Details for: RPE

Gene ID: 6120

Symbol: RPE

Ensembl ID: ENSG00000197713

Description: ribulose-5-phosphate-3-epimerase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 55.1621
    Cell Significance Index: -22.4100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 49.5251
    Cell Significance Index: -25.4800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 23.5456
    Cell Significance Index: -22.4800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.7164
    Cell Significance Index: -23.3500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.5171
    Cell Significance Index: -26.1600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.4373
    Cell Significance Index: -11.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.7614
    Cell Significance Index: 174.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.7461
    Cell Significance Index: 203.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6917
    Cell Significance Index: 339.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.4357
    Cell Significance Index: 413.1100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3056
    Cell Significance Index: 1178.8800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0354
    Cell Significance Index: 112.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9741
    Cell Significance Index: 158.4300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9724
    Cell Significance Index: 58.3800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.8590
    Cell Significance Index: 32.5300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8479
    Cell Significance Index: 168.2700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.7897
    Cell Significance Index: 34.9300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7244
    Cell Significance Index: 259.8400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5947
    Cell Significance Index: 15.9400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5077
    Cell Significance Index: 35.1100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4475
    Cell Significance Index: 11.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4337
    Cell Significance Index: 22.5300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3939
    Cell Significance Index: 215.1000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.3839
    Cell Significance Index: 39.2200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3656
    Cell Significance Index: 65.9200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3565
    Cell Significance Index: 21.9100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3332
    Cell Significance Index: 18.7000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2972
    Cell Significance Index: 40.8100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2636
    Cell Significance Index: 20.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2534
    Cell Significance Index: 7.3000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2463
    Cell Significance Index: 46.8700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2371
    Cell Significance Index: 29.1500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2308
    Cell Significance Index: 15.5200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1945
    Cell Significance Index: 9.0700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1637
    Cell Significance Index: 4.4600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1543
    Cell Significance Index: 68.2000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0788
    Cell Significance Index: 9.3000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0774
    Cell Significance Index: 1.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0728
    Cell Significance Index: 3.3000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0624
    Cell Significance Index: 1.7800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0619
    Cell Significance Index: 2.9100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0410
    Cell Significance Index: 77.1900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0256
    Cell Significance Index: 11.6100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0251
    Cell Significance Index: 46.3000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0225
    Cell Significance Index: 34.5900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0207
    Cell Significance Index: 13.1200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0072
    Cell Significance Index: 9.7500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0005
    Cell Significance Index: -0.0600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0009
    Cell Significance Index: -0.1100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0164
    Cell Significance Index: -1.0600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0165
    Cell Significance Index: -12.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0167
    Cell Significance Index: -12.6700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0283
    Cell Significance Index: -20.9800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0297
    Cell Significance Index: -4.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0426
    Cell Significance Index: -24.0400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0429
    Cell Significance Index: -1.0300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0454
    Cell Significance Index: -28.3800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0520
    Cell Significance Index: -3.6800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0555
    Cell Significance Index: -3.5000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0610
    Cell Significance Index: -1.3000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0657
    Cell Significance Index: -4.9000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0807
    Cell Significance Index: -2.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0829
    Cell Significance Index: -14.1600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1359
    Cell Significance Index: -2.2800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1395
    Cell Significance Index: -3.0600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1402
    Cell Significance Index: -29.5300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1600
    Cell Significance Index: -18.3400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1693
    Cell Significance Index: -5.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1703
    Cell Significance Index: -17.7300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1745
    Cell Significance Index: -2.9900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1902
    Cell Significance Index: -4.1200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1973
    Cell Significance Index: -2.1500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2272
    Cell Significance Index: -3.1000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2280
    Cell Significance Index: -6.0000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2777
    Cell Significance Index: -21.9900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2973
    Cell Significance Index: -15.6100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3001
    Cell Significance Index: -18.4000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3259
    Cell Significance Index: -8.3300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3317
    Cell Significance Index: -9.2700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3362
    Cell Significance Index: -4.1700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3482
    Cell Significance Index: -11.0900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3636
    Cell Significance Index: -18.9400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3703
    Cell Significance Index: -3.4100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3752
    Cell Significance Index: -18.9600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3845
    Cell Significance Index: -12.5900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3952
    Cell Significance Index: -11.3300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4034
    Cell Significance Index: -12.9200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4389
    Cell Significance Index: -6.4800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4547
    Cell Significance Index: -9.6500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4553
    Cell Significance Index: -10.5200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4815
    Cell Significance Index: -14.1400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4837
    Cell Significance Index: -9.4400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4844
    Cell Significance Index: -9.7300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5292
    Cell Significance Index: -13.2000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5318
    Cell Significance Index: -18.6300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5430
    Cell Significance Index: -19.9300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5502
    Cell Significance Index: -10.8800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5700
    Cell Significance Index: -11.9300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5758
    Cell Significance Index: -16.9600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.5822
    Cell Significance Index: -7.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RPE is a homodimeric enzyme, composed of two identical subunits, which catalyzes the interconversion of ribulose-5-phosphate (R5P) and D-ribulose-5-phosphate (D-R5P). This reaction is a critical step in the non-oxidative branch of the PPP, which generates NADPH and pentoses for anabolic and redox reactions. RPE has been shown to be highly expressed in the brain, particularly in glutamatergic and GABAergic neurons, where it plays a crucial role in maintaining the redox balance and supporting neuronal function. **Pathways and Functions:** RPE is involved in the following pathways: 1. **Pentose Phosphate Pathway (PPP):** RPE is a key enzyme in the non-oxidative branch of the PPP, generating NADPH and pentoses for various cellular functions, including energy metabolism, lipid synthesis, and antioxidant defense. 2. **Carbohydrate Metabolism:** RPE is involved in the regulation of carbohydrate metabolism, particularly in the generation of pentoses and NADPH, which are essential for energy metabolism and redox reactions. 3. **Redox Balance:** RPE helps maintain the redox balance in the brain by generating NADPH, which is a critical antioxidant that protects against oxidative stress and inflammation. 4. **Neurotransmitter Synthesis:** RPE has been shown to play a role in the synthesis of neurotransmitters, such as GABA and glutamate, by providing the necessary precursors and cofactors. **Clinical Significance:** Dysregulation of RPE has been implicated in various neurological disorders, including: 1. **Neurodegenerative Diseases:** RPE dysfunction has been linked to neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, where oxidative stress and inflammation play a critical role. 2. **Neurodevelopmental Disorders:** RPE has been implicated in neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia, where disruptions in carbohydrate metabolism and redox balance may contribute to disease pathogenesis. 3. **Cancer:** RPE has been shown to be overexpressed in certain types of cancer, where it may contribute to tumor growth and progression by generating NADPH and promoting glycolysis. In conclusion, RPE is a critical enzyme involved in the pentose phosphate pathway, carbohydrate metabolism, and redox balance in the brain. Its dysregulation has been implicated in various neurological disorders, highlighting the need for further research into the functional significance of RPE in maintaining brain health and preventing disease.

Genular Protein ID: 428788798

Symbol: RPE_HUMAN

Name: Ribulose-phosphate 3-epimerase

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11124703

Title: Characterization of 16 novel human genes showing high similarity to yeast sequences.

PubMed ID: 11124703

DOI: 10.1002/1097-0061(200101)18:1<69::aid-yea647>3.0.co;2-h

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 20923965

Title: Conversion of D-ribulose 5-phosphate to D-xylulose 5-phosphate: new insights from structural and biochemical studies on human RPE.

PubMed ID: 20923965

DOI: 10.1096/fj.10-171207

Sequence Information:

  • Length: 228
  • Mass: 24928
  • Checksum: 447130018AC52331
  • Sequence:
  • MASGCKIGPS ILNSDLANLG AECLRMLDSG ADYLHLDVMD GHFVPNITFG HPVVESLRKQ 
    LGQDPFFDMH MMVSKPEQWV KPMAVAGANQ YTFHLEATEN PGALIKDIRE NGMKVGLAIK 
    PGTSVEYLAP WANQIDMALV MTVEPGFGGQ KFMEDMMPKV HWLRTQFPSL DIEVDGGVGP 
    DTVHKCAEAG ANMIVSGSAI MRSEDPRSVI NLLRNVCSEA AQKRSLDR

Genular Protein ID: 2158693098

Symbol: C9IZU8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 225
  • Mass: 24916
  • Checksum: 9190B83DE21DC8AA
  • Sequence:
  • MASGCKIGPS ILNSDLANLG AECLRMLDSG ADYLHLDVMD GHFVPNITFG HPVVESLRKQ 
    LGQDPFFDMH MMVSKPEQWV KPMAVAGANQ YTFHLEATEN PGALIKDIRE NGMKVGLAIK 
    PGTSVEYLAP WANQIDMALV MTVEPGFGGQ KFMEDMMPKV HWLRTQFPSL DIEVDGGVGP 
    DTVHKCAEIG VQWRDLCSLQ SLPAGFKRFS CLSLLSSWDY RQELT

Genular Protein ID: 231127074

Symbol: C9J9T0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 191
  • Mass: 20972
  • Checksum: 32E89895D4ED7B46
  • Sequence:
  • MASGCKIGPS ILNSDLANLG AECLRMLDSG ADYLHLDVMD GHFVPNITFG HPVVESLRKQ 
    LGQDPFFDMH MMVSKPEQWV KPMAVAGANQ YTFHLEATEN PGALIKDIRE NGMKVGLAIK 
    PGTSVEYLAP WANQIDMALV MTVEPGFGGQ KFMEDMMPKV HWLRTQFPSL DIEVDGGVGP 
    DTVHKCAEEL T

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.