RANGAP1 | ENSG00000100401 | NCBI 5905

Details for: RANGAP1

Gene ID: 5905

Symbol: RANGAP1

Ensembl ID: ENSG00000100401

Description: Ran GTPase activating protein 1

Associated with

Amplification of signal from the kinetochores
(R-HSA-141424)
Amplification of signal from unattached kinetochores via a mad2 inhibitory signal
(R-HSA-141444)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Disease
(R-HSA-1643685)
Eml4 and nudc in mitotic spindle formation
(R-HSA-9648025)
Hiv infection
(R-HSA-162906)
Hiv life cycle
(R-HSA-162587)
Host interactions of hiv factors
(R-HSA-162909)
Infectious disease
(R-HSA-5663205)
Interactions of rev with host cellular proteins
(R-HSA-177243)
Late phase of hiv life cycle
(R-HSA-162599)
Metabolism of proteins
(R-HSA-392499)
Mitotic anaphase
(R-HSA-68882)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Nuclear envelope (ne) reassembly
(R-HSA-2995410)
Post-translational protein modification
(R-HSA-597592)
Postmitotic nuclear pore complex (npc) reformation
(R-HSA-9615933)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Rev-mediated nuclear export of hiv rna
(R-HSA-165054)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate formins
(R-HSA-5663220)
Separation of sister chromatids
(R-HSA-2467813)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Sumoylation of dna replication proteins
(R-HSA-4615885)
Sumoylation of nuclear envelope proteins
(R-HSA-9793242)
Viral infection pathways
(R-HSA-9824446)
Activation of gtpase activity
(GO:0090630)
Aggresome
(GO:0016235)
Axon cytoplasm
(GO:1904115)
Cadherin binding
(GO:0045296)
Cellular response to vasopressin
(GO:1904117)
Cytoplasm
(GO:0005737)
Cytoplasmic periphery of the nuclear pore complex
(GO:1990723)
Cytosol
(GO:0005829)
Dendrite
(GO:0030425)
Gtpase activator activity
(GO:0005096)
Intracellular membrane-bounded organelle
(GO:0043231)
Kinetochore
(GO:0000776)
Mitotic spindle
(GO:0072686)
Negative regulation of protein export from nucleus
(GO:0046826)
Nuclear envelope
(GO:0005635)
Nuclear export
(GO:0051168)
Nuclear membrane
(GO:0031965)
Nuclear pore
(GO:0005643)
Nuclear pore cytoplasmic filaments
(GO:0044614)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Protein binding
(GO:0005515)
Protein sumoylation
(GO:0016925)
Response to axon injury
(GO:0048678)
Rna binding
(GO:0003723)
Signal transduction
(GO:0007165)
Small gtpase binding
(GO:0031267)
Sumo ligase complex
(GO:0106068)
Ubiquitin protein ligase binding
(GO:0031625)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 140.1522
Cell Significance Index: -21.8000
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 99.2338
Cell Significance Index: -25.1700
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 62.9934
Cell Significance Index: -25.9500
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 52.2822
Cell Significance Index: -21.2400
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 22.3725
Cell Significance Index: -21.3600
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 21.1200
Cell Significance Index: -26.0400
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 10.7604
Cell Significance Index: -33.0500
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 9.2017
Cell Significance Index: -24.6500
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 6.8695
Cell Significance Index: 113.2000
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 6.7447
Cell Significance Index: -26.6200
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 6.4288
Cell Significance Index: -14.0700
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.6708
Cell Significance Index: 44.7700
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.4446
Cell Significance Index: 289.7800
Cell Name: epidermal cell (CL0000362)
Fold Change: 1.2952
Cell Significance Index: 2.9200
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.1383
Cell Significance Index: 112.6000
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.1050
Cell Significance Index: 57.4000
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.0366
Cell Significance Index: 28.9700
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.9942
Cell Significance Index: 28.6500
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.9910
Cell Significance Index: 894.8300
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.8007
Cell Significance Index: 158.9000
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.7205
Cell Significance Index: 117.1900
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.7082
Cell Significance Index: 127.6700
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.6586
Cell Significance Index: 18.8800
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.6207
Cell Significance Index: 76.3300
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.5826
Cell Significance Index: 5.3700
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.5764
Cell Significance Index: 16.4500
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.5760
Cell Significance Index: 206.5900
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.5603
Cell Significance Index: 14.9600
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.4423
Cell Significance Index: 12.0400
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.3839
Cell Significance Index: 18.0500
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.3836
Cell Significance Index: 8.3100
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.3792
Cell Significance Index: 9.9700
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.3145
Cell Significance Index: 139.0400
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.2783
Cell Significance Index: 10.5400
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2778
Cell Significance Index: 151.7000
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.2762
Cell Significance Index: 18.5700
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.2739
Cell Significance Index: 16.4500
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.2738
Cell Significance Index: 12.1100
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2239
Cell Significance Index: 10.1500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.2197
Cell Significance Index: 16.3700
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.2142
Cell Significance Index: 13.5000
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.2141
Cell Significance Index: 31.1200
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.1964
Cell Significance Index: 15.0800
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.1952
Cell Significance Index: 4.8800
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.1784
Cell Significance Index: 21.0400
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1564
Cell Significance Index: 10.8200
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.1305
Cell Significance Index: 8.4200
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1216
Cell Significance Index: 5.6700
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0936
Cell Significance Index: 12.8500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0871
Cell Significance Index: 3.0600
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0813
Cell Significance Index: 5.7500
Cell Name: lactocyte (CL0002325)
Fold Change: 0.0689
Cell Significance Index: 8.9000
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0546
Cell Significance Index: 10.3900
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0459
Cell Significance Index: 86.4800
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0417
Cell Significance Index: 76.8200
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0414
Cell Significance Index: 7.0700
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0314
Cell Significance Index: 48.2900
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0155
Cell Significance Index: 21.1200
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0139
Cell Significance Index: 0.3000
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.0111
Cell Significance Index: 0.5800
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0034
Cell Significance Index: 2.1600
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0209
Cell Significance Index: -15.8500
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0223
Cell Significance Index: -16.3300
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0280
Cell Significance Index: -20.7500
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0305
Cell Significance Index: -13.8400
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0432
Cell Significance Index: -24.3800
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0459
Cell Significance Index: -28.6400
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0487
Cell Significance Index: -5.5800
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0544
Cell Significance Index: -5.5600
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0695
Cell Significance Index: -3.6500
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0725
Cell Significance Index: -20.8700
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.0811
Cell Significance Index: -0.4900
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0849
Cell Significance Index: -9.8900
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0878
Cell Significance Index: -11.2600
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.1065
Cell Significance Index: -1.2700
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1150
Cell Significance Index: -7.0700
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1280
Cell Significance Index: -7.1900
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1394
Cell Significance Index: -29.3700
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.1869
Cell Significance Index: -2.5500
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.1900
Cell Significance Index: -3.2000
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.2055
Cell Significance Index: -7.1400
Cell Name: decidual cell (CL2000002)
Fold Change: -0.2365
Cell Significance Index: -3.8000
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2415
Cell Significance Index: -25.1500
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2708
Cell Significance Index: -21.4500
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.2920
Cell Significance Index: -4.3100
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2997
Cell Significance Index: -9.6000
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3068
Cell Significance Index: -18.8100
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.3752
Cell Significance Index: -6.4300
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.3974
Cell Significance Index: -11.6700
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: -0.4236
Cell Significance Index: -3.6400
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: -0.4282
Cell Significance Index: -2.6400
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.4345
Cell Significance Index: -10.4200
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.4346
Cell Significance Index: -13.8400
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.4444
Cell Significance Index: -9.7300
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.4601
Cell Significance Index: -9.7700
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.4624
Cell Significance Index: -15.1400
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.4910
Cell Significance Index: -6.9900
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.4916
Cell Significance Index: -9.7200
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.4936
Cell Significance Index: -8.2600
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.5081
Cell Significance Index: -17.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** RANGAP1 is a GTPase-activating protein (GAP) that specifically activates the small GTPase Ran. This activation is essential for Ran's downstream functions, including the regulation of nuclear export, mitotic spindle formation, and cytoskeleton dynamics. RANGAP1 is highly expressed in various cell types, including neurons, muscle cells, and epithelial cells. **Pathways and Functions** RANGAP1 is involved in several key pathways, including: 1. **Cell Cycle Regulation**: RANGAP1 regulates the cell cycle by controlling the activity of Ran, which is essential for the proper progression of the cell cycle. 2. **Protein Transport**: RANGAP1 regulates the nuclear export of proteins, including the HIV-1 Rev protein, which is essential for the viral life cycle. 3. **Cytoskeleton Dynamics**: RANGAP1 regulates the cytoskeleton dynamics by controlling the activity of Ran, which is essential for cell shape, motility, and division. 4. **Signal Transduction**: RANGAP1 is involved in signal transduction pathways, including those mediated by Rho GTPases, which regulate cell migration, adhesion, and proliferation. **Clinical Significance** RANGAP1 has been implicated in various diseases, including: 1. **HIV-1 Infection**: RANGAP1 is essential for the nuclear export of HIV-1 Rev protein, which is critical for the viral life cycle. 2. **Cancer**: RANGAP1 has been implicated in the regulation of cell cycle and protein transport, which are critical for cancer development and progression. 3. **Neurological Disorders**: RANGAP1 has been implicated in the regulation of cytoskeleton dynamics and signal transduction, which are critical for neuronal function and development. 4. **Muscle Diseases**: RANGAP1 has been implicated in the regulation of muscle cell function and development, which are critical for muscle function and development. **Significantly Expressed Cells** RANGAP1 is highly expressed in various cell types, including: 1. **Early Promyelocyte**: RANGAP1 is highly expressed in early promyelocytes, which are precursor cells to neutrophils. 2. **Dopaminergic Neurons**: RANGAP1 is highly expressed in dopaminergic neurons, which are critical for motor control and reward processing. 3. **Glutamatergic Cortical Neurons**: RANGAP1 is highly expressed in glutamatergic cortical neurons, which are critical for learning and memory. 4. **Corticothalamic-Projecting Glutamatergic Cortical Neurons**: RANGAP1 is highly expressed in corticothalamic-projecting glutamatergic cortical neurons, which are critical for sensory processing and integration. In conclusion, RANGAP1 is a critical gene that regulates various cellular processes, including cell cycle regulation, protein transport, and signal transduction. Its dysregulation has been implicated in various diseases, including HIV-1 infection, cancer, and neurological disorders. Further research is needed to fully understand the mechanisms of RANGAP1 and its role in human disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Ran GTPase-activating protein 1
Q9BSK3_HUMAN

Genular Protein ID: 2168566184

Symbol: RAGP1_HUMAN

Name: Ran GTPase-activating protein 1

UniProtKB Accession Codes:

P46060 Q96JJ2

Database IDs:

Citations:

PubMed ID: 7878053

Title: Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport.

PubMed ID: 7878053

DOI: 10.1073/pnas.92.5.1749

PubMed ID: 11347906

Title: Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 11347906

DOI: 10.1093/dnares/8.2.85

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8146159

Title: RanGAP1 induces GTPase activity of nuclear Ras-related Ran.

PubMed ID: 8146159

DOI: 10.1073/pnas.91.7.2587

PubMed ID: 7891706

Title: Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing.

PubMed ID: 7891706

DOI: 10.1128/mcb.15.4.2117

PubMed ID: 8973340

Title: Ubiquitous expression and testis-specific alternative polyadenylation of mRNA for the human Ran GTPase activator RanGAP1.

PubMed ID: 8973340

DOI: 10.1016/s0378-1119(96)00389-7

PubMed ID: 8896452

Title: Identification of different roles for RanGDP and RanGTP in nuclear protein import.

PubMed ID: 8896452

DOI: 10.1002/j.1460-2075.1996.tb00943.x

PubMed ID: 11854305

Title: SUMO-1 targets RanGAP1 to kinetochores and mitotic spindles.

PubMed ID: 11854305

DOI: 10.1083/jcb.200110109

PubMed ID: 15037602

Title: RanGAP1*SUMO1 is phosphorylated at the onset of mitosis and remains associated with RanBP2 upon NPC disassembly.

PubMed ID: 15037602

DOI: 10.1083/jcb.200309126

PubMed ID: 14729961

Title: RanBP2/Nup358 provides a major binding site for NXF1-p15 dimers at the nuclear pore complex and functions in nuclear mRNA export.

PubMed ID: 14729961

DOI: 10.1128/mcb.24.3.1155-1167.2004

PubMed ID: 16428860

Title: Phosphorylation of RanGAP1 stabilizes its interaction with Ran and RanBP1.

PubMed ID: 16428860

DOI: 10.1247/csf.30.69

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18093978

Title: Nuclear tumor necrosis factor receptor-associated factor 6 in lymphoid cells negatively regulates c-Myb-mediated transactivation through small ubiquitin-related modifier-1 modification.

PubMed ID: 18093978

DOI: 10.1074/jbc.m706307200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20388717

Title: In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification.

PubMed ID: 20388717

DOI: 10.1074/jbc.m110.106955

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 26304119

Title: MYCBP2 is a guanosine exchange factor for Ran protein and determines its localization in neurons of dorsal root ganglia.

PubMed ID: 26304119

DOI: 10.1074/jbc.m115.646901

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 27160050

Title: The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes.

PubMed ID: 27160050

DOI: 10.1038/ncomms11482

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 15931224

Title: Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex.

PubMed ID: 15931224

DOI: 10.1038/nature03588

PubMed ID: 17099698

Title: SUMO protease SENP1 induces isomerization of the scissile peptide bond.

PubMed ID: 17099698

DOI: 10.1038/nsmb1172

PubMed ID: 22194619

Title: Determinants of small ubiquitin-like modifier 1 (SUMO1) protein specificity, E3 ligase, and SUMO-RanGAP1 binding activities of nucleoporin RanBP2.

PubMed ID: 22194619

DOI: 10.1074/jbc.m111.321141

Sequence Information:

Length: 587
Mass: 63542
Checksum: 3C18068AAC06B98F
Sequence:

MASEDIAKLA ETLAKTQVAG GQLSFKGKSL KLNTAEDAKD VIKEIEDFDS LEALRLEGNT 
VGVEAARVIA KALEKKSELK RCHWSDMFTG RLRTEIPPAL ISLGEGLITA GAQLVELDLS 
DNAFGPDGVQ GFEALLKSSA CFTLQELKLN NCGMGIGGGK ILAAALTECH RKSSAQGKPL 
ALKVFVAGRN RLENDGATAL AEAFRVIGTL EEVHMPQNGI NHPGITALAQ AFAVNPLLRV 
INLNDNTFTE KGAVAMAETL KTLRQVEVIN FGDCLVRSKG AVAIADAIRG GLPKLKELNL 
SFCEIKRDAA LAVAEAMADK AELEKLDLNG NTLGEEGCEQ LQEVLEGFNM AKVLASLSDD 
EDEEEEEEGE EEEEEAEEEE EEDEEEEEEE EEEEEEEPQQ RGQGEKSATP SRKILDPNTG 
EPAPVLSSPP PADVSTFLAF PSPEKLLRLG PKSSVLIAQQ TDTSDPEKVV SAFLKVSSVF 
KDEATVRMAV QDAVDALMQK AFNSSSFNSN TFLTRLLVHM GLLKSEDKVK AIANLYGPLM 
ALNHMVQQDY FPKALAPLLL AFVTKPNSAL ESCSFARHSL LQTLYKV

Genular Protein ID: 1572771219

Symbol: Q9BSK3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9BSK3

Database IDs:

Sequence Information:

Length: 213
Mass: 23540
Checksum: 0C663A409DB3943D
Sequence:

EAEEEEEEDE EEEEEEEEEE EEEPQQRGQG EKSATPSRKI LDPNTGEPAP VLSSPPPADV 
STFLAFPSPE KLLRLGPKSS VLIAQQTDTS DPEKVVSAFL KVSSVFKDEA TVRMAVQDAV 
DALMQKAFNS SSFNSNTFLT RLLVHMGLLK SEDKVKAIAN LYGPLMALNH MVQQDYFPKA 
LAPLLLAFVT KPNSALESCS FARHSLLQTL YKV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RANGAP1

Associated with

Cells (max top 100)

Other Information

Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport. PubMed ID: 7878053

Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 11347906

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. PubMed ID: 12168954

A genome annotation-driven approach to cloning the human ORFeome. PubMed ID: 15461802

The DNA sequence of human chromosome 22. PubMed ID: 10591208

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

RanGAP1 induces GTPase activity of nuclear Ras-related Ran. PubMed ID: 8146159

Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing. PubMed ID: 7891706

Ubiquitous expression and testis-specific alternative polyadenylation of mRNA for the human Ran GTPase activator RanGAP1. PubMed ID: 8973340

Identification of different roles for RanGDP and RanGTP in nuclear protein import. PubMed ID: 8896452

SUMO-1 targets RanGAP1 to kinetochores and mitotic spindles. PubMed ID: 11854305

RanGAP1*SUMO1 is phosphorylated at the onset of mitosis and remains associated with RanBP2 upon NPC disassembly. PubMed ID: 15037602

RanBP2/Nup358 provides a major binding site for NXF1-p15 dimers at the nuclear pore complex and functions in nuclear mRNA export. PubMed ID: 14729961

Phosphorylation of RanGAP1 stabilizes its interaction with Ran and RanBP1. PubMed ID: 16428860

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Nuclear tumor necrosis factor receptor-associated factor 6 in lymphoid cells negatively regulates c-Myb-mediated transactivation through small ubiquitin-related modifier-1 modification. PubMed ID: 18093978

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification. PubMed ID: 20388717

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Uncovering global SUMOylation signaling networks in a site-specific manner. PubMed ID: 25218447

Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. PubMed ID: 25114211

SUMO-2 orchestrates chromatin modifiers in response to DNA damage. PubMed ID: 25772364

MYCBP2 is a guanosine exchange factor for Ran protein and determines its localization in neurons of dorsal root ganglia. PubMed ID: 26304119

System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. PubMed ID: 25755297

The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes. PubMed ID: 27160050

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex. PubMed ID: 15931224

SUMO protease SENP1 induces isomerization of the scissile peptide bond. PubMed ID: 17099698

Determinants of small ubiquitin-like modifier 1 (SUMO1) protein specificity, E3 ligase, and SUMO-RanGAP1 binding activities of nucleoporin RanBP2. PubMed ID: 22194619