of immune cells, including neutrophils and T cells. RAB5B is also highly expressed in the endosomal system, where it regulates the trafficking and processing of proteins. **Pathways and Functions:** RAB5B is integral to several key pathways, including: 1. **Antigen Processing and Presentation:** RAB5B regulates the trafficking of antigens from the plasma membrane to the endosomal system, where they are processed and presented to T cells, thereby initiating an immune response. 2. **Clathrin-Mediated Endocytosis:** RAB5B interacts with clathrin and other endocytic proteins to regulate the internalization of receptors and ligands, influencing cell signaling and immune responses. 3. **Vesicle-Mediated Transport:** RAB5B regulates the formation and trafficking of endosomes, including melanosomes, which are essential for melanosome formation and function. 4. **Immune System Function:** RAB5B plays a crucial role in the regulation of immune cell function, including neutrophil degranulation and T cell activation. **Clinical Significance:** Dysregulation of RAB5B has been implicated in various diseases, including: 1. **Infectious Diseases:** RAB5B has been shown to play a role in the entry and replication of respiratory syncytial virus (RSV) and other viruses, highlighting its importance in viral infection pathways. 2. **Autoimmune Diseases:** Alterations in RAB5B expression and function have been linked to autoimmune diseases, such as rheumatoid arthritis and lupus, where it may contribute to the development and progression of autoimmune responses. 3. **Cancer:** RAB5B has been identified as a potential oncogene, with its overexpression contributing to cancer progression and metastasis. 4. **Neurological Disorders:** RAB5B has been implicated in the regulation of synaptic vesicle trafficking and neurotransmitter release, highlighting its potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, RAB5B is a multifaceted gene that plays a critical role in various cellular processes, including antigen processing and presentation, endocytosis, and vesicle-mediated transport. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its role in immune system function and disease. Further research is needed to elucidate the mechanisms by which RAB5B regulates immune responses and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 1091134080

Symbol: RAB5B_HUMAN

Name: Ras-related protein Rab-5B

UniProtKB Accession Codes:

P61020 A8K982 B4DKD7 P35239 P35277 Q6PIK9 Q86TH0 Q8IXL2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 10 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 13 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 6 RefSeq 5 Rhea 2 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1541686

Title: Identification and subcellular localization of human rab5b, a new member of the ras-related superfamily of GTPases.

PubMed ID: 1541686

DOI: 10.1172/jci115683

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10491193

Title: Direct interaction of EEA1 with Rab5b.

PubMed ID: 10491193

DOI: 10.1046/j.1432-1327.1999.00743.x

PubMed ID: 11733506

Title: A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5.

PubMed ID: 11733506

DOI: 10.1074/jbc.m106276200

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29125462

Title: Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.

PubMed ID: 29125462

DOI: 10.7554/elife.31012

PubMed ID: 32974215

Title: The Salmonella effector SseK3 targets small Rab GTPases.

PubMed ID: 32974215

DOI: 10.3389/fcimb.2020.00419

Sequence Information:

  • Length: 215
  • Mass: 23707
  • Checksum: D47AD834BCF8B591
  • Sequence:
    • MTSRSTARPN GQPQASKICQ FKLVLLGESA VGKSSLVLRF VKGQFHEYQE STIGAAFLTQ 
SVCLDDTTVK FEIWDTAGQE RYHSLAPMYY RGAQAAIVVY DITNQETFAR AKTWVKELQR 
QASPSIVIAL AGNKADLANK RMVEYEEAQA YADDNSLLFM ETSAKTAMNV NDLFLAIAKK 
LPKSEPQNLG GAAGRSRGVD LHEQSQQNKS QCCSN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.