RPA3 | ENSG00000106399 | NCBI 6119

Details for: RPA3

Gene ID: 6119

Symbol: RPA3

Ensembl ID: ENSG00000106399

Description: replication protein A3

Associated with

Activation of atr in response to replication stress
(R-HSA-176187)
Activation of the pre-replicative complex
(R-HSA-68962)
Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to heat stress
(R-HSA-3371556)
Chromosome maintenance
(R-HSA-73886)
Defective homologous recombination repair (hrr) due to brca2 loss of function
(R-HSA-9701190)
Disease
(R-HSA-1643685)
Diseases of dna double-strand break repair
(R-HSA-9675136)
Diseases of dna repair
(R-HSA-9675135)
Dna damage bypass
(R-HSA-73893)
Dna double-strand break repair
(R-HSA-5693532)
Dna replication pre-initiation
(R-HSA-69002)
Dna strand elongation
(R-HSA-69190)
Dual incision in gg-ner
(R-HSA-5696400)
Dual incision in tc-ner
(R-HSA-6782135)
Extension of telomeres
(R-HSA-180786)
Fanconi anemia pathway
(R-HSA-6783310)
Formation of incision complex in gg-ner
(R-HSA-5696395)
G1/s transition
(R-HSA-69206)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
Gap-filling dna repair synthesis and ligation in gg-ner
(R-HSA-5696397)
Gap-filling dna repair synthesis and ligation in tc-ner
(R-HSA-6782210)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Global genome nucleotide excision repair (gg-ner)
(R-HSA-5696399)
Hdr through homologous recombination (hrr)
(R-HSA-5685942)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Hdr through single strand annealing (ssa)
(R-HSA-5685938)
Homologous dna pairing and strand exchange
(R-HSA-5693579)
Homology directed repair
(R-HSA-5693538)
Hsf1 activation
(R-HSA-3371511)
Impaired brca2 binding to rad51
(R-HSA-9709570)
Lagging strand synthesis
(R-HSA-69186)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Mismatch repair (mmr) directed by msh2:msh3 (mutsbeta)
(R-HSA-5358606)
Mismatch repair (mmr) directed by msh2:msh6 (mutsalpha)
(R-HSA-5358565)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Nucleotide excision repair
(R-HSA-5696398)
Pcna-dependent long patch base excision repair
(R-HSA-5651801)
Presynaptic phase of homologous dna pairing and strand exchange
(R-HSA-5693616)
Processing of dna double-strand break ends
(R-HSA-5693607)
Processive synthesis on the c-strand of the telomere
(R-HSA-174414)
Processive synthesis on the lagging strand
(R-HSA-69183)
Recognition of dna damage by pcna-containing replication complex
(R-HSA-110314)
Regulation of hsf1-mediated heat shock response
(R-HSA-3371453)
Regulation of tp53 activity
(R-HSA-5633007)
Regulation of tp53 activity through phosphorylation
(R-HSA-6804756)
Removal of the flap intermediate
(R-HSA-69166)
Removal of the flap intermediate from the c-strand
(R-HSA-174437)
Reproduction
(R-HSA-1474165)
Resolution of abasic sites (ap sites)
(R-HSA-73933)
Resolution of ap sites via the multiple-nucleotide patch replacement pathway
(R-HSA-110373)
Rna polymerase ii transcription
(R-HSA-73857)
S phase
(R-HSA-69242)
Synthesis of dna
(R-HSA-69239)
Telomere c-strand (lagging strand) synthesis
(R-HSA-174417)
Termination of translesion dna synthesis
(R-HSA-5656169)
Transcription-coupled nucleotide excision repair (tc-ner)
(R-HSA-6781827)
Transcriptional regulation by tp53
(R-HSA-3700989)
Translesion synthesis by polh
(R-HSA-110320)
Translesion synthesis by poli
(R-HSA-5656121)
Translesion synthesis by polk
(R-HSA-5655862)
Translesion synthesis by rev1
(R-HSA-110312)
Translesion synthesis by y family dna polymerases bypasses lesions on dna template
(R-HSA-110313)
Base-excision repair
(GO:0006284)
Damaged dna binding
(GO:0003684)
Dna repair
(GO:0006281)
Dna replication
(GO:0006260)
Dna replication factor a complex
(GO:0005662)
Double-strand break repair via homologous recombination
(GO:0000724)
Mismatch repair
(GO:0006298)
Nucleoplasm
(GO:0005654)
Nucleotide-excision repair
(GO:0006289)
Protein binding
(GO:0005515)
Regulation of cell population proliferation
(GO:0042127)
Regulation of mitotic cell cycle
(GO:0007346)
Single-stranded dna binding
(GO:0003697)
Site of double-strand break
(GO:0035861)
Telomere maintenance
(GO:0000723)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: embryonic stem cell (CL0002322)
Fold Change: 104.3579
Cell Significance Index: -42.9900
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 90.2943
Cell Significance Index: -42.6300
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 88.4169
Cell Significance Index: -35.9200
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 80.9413
Cell Significance Index: -41.6400
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 63.6343
Cell Significance Index: -42.7000
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 38.3821
Cell Significance Index: -36.6500
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 11.5180
Cell Significance Index: -30.8600
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 8.8069
Cell Significance Index: -27.0500
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 7.0822
Cell Significance Index: -15.5000
Cell Name: abnormal cell (CL0001061)
Fold Change: 3.5645
Cell Significance Index: 364.1100
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 3.3293
Cell Significance Index: 230.2400
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 3.0372
Cell Significance Index: 32.2700
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 2.5630
Cell Significance Index: 68.5600
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.4240
Cell Significance Index: 285.8600
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.3779
Cell Significance Index: 18.8000
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 1.3595
Cell Significance Index: 14.7800
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.2852
Cell Significance Index: 701.8600
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.0886
Cell Significance Index: 31.9700
Cell Name: peg cell (CL4033014)
Fold Change: 1.0704
Cell Significance Index: 24.7300
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.8757
Cell Significance Index: 107.6800
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.8550
Cell Significance Index: 378.0300
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.8357
Cell Significance Index: 52.6700
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.8203
Cell Significance Index: 147.8800
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.8183
Cell Significance Index: 162.3900
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.7993
Cell Significance Index: 41.5200
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.7726
Cell Significance Index: 54.6400
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.7273
Cell Significance Index: 33.9100
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.7035
Cell Significance Index: 114.4200
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.6646
Cell Significance Index: 18.0900
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.6506
Cell Significance Index: 7.7600
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.6394
Cell Significance Index: 22.2200
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.6096
Cell Significance Index: 12.7600
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.5883
Cell Significance Index: 43.8500
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.5766
Cell Significance Index: 5.3100
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.5228
Cell Significance Index: 71.7900
Cell Name: kidney cell (CL1000497)
Fold Change: 0.5060
Cell Significance Index: 4.0400
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.4801
Cell Significance Index: 12.8200
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.4073
Cell Significance Index: 26.2800
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.3887
Cell Significance Index: 10.2200
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.3677
Cell Significance Index: 17.2800
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.3553
Cell Significance Index: 71.2800
Cell Name: odontoblast (CL0000060)
Fold Change: 0.3299
Cell Significance Index: 42.2900
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.3254
Cell Significance Index: 7.0500
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.2984
Cell Significance Index: 7.4600
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.2966
Cell Significance Index: 22.7600
Cell Name: lactocyte (CL0002325)
Fold Change: 0.2441
Cell Significance Index: 31.5400
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2039
Cell Significance Index: 38.8100
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.1812
Cell Significance Index: 10.1700
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.1402
Cell Significance Index: 4.4900
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.1392
Cell Significance Index: 7.3100
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.1292
Cell Significance Index: 7.9400
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1208
Cell Significance Index: 109.1200
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0993
Cell Significance Index: 9.8300
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0658
Cell Significance Index: 23.6100
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0628
Cell Significance Index: 115.7700
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0555
Cell Significance Index: 85.3800
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0486
Cell Significance Index: 91.6000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0450
Cell Significance Index: 34.0600
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0340
Cell Significance Index: 24.9000
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.0179
Cell Significance Index: 0.1500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0141
Cell Significance Index: 19.1100
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0142
Cell Significance Index: -9.0100
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0176
Cell Significance Index: -3.0000
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0244
Cell Significance Index: -16.9000
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0391
Cell Significance Index: -28.9800
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0435
Cell Significance Index: -6.3200
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0473
Cell Significance Index: -21.4600
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0535
Cell Significance Index: -0.8900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0633
Cell Significance Index: -35.7000
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0727
Cell Significance Index: -45.4200
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0811
Cell Significance Index: -23.3300
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1033
Cell Significance Index: -12.0400
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1049
Cell Significance Index: -2.6800
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1281
Cell Significance Index: -4.5000
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.1465
Cell Significance Index: -6.6400
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.1505
Cell Significance Index: -1.7100
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: -0.1519
Cell Significance Index: -1.3100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2060
Cell Significance Index: -23.6100
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2061
Cell Significance Index: -43.4200
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2218
Cell Significance Index: -9.8100
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2432
Cell Significance Index: -12.6700
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.2439
Cell Significance Index: -2.5300
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2498
Cell Significance Index: -19.7900
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.2850
Cell Significance Index: -4.2700
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.2992
Cell Significance Index: -17.9600
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.3111
Cell Significance Index: -11.7800
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.3135
Cell Significance Index: -8.7600
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.3392
Cell Significance Index: -7.2300
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3649
Cell Significance Index: -37.9900
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.3874
Cell Significance Index: -5.7200
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.3919
Cell Significance Index: -26.3500
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.5421
Cell Significance Index: -9.2900
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.5768
Cell Significance Index: -16.6200
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.5851
Cell Significance Index: -35.8700
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.6442
Cell Significance Index: -9.1700
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.6830
Cell Significance Index: -34.5200
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: -0.7011
Cell Significance Index: -4.3200
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.8037
Cell Significance Index: -21.5400
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.8131
Cell Significance Index: -19.5000
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.8259
Cell Significance Index: -21.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **Structural Composition:** RPA3 is a 14-kDa subunit of the RPA complex, composed of three subunits: RPA1, RPA2, and RPA3. 2. **Function:** RPA3 is involved in DNA replication, repair, and transcriptional regulation. 3. **Cellular Localization:** RPA3 is primarily found in the nucleus, where it plays a critical role in maintaining genome stability. 4. **Expression:** RPA3 is significantly expressed in various cell types, including erythroid progenitor cells, extravillous trophoblasts, and kidney collecting duct intercalated cells. **Pathways and Functions:** 1. **DNA Replication:** RPA3 plays a crucial role in unwinding DNA, binding ssDNA, and facilitating the assembly of the pre-replicative complex. 2. **DNA Damage Response:** RPA3 is involved in the activation of the ATR pathway in response to replication stress, as well as the regulation of cell cycle checkpoints. 3. **Transcriptional Regulation:** RPA3 interacts with transcription factors, such as TP53, to regulate gene expression. 4. **Cell Cycle Regulation:** RPA3 is involved in the regulation of the cell cycle, including the G1/S transition and the G2/M checkpoint. 5. **Base Excision Repair:** RPA3 is involved in the base excision repair pathway, which repairs damaged DNA bases. **Clinical Significance:** 1. **Cancer:** Dysregulation of RPA3 has been linked to various cancers, including breast, ovarian, and colon cancer. 2. **Fanconi Anemia:** RPA3 is a key component of the Fanconi anemia pathway, which is involved in the repair of interstrand DNA crosslinks. 3. **Genome Instability:** RPA3 dysregulation has been implicated in genome instability, which is a hallmark of many cancers. 4. **Neurological Disorders:** RPA3 has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, RPA3 is a multifaceted protein that plays a critical role in maintaining genome stability and cellular homeostasis. Its dysregulation has been linked to various diseases, including cancer and Fanconi anemia. Further research is needed to fully elucidate the role of RPA3 in maintaining genome stability and to understand its implications in human disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Replication protein A 14 kDa subunit

Genular Protein ID: 1943548268

Symbol: RFA3_HUMAN

Name: Replication protein A 14 kDa subunit

UniProtKB Accession Codes:

P35244 Q549U6

Database IDs:

Citations:

PubMed ID: 8454588

Title: Cloning, overexpression, and genomic mapping of the 14-kDa subunit of human replication protein A.

PubMed ID: 8454588

DOI: 10.1016/s0021-9258(18)53229-4

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7697716

Title: Mammalian DNA nucleotide excision repair reconstituted with purified protein components.

PubMed ID: 7697716

DOI: 10.1016/0092-8674(95)90289-9

PubMed ID: 7760808

Title: Rpa4, a homolog of the 34-kilodalton subunit of the replication protein A complex.

PubMed ID: 7760808

DOI: 10.1128/mcb.15.6.3119

PubMed ID: 9430682

Title: The evolutionarily conserved zinc finger motif in the largest subunit of human replication protein A is required for DNA replication and mismatch repair but not for nucleotide excision repair.

PubMed ID: 9430682

DOI: 10.1074/jbc.273.3.1453

PubMed ID: 9765279

Title: Replication protein A stimulates long patch DNA base excision repair.

PubMed ID: 9765279

DOI: 10.1074/jbc.273.42.27492

PubMed ID: 17596542

Title: FANCJ (BACH1) helicase forms DNA damage inducible foci with replication protein A and interacts physically and functionally with the single-stranded DNA-binding protein.

PubMed ID: 17596542

DOI: 10.1182/blood-2006-11-057273

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19116208

Title: An alternative form of replication protein a prevents viral replication in vitro.

PubMed ID: 19116208

DOI: 10.1074/jbc.m808963200

PubMed ID: 19010961

Title: Evidence for direct contact between the RPA3 subunit of the human replication protein A and single-stranded DNA.

PubMed ID: 19010961

DOI: 10.1093/nar/gkn895

PubMed ID: 19996105

Title: An alternative form of replication protein a expressed in normal human tissues supports DNA repair.

PubMed ID: 19996105

DOI: 10.1074/jbc.m109.079418

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24332808

Title: PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.

PubMed ID: 24332808

DOI: 10.1016/j.molcel.2013.11.002

PubMed ID: 26474068

Title: RFWD3-dependent ubiquitination of RPA regulates repair at stalled replication forks.

PubMed ID: 26474068

DOI: 10.1016/j.molcel.2015.09.011

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 11927569

Title: Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA.

PubMed ID: 11927569

DOI: 10.1093/emboj/21.7.1855

Sequence Information:

Length: 121
Mass: 13569
Checksum: 3FD99851959FB498
Sequence:

MVDMMDLPRS RINAGMLAQF IDKPVCFVGR LEKIHPTGKM FILSDGEGKN GTIELMEPLD 
EEISGIVEVV GRVTAKATIL CTSYVQFKED SHPFDLGLYN EAVKIIHDFP QFYPLGIVQH 
D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RPA3

Associated with

Cells (max top 100)

Other Information

Cloning, overexpression, and genomic mapping of the 14-kDa subunit of human replication protein A. PubMed ID: 8454588

The DNA sequence of human chromosome 7. PubMed ID: 12853948

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mammalian DNA nucleotide excision repair reconstituted with purified protein components. PubMed ID: 7697716

Rpa4, a homolog of the 34-kilodalton subunit of the replication protein A complex. PubMed ID: 7760808

The evolutionarily conserved zinc finger motif in the largest subunit of human replication protein A is required for DNA replication and mismatch repair but not for nucleotide excision repair. PubMed ID: 9430682

Replication protein A stimulates long patch DNA base excision repair. PubMed ID: 9765279

FANCJ (BACH1) helicase forms DNA damage inducible foci with replication protein A and interacts physically and functionally with the single-stranded DNA-binding protein. PubMed ID: 17596542

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

An alternative form of replication protein a prevents viral replication in vitro. PubMed ID: 19116208

Evidence for direct contact between the RPA3 subunit of the human replication protein A and single-stranded DNA. PubMed ID: 19010961

An alternative form of replication protein a expressed in normal human tissues supports DNA repair. PubMed ID: 19996105

Initial characterization of the human central proteome. PubMed ID: 21269460

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. PubMed ID: 24332808

RFWD3-dependent ubiquitination of RPA regulates repair at stalled replication forks. PubMed ID: 26474068

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA. PubMed ID: 11927569