Details for: SGCG

Gene ID: 6445

Symbol: SGCG

Ensembl ID: ENSG00000102683

Description: sarcoglycan gamma

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 4.7903
    Cell Significance Index: 116.8800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 4.1008
    Cell Significance Index: 105.4100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 3.6121
    Cell Significance Index: 277.1900
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 3.1651
    Cell Significance Index: 51.0700
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 2.9216
    Cell Significance Index: 36.7900
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.6487
    Cell Significance Index: 10.2000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9320
    Cell Significance Index: 42.2500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.8121
    Cell Significance Index: 15.8500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6130
    Cell Significance Index: 116.6700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4895
    Cell Significance Index: 48.4200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.4698
    Cell Significance Index: 11.3800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4250
    Cell Significance Index: 383.7500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.3862
    Cell Significance Index: 9.6300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.3360
    Cell Significance Index: 5.3300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2998
    Cell Significance Index: 6.5000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2642
    Cell Significance Index: 119.9300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2511
    Cell Significance Index: 50.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1987
    Cell Significance Index: 13.3600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1736
    Cell Significance Index: 28.2300
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.1708
    Cell Significance Index: 1.5500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1593
    Cell Significance Index: 2.7300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1262
    Cell Significance Index: 13.7300
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.1151
    Cell Significance Index: 0.5600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0684
    Cell Significance Index: 1.0100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0561
    Cell Significance Index: 38.8100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0330
    Cell Significance Index: 2.2900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0141
    Cell Significance Index: 2.0500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0107
    Cell Significance Index: 4.7500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0050
    Cell Significance Index: 9.4400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0028
    Cell Significance Index: 0.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0009
    Cell Significance Index: -0.1800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0021
    Cell Significance Index: -2.8000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0027
    Cell Significance Index: -4.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0028
    Cell Significance Index: -5.2300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0030
    Cell Significance Index: -1.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0067
    Cell Significance Index: -4.2800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0091
    Cell Significance Index: -0.3200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0111
    Cell Significance Index: -0.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0121
    Cell Significance Index: -8.9400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0133
    Cell Significance Index: -10.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0143
    Cell Significance Index: -7.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0148
    Cell Significance Index: -8.3500
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0194
    Cell Significance Index: -0.2900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0224
    Cell Significance Index: -0.5600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0247
    Cell Significance Index: -0.5200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0266
    Cell Significance Index: -3.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0275
    Cell Significance Index: -4.7000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0286
    Cell Significance Index: -8.2300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0316
    Cell Significance Index: -1.9400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0352
    Cell Significance Index: -6.3500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0406
    Cell Significance Index: -8.5500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0578
    Cell Significance Index: -3.5600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0611
    Cell Significance Index: -8.3900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0618
    Cell Significance Index: -7.6000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0656
    Cell Significance Index: -2.0900
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.0689
    Cell Significance Index: -0.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0715
    Cell Significance Index: -7.4400
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0725
    Cell Significance Index: -0.9500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0729
    Cell Significance Index: -8.4900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0730
    Cell Significance Index: -1.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0800
    Cell Significance Index: -9.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0828
    Cell Significance Index: -8.4600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0850
    Cell Significance Index: -1.7800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0955
    Cell Significance Index: -1.2300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0983
    Cell Significance Index: -3.1100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1136
    Cell Significance Index: -6.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1197
    Cell Significance Index: -5.5800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1220
    Cell Significance Index: -3.4100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1331
    Cell Significance Index: -9.9200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1402
    Cell Significance Index: -7.8700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1459
    Cell Significance Index: -7.6600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1472
    Cell Significance Index: -6.5100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1495
    Cell Significance Index: -3.9300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1538
    Cell Significance Index: -8.0100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1639
    Cell Significance Index: -4.8300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1767
    Cell Significance Index: -6.6900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1785
    Cell Significance Index: -1.9400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1794
    Cell Significance Index: -8.4300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1863
    Cell Significance Index: -6.5300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2072
    Cell Significance Index: -2.9800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2171
    Cell Significance Index: -5.9100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2227
    Cell Significance Index: -7.2900
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.2254
    Cell Significance Index: -3.0400
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.2302
    Cell Significance Index: -2.1900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2317
    Cell Significance Index: -3.4200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2355
    Cell Significance Index: -3.0800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2390
    Cell Significance Index: -8.3100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2566
    Cell Significance Index: -4.3000
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.2574
    Cell Significance Index: -2.8400
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.2726
    Cell Significance Index: -2.6100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2730
    Cell Significance Index: -10.0200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2813
    Cell Significance Index: -5.9700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2823
    Cell Significance Index: -6.0400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2835
    Cell Significance Index: -8.0900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2847
    Cell Significance Index: -7.1100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2899
    Cell Significance Index: -7.7400
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.2916
    Cell Significance Index: -3.5200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2918
    Cell Significance Index: -7.2800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2980
    Cell Significance Index: -4.2800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3022
    Cell Significance Index: -6.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane protein**: SGCG is a transmembrane protein, with a hydrophobic transmembrane domain that anchors it to the plasma membrane. 2. **Sarcoglycan complex component**: SGCG is a subunit of the sarcoglycan complex, which is essential for maintaining the structural integrity and function of muscle cells. 3. **Muscle cell-specific expression**: SGCG is primarily expressed in muscle cells, including cardiac myocytes, skeletal muscle cells, and smooth muscle cells. 4. **Cardiac and skeletal muscle development**: SGCG plays a critical role in the development and maintenance of cardiac and skeletal muscle tissue. **Pathways and Functions:** 1. **Sarcoglycan complex formation**: SGCG interacts with other sarcoglycan subunits to form the sarcoglycan complex, which is essential for maintaining muscle cell structure and function. 2. **Cell surface anchoring**: SGCG anchors the sarcoglycan complex to the plasma membrane, providing a link between the cytoskeleton and the extracellular matrix. 3. **Muscle cell signaling**: SGCG is involved in muscle cell signaling pathways, including the regulation of muscle cell growth and differentiation. 4. **Mechanical stress response**: SGCG is activated in response to mechanical stress, such as muscle injury or overload, and plays a role in regulating the muscle cell response to injury. **Clinical Significance:** 1. **Muscular dystrophies**: Mutations in the SGCG gene have been associated with various muscular dystrophies, including LGMD2C and cardiac-related disorders. 2. **Cardiac-related disorders**: SGCG mutations have been linked to cardiac arrhythmias, congestive heart failure, and sudden cardiac death. 3. **Skeletal muscle disorders**: SGCG mutations have been associated with skeletal muscle disorders, including muscle weakness and wasting. 4. **Therapeutic potential**: Understanding the role of SGCG in muscle cell development and function has implications for the development of novel therapeutic strategies for muscular dystrophies and cardiac-related disorders. In conclusion, the Sarcoglycan Gamma gene (SGCG) is a critical component of the sarcoglycan complex, essential for maintaining the structural integrity and function of muscle cells. Mutations in the SGCG gene have significant implications for cardiac and skeletal muscle development and function, highlighting the importance of this gene in the pathogenesis of muscular dystrophies and cardiac-related disorders. Further research is needed to fully elucidate the role of SGCG in muscle cell development and function and to develop novel therapeutic strategies for these complex disorders.

Genular Protein ID: 2115355569

Symbol: SGCG_HUMAN

Name: Gamma-sarcoglycan

UniProtKB Accession Codes:

Q13326 Q32M32 Q5T9J6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 4 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 Ensembl 1 GO 9 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 7481775

Title: Mutations in the dystrophin-associated protein gamma-sarcoglycan in chromosome 13 muscular dystrophy.

PubMed ID: 7481775

DOI: 10.1126/science.270.5237.819

PubMed ID: 8900232

Title: Mild and severe muscular dystrophy caused by a single gamma-sarcoglycan mutation.

PubMed ID: 8900232

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10629222

Title: Filamin 2 (FLN2): a muscle-specific sarcoglycan interacting protein.

PubMed ID: 10629222

DOI: 10.1083/jcb.148.1.115

PubMed ID: 8968757

Title: A founder mutation in the gamma-sarcoglycan gene of Gypsies possibly predating their migration out of India.

PubMed ID: 8968757

DOI: 10.1093/hmg/5.12.2019

PubMed ID: 10714584

Title: Severe gamma-sarcoglycanopathy caused by a novel missense mutation and a large deletion.

PubMed ID: 10714584

DOI: 10.1016/s0960-8966(99)00063-2

PubMed ID: 30345904

Title: The impact of PYROXD1 deficiency on cellular respiration and correlations with genetic analyses of limb-girdle muscular dystrophy in Saudi Arabia and Sudan.

PubMed ID: 30345904

DOI: 10.1152/physiolgenomics.00036.2018

Sequence Information:

  • Length: 291
  • Mass: 32379
  • Checksum: 6CF219706ABFB77B
  • Sequence:
    • MVREQYTTAT EGICIERPEN QYVYKIGIYG WRKRCLYLFV LLLLIILVVN LALTIWILKV 
MWFSPAGMGH LCVTKDGLRL EGESEFLFPL YAKEIHSRVD SSLLLQSTQN VTVNARNSEG 
EVTGRLKVGP KMVEVQNQQF QINSNDGKPL FTVDEKEVVV GTDKLRVTGP EGALFEHSVE 
TPLVRADPFQ DLRLESPTRS LSMDAPRGVH IQAHAGKIEA LSQMDILFHS SDGMLVLDAE 
TVCLPKLVQG TWGPSGSSQS LYEICVCPDG KLYLSVAGVS TTCQEHNHIC L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.