Details for: RTN2

Gene ID: 6253

Symbol: RTN2

Ensembl ID: ENSG00000125744

Description: reticulon 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 105.6284
    Cell Significance Index: -16.4300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 58.1131
    Cell Significance Index: -14.7400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 33.5294
    Cell Significance Index: -15.8300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 30.3502
    Cell Significance Index: -12.3300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 29.6859
    Cell Significance Index: -15.2700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.3338
    Cell Significance Index: -16.4400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.7711
    Cell Significance Index: -15.4600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.1713
    Cell Significance Index: -16.4600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 3.3890
    Cell Significance Index: 82.6900
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 2.9358
    Cell Significance Index: 47.3700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.8734
    Cell Significance Index: -4.1000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1493
    Cell Significance Index: 15.6800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.0786
    Cell Significance Index: 9.0600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.8175
    Cell Significance Index: 17.9000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.8006
    Cell Significance Index: 9.9300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7544
    Cell Significance Index: 151.3400
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.6724
    Cell Significance Index: 7.0200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6561
    Cell Significance Index: 592.3700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.6329
    Cell Significance Index: 33.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5195
    Cell Significance Index: 14.1400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4560
    Cell Significance Index: 23.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4454
    Cell Significance Index: 51.9100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.3739
    Cell Significance Index: 4.0700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3711
    Cell Significance Index: 60.3500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3675
    Cell Significance Index: 22.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3286
    Cell Significance Index: 117.8700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3092
    Cell Significance Index: 19.4900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3048
    Cell Significance Index: 22.7200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2970
    Cell Significance Index: 32.3100
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: 0.2500
    Cell Significance Index: 4.0200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2428
    Cell Significance Index: 6.2400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2123
    Cell Significance Index: 146.8000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1911
    Cell Significance Index: 8.9100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.1899
    Cell Significance Index: 1.1800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1668
    Cell Significance Index: 31.7500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1559
    Cell Significance Index: 15.4200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1559
    Cell Significance Index: 10.7800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1414
    Cell Significance Index: 3.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1246
    Cell Significance Index: 22.4700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1236
    Cell Significance Index: 15.8400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1006
    Cell Significance Index: 4.4500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0906
    Cell Significance Index: 5.4400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0805
    Cell Significance Index: 10.4000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0750
    Cell Significance Index: 2.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0658
    Cell Significance Index: 8.0900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0629
    Cell Significance Index: 2.3800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0530
    Cell Significance Index: 23.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0525
    Cell Significance Index: 28.6800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0258
    Cell Significance Index: 0.6900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0250
    Cell Significance Index: 3.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0226
    Cell Significance Index: 1.0600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0181
    Cell Significance Index: 0.3100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0031
    Cell Significance Index: 0.6200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0021
    Cell Significance Index: 0.0600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0004
    Cell Significance Index: -0.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0037
    Cell Significance Index: -0.1300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0062
    Cell Significance Index: -0.7300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0065
    Cell Significance Index: -0.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0068
    Cell Significance Index: -12.7900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0088
    Cell Significance Index: -16.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0098
    Cell Significance Index: -15.1200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0098
    Cell Significance Index: -0.6900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0144
    Cell Significance Index: -19.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0164
    Cell Significance Index: -12.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0171
    Cell Significance Index: -12.9400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0182
    Cell Significance Index: -13.5100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0191
    Cell Significance Index: -12.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0248
    Cell Significance Index: -11.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0282
    Cell Significance Index: -15.8900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0283
    Cell Significance Index: -0.7900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0305
    Cell Significance Index: -19.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0315
    Cell Significance Index: -1.4300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0446
    Cell Significance Index: -12.8400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0586
    Cell Significance Index: -6.7200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0706
    Cell Significance Index: -5.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0783
    Cell Significance Index: -8.0000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0809
    Cell Significance Index: -0.6600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0837
    Cell Significance Index: -12.1700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0898
    Cell Significance Index: -18.9100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0902
    Cell Significance Index: -1.5100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0905
    Cell Significance Index: -15.4600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1135
    Cell Significance Index: -6.3700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1528
    Cell Significance Index: -7.9600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1561
    Cell Significance Index: -16.2500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1603
    Cell Significance Index: -9.8300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1649
    Cell Significance Index: -10.6400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1728
    Cell Significance Index: -3.6800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1785
    Cell Significance Index: -14.1400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1900
    Cell Significance Index: -2.2700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1951
    Cell Significance Index: -4.1400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1969
    Cell Significance Index: -6.2700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2049
    Cell Significance Index: -2.9400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2190
    Cell Significance Index: -7.1700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2198
    Cell Significance Index: -7.0400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2553
    Cell Significance Index: -2.9000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2632
    Cell Significance Index: -7.0400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2804
    Cell Significance Index: -7.0100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2883
    Cell Significance Index: -5.7000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2925
    Cell Significance Index: -10.2500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3015
    Cell Significance Index: -3.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell Surface and Endoplasmic Reticulum Association:** RTN2 is associated with the cell surface and endoplasmic reticulum, suggesting its involvement in cellular signaling and protein trafficking. 2. **Intermediate Filament Formation:** RTN2 is a component of intermediate filaments, which provide structural support to cells and are involved in maintaining cellular integrity. 3. **Protein Binding:** RTN2 has been shown to bind to various proteins, including amyloid-beta, suggesting its role in protein aggregation and regulation. 4. **Significant Expression in Specific Cell Types:** RTN2 is expressed in a range of cell types, including those involved in muscle development, neuronal function, and immune responses. **Pathways and Functions:** 1. **Negative Regulation of Amyloid-Beta Formation:** RTN2 has been shown to inhibit the formation of amyloid-beta, a protein associated with neurodegenerative diseases such as Alzheimer's. 2. **Regulation of Glucose Import:** RTN2 may play a role in regulating glucose import into cells, which is essential for cellular energy production. 3. **Protein Binding and Trafficking:** RTN2's ability to bind to proteins and regulate their trafficking is crucial for maintaining cellular homeostasis. 4. **Cell Surface and Endoplasmic Reticulum Function:** RTN2's association with the cell surface and endoplasmic reticulum suggests its involvement in cellular signaling and protein trafficking. **Clinical Significance:** 1. **Neurodegenerative Diseases:** RTN2's involvement in amyloid-beta formation and regulation suggests its potential role in neurodegenerative diseases such as Alzheimer's and Parkinson's. 2. **Muscle Disorders:** RTN2's expression in skeletal muscle satellite stem cells and its role in regulating glucose import may be relevant to muscle disorders such as muscular dystrophy. 3. **Cancer:** RTN2's expression in various cell types, including placental villous trophoblast and pulmonary interstitial fibroblast, suggests its potential role in cancer development and progression. 4. **Immunological Disorders:** RTN2's involvement in protein binding and trafficking may be relevant to immunological disorders such as autoimmune diseases. In conclusion, RTN2 is a multifunctional protein that plays a crucial role in various cellular processes, including cell surface and endoplasmic reticulum formation, protein binding, and regulation of glucose import. Its involvement in negative regulation of amyloid-beta formation, regulation of glucose import, and protein binding makes it a potential therapeutic target for various diseases, including neurodegenerative disorders, muscle disorders, and immunological disorders.

Genular Protein ID: 3263583975

Symbol: RTN2_HUMAN

Name: Reticulon-2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9693037

Title: cDNA cloning, genomic organization, and expression of the human RTN2 gene, a member of a gene family encoding reticulons.

PubMed ID: 9693037

DOI: 10.1006/geno.1997.5175

PubMed ID: 9530622

Title: Molecular cloning of a novel mouse gene with predominant muscle and neural expression.

PubMed ID: 9530622

DOI: 10.1007/s003359900748

PubMed ID: 12832288

Title: A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family.

PubMed ID: 12832288

DOI: 10.1096/fj.02-1166hyp

PubMed ID: 15286784

Title: Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation.

PubMed ID: 15286784

DOI: 10.1038/nm1088

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22232211

Title: Mutations in the ER-shaping protein reticulon 2 cause the axon-degenerative disorder hereditary spastic paraplegia type 12.

PubMed ID: 22232211

DOI: 10.1172/jci60560

PubMed ID: 25612671

Title: Identification and characterization of TMEM33 as a reticulon-binding protein.

PubMed ID: 25612671

Sequence Information:

  • Length: 545
  • Mass: 59264
  • Checksum: 971FD2F909E1E9E6
  • Sequence:
  • MGQVLPVFAH CKEAPSTASS TPDSTEGGND DSDFRELHTA REFSEEDEEE TTSQDWGTPR 
    ELTFSYIAFD GVVGSGGRRD STARRPRPQG RSVSEPRDQH PQPSLGDSLE SIPSLSQSPE 
    PGRRGDPDTA PPSERPLEDL RLRLDHLGWV ARGTGSGEDS STSSSTPLED EEPQEPNRLE 
    TGEAGEELDL RLRLAQPSSP EVLTPQLSPG SGTPQAGTPS PSRSRDSNSG PEEPLLEEEE 
    KQWGPLEREP VRGQCLDSTD QLEFTVEPRL LGTAMEWLKT SLLLAVYKTV PILELSPPLW 
    TAIGWVQRGP TPPTPVLRVL LKWAKSPRSS GVPSLSLGAD MGSKVADLLY WKDTRTSGVV 
    FTGLMVSLLC LLHFSIVSVA AHLALLLLCG TISLRVYRKV LQAVHRGDGA NPFQAYLDVD 
    LTLTREQTER LSHQITSRVV SAATQLRHFF LVEDLVDSLK LALLFYILTF VGAIFNGLTL 
    LILGVIGLFT IPLLYRQHQA QIDQYVGLVT NQLSHIKAKI RAKIPGTGAL ASAAAAVSGS 
    KAKAE

Genular Protein ID: 4265172808

Symbol: A8K7F2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 472
  • Mass: 51296
  • Checksum: 4CD598862AD643D4
  • Sequence:
  • MGQVLPVFAH CKEAPSTASS TPDSTEGGND DSDFRELHTA REFSEEDEEE TTSQDWGTPR 
    ELTFSYIAFD GVVGSGGRRD STARRPRPQG RSVSEPRDQH PQPSLGDSLE SIPSLSQSPE 
    PGRRGDPDTA PPSERPLEDL RLRLDHLGWV ARGTGSGEDS STSSSTPLED EEPQEPNRLE 
    TGEAGEELDL RLRLAQPSSP EVLTPQLSPG SGTPQAGTPS PSRSRDSNSG PEEPLLEEEE 
    KQWGPLEREP VRGQCLDSTD QLEFTVEPRL LVADLLYWKD TRTSGVVFTG LMVSLLCLLH 
    FSIVSVAAHL ALLLLCGTIS LRVCRKVLQA VHRGDGANPF QAYLDVDLTL TREQTGRLSH 
    QITSRVVSAA TQLRHFFLVE DLVDSLKLAL LFYILTFVGA IFNGLTLLIL GVIGLFTIPL 
    LYRQHQAQID QYVGLVTNQL SHIKAKIRAK IPGTGALASA AAAVSGSKAK AE

Genular Protein ID: 546638114

Symbol: Q6GMT0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 545
  • Mass: 59324
  • Checksum: 971FD2F909F1E8E6
  • Sequence:
  • MGQVLPVFAH CKEAPSTASS TPDSTEGGND DSDFRELHTA REFSEEDEEE TTSQDWGTPR 
    ELTFSYIAFD GVVGSGGRRD STARRPRPQG RSVSEPRDQH PQPSLGDSLE SIPSLSQSPE 
    PGRRGDPDTA PPSERPLEDL RLRLDHLGWV ARGTGSGEDS STSSSTPLED EEPQEPNRLE 
    TGEAGEELDL RLRLAQPSSP EVLTPQLSPG SGTPQAGTPS PSRSRDSNSG PEEPLLEEEE 
    KQWGPLEREP VRGQCLDSTD QLEFTVEPRL LGTAMEWLKT SLLLAVYKTV PILELSPPLW 
    TAIGWVQRGP TPPTPVLRVL LKWAKSPRSS GVPSLSLGAD MGSKVADLLY WKDTRTSGVV 
    FTGLMVSLLC LLHFSIVSVA AHLALLLLCG TISLRVYRKV LQAVHRGDGA NPFQAYLDVD 
    LTLTREQTER LSHQITSRVV SAATQLRHFF LVEDLVDSLK LALLFYILTF VGAIFNGLTL 
    LILGVIGLFT IPLLYRQHQA QIDQYVGLVT NQLSHIKAKI RAKIPGTGAL AFAAAAVSGS 
    KAKAE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.