Details for: RLN2

Gene ID: 6019

Symbol: RLN2

Ensembl ID: ENSG00000107014

Description: relaxin 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 17.4869
    Cell Significance Index: -2.7200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 8.6736
    Cell Significance Index: -2.2000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.3196
    Cell Significance Index: -2.8600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.4334
    Cell Significance Index: 23.6200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.7541
    Cell Significance Index: -2.0200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6522
    Cell Significance Index: 13.8900
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.3999
    Cell Significance Index: 4.0100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3756
    Cell Significance Index: 22.5500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3272
    Cell Significance Index: 35.5900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2433
    Cell Significance Index: 5.6200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2419
    Cell Significance Index: 39.3400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2365
    Cell Significance Index: 213.5000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2133
    Cell Significance Index: 40.6000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2035
    Cell Significance Index: 12.8300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.2034
    Cell Significance Index: 2.9200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.1832
    Cell Significance Index: 4.6800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1531
    Cell Significance Index: 10.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1136
    Cell Significance Index: 13.4000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.1077
    Cell Significance Index: 0.8600
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.0941
    Cell Significance Index: 1.0000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0931
    Cell Significance Index: 9.2100
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.0678
    Cell Significance Index: 0.7100
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.0656
    Cell Significance Index: 0.5000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.0593
    Cell Significance Index: 0.3700
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.0588
    Cell Significance Index: 0.3900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0518
    Cell Significance Index: 28.3000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0403
    Cell Significance Index: 17.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0388
    Cell Significance Index: 2.8900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0342
    Cell Significance Index: 0.9300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0326
    Cell Significance Index: 0.9400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0291
    Cell Significance Index: 0.6300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0255
    Cell Significance Index: 0.7500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0250
    Cell Significance Index: 1.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0227
    Cell Significance Index: 1.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0211
    Cell Significance Index: 0.7400
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.0164
    Cell Significance Index: 0.1700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0154
    Cell Significance Index: 0.8100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0076
    Cell Significance Index: 0.8800
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.0047
    Cell Significance Index: 0.0600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0034
    Cell Significance Index: 0.1100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0007
    Cell Significance Index: -0.4900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0013
    Cell Significance Index: -0.9500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0013
    Cell Significance Index: -2.4900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0016
    Cell Significance Index: -0.4500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0017
    Cell Significance Index: -3.1900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0019
    Cell Significance Index: -2.9700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0023
    Cell Significance Index: -3.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0024
    Cell Significance Index: -1.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0026
    Cell Significance Index: -0.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0032
    Cell Significance Index: -1.8100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0038
    Cell Significance Index: -2.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0048
    Cell Significance Index: -0.9600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0048
    Cell Significance Index: -3.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0053
    Cell Significance Index: -2.3900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0064
    Cell Significance Index: -2.3100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0069
    Cell Significance Index: -0.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0071
    Cell Significance Index: -0.7300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0073
    Cell Significance Index: -0.4500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0076
    Cell Significance Index: -1.0400
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0078
    Cell Significance Index: -0.0600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0081
    Cell Significance Index: -0.5800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0093
    Cell Significance Index: -1.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0093
    Cell Significance Index: -1.5800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0106
    Cell Significance Index: -0.5000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0117
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0118
    Cell Significance Index: -1.3500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0122
    Cell Significance Index: -2.5800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0133
    Cell Significance Index: -0.6200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0141
    Cell Significance Index: -1.7300
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0151
    Cell Significance Index: -0.1700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0161
    Cell Significance Index: -2.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0169
    Cell Significance Index: -2.4600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0174
    Cell Significance Index: -0.3000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0184
    Cell Significance Index: -0.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0187
    Cell Significance Index: -0.5000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0202
    Cell Significance Index: -0.5600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0265
    Cell Significance Index: -2.1000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0271
    Cell Significance Index: -0.3700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0271
    Cell Significance Index: -2.8200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0273
    Cell Significance Index: -0.2700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0280
    Cell Significance Index: -1.4200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0283
    Cell Significance Index: -1.0400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0339
    Cell Significance Index: -0.8700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0403
    Cell Significance Index: -3.0900
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0404
    Cell Significance Index: -0.2400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0410
    Cell Significance Index: -0.5200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0410
    Cell Significance Index: -2.7600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0428
    Cell Significance Index: -2.6300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0440
    Cell Significance Index: -1.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0440
    Cell Significance Index: -2.4700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0441
    Cell Significance Index: -0.6700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0441
    Cell Significance Index: -0.7000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0450
    Cell Significance Index: -2.9000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0455
    Cell Significance Index: -1.3400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0487
    Cell Significance Index: -1.1800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0508
    Cell Significance Index: -1.3400
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0564
    Cell Significance Index: -0.5400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0585
    Cell Significance Index: -2.0500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0623
    Cell Significance Index: -0.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RLN2 is a member of the relaxin family, characterized by its ability to bind to specific G protein-coupled receptors (GPCRs). The RELN2 gene encodes for the precursor protein REL2_HUMAN (Prorelaxin H2), which undergoes post-translational processing to produce the mature hormone. RLN2 is predominantly expressed in tissues involved in reproductive and immune functions, including the thymus, intestine, retina, and cerebral cortex. Its expression patterns and tissue distribution suggest a complex interplay between reproductive and immune processes. **Pathways and Functions:** RLN2 exerts its effects through the activation of specific GPCRs, which trigger a cascade of downstream signaling events. The RLN2 signaling pathway involves the activation of Gαs proteins, leading to the stimulation of adenylyl cyclase activity and increased cAMP levels. This, in turn, modulates various cellular processes, including: 1. **Immune regulation:** RLN2 has been shown to influence immune cell function, including the activation and proliferation of T cells, and the production of cytokines. 2. **Angiogenesis:** RLN2 promotes angiogenesis, the formation of new blood vessels, which is critical for tissue development and repair. 3. **Gene expression:** RLN2 regulates gene expression by modulating the activity of transcription factors and chromatin remodeling complexes. 4. **Catalytic activity:** RLN2 influences the activity of various enzymes, including phospholipases and kinases. **Clinical Significance:** The discovery of RLN2's immunomodulatory functions has significant implications for our understanding of immune-related disorders, such as autoimmune diseases and cancer. The RLN2 signaling pathway may serve as a novel therapeutic target for the treatment of conditions characterized by dysregulated immune responses. Additionally, the role of RLN2 in angiogenesis and tissue development highlights its potential as a biomarker for various diseases, including cardiovascular and metabolic disorders. In conclusion, RLN2 is a multifunctional peptide hormone that plays a critical role in regulating immune cell function, angiogenesis, and gene expression. Further research is needed to fully elucidate the mechanisms underlying RLN2's effects and to explore its therapeutic potential in various diseases.

Genular Protein ID: 2527825208

Symbol: REL2_HUMAN

Name: Prorelaxin H2

UniProtKB Accession Codes:

P04090 A0AVM0 Q99936 Q9UCX3 Q9UQJ2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 6548702

Title: Relaxin gene expression in human ovaries and the predicted structure of a human preprorelaxin by analysis of cDNA clones.

PubMed ID: 6548702

DOI: 10.1002/j.1460-2075.1984.tb02135.x

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8735594

Title: Expression of human relaxin genes: characterization of a novel alternatively-spliced human relaxin mRNA species.

PubMed ID: 8735594

DOI: 10.1016/0303-7207(96)03770-7

PubMed ID: 10601981

Title: Analysis of the 5'-upstream regions of the human relaxin H1 and H2 genes and their chromosomal localization on chromosome 9p24.1 by radiation hybrid and breakpoint mapping.

PubMed ID: 10601981

DOI: 10.1677/jme.0.0230355

PubMed ID: 1572287

Title: Human seminal relaxin is a product of the same gene as human luteal relaxin.

PubMed ID: 1572287

DOI: 10.1210/endo.130.5.1572287

PubMed ID: 2076464

Title: Structural characterization by mass spectrometry of native and recombinant human relaxin.

PubMed ID: 2076464

DOI: 10.1002/bms.1200191105

PubMed ID: 2040595

Title: Total synthesis of human relaxin and human relaxin derivatives by solid-phase peptide synthesis and site-directed chain combination.

PubMed ID: 2040595

DOI: 10.1016/s0021-9258(18)99082-4

PubMed ID: 1656049

Title: X-ray structure of human relaxin at 1.5 A. Comparison to insulin and implications for receptor binding determinants.

PubMed ID: 1656049

DOI: 10.1016/0022-2836(91)90796-9

Sequence Information:

  • Length: 185
  • Mass: 21043
  • Checksum: AC73DBDE2090091B
  • Sequence:
    • MPRLFFFHLL GVCLLLNQFS RAVADSWMEE VIKLCGRELV RAQIAICGMS TWSKRSLSQE 
DAPQTPRPVA EIVPSFINKD TETINMMSEF VANLPQELKL TLSEMQPALP QLQQHVPVLK 
DSSLLFEEFK KLIRNRQSEA ADSSPSELKY LGLDTHSRKK RQLYSALANK CCHVGCTKRS 
LARFC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.