Details for: RGS3

Gene ID: 5998

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: RGS3

Ensembl ID: ENSG00000138835

Description: regulator of G protein signaling 3

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • retina horizontal cell CL0000745
    CSI 17.28
    rCSI 26.33%
    PRS 79.45
  • regular atrial cardiac myocyte CL0002129
    CSI 10.02
    rCSI 32.27%
    PRS 79.44
  • endothelial cell of placenta CL0009092
    CSI 7.74
    rCSI 38.14%
    PRS 89.24
  • lung ciliated cell CL1000271
    CSI 5.95
    rCSI 6.88%
    PRS 75.3
  • type EC enteroendocrine cell CL0000577
    CSI 5.37
    rCSI 19.06%
    PRS 86
  • renal interstitial pericyte CL1001318
    CSI 4.7
    rCSI 12.97%
    PRS 78.07
  • effector memory CD8-positive, alpha-beta T cell CL0000913
    CSI 4.42
    rCSI 4.02%
    PRS 92.77
  • podocyte CL0000653
    CSI 4.16
    rCSI 18.47%
    PRS 83.22
  • interstitial cell of Cajal CL0002088
    CSI 3.77
    rCSI 4.8%
    PRS 87.32
  • T follicular helper cell CL0002038
    CSI 3.57
    rCSI 2.67%
    PRS 93.42
  • intrahepatic cholangiocyte CL0002538
    CSI 3.54
    rCSI 8.5%
    PRS 85.54
  • effector CD8-positive, alpha-beta T cell CL0001050
    CSI 3.18
    rCSI 2.42%
    PRS 93.54
  • alveolar type 1 fibroblast cell CL4028004
    CSI 3.15
    rCSI 3.45%
    PRS 84.39
  • subcutaneous adipocyte CL0002521
    CSI 3.03
    rCSI 15.51%
    PRS 85.56
  • bronchus fibroblast of lung CL2000093
    CSI 2.99
    rCSI 2.43%
    PRS 82.1
  • perivascular cell CL4033054
    CSI 2.94
    rCSI 4.02%
    PRS 86.87
  • radial glial cell CL0000681
    CSI 2.93
    rCSI 4.07%
    PRS 81.07
  • epithelial cell of lung CL0000082
    CSI 2.75
    rCSI 2.28%
    PRS 83.69
  • skin fibroblast CL0002620
    CSI 2.56
    rCSI 2.21%
    PRS 83.04
  • neural crest cell CL0011012
    CSI 2.44
    rCSI 1.93%
    PRS 72.38
  • stem cell CL0000034
    CSI 2.43
    rCSI 2.35%
    PRS 76.66
  • cardiac endothelial cell CL0010008
    CSI 2.42
    rCSI 9.78%
    PRS 82.65
  • fibroblast of lung CL0002553
    CSI 2.42
    rCSI 2.25%
    PRS 83.41
  • blood vessel endothelial cell CL0000071
    CSI 2.41
    rCSI 4.99%
    PRS 79.57
  • chondrocyte CL0000138
    CSI 2.3
    rCSI 3.66%
    PRS 76.14
  • choroid plexus epithelial cell CL0000706
    CSI 2.29
    rCSI 3.75%
    PRS 72.68
  • endothelial cell of periportal hepatic sinusoid CL0019021
    CSI 2.27
    rCSI 10.43%
    PRS 86.43
  • mucous neck cell CL0000651
    CSI 2.23
    rCSI 3.22%
    PRS 88.37
  • cerebral cortex endothelial cell CL1001602
    CSI 2.23
    rCSI 3.86%
    PRS 74.74
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 2.2
    rCSI 5.01%
    PRS 76.19
  • retinal blood vessel endothelial cell CL0002585
    CSI 2.19
    rCSI 3.5%
    PRS 85.99
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 2.19
    rCSI 2.53%
    PRS 75
  • glioblast CL0000030
    CSI 2.18
    rCSI 3.48%
    PRS 74.37
  • enteric smooth muscle cell CL0002504
    CSI 2.17
    rCSI 3.1%
    PRS 83.35
  • mesodermal cell CL0000222
    CSI 2.03
    rCSI 2.44%
    PRS 80.75
  • lung endothelial cell CL1001567
    CSI 1.98
    rCSI 4.61%
    PRS 91.85
  • ciliated cell CL0000064
    CSI 1.95
    rCSI 3.16%
    PRS 77.43
  • endothelial cell of uterus CL0009095
    CSI 1.93
    rCSI 14.08%
    PRS 89.58
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 1.92
    rCSI 3.39%
    PRS 64.96
  • fallopian tube secretory epithelial cell CL4030006
    CSI 1.91
    rCSI 1.84%
    PRS 82.07
  • mononuclear phagocyte CL0000113
    CSI 1.85
    rCSI 4.07%
    PRS 85.99
  • hepatocyte CL0000182
    CSI 1.82
    rCSI 3.26%
    PRS 81.85
  • ependymal cell CL0000065
    CSI 1.82
    rCSI 3.69%
    PRS 61.75
  • endocardial cell CL0002350
    CSI 1.82
    rCSI 8.7%
    PRS 78.92
  • lung secretory cell CL1000272
    CSI 1.81
    rCSI 4.48%
    PRS 82.69
  • colon epithelial cell CL0011108
    CSI 1.79
    rCSI 1.87%
    PRS 80.1
  • astrocyte of the cerebral cortex CL0002605
    CSI 1.74
    rCSI 3.89%
    PRS 66.31
  • renal principal cell CL0005009
    CSI 1.68
    rCSI 4.37%
    PRS 82.68
  • endothelial cell of pericentral hepatic sinusoid CL0019022
    CSI 1.66
    rCSI 5.12%
    PRS 86.34
  • ciliated epithelial cell CL0000067
    CSI 1.66
    rCSI 1.46%
    PRS 72.29
  • vascular associated smooth muscle cell CL0000359
    CSI 1.65
    rCSI 5.35%
    PRS 80.73
  • mesenchymal cell CL0008019
    CSI 1.61
    rCSI 4.09%
    PRS 76.44
  • epithelial cell of proximal tubule CL0002306
    CSI 1.6
    rCSI 3.92%
    PRS 75.08
  • pulmonary artery endothelial cell CL1001568
    CSI 1.59
    rCSI 2.16%
    PRS 90.05
  • odontoblast CL0000060
    CSI 1.55
    rCSI 35.1%
    PRS 90.97
  • club cell CL0000158
    CSI 1.55
    rCSI 2.27%
    PRS 77.44
  • peripheral nervous system neuron CL2000032
    CSI 1.54
    rCSI 2.1%
    PRS 74.59
  • basal cell CL0000646
    CSI 1.5
    rCSI 2%
    PRS 80.84
  • cardiac muscle cell CL0000746
    CSI 1.48
    rCSI 2.12%
    PRS 72.89
  • CD8-positive, alpha-beta cytotoxic T cell CL0000794
    CSI 1.46
    rCSI 1.74%
    PRS 94.98
  • kidney epithelial cell CL0002518
    CSI 1.45
    rCSI 2.77%
    PRS 94.05
  • lung pericyte CL0009089
    CSI 1.41
    rCSI 3.73%
    PRS 88.6
  • kidney distal convoluted tubule epithelial cell CL1000849
    CSI 1.37
    rCSI 14.55%
    PRS 78.69
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 1.3
    rCSI 3.37%
    PRS 78.36
  • intestinal tuft cell CL0019032
    CSI 1.3
    rCSI 1.98%
    PRS 85.95
  • tracheobronchial smooth muscle cell CL0019019
    CSI 1.27
    rCSI 2.23%
    PRS 87.19
  • pancreatic ductal cell CL0002079
    CSI 1.26
    rCSI 2.45%
    PRS 85.48
  • megakaryocyte CL0000556
    CSI 1.18
    rCSI 5.11%
    PRS 86.93
  • pancreatic stellate cell CL0002410
    CSI 1.13
    rCSI 6.58%
    PRS 85.95
  • kidney connecting tubule epithelial cell CL1000768
    CSI 1.07
    rCSI 2.72%
    PRS 73.59
  • effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062
    CSI 1
    rCSI 5.04%
    PRS 92.72
  • platelet CL0000233
    CSI 0.9
    rCSI 3.75%
    PRS 79.68
  • microcirculation associated smooth muscle cell CL0008035
    CSI 0.8
    rCSI 2.32%
    PRS 81.98
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 0.65
    rCSI 2.03%
    PRS 69.38
  • vasa recta descending limb cell CL1001285
    CSI 0.61
    rCSI 4.86%
    PRS 89.88
  • regular ventricular cardiac myocyte CL0002131
    CSI 0.56
    rCSI 3.49%
    PRS 74.75
  • vein endothelial cell of respiratory system CL4033008
    CSI 0.41
    rCSI 2.82%
    PRS 88.23
  • mesenchymal stem cell CL0000134
    CSI 0.2
    rCSI 2.18%
    PRS 87.19

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [RGS3](/details-gene/5998) (Regulator of G protein signaling 3) is a protein-coding gene located on chromosome 9q32. As a member of the RGS family, it functions primarily as a GTPase-activating protein (GAP) for G alpha subunits of heterotrimeric G proteins. This activity accelerates GTP hydrolysis, effectively terminating G protein-coupled receptor (GPCR) signaling and acting as a negative regulator. **Overall**, expression data indicate that [RGS3](/details-gene/5998) is a highly significant gene in diverse, specialized cell types, including [retina horizontal cell](/details-cell/CL0000745), [regular atrial cardiac myocyte](/details-cell/CL0002129), and [endothelial cell of placenta](/details-cell/CL0009092), suggesting it plays a critical role in fine-tuning signal transduction in tissues with high metabolic and signaling demands. Several transcript variants and protein isoforms have been identified, some of which exhibit distinct subcellular localizations and functions, including nuclear localization and induction of apoptosis [Link](https://doi.org/10.1074/jbc.m910079199). ## Cellular Roles and Expression Landscape The expression profile of [RGS3](/details-gene/5998) reveals its importance across multiple physiological systems, often in cells that are highly responsive to external signals. **Overall**, it shows the highest significance in the [retina horizontal cell](/details-cell/CL0000745) (CSI: 17.28), a neuron critical for processing visual information, where precise temporal control of signaling is paramount. Its functional importance extends to the cardiovascular system, with very high significance in [regular atrial cardiac myocyte](/details-cell/CL0002129) (CSI: 10.02) and [endothelial cell of placenta](/details-cell/CL0009092) (CSI: 7.74). This suggests a key role in modulating cardiac contractility, heart rate, and vascular tone. The gene is also prominent in various other specialized cell types, including [lung ciliated cell](/details-cell/CL1000271), [podocyte](/details-cell/CL0000653) in the kidney, and [interstitial cell of Cajal](/details-cell/CL0002088) in the gut, highlighting its role in regulating motility and filtration processes. Furthermore, [RGS3](/details-gene/5998) is significantly expressed in subsets of the immune system, particularly in [effector memory CD8-positive, alpha-beta T cell](/details-cell/CL0000913) (CSI: 4.42), [T follicular helper cell](/details-cell/CL0002038) (CSI: 3.57), and [effector CD8-positive, alpha-beta T cell](/details-cell/CL0001050) (CSI: 3.18). This pattern is consistent with a function in modulating T cell activation, differentiation, and migration in response to chemokine and antigen receptor signaling. ## Pathways and Molecular Function Functionally, [RGS3](/details-gene/5998) is a core component of intracellular signal transduction pathways. Its primary molecular function is [GTPase activator activity](/details-go/GO:0005096), which it uses to negatively regulate the [G protein-coupled receptor signaling pathway](/details-go/GO:0007186). Research confirms its ability to inhibit G protein-mediated signaling by binding to G alpha subunits, such as Galpha11, and facilitating its translocation to the membrane [Link](https://doi.org/10.1128/mcb.19.1.714). Its involvement is annotated in key Reactome pathways, including [G alpha (i) signalling events](/details-pathway/R-HSA-418594) and [G alpha (q) signalling events](/details-pathway/R-HSA-416476), which are central to cellular responses involving calcium mobilization and adenylyl cyclase inhibition. Studies have demonstrated that [RGS3](/details-gene/5998) can inhibit downstream effectors such as inositol phosphate production and the activation of both the mitogen-activated protein kinase (MAPK) and Akt signaling cascades [Link](https://doi.org/10.1074/jbc.m100089200), [Link](https://doi.org/10.1038/379742a0). The protein is found in the [cytosol](/details-go/GO:0005829), [plasma membrane](/details-go/GO:0005886), and, for certain isoforms, the [nucleus](/details-go/GO:0005634), underscoring its capacity to modulate signaling at multiple cellular locations. ## Research Directions The diverse expression pattern of [RGS3](/details-gene/5998) in highly specialized and critical cell types suggests it is a key homeostatic regulator. Future research should focus on its cell-specific roles and its potential as a therapeutic modulator in disease. Based on the available data, several testable hypotheses can be proposed: 1. In [regular atrial cardiac myocyte](/details-cell/CL0002129), [RGS3](/details-gene/5998) acts as a critical brake on beta-adrenergic receptor signaling. Its downregulation or dysfunction could contribute to atrial tachyarrhythmias by permitting excessive signaling in response to sympathetic stimulation. 2. In [effector memory CD8-positive, alpha-beta T cell](/details-cell/CL0000913), [RGS3](/details-gene/5998) fine-tunes chemokine receptor sensitivity, thereby controlling the trafficking and retention of these cells in peripheral tissues and preventing excessive immunopathology. 3. In [retina horizontal cell](/details-cell/CL0000745), [RGS3](/details-gene/5998) is essential for shaping the temporal dynamics of the visual signal by rapidly terminating GPCR signaling cascades that modulate lateral inhibition in the outer plexiform layer. To test the first hypothesis regarding its cardiac role, a compelling experiment would involve the use of a cardiomyocyte-specific conditional knockout mouse model of [RGS3](/details-gene/5998). These mice could be subjected to telemetry ECG monitoring at baseline and after challenge with a beta-adrenergic agonist like isoproterenol. An increased susceptibility to induced or spontaneous atrial arrhythmias compared to wild-type littermates would provide strong evidence for its protective role in maintaining cardiac rhythm. As a therapeutic target, [RGS3](/details-gene/5998) presents a dual opportunity. In diseases characterized by GPCR hyper-activation, such as certain cardiac arrhythmias or chronic inflammatory states, developing small molecules that stabilize or enhance the GAP activity of [RGS3](/details-gene/5998) could be a viable therapeutic strategy (activation). Conversely, in contexts where enhanced GPCR signaling is desired, such as blunted responses in certain endocrine disorders, targeted inhibition of [RGS3](/details-gene/5998) could restore signaling. However, its expression in multiple critical tissues necessitates the development of highly targeted therapies to avoid significant off-target effects.

Genular Protein ID: 3168352862

Symbol: RGS3_HUMAN

Name: Regulator of G-protein signaling 3

UniProtKB Accession Codes:

P49796 A6NHA0 A8K0V1 B3KUB2 Q5VXB8 Q5VXC1 Q5VZ05 Q5VZ06 Q6ZRM5 Q8IUQ1 Q8NC47 Q8NFN4 Q8NFN5 Q8NFN6 Q8TD59 Q8TD68 Q8WV02 Q8WXA0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 20 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 8 RNAct 1 Reactome 2 RefSeq 20 SMART 3 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8602223

Title: Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family.

PubMed ID: 8602223

DOI: 10.1038/379742a0

PubMed ID: 12036301

Title: Additional 5' exons in the RGS3 locus generate multiple mRNA transcripts, one of which accounts for the origin of human PDZ-RGS3.

PubMed ID: 12036301

DOI: 10.1006/geno.2002.6773

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9858594

Title: RGS3 inhibits G protein-mediated signaling via translocation to the membrane and binding to Galpha11.

PubMed ID: 9858594

DOI: 10.1128/mcb.19.1.714

PubMed ID: 10749886

Title: Regulator of G protein signaling RGS3T is localized to the nucleus and induces apoptosis.

PubMed ID: 10749886

DOI: 10.1074/jbc.m910079199

PubMed ID: 11294858

Title: Regulator of G-protein signaling 3 (RGS3) inhibits G-beta1/gamma2-induced inositol phosphate production, mitogen-activated protein kinase activation, and Akt activation.

PubMed ID: 11294858

DOI: 10.1074/jbc.m100089200

PubMed ID: 16884686

Title: Identification and Herc5-mediated ISGylation of novel target proteins.

PubMed ID: 16884686

DOI: 10.1016/j.bbrc.2006.07.076

PubMed ID: 17487921

Title: Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.

PubMed ID: 17487921

DOI: 10.1002/elps.200600782

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

Sequence Information:

  • Length: 1198
  • Mass: 132336
  • Checksum: E615DA49022EFFE4
  • Sequence:
    • MPVIPALWEV EMGRSQGQEI ETILANRSHS DSTPLPNFLS GSHRPECCTC RLLTASGAQD 
SLPFGRRLYS GPWRSCEEVC HVSVLSVLST SCGLSLSLPI FPGWMEWLSP DIALPRRDEW 
TQTSPARKRI THAKVQGAGQ LRLSIDAQDR VLLLHIIEGK GLISKQPGTC DPYVKISLIP 
EDSRLRHQKT QTVPDCRDPA FHEHFFFPVQ EEDDQKRLLV TVWNRASQSR QSGLIGCMSF 
GVKSLLTPDK EISGWYYLLG EHLGRTKHLK VARRRLRPLR DPLLRMPGGG DTENGKKLKI 
TIPRGKDGFG FTICCDSPVR VQAVDSGGPA ERAGLQQLDT VLQLNERPVE HWKCVELAHE 
IRSCPSEIIL LVWRMVPQVK PGPDGGVLRR ASCKSTHDLQ SPPNKREKNC THGVQARPEQ 
RHSCHLVCDS SDGLLLGGWE RYTEVAKRGG QHTLPALSRA TAPTDPNYII LAPLNPGSQL 
LRPVYQEDTI PEESGSPSKG KSYTGLGKKS RLMKTVQTMK GHGNYQNCPV VRPHATHSSY 
GTYVTLAPKV LVFPVFVQPL DLCNPARTLL LSEELLLYEG RNKAAEVTLF AYSDLLLFTK 
EDEPGRCDVL RNPLYLQSVK LQEGSSEDLK FCVLYLAEKA ECLFTLEAHS QEQKKRVCWC 
LSENIAKQQQ LAASPPDSKM FETEADEKRE MALEEGKGPG AEDSPPSKEP SPGQELPPGQ 
DLPPNKDSPS GQEPAPSQEP LSSKDSATSE GSPPGPDAPP SKDVPPCQEP PPAQDLSPCQ 
DLPAGQEPLP HQDPLLTKDL PAIQESPTRD LPPCQDLPPS QVSLPAKALT EDTMSSGDLL 
AATGDPPAAP RPAFVIPEVR LDSTYSQKAG AEQGCSGDEE DAEEAEEVEE GEEGEEDEDE 
DTSDDNYGER SEAKRSSMIE TGQGAEGGLS LRVQNSLRRR THSEGSLLQE PRGPCFASDT 
TLHCSDGEGA ASTWGMPSPS TLKKELGRNG GSMHHLSLFF TGHRKMSGAD TVGDDDEASR 
KRKSKNLAKD MKNKLGIFRR RNESPGAPPA GKADKMMKSF KPTSEEALKW GESLEKLLVH 
KYGLAVFQAF LRTEFSEENL EFWLACEDFK KVKSQSKMAS KAKKIFAEYI AIQACKEVNL 
DSYTREHTKD NLQSVTRGCF DLAQKRIFGL MEKDSYPRFL RSDLYLDLIN QKKMSPPL

Genular Protein ID: 1301095048

Symbol: B3KWG8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KWG8

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 5 InterPro 10 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 6 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 2 SAM 2 SMART 3 SUPFAM 4

Sequence Information:

  • Length: 1088
  • Mass: 120200
  • Checksum: 0ABAE7F29B9F783C
  • Sequence:
    • MPRTGFCCFT VSLFVWMDMS MCVSLSRCVC VYVSIHPPQC LNSLLVIEGK GLISKQPGTC 
DPYVKISLIP EDSRLRHQKT QTVPDCRDPA FHEHFFFPVQ EEDDQKRLLV TVWNRASQSR 
QSGLIGCMSF GVKSLLTPDK EISGWYYLLG EHLGRTKHLK VARRRLRPLR DPLLRMPGGG 
DTENGKKLKI TIPRGKDGFG FTICCDSPVR VQAVDSGGPA ERAGLQQLDT VLQLNERPVE 
HWKCVELAHE IRSCPSEIIL LVWRMVPQVK PGPDGGVLRR ASCKSTHDLQ SPPNKREKNC 
THGVQARPEQ RHSCHLVCDS SDGLLLGGWE RYTEVAKRGG QHTLPALSRA TAPTDPNYII 
LAPLNPGSQL LRPVYQEYTI PEESGSPSKG KSYTGLGKKS RLMKTVQTMK GHGNYQNCPV 
VRPHATHSSY GTYVTLAPKV LVFPVFVQPL DLCNPARTLL LSEGLLLYEG RNKAAEVTLF 
AYSDLLLFTK EDEPGRCDVL RNPLYLQSVK LQEGSSEDLK FCVLYLAEKA ECLFTLEAHS 
QEQKKRVCWC LSENIAKQQQ LAASPPDSKM FETEADEKRE MALEEGKGPG AEDSPPSKEP 
SPGQELPPGQ DLPPNKDSPS GQEPAPSQEP LSSKDSATSE GSPPGPDAPP SKDVPPCQEP 
PPAQDLSPCQ DLPAGQEPLP HQDPLLTKDL PAIQESPTRD LPPCQDLPPS QVSLPAKALT 
EDTMSSGDLL AATGDPPAAP RPAFVIPEVR LDSTYSQKAG AEQGCSGDEE DAEEAEEVEE 
GEEGEEDEDE DTSDDNYGER SEAKRSSMIE TGQGAEGGLS LRVQNSLRRR THSEGSLLQE 
PRGPCFASDT TLHCSDGEGA ASTWGMPSPS TLKKELGRNG GSMHHLSLFF TGHRKMSGAD 
TVGDDDEASR KRKSKNLAKD MKNKLGIFRR RNESPGAPPA GKADKMMKSF KPTSEEALKW 
GESLEKLLVH KYGLAVFQAF LRTEFSEENL EFWLACEDFK KVKSQSKMAS KAKKIFAEYI 
AIQACKEVNL DSYTREHTKD NLQSVTRGCF DLAQKRIFGL MEKDSYPRFL RSDLYLDLIN 
QKKMSPPL

Genular Protein ID: 3228257788

Symbol: H7BXY1_HUMAN

Name: N/A

UniProtKB Accession Codes:

H7BXY1

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 2 SAM 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 17487921

Title: Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.

PubMed ID: 17487921

DOI: 10.1002/elps.200600782

Sequence Information:

  • Length: 168
  • Mass: 19456
  • Checksum: 290452760ABF9C72
  • Sequence:
    • MKNKLGIFRR RNESPGAPPA GKADKMMKSF KPTSEEALKW GESLEKLLVH KYGLAVFQAF 
LRTEFSEENL EFWLACEDFK KVKSQSKMAS KAKKIFAEYI AIQACKEVNL DSYTREHTKD 
NLQSVTRGCF DLAQKRIFGL MEKDSYPRFL RSDLYLDLIN QKKMSPPL

Genular Protein ID: 262597269

Symbol: B3KVT7_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KVT7

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 2 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 519
  • Mass: 56601
  • Checksum: C7CFE3FFCB43E5A8
  • Sequence:
    • MFETEADEKR EMALEEGKGP GAEDSPPSKE PSPGQELPPG QDLPPNKDSP SGQEPAPSQE 
PLSSKDSATS EGSPPGPDAP PSKDVPPCQE PPPAQDLSPC QDLPAGQEPL PHQDPLLTKD 
LPAIQESPTR DLPPCQDLPP SQVSLPAKAL TEDTMSSGDL LAATGDPPAA PRPAFVIPEV 
RLDSTYSQKA GAEQGCSGDE EDAEEAEEVE EGEEGEEDED EDTSDDNYGE RSEAKRSSMI 
ETGQGAEGGL SLRVQNSLRR RTHSEGSLLQ EPRGPCFASD TTLHCSDGEG AASTWGMPSP 
STLKKELGRN GGSMHHLSLF FTGHRKMSGA DTVGDDDEAS RKRKSKNLAK DMKNKLGIFR 
RRNESPGAPP AGKADKMMKS FKPTSKEALK WGESLEKLLV HKYGLAVFQA FLRTEFSEEN 
LEFWLACEDF KKVKSQSKMA SKAKKIFAEY IAIQACKEVN LDSYTREHTK DNLQSVTRGC 
FDLAQKRIFG LMEKDSYPRF LRSDLYLDLI NQKKMSPPL

Genular Protein ID: 1208322531

Symbol: Q53GP3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53GP3

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 2 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 2

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

Sequence Information:

  • Length: 415
  • Mass: 45848
  • Checksum: C9926F3DC739CD98
  • Sequence:
    • ITIPRGKDGF GFTICCDSPV RVQAVDSGGP AERAGLQQLD TVLQLNERPV EHWKCAELAH 
EIRSCPSEII LLVWRMVPQV KPGPDGGVLR RASCKSTHDL QSPPNKREKN CTHGVQARPE 
QRHSCHLVCD SSDGLLLGGW ERYTEVAKRG GQHTLPALSR ATAPTDPNYI ILAPLNPGSQ 
LLRPVYQEDT IPEESGSPSK GKSYTGLGKK SRLMKTVQTM KGHGNYQNCP VVRPHATHSS 
YGTYVTLAPK VLVFPVFVQP LDLCNPARTL LLSEELLLYE GRNKAAEVTL FAYSDLLLFT 
KEDEPGRCDV LRNPLYLRSV KLQEGSSEDL KFCVLYLAEK AECLFTLEAH SQEQKKRVCW 
CLSENIAKQQ QLAASPPDSK KLHPFGSLQQ EMGPVNSTNA TQDRSFTSPG QTLIG