Details for: SALL1

Gene ID: 6299

Symbol: SALL1

Ensembl ID: ENSG00000103449

Description: spalt like transcription factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 45.2001
    Cell Significance Index: -21.3400
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.1220
    Cell Significance Index: 12.5400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.1206
    Cell Significance Index: 29.4700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.8243
    Cell Significance Index: 28.6500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4755
    Cell Significance Index: 94.3700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2603
    Cell Significance Index: 142.1800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.2376
    Cell Significance Index: 3.4500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1657
    Cell Significance Index: 59.4500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0289
    Cell Significance Index: 3.7000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0247
    Cell Significance Index: 18.0900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.0075
    Cell Significance Index: 0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0086
    Cell Significance Index: -16.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0119
    Cell Significance Index: -16.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0121
    Cell Significance Index: -18.6600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0122
    Cell Significance Index: -22.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0189
    Cell Significance Index: -2.5900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0328
    Cell Significance Index: -24.3000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0376
    Cell Significance Index: -23.5000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0404
    Cell Significance Index: -22.7600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0405
    Cell Significance Index: -0.9800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0493
    Cell Significance Index: -22.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0511
    Cell Significance Index: -3.1400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0621
    Cell Significance Index: -17.8700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0986
    Cell Significance Index: -19.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1137
    Cell Significance Index: -20.5000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1216
    Cell Significance Index: -25.6000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1308
    Cell Significance Index: -22.3300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1331
    Cell Significance Index: -13.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1401
    Cell Significance Index: -20.3600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1591
    Cell Significance Index: -12.6000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1664
    Cell Significance Index: -20.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1746
    Cell Significance Index: -20.0000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1805
    Cell Significance Index: -21.0400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1986
    Cell Significance Index: -20.6800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2092
    Cell Significance Index: -27.0300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2416
    Cell Significance Index: -4.0700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2560
    Cell Significance Index: -5.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2911
    Cell Significance Index: -22.3400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3161
    Cell Significance Index: -8.1300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3283
    Cell Significance Index: -18.4200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3328
    Cell Significance Index: -22.3800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3426
    Cell Significance Index: -21.5900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3646
    Cell Significance Index: -27.1700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3681
    Cell Significance Index: -22.5700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.3874
    Cell Significance Index: -5.5100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3967
    Cell Significance Index: -5.8600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4145
    Cell Significance Index: -12.2100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4289
    Cell Significance Index: -22.2800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4377
    Cell Significance Index: -22.9800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.4393
    Cell Significance Index: -19.9100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.4455
    Cell Significance Index: -11.1100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.4581
    Cell Significance Index: -7.3500
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.4704
    Cell Significance Index: -5.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4755
    Cell Significance Index: -22.3500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4829
    Cell Significance Index: -11.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4996
    Cell Significance Index: -22.1000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.5248
    Cell Significance Index: -21.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5279
    Cell Significance Index: -24.6200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.5283
    Cell Significance Index: -4.4900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5742
    Cell Significance Index: -21.0800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5884
    Cell Significance Index: -22.2800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6300
    Cell Significance Index: -22.0700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6353
    Cell Significance Index: -17.0000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6564
    Cell Significance Index: -10.9900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6593
    Cell Significance Index: -21.5900
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.6848
    Cell Significance Index: -4.3000
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.6891
    Cell Significance Index: -6.2100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.6914
    Cell Significance Index: -11.9600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6936
    Cell Significance Index: -22.0900
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.7162
    Cell Significance Index: -4.2500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.7190
    Cell Significance Index: -22.7400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.7372
    Cell Significance Index: -15.4300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.7490
    Cell Significance Index: -8.7400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.7538
    Cell Significance Index: -38.0900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7629
    Cell Significance Index: -21.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.7715
    Cell Significance Index: -21.0000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.7813
    Cell Significance Index: -10.8400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7885
    Cell Significance Index: -22.5000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.7951
    Cell Significance Index: -21.2300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.8150
    Cell Significance Index: -17.6100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.8340
    Cell Significance Index: -20.8300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.8350
    Cell Significance Index: -13.7600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.8367
    Cell Significance Index: -20.8700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.8394
    Cell Significance Index: -9.0000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8528
    Cell Significance Index: -22.8500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.8627
    Cell Significance Index: -14.5100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.8717
    Cell Significance Index: -22.2100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.8795
    Cell Significance Index: -17.3100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.9237
    Cell Significance Index: -19.7500
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.9370
    Cell Significance Index: -10.3500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.9378
    Cell Significance Index: -18.7000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.9421
    Cell Significance Index: -19.1700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.9541
    Cell Significance Index: -23.2800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.9545
    Cell Significance Index: -20.9000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.9776
    Cell Significance Index: -22.5900
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.9942
    Cell Significance Index: -11.6900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.9985
    Cell Significance Index: -20.8400
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -1.0001
    Cell Significance Index: -7.6500
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -1.0081
    Cell Significance Index: -14.3400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -1.0255
    Cell Significance Index: -14.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SALL1 is a member of the Spalt-like transcription factor family, characterized by its ability to bind to specific DNA sequences and regulate gene expression. It is a transcriptional repressor, which means it can inhibit the transcription of target genes. SALL1 is also a transcriptional activator, as it can regulate the expression of certain genes involved in cell proliferation and differentiation. The gene is highly conserved across species, suggesting its critical role in evolutionarily conserved developmental processes. **Pathways and Functions:** SALL1 is involved in various signaling pathways, including: 1. **Wnt signaling pathway:** SALL1 is a positive regulator of Wnt signaling, which is crucial for cell proliferation, differentiation, and organogenesis. 2. **Pou5f1 (Oct4), Sox2, and Nanog activation:** SALL1 interacts with these transcription factors to regulate the expression of genes involved in pluripotency and stem cell maintenance. 3. **DNA-templated transcription:** SALL1 regulates the transcription of target genes by binding to specific DNA sequences and recruiting transcriptional machinery. 4. **RNA polymerase II-specific transcription:** SALL1 can regulate the expression of genes involved in cell proliferation and differentiation by interacting with RNA polymerase II. **Clinical Significance:** SALL1 is significantly expressed in various types of cancer, including: 1. **Testicular germ cell tumors:** SALL1 is a diagnostic marker for these cancers, and its expression is often used to distinguish them from other types of tumors. 2. **Germ cell tumors of the ovary:** SALL1 is also expressed in ovarian germ cell tumors, making it a potential diagnostic marker. 3. **Cancer stem cells:** SALL1 is involved in the regulation of stem cell maintenance and tumorigenesis, making it a potential target for cancer therapy. Furthermore, SALL1 is involved in various developmental disorders, including: 1. **Urogenital anomalies:** SALL1 is involved in the development of the ureteric bud and kidney development, making it a potential target for the treatment of urogenital anomalies. 2. **Neurodevelopmental disorders:** SALL1 is expressed in the olfactory bulb and involved in the development of olfactory neurons, making it a potential target for the treatment of neurodevelopmental disorders. In conclusion, SALL1 is a complex transcription factor involved in various developmental processes and clinical applications. Its role in regulating cell fate determination, stem cell maintenance, and tumorigenesis makes it a promising target for cancer therapy and developmental disorders. Further research is needed to fully understand the mechanisms of SALL1 and its clinical significance.

Genular Protein ID: 1745430672

Symbol: SALL1_HUMAN

Name: Sal-like protein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9973281

Title: Molecular analysis of SALL1 mutations in Townes-Brocks syndrome.

PubMed ID: 9973281

DOI: 10.1086/302238

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 10533063

Title: Townes-Brocks syndrome: detection of a SALL1 mutation hot spot and evidence for a position effect in one patient.

PubMed ID: 10533063

DOI: 10.1002/(sici)1098-1004(199911)14:5<377::aid-humu3>3.0.co;2-a

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 8975705

Title: Isolation, characterization, and organ-specific expression of two novel human zinc finger genes related to the Drosophila gene spalt.

PubMed ID: 8975705

DOI: 10.1006/geno.1996.0631

PubMed ID: 9425907

Title: Mutations in the SALL1 putative transcription factor gene cause Townes-Brocks syndrome.

PubMed ID: 9425907

DOI: 10.1038/ng0198-81

PubMed ID: 16545361

Title: The vertebrate spalt genes in development and disease.

PubMed ID: 16545361

DOI: 10.1016/j.ydbio.2006.02.009

PubMed ID: 18297069

Title: Mutations in the cyclin family member FAM58A cause an X-linked dominant disorder characterized by syndactyly, telecanthus and anogenital and renal malformations.

PubMed ID: 18297069

DOI: 10.1038/ng.86

PubMed ID: 10928856

Title: A SALL1 mutation causes a branchio-oto-renal syndrome-like phenotype.

PubMed ID: 10928856

DOI: 10.1136/jmg.37.6.458

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 1324
  • Mass: 140405
  • Checksum: 41AFA91ADEBEEF8C
  • Sequence:
  • MSRRKQAKPQ HFQSDPEVAS LPRRDGDTEK GQPSRPTKSK DAHVCGRCCA EFFELSDLLL 
    HKKNCTKNQL VLIVNENPAS PPETFSPSPP PDNPDEQMND TVNKTDQVDC SDLSEHNGLD 
    REESMEVEAP VANKSGSGTS SGSHSSTAPS SSSSSSSSSG GGGSSSTGTS AITTSLPQLG 
    DLTTLGNFSV INSNVIIENL QSTKVAVAQF SQEARCGGAS GGKLAVPALM EQLLALQQQQ 
    IHQLQLIEQI RHQILLLASQ NADLPTSSSP SQGTLRTSAN PLSTLSSHLS QQLAAAAGLA 
    QSLASQSASI SGVKQLPPIQ LPQSSSGNTI IPSNSGSSPN MNILAAAVTT PSSEKVASSA 
    GASHVSNPAV SSSSSPAFAI SSLLSPASNP LLPQQASANS VFPSPLPNIG TTAEDLNSLS 
    ALAQQRKSKP PNVTAFEAKS TSDEAFFKHK CRFCAKVFGS DSALQIHLRS HTGERPFKCN 
    ICGNRFSTKG NLKVHFQRHK EKYPHIQMNP YPVPEHLDNI PTSTGIPYGM SIPPEKPVTS 
    WLDTKPVLPT LTTSVGLPLP PTLPSLIPFI KTEEPAPIPI SHSATSPPGS VKSDSGGPES 
    ATRNLGGLPE EAEGSTLPPS GGKSEESGMV TNSVPTASSS VLSSPAADCG PAGSATTFTN 
    PLLPLMSEQF KAKFPFGGLL DSAQASETSK LQQLVENIDK KATDPNECII CHRVLSCQSA 
    LKMHYRTHTG ERPFKCKICG RAFTTKGNLK THYSVHRAMP PLRVQHSCPI CQKKFTNAVV 
    LQQHIRMHMG GQIPNTPVPD SYSESMESDT GSFDEKNFDD LDNFSDENME DCPEGSIPDT 
    PKSADASQDS LSSSPLPLEM SSIAALENQM KMINAGLAEQ LQASLKSVEN GSIEGDVLTN 
    DSSSVGGDME SQSAGSPAIS ESTSSMQALS PSNSTQEFHK SPSIEEKPQR AVPSEFANGL 
    SPTPVNGGAL DLTSSHAEKI IKEDSLGILF PFRDRGKFKN TACDICGKTF ACQSALDIHY 
    RSHTKERPFI CTVCNRGFST KGNLKQHMLT HQMRDLPSQL FEPSSNLGPN QNSAVIPANS 
    LSSLIKTEVN GFVHVSPQDS KDTPTSHVPS GPLSSSATSP VLLPALPRRT PKQHYCNTCG 
    KTFSSSSALQ IHERTHTGEK PFACTICGRA FTTKGNLKVH MGTHMWNSTP ARRGRRLSVD 
    GPMTFLGGNP VKFPEMFQKD LAARSGSGDP SSFWNQYAAA LSNGLAMKAN EISVIQNGGI 
    PPIPGSLGSG NSSPVSGLTG NLERLQNSEP NAPLAGLEKM ASSENGTNFR FTRFVEDSKE 
    IVTS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.