Details for: RORC
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 42.7528
Cell Significance Index: -6.6500 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 13.8951
Cell Significance Index: -5.6500 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 8.7926
Cell Significance Index: -5.9000 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 5.9492
Cell Significance Index: -5.6800 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 5.4017
Cell Significance Index: -6.6600 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 2.4843
Cell Significance Index: -6.6600 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.4630
Cell Significance Index: 24.6500 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 1.2794
Cell Significance Index: -2.8000 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.0767
Cell Significance Index: 50.2000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.0612
Cell Significance Index: 48.1000 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.0178
Cell Significance Index: 29.3300 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.9750
Cell Significance Index: 106.0600 - Cell Name: precursor cell (CL0011115)
Fold Change: 0.8822
Cell Significance Index: 6.6900 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.7598
Cell Significance Index: 16.4600 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.7301
Cell Significance Index: 118.7400 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.5498
Cell Significance Index: 38.0200 - Cell Name: epidermal cell (CL0000362)
Fold Change: 0.5323
Cell Significance Index: 1.2000 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.5294
Cell Significance Index: 27.5000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4618
Cell Significance Index: 417.0000 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.4596
Cell Significance Index: 6.2700 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3896
Cell Significance Index: 38.5400 - Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 0.3813
Cell Significance Index: 1.4600 - Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.3765
Cell Significance Index: 4.0800 - Cell Name: peg cell (CL4033014)
Fold Change: 0.3121
Cell Significance Index: 7.2100 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.2843
Cell Significance Index: 8.3500 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.2635
Cell Significance Index: 6.4300 - Cell Name: epithelial cell of sweat gland (CL1000448)
Fold Change: 0.2379
Cell Significance Index: 0.1700 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.2367
Cell Significance Index: 46.9800 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 0.2113
Cell Significance Index: 2.7100 - Cell Name: seromucus secreting cell (CL0000159)
Fold Change: 0.2095
Cell Significance Index: 4.3700 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1878
Cell Significance Index: 6.6000 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.1668
Cell Significance Index: 19.4400 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.1666
Cell Significance Index: 2.5100 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.1479
Cell Significance Index: 3.1500 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.1403
Cell Significance Index: 10.4600 - Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.1333
Cell Significance Index: 1.8500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.1268
Cell Significance Index: 5.9600 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1219
Cell Significance Index: 66.5600 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1205
Cell Significance Index: 20.5800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1190
Cell Significance Index: 22.6400 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.1175
Cell Significance Index: 0.7800 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.1165
Cell Significance Index: 3.1200 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.1141
Cell Significance Index: 1.7100 - Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.1129
Cell Significance Index: 1.1700 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.1093
Cell Significance Index: 3.5000 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1080
Cell Significance Index: 47.7600 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.1027
Cell Significance Index: 0.7900 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.0972
Cell Significance Index: 2.6500 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.0812
Cell Significance Index: 0.8400 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.0772
Cell Significance Index: 11.2200 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.0744
Cell Significance Index: 0.6900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0718
Cell Significance Index: 5.5100 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0621
Cell Significance Index: 4.3900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.0568
Cell Significance Index: 6.5100 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0516
Cell Significance Index: 1.2900 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.0474
Cell Significance Index: 0.7000 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.0385
Cell Significance Index: 0.9900 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0369
Cell Significance Index: 69.5400 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.0233
Cell Significance Index: 3.0100 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0209
Cell Significance Index: 3.7700 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0181
Cell Significance Index: 13.2400 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0120
Cell Significance Index: 0.3400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0101
Cell Significance Index: 6.4400 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0061
Cell Significance Index: 4.6100 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 0.0049
Cell Significance Index: 0.0300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0036
Cell Significance Index: -6.6900 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0044
Cell Significance Index: -6.8400 - Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -0.0047
Cell Significance Index: -0.0500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0048
Cell Significance Index: -6.4800 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0049
Cell Significance Index: -3.6400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0072
Cell Significance Index: -4.0400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0073
Cell Significance Index: -0.9000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0106
Cell Significance Index: -6.6500 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0111
Cell Significance Index: -1.1300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0142
Cell Significance Index: -6.4600 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0164
Cell Significance Index: -5.8800 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0185
Cell Significance Index: -3.7200 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0202
Cell Significance Index: -5.8200 - Cell Name: type II muscle cell (CL0002212)
Fold Change: -0.0248
Cell Significance Index: -0.4000 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0283
Cell Significance Index: -5.9600 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0286
Cell Significance Index: -1.1700 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0321
Cell Significance Index: -1.6200 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0331
Cell Significance Index: -2.6200 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0370
Cell Significance Index: -5.0800 - Cell Name: slow muscle cell (CL0000189)
Fold Change: -0.0388
Cell Significance Index: -0.5800 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0548
Cell Significance Index: -3.3600 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0572
Cell Significance Index: -6.7400 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0632
Cell Significance Index: -6.5800 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: -0.0641
Cell Significance Index: -0.5100 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: -0.0816
Cell Significance Index: -0.4700 - Cell Name: enterocyte (CL0000584)
Fold Change: -0.0838
Cell Significance Index: -0.5200 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: -0.0843
Cell Significance Index: -0.8800 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0958
Cell Significance Index: -5.8900 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0964
Cell Significance Index: -6.4800 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0973
Cell Significance Index: -2.4300 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.1002
Cell Significance Index: -1.4800 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1089
Cell Significance Index: -5.6700 - Cell Name: salivary gland glandular cell (CL1001596)
Fold Change: -0.1312
Cell Significance Index: -0.7300 - Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: -0.1314
Cell Significance Index: -0.5000 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.1379
Cell Significance Index: -1.9800
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2806568384
Symbol: RORG_HUMAN
Name: Nuclear receptor ROR-gamma
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7811290
Title: ROR gamma: the third member of ROR/RZR orphan receptor subfamily that is highly expressed in skeletal muscle.
PubMed ID: 7811290
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 18368049
Title: TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function.
PubMed ID: 18368049
DOI: 10.1038/nature06878
PubMed ID: 19381306
Title: Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism.
PubMed ID: 19381306
DOI: 10.1621/nrs.07003
PubMed ID: 20211758
Title: A second class of nuclear receptors for oxysterols: Regulation of RORalpha and RORgamma activity by 24S-hydroxycholesterol (cerebrosterol).
PubMed ID: 20211758
PubMed ID: 19965867
Title: Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands.
PubMed ID: 19965867
PubMed ID: 21853531
Title: Adipogenesis and insulin sensitivity in obesity are regulated by retinoid-related orphan receptor gamma.
PubMed ID: 21853531
PubMed ID: 21499262
Title: Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand.
PubMed ID: 21499262
DOI: 10.1038/nature10075
PubMed ID: 22170608
Title: Cryptochromes mediate rhythmic repression of the glucocorticoid receptor.
PubMed ID: 22170608
DOI: 10.1038/nature10700
PubMed ID: 22789990
Title: Action of RORs and their ligands in (patho)physiology.
PubMed ID: 22789990
PubMed ID: 26160376
Title: Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations.
PubMed ID: 26160376
PubMed ID: 20203100
Title: Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma.
PubMed ID: 20203100
DOI: 10.1210/me.2009-0507
Sequence Information:
- Length: 518
- Mass: 58195
- Checksum: 7F423140BD7922BE
- Sequence:
MDRAPQRQHR ASRELLAAKK THTSQIEVIP CKICGDKSSG IHYGVITCEG CKGFFRRSQR CNAAYSCTRQ QNCPIDRTSR NRCQHCRLQK CLALGMSRDA VKFGRMSKKQ RDSLHAEVQK QLQQRQQQQQ EPVVKTPPAG AQGADTLTYT LGLPDGQLPL GSSPDLPEAS ACPPGLLKAS GSGPSYSNNL AKAGLNGASC HLEYSPERGK AEGRESFYST GSQLTPDRCG LRFEEHRHPG LGELGQGPDS YGSPSFRSTP EAPYASLTEI EHLVQSVCKS YRETCQLRLE DLLRQRSNIF SREEVTGYQR KSMWEMWERC AHHLTEAIQY VVEFAKRLSG FMELCQNDQI VLLKAGAMEV VLVRMCRAYN ADNRTVFFEG KYGGMELFRA LGCSELISSI FDFSHSLSAL HFSEDEIALY TALVLINAHR PGLQEKRKVE QLQYNLELAF HHHLCKTHRQ SILAKLPPKG KLRSLCSQHV ERLQIFQHLH PIVVQAAFPP LYKELFSTET ESPVGLSK
Genular Protein ID: 1184846308
Symbol: F1D8P6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 497
- Mass: 55813
- Checksum: 6D0048673483EA11
- Sequence:
MRTQIEVIPC KICGDKSSGI HYGVITCEGC KGFFRRSQRC NAAYSCTRQQ NCPIDRTSRN RCQHCRLQKC LALGMSRDAV KFGRMSKKQR DSLHAEVQKQ LQQRQQQQQE PVVKTPPAGA QGADTLTYTL GLPDGQLPLG SSPDLPEASA CPPGLLKASG SGPSYSNNLA KAGLNGASCH LEYSPERGKA EGRESFYSTG SQLTPDRCGL RFEEHRHPGL GELGQGPDSY GSPSFRSTPE APYASLTEIE HLVQSVCKSY RETCQLRLED LLRQRSNIFS REEVTGYQRK SMWEMWERCA HHLTEAIQYV VEFAKRLSGF MELCQNDQIV LLKAGAMEVV LVRMCRAYNA DNRTVFFEGK YGGMELFRAL GCSELISSIF DFSHSLSALH FSEDEIALYT ALVLINAHRP GLQEKRKVEQ LQYNLELAFH HHLCKTHRQS ILAKLPPKGK LRSLCSQHVE RLQIFQHLHP IVVQAAFPPL YKELFSTETE SPVGLSK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.