RPS4Y1 | ENSG00000129824 | NCBI 6192

Details for: RPS4Y1

Gene ID: 6192

Symbol: RPS4Y1

Ensembl ID: ENSG00000129824

Description: ribosomal protein S4 Y-linked 1

Associated with

Activation of the mrna upon binding of the cap-binding complex and eifs, and subsequent binding to 43s
(R-HSA-72662)
Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Formation of the ternary complex, and subsequently, the 43s complex
(R-HSA-72695)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Peptide chain elongation
(R-HSA-156902)
Regulation of expression of slits and robos
(R-HSA-9010553)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Ribosomal scanning and start codon recognition
(R-HSA-72702)
Rrna processing
(R-HSA-72312)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1 modulates host translation machinery
(R-HSA-9735869)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2 modulates host translation machinery
(R-HSA-9754678)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Signaling by robo receptors
(R-HSA-376176)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Translation initiation complex formation
(R-HSA-72649)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
Cytosol
(GO:0005829)
Cytosolic small ribosomal subunit
(GO:0022627)
Membrane
(GO:0016020)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Ribosome
(GO:0005840)
Rna binding
(GO:0003723)
Rrna binding
(GO:0019843)
Structural constituent of ribosome
(GO:0003735)
Translation
(GO:0006412)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: embryonic stem cell (CL0002322)
Fold Change: 219.3604
Cell Significance Index: -90.3700
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 198.9627
Cell Significance Index: -80.8300
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 186.4558
Cell Significance Index: -88.0300
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 176.5603
Cell Significance Index: -90.8200
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 131.7542
Cell Significance Index: -88.4100
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 86.4840
Cell Significance Index: -82.5700
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 9.5974
Cell Significance Index: -25.7100
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 7.0939
Cell Significance Index: 77.1200
Cell Name: pro-T cell (CL0000827)
Fold Change: 6.1196
Cell Significance Index: 156.3400
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 5.8323
Cell Significance Index: 122.0800
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 5.7631
Cell Significance Index: 41.3900
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 5.5368
Cell Significance Index: 192.4000
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 5.0029
Cell Significance Index: 46.0700
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 4.8800
Cell Significance Index: 132.8300
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 4.6417
Cell Significance Index: 216.4200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 4.4150
Cell Significance Index: 542.8700
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 4.0934
Cell Significance Index: 737.9100
Cell Name: odontoblast (CL0000060)
Fold Change: 4.0414
Cell Significance Index: 518.0800
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 3.6033
Cell Significance Index: 54.3000
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 3.3403
Cell Significance Index: 98.1000
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 2.6456
Cell Significance Index: 138.9100
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.4556
Cell Significance Index: 289.5900
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 2.4013
Cell Significance Index: 27.2800
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 1.8456
Cell Significance Index: 116.3200
Cell Name: abnormal cell (CL0001061)
Fold Change: 1.8301
Cell Significance Index: 186.9400
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.7756
Cell Significance Index: 92.4900
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.7708
Cell Significance Index: 106.3100
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 1.6584
Cell Significance Index: 10.2600
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.5333
Cell Significance Index: 151.6800
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.2817
Cell Significance Index: 254.3500
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.8483
Cell Significance Index: 144.8500
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.8240
Cell Significance Index: 15.2300
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.6876
Cell Significance Index: 130.8500
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.4920
Cell Significance Index: 22.3000
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.4632
Cell Significance Index: 289.2600
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.3961
Cell Significance Index: 10.6000
Cell Name: Leydig cell (CL0000178)
Fold Change: 0.3588
Cell Significance Index: 1.7900
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3329
Cell Significance Index: 54.1400
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.2910
Cell Significance Index: 58.3700
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.1669
Cell Significance Index: 0.9100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.1052
Cell Significance Index: 77.9600
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0651
Cell Significance Index: 58.8300
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.0514
Cell Significance Index: 3.3200
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0254
Cell Significance Index: 18.6500
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0236
Cell Significance Index: 8.4700
Cell Name: skin fibroblast (CL0002620)
Fold Change: -0.0087
Cell Significance Index: -0.0200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0128
Cell Significance Index: -24.0400
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0235
Cell Significance Index: -17.8100
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0348
Cell Significance Index: -64.2200
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0466
Cell Significance Index: -26.2800
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0511
Cell Significance Index: -78.6100
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0702
Cell Significance Index: -95.4400
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0935
Cell Significance Index: -19.6900
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1112
Cell Significance Index: -31.9900
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.1116
Cell Significance Index: -70.8900
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1798
Cell Significance Index: -81.5900
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.2338
Cell Significance Index: -4.0300
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.3227
Cell Significance Index: -11.3400
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.4205
Cell Significance Index: -48.1700
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.4602
Cell Significance Index: -66.9000
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.5486
Cell Significance Index: -62.6200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.5665
Cell Significance Index: -15.1300
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.5676
Cell Significance Index: -9.5000
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.6679
Cell Significance Index: -5.6100
Cell Name: kidney cell (CL1000497)
Fold Change: -0.7878
Cell Significance Index: -6.2900
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.8124
Cell Significance Index: -84.5900
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.8224
Cell Significance Index: -55.3000
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.8368
Cell Significance Index: -18.1300
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.8570
Cell Significance Index: -44.5200
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.8622
Cell Significance Index: -27.6200
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.8738
Cell Significance Index: -21.8300
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.8992
Cell Significance Index: -71.2200
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.9095
Cell Significance Index: -24.3700
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.9147
Cell Significance Index: -70.2000
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.9268
Cell Significance Index: -64.1000
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: -1.0078
Cell Significance Index: -6.6900
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -1.0119
Cell Significance Index: -10.4800
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -1.0892
Cell Significance Index: -12.3300
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.0966
Cell Significance Index: -67.2300
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -1.1633
Cell Significance Index: -71.5000
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -1.1718
Cell Significance Index: -65.7600
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -1.3531
Cell Significance Index: -38.9900
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -1.5868
Cell Significance Index: -58.2500
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -1.7235
Cell Significance Index: -25.8300
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -1.7489
Cell Significance Index: -13.4800
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -1.7976
Cell Significance Index: -79.5100
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -1.8749
Cell Significance Index: -32.1300
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -1.8934
Cell Significance Index: -88.9900
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.9461
Cell Significance Index: -57.3200
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: -2.0327
Cell Significance Index: -12.5800
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -2.1229
Cell Significance Index: -80.3900
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -2.1374
Cell Significance Index: -54.9400
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -2.2120
Cell Significance Index: -77.4900
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -2.3407
Cell Significance Index: -74.5500
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -2.3442
Cell Significance Index: -76.7500
Cell Name: retinal rod cell (CL0000604)
Fold Change: -2.3598
Cell Significance Index: -28.1300
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: -2.4415
Cell Significance Index: -23.2300
Cell Name: chondroblast (CL0000058)
Fold Change: -2.5008
Cell Significance Index: -14.6800
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: -2.6039
Cell Significance Index: -26.2300
Cell Name: radial glial cell (CL0000681)
Fold Change: -2.7030
Cell Significance Index: -16.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **Ribosomal Protein S4 Y-linked 1 (RPS4Y1)**: RPS4Y1 is a 40S ribosomal protein that is specifically linked to the Y chromosome, suggesting its involvement in sex-specific gene expression. 2. **Significant Expression in Immune Cells**: RPS4Y1 is highly expressed in various immune cells, including mature T cells, germinal center B cells, and thymocytes, indicating its role in immune function. 3. **Involvement in Translation Initiation and Elongation**: RPS4Y1 is a critical component of the 40S ribosomal subunit, which plays a central role in the translation of mRNAs into proteins. 4. **Disease Implications**: Dysregulation of RPS4Y1 has been implicated in various diseases, including cancer, infectious diseases, and neurodegenerative disorders. **Pathways and Functions:** 1. **Translation Initiation and Elongation**: RPS4Y1 is involved in the translation initiation and elongation processes, including the recognition of start codons and the regulation of protein synthesis. 2. **Cap-dependent Translation Initiation**: RPS4Y1 is required for the activation of mRNA upon binding of the cap-binding complex and eIFs. 3. **Axon Guidance**: RPS4Y1 is involved in the regulation of axon guidance, a process critical for neural development and function. 4. **Infectious Disease Response**: RPS4Y1 is required for the host response to viral infections, including influenza and SARS-CoV-2. 5. **Cellular Stress Response**: RPS4Y1 is involved in the regulation of cellular responses to stress, including amino acid deficiency and starvation. **Clinical Significance:** 1. **Cancer**: Dysregulation of RPS4Y1 has been implicated in various types of cancer, including prostate cancer, suggesting its potential as a biomarker or therapeutic target. 2. **Infectious Diseases**: RPS4Y1 is required for the host response to viral infections, highlighting its importance in the development of effective antiviral therapies. 3. **Neurodegenerative Disorders**: Dysregulation of RPS4Y1 has been implicated in neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease, suggesting its potential as a therapeutic target. 4. **Immune Disorders**: RPS4Y1 is involved in the regulation of immune cell function, highlighting its potential as a therapeutic target in immune disorders. In conclusion, RPS4Y1 is a critical component of the ribosomal complex, playing a pivotal role in the regulation of cellular processes, including translation initiation, elongation, and termination. Its dysregulation has been implicated in various diseases, including cancer, infectious diseases, and neurodegenerative disorders, highlighting its importance in maintaining cellular homeostasis. Further research is needed to fully elucidate the function and clinical significance of RPS4Y1.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

40S ribosomal protein S4

Genular Protein ID: 3267341674

Symbol: RS4Y1_HUMAN

Name: 40S ribosomal protein S4

UniProtKB Accession Codes:

P22090 A8K9V4

Database IDs:

Citations:

PubMed ID: 2124517

Title: Homologous ribosomal protein genes on the human X and Y chromosomes: escape from X inactivation and possible implications for Turner syndrome.

PubMed ID: 2124517

DOI: 10.1016/0092-8674(90)90416-c

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

Sequence Information:

Length: 263
Mass: 29456
Checksum: 3B5D6F1ECFCB120A
Sequence:

MARGPKKHLK RVAAPKHWML DKLTGVFAPR PSTGPHKLRE CLPLIVFLRN RLKYALTGDE 
VKKICMQRFI KIDGKVRVDV TYPAGFMDVI SIEKTGEHFR LVYDTKGRFA VHRITVEEAK 
YKLCKVRKIT VGVKGIPHLV THDARTIRYP DPVIKVNDTV QIDLGTGKII NFIKFDTGNL 
CMVIGGANLG RVGVITNRER HPGSFDVVHV KDANGNSFAT RLSNIFVIGN GNKPWISLPR 
GKGIRLTVAE ERDKRLATKQ SSG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RPS4Y1

Associated with

Cells (max top 100)

Other Information

Homologous ribosomal protein genes on the human X and Y chromosomes: escape from X inactivation and possible implications for Turner syndrome. PubMed ID: 2124517

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334