Details for: S100A13

Gene ID: 6284

Symbol: S100A13

Ensembl ID: ENSG00000189171

Description: S100 calcium binding protein A13

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 383.2969
    Cell Significance Index: -59.6200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 234.9756
    Cell Significance Index: -59.6000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 145.3097
    Cell Significance Index: -59.8600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 120.7419
    Cell Significance Index: -57.0100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 86.7296
    Cell Significance Index: -58.2000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 48.5622
    Cell Significance Index: -59.8800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.9455
    Cell Significance Index: -56.1100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.1671
    Cell Significance Index: -59.8500
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 8.0320
    Cell Significance Index: 40.0700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 7.1184
    Cell Significance Index: 56.8400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 7.0545
    Cell Significance Index: 43.4200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 6.6274
    Cell Significance Index: 153.1200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 5.0313
    Cell Significance Index: 34.0900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.0348
    Cell Significance Index: 115.6600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.9069
    Cell Significance Index: 536.5300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 3.6868
    Cell Significance Index: 472.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.6336
    Cell Significance Index: 170.7800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.4120
    Cell Significance Index: 60.3000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 3.2446
    Cell Significance Index: 36.8600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.9535
    Cell Significance Index: 220.1200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.7576
    Cell Significance Index: 1506.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.6655
    Cell Significance Index: 124.2800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.6518
    Cell Significance Index: 72.1800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.4291
    Cell Significance Index: 313.8200
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.2459
    Cell Significance Index: 16.1300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.6426
    Cell Significance Index: 178.6600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.6032
    Cell Significance Index: 42.1600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.5339
    Cell Significance Index: 53.3000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.4734
    Cell Significance Index: 181.1700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1673
    Cell Significance Index: 70.0800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.1291
    Cell Significance Index: 14.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1188
    Cell Significance Index: 201.6800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9828
    Cell Significance Index: 434.5200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.9201
    Cell Significance Index: 19.2600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4686
    Cell Significance Index: 33.1400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3700
    Cell Significance Index: 36.6000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2913
    Cell Significance Index: 55.4400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2854
    Cell Significance Index: 14.4200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1973
    Cell Significance Index: 3.8500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1626
    Cell Significance Index: 27.7700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1530
    Cell Significance Index: 2.5600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1458
    Cell Significance Index: 28.9300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0949
    Cell Significance Index: 71.8400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0894
    Cell Significance Index: 14.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0800
    Cell Significance Index: 58.6400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0447
    Cell Significance Index: 0.2700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0333
    Cell Significance Index: 0.8900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0136
    Cell Significance Index: 25.1400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0076
    Cell Significance Index: 0.2200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0057
    Cell Significance Index: 0.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0048
    Cell Significance Index: 8.9700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0215
    Cell Significance Index: -33.0600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0225
    Cell Significance Index: -0.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0339
    Cell Significance Index: -25.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0489
    Cell Significance Index: -66.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0519
    Cell Significance Index: -5.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0585
    Cell Significance Index: -37.1300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0704
    Cell Significance Index: -43.9600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0876
    Cell Significance Index: -49.4200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1001
    Cell Significance Index: -11.4700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1030
    Cell Significance Index: -46.7600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1380
    Cell Significance Index: -39.7000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1590
    Cell Significance Index: -57.0300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1878
    Cell Significance Index: -4.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.2186
    Cell Significance Index: -43.8600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2249
    Cell Significance Index: -26.2200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2272
    Cell Significance Index: -3.4100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2285
    Cell Significance Index: -48.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2568
    Cell Significance Index: -11.6400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2593
    Cell Significance Index: -13.4700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2760
    Cell Significance Index: -5.9800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2802
    Cell Significance Index: -7.8300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3109
    Cell Significance Index: -3.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3395
    Cell Significance Index: -49.3500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3812
    Cell Significance Index: -30.1900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4163
    Cell Significance Index: -49.0900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4219
    Cell Significance Index: -3.4400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4639
    Cell Significance Index: -52.9500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4786
    Cell Significance Index: -6.5300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5211
    Cell Significance Index: -15.3500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.5344
    Cell Significance Index: -21.9000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5653
    Cell Significance Index: -58.8600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.7352
    Cell Significance Index: -56.4200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7492
    Cell Significance Index: -47.2200
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.7796
    Cell Significance Index: -4.5800
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.7874
    Cell Significance Index: -8.2200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.9255
    Cell Significance Index: -62.2300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.9347
    Cell Significance Index: -25.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9454
    Cell Significance Index: -57.9600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.9704
    Cell Significance Index: -59.6500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9719
    Cell Significance Index: -31.1300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.0590
    Cell Significance Index: -27.2200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -1.0632
    Cell Significance Index: -16.4500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.0644
    Cell Significance Index: -59.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.1363
    Cell Significance Index: -59.6600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.1474
    Cell Significance Index: -42.1200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.2345
    Cell Significance Index: -12.7800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.3357
    Cell Significance Index: -12.3000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.3937
    Cell Significance Index: -28.9100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.4215
    Cell Significance Index: -38.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** S100A13 is a small, cytosolic protein that exhibits calcium-dependent protein binding activity, which is essential for its function. It is primarily expressed in various cell types, including thyroid follicular cells, epithelial cells of the lung, skeletal muscle satellite stem cells, and fibroblasts from different tissues. S100A13 has been shown to interact with various proteins, including FGF receptors, rage receptors, and zinc ions, which are involved in signaling pathways that regulate cell proliferation, differentiation, and survival. **Pathways and Functions:** The calcium-binding activity of S100A13 is crucial for its function, as it regulates the activity of various signaling pathways, including: 1. **Mast cell degranulation:** S100A13 has been shown to regulate the degranulation of mast cells, which play a key role in allergic responses and inflammation. 2. **Cytokine production:** S100A13 is involved in the regulation of cytokine production, which is essential for the initiation and maintenance of immune responses. 3. **Cell population proliferation:** S100A13 regulates the proliferation of various cell types, including immune cells and stem cells. 4. **Protein homodimerization activity:** S100A13 can form homodimers with itself, which is essential for its function and regulation of signaling pathways. **Clinical Significance:** S100A13 has been implicated in various diseases, including: 1. **Asthma:** S100A13 has been shown to be overexpressed in asthma and plays a role in the regulation of mast cell degranulation and cytokine production. 2. **Allergic rhinitis:** S100A13 has been implicated in the pathogenesis of allergic rhinitis, where it regulates the production of cytokines and the activation of immune cells. 3. **Cancer:** S100A13 has been shown to be overexpressed in various types of cancer, including breast, lung, and colon cancer, where it regulates cell proliferation and survival. 4. **Neurological disorders:** S100A13 has been implicated in the pathogenesis of various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis, where it regulates the activity of immune cells and cytokine production. In conclusion, S100A13 is a multifaceted protein that plays a crucial role in immune regulation, cellular homeostasis, and disease pathogenesis. Further research is necessary to fully understand the mechanisms of action of S100A13 and its implications in various diseases.

Genular Protein ID: 3574182366

Symbol: S10AD_HUMAN

Name: Protein S100-A13

UniProtKB Accession Codes:

Q99584 Q52PI9 Q6FGF8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 7 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 EMBL 8 Ensembl 5 EvolutionaryTrace 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 12 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 12 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8878558

Title: Characterization of the human and mouse cDNAs coding for S100A13, a new member of the S100 protein family.

PubMed ID: 8878558

DOI: 10.1006/bbrc.1996.1551

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12746488

Title: S100A13 mediates the copper-dependent stress-induced release of IL-1alpha from both human U937 and murine NIH 3T3 cells.

PubMed ID: 12746488

DOI: 10.1242/jcs.00471

PubMed ID: 20863990

Title: Effect of human S100A13 gene silencing on FGF-1 transportation in human endothelial cells.

PubMed ID: 20863990

DOI: 10.1016/s0929-6646(10)60103-9

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 16145699

Title: Structural interplay between calcium(II) and copper(II) binding to S100A13 protein.

PubMed ID: 16145699

DOI: 10.1002/anie.200500540

PubMed ID: 17374362

Title: Crystal structure study on human S100A13 at 2.0 A resolution.

PubMed ID: 17374362

DOI: 10.1016/j.bbrc.2007.03.014

PubMed ID: 18259052

Title: Structure of calcium-bound human S100A13 at pH 7.5 at 1.8 A resolution.

PubMed ID: 18259052

DOI: 10.1107/s1744309107068236

PubMed ID: 19284995

Title: S100A13-C2A binary complex structure-a key component in the acidic fibroblast growth factor for the non-classical pathway.

PubMed ID: 19284995

DOI: 10.1016/j.bbrc.2009.01.143

PubMed ID: 21270123

Title: The IL1alpha-S100A13 heterotetrameric complex structure: a component in the non-classical pathway for interleukin 1alpha secretion.

PubMed ID: 21270123

DOI: 10.1074/jbc.m110.201954

Sequence Information:

  • Length: 98
  • Mass: 11471
  • Checksum: 1D1BE57F3CD49E81
  • Sequence:
    • MAAEPLTELE ESIETVVTTF FTFARQEGRK DSLSVNEFKE LVTQQLPHLL KDVGSLDEKM 
KSLDVNQDSE LKFNEYWRLI GELAKEIRKK KDLKIRKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.