Details for: RORC

Gene ID: 6097

Symbol: RORC

Ensembl ID: ENSG00000143365

Description: RAR related orphan receptor C

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 42.7528
    Cell Significance Index: -6.6500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 13.8951
    Cell Significance Index: -5.6500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 8.7926
    Cell Significance Index: -5.9000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 5.9492
    Cell Significance Index: -5.6800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.4017
    Cell Significance Index: -6.6600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.4843
    Cell Significance Index: -6.6600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.4630
    Cell Significance Index: 24.6500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.2794
    Cell Significance Index: -2.8000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.0767
    Cell Significance Index: 50.2000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0612
    Cell Significance Index: 48.1000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0178
    Cell Significance Index: 29.3300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9750
    Cell Significance Index: 106.0600
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.8822
    Cell Significance Index: 6.6900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7598
    Cell Significance Index: 16.4600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7301
    Cell Significance Index: 118.7400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5498
    Cell Significance Index: 38.0200
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.5323
    Cell Significance Index: 1.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5294
    Cell Significance Index: 27.5000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4618
    Cell Significance Index: 417.0000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4596
    Cell Significance Index: 6.2700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3896
    Cell Significance Index: 38.5400
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.3813
    Cell Significance Index: 1.4600
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.3765
    Cell Significance Index: 4.0800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.3121
    Cell Significance Index: 7.2100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2843
    Cell Significance Index: 8.3500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.2635
    Cell Significance Index: 6.4300
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.2379
    Cell Significance Index: 0.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2367
    Cell Significance Index: 46.9800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.2113
    Cell Significance Index: 2.7100
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.2095
    Cell Significance Index: 4.3700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1878
    Cell Significance Index: 6.6000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1668
    Cell Significance Index: 19.4400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1666
    Cell Significance Index: 2.5100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1479
    Cell Significance Index: 3.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1403
    Cell Significance Index: 10.4600
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.1333
    Cell Significance Index: 1.8500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1268
    Cell Significance Index: 5.9600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1219
    Cell Significance Index: 66.5600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1205
    Cell Significance Index: 20.5800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1190
    Cell Significance Index: 22.6400
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.1175
    Cell Significance Index: 0.7800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1165
    Cell Significance Index: 3.1200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1141
    Cell Significance Index: 1.7100
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.1129
    Cell Significance Index: 1.1700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1093
    Cell Significance Index: 3.5000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1080
    Cell Significance Index: 47.7600
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.1027
    Cell Significance Index: 0.7900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0972
    Cell Significance Index: 2.6500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0812
    Cell Significance Index: 0.8400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0772
    Cell Significance Index: 11.2200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0744
    Cell Significance Index: 0.6900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0718
    Cell Significance Index: 5.5100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0621
    Cell Significance Index: 4.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0568
    Cell Significance Index: 6.5100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0516
    Cell Significance Index: 1.2900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0474
    Cell Significance Index: 0.7000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0385
    Cell Significance Index: 0.9900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0369
    Cell Significance Index: 69.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0233
    Cell Significance Index: 3.0100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0209
    Cell Significance Index: 3.7700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0181
    Cell Significance Index: 13.2400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0120
    Cell Significance Index: 0.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0101
    Cell Significance Index: 6.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0061
    Cell Significance Index: 4.6100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.0049
    Cell Significance Index: 0.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0036
    Cell Significance Index: -6.6900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0044
    Cell Significance Index: -6.8400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.0047
    Cell Significance Index: -0.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0048
    Cell Significance Index: -6.4800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0049
    Cell Significance Index: -3.6400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0072
    Cell Significance Index: -4.0400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0073
    Cell Significance Index: -0.9000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0106
    Cell Significance Index: -6.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0111
    Cell Significance Index: -1.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0142
    Cell Significance Index: -6.4600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0164
    Cell Significance Index: -5.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0185
    Cell Significance Index: -3.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0202
    Cell Significance Index: -5.8200
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0248
    Cell Significance Index: -0.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0283
    Cell Significance Index: -5.9600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0286
    Cell Significance Index: -1.1700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0321
    Cell Significance Index: -1.6200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0331
    Cell Significance Index: -2.6200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0370
    Cell Significance Index: -5.0800
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0388
    Cell Significance Index: -0.5800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0548
    Cell Significance Index: -3.3600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0572
    Cell Significance Index: -6.7400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0632
    Cell Significance Index: -6.5800
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0641
    Cell Significance Index: -0.5100
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.0816
    Cell Significance Index: -0.4700
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0838
    Cell Significance Index: -0.5200
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0843
    Cell Significance Index: -0.8800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0958
    Cell Significance Index: -5.8900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0964
    Cell Significance Index: -6.4800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0973
    Cell Significance Index: -2.4300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1002
    Cell Significance Index: -1.4800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1089
    Cell Significance Index: -5.6700
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: -0.1312
    Cell Significance Index: -0.7300
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.1314
    Cell Significance Index: -0.5000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1379
    Cell Significance Index: -1.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RORC is a member of the nuclear receptor superfamily, characterized by its ability to regulate gene expression through DNA binding and transcriptional activation. It is highly expressed in various cell types, including immune cells, epithelial cells, and progenitor cells. RORC is also known for its unique ability to bind to specific DNA sequences, allowing it to regulate the expression of target genes involved in immune responses, cell differentiation, and development. **Pathways and Functions:** RORC plays a multifaceted role in various biological processes, including: 1. **Immune Regulation:** RORC is involved in the regulation of immune responses, particularly in the differentiation of T-helper 17 (Th17) cells, which are crucial for fighting fungal infections and autoimmune diseases. 2. **Cytokine Signaling:** RORC modulates the expression of cytokines, such as IL-4 and IL-13, which are essential for the development of allergic responses and asthma. 3. **Cell Differentiation:** RORC regulates the differentiation of immune cells, including Th17 cells, NKp44-positive group 3 innate lymphoid cells, and granulocyte-monocyte progenitor cells. 4. **Development:** RORC is involved in the development of various tissues, including the brain, liver, and adipose tissue. 5. **Metabolism:** RORC regulates glucose and lipid metabolism, influencing energy homeostasis and insulin sensitivity. **Clinical Significance:** Dysregulation of RORC has been implicated in various diseases, including: 1. **Autoimmune Disorders:** RORC mutations have been associated with autoimmune diseases, such as psoriasis and rheumatoid arthritis. 2. **Cancer:** RORC is overexpressed in certain types of cancer, including lymphoma and leukemia. 3. **Metabolic Disorders:** RORC dysregulation has been linked to metabolic disorders, such as obesity and type 2 diabetes. 4. **Neurological Disorders:** RORC has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, RORC is a critical transcription factor involved in various biological processes, including immune regulation, development, and metabolism. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the molecular mechanisms underlying RORC function and its role in human health and disease.

Genular Protein ID: 2806568384

Symbol: RORG_HUMAN

Name: Nuclear receptor ROR-gamma

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7811290

Title: ROR gamma: the third member of ROR/RZR orphan receptor subfamily that is highly expressed in skeletal muscle.

PubMed ID: 7811290

DOI: 10.1006/bbrc.1994.2902

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18368049

Title: TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function.

PubMed ID: 18368049

DOI: 10.1038/nature06878

PubMed ID: 19381306

Title: Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism.

PubMed ID: 19381306

DOI: 10.1621/nrs.07003

PubMed ID: 20211758

Title: A second class of nuclear receptors for oxysterols: Regulation of RORalpha and RORgamma activity by 24S-hydroxycholesterol (cerebrosterol).

PubMed ID: 20211758

DOI: 10.1016/j.bbalip.2010.02.012

PubMed ID: 19965867

Title: Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands.

PubMed ID: 19965867

DOI: 10.1074/jbc.m109.080614

PubMed ID: 21853531

Title: Adipogenesis and insulin sensitivity in obesity are regulated by retinoid-related orphan receptor gamma.

PubMed ID: 21853531

DOI: 10.1002/emmm.201100172

PubMed ID: 21499262

Title: Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand.

PubMed ID: 21499262

DOI: 10.1038/nature10075

PubMed ID: 22170608

Title: Cryptochromes mediate rhythmic repression of the glucocorticoid receptor.

PubMed ID: 22170608

DOI: 10.1038/nature10700

PubMed ID: 22789990

Title: Action of RORs and their ligands in (patho)physiology.

PubMed ID: 22789990

DOI: 10.1016/j.tem.2012.05.012

PubMed ID: 26160376

Title: Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations.

PubMed ID: 26160376

DOI: 10.1126/science.aaa4282

PubMed ID: 20203100

Title: Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma.

PubMed ID: 20203100

DOI: 10.1210/me.2009-0507

Sequence Information:

  • Length: 518
  • Mass: 58195
  • Checksum: 7F423140BD7922BE
  • Sequence:
  • MDRAPQRQHR ASRELLAAKK THTSQIEVIP CKICGDKSSG IHYGVITCEG CKGFFRRSQR 
    CNAAYSCTRQ QNCPIDRTSR NRCQHCRLQK CLALGMSRDA VKFGRMSKKQ RDSLHAEVQK 
    QLQQRQQQQQ EPVVKTPPAG AQGADTLTYT LGLPDGQLPL GSSPDLPEAS ACPPGLLKAS 
    GSGPSYSNNL AKAGLNGASC HLEYSPERGK AEGRESFYST GSQLTPDRCG LRFEEHRHPG 
    LGELGQGPDS YGSPSFRSTP EAPYASLTEI EHLVQSVCKS YRETCQLRLE DLLRQRSNIF 
    SREEVTGYQR KSMWEMWERC AHHLTEAIQY VVEFAKRLSG FMELCQNDQI VLLKAGAMEV 
    VLVRMCRAYN ADNRTVFFEG KYGGMELFRA LGCSELISSI FDFSHSLSAL HFSEDEIALY 
    TALVLINAHR PGLQEKRKVE QLQYNLELAF HHHLCKTHRQ SILAKLPPKG KLRSLCSQHV 
    ERLQIFQHLH PIVVQAAFPP LYKELFSTET ESPVGLSK

Genular Protein ID: 1184846308

Symbol: F1D8P6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 497
  • Mass: 55813
  • Checksum: 6D0048673483EA11
  • Sequence:
  • MRTQIEVIPC KICGDKSSGI HYGVITCEGC KGFFRRSQRC NAAYSCTRQQ NCPIDRTSRN 
    RCQHCRLQKC LALGMSRDAV KFGRMSKKQR DSLHAEVQKQ LQQRQQQQQE PVVKTPPAGA 
    QGADTLTYTL GLPDGQLPLG SSPDLPEASA CPPGLLKASG SGPSYSNNLA KAGLNGASCH 
    LEYSPERGKA EGRESFYSTG SQLTPDRCGL RFEEHRHPGL GELGQGPDSY GSPSFRSTPE 
    APYASLTEIE HLVQSVCKSY RETCQLRLED LLRQRSNIFS REEVTGYQRK SMWEMWERCA 
    HHLTEAIQYV VEFAKRLSGF MELCQNDQIV LLKAGAMEVV LVRMCRAYNA DNRTVFFEGK 
    YGGMELFRAL GCSELISSIF DFSHSLSALH FSEDEIALYT ALVLINAHRP GLQEKRKVEQ 
    LQYNLELAFH HHLCKTHRQS ILAKLPPKGK LRSLCSQHVE RLQIFQHLHP IVVQAAFPPL 
    YKELFSTETE SPVGLSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.