SCG5 | ENSG00000166922 | NCBI 6447

Details for: SCG5

Gene ID: 6447

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: SCG5

Ensembl ID: ENSG00000166922

Description: secretogranin V

Cell Significance Landscape

Display Count:

Associated with

Enzyme inhibitor activity
(GO:0004857)
Enzyme regulator activity
(GO:0030234)
Extracellular region
(GO:0005576)
Gtp binding
(GO:0005525)
Intracellular protein transport
(GO:0006886)
Neuropeptide signaling pathway
(GO:0007218)
Nucleus
(GO:0005634)
Peptide hormone processing
(GO:0016486)
Protein binding
(GO:0005515)
Regulation of hormone secretion
(GO:0046883)
Secretory granule
(GO:0030141)
Unfolded protein binding
(GO:0051082)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

pancreatic A cell CL0000171

CSI 62.02

rCSI 64.97%

PRS 91.35
pancreatic D cell CL0000173

CSI 56.6

rCSI 55.66%

PRS 91.04
type L enteroendocrine cell CL0002279

CSI 34.32

rCSI 64.42%

PRS 91.53
type B pancreatic cell CL0000169

CSI 31.58

rCSI 69.91%

PRS 89.24
enteroendocrine cell CL0000164

CSI 25.02

rCSI 34.18%

PRS 87.92
peripheral nervous system neuron CL2000032

CSI 21.69

rCSI 29.56%

PRS 82.7
progenitor cell CL0011026

CSI 18.69

rCSI 39.74%

PRS 83.33
neural crest cell CL0011012

CSI 17.75

rCSI 14.03%

PRS 81.69
myofibroblast cell CL0000186

CSI 15.75

rCSI 21.81%

PRS 85.96
pancreatic epsilon cell CL0005019

CSI 14.83

rCSI 69.12%

PRS 93.04
pancreatic PP cell CL0002275

CSI 14.55

rCSI 57.92%

PRS 92.91
interneuron CL0000099

CSI 14.04

rCSI 28.19%

PRS 82.77
lung neuroendocrine cell CL1000223

CSI 13.49

rCSI 19.95%

PRS 91.18
epithelial cell CL0000066

CSI 13.4

rCSI 20.59%

PRS 77.85
enteroendocrine cell of colon CL0009042

CSI 13.15

rCSI 61.66%

PRS 91.98
radial glial cell CL0000681

CSI 12.83

rCSI 17.82%

PRS 87.84
enteroendocrine cell of small intestine CL0009006

CSI 12.77

rCSI 28.11%

PRS 92.56
retina horizontal cell CL0000745

CSI 11.89

rCSI 18.13%

PRS 86.21
differentiation-committed oligodendrocyte precursor CL4023059

CSI 11.85

rCSI 21.53%

PRS 82.59
glioblast CL0000030

CSI 11.8

rCSI 18.83%

PRS 81.7
type EC enteroendocrine cell CL0000577

CSI 11.74

rCSI 41.67%

PRS 90.66
P/D1 enteroendocrine cell CL0002268

CSI 10.39

rCSI 56.59%

PRS 92.02
cerebral cortex endothelial cell CL1001602

CSI 10.12

rCSI 17.51%

PRS 83.5
VIP GABAergic cortical interneuron CL4023016

CSI 9.44

rCSI 11.27%

PRS 75.51
glial cell CL0000125

CSI 9.23

rCSI 35.14%

PRS 82.47
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 8.28

rCSI 9.56%

PRS 82.14
neuroblast (sensu Vertebrata) CL0000031

CSI 8.27

rCSI 10.62%

PRS 85.84
pvalb GABAergic cortical interneuron CL4023018

CSI 8.1

rCSI 10.08%

PRS 73.32
inhibitory interneuron CL0000498

CSI 7.82

rCSI 18.04%

PRS 79.85
choroid plexus epithelial cell CL0000706

CSI 7.8

rCSI 12.77%

PRS 81.67
cerebral cortex neuron CL0010012

CSI 7.72

rCSI 31.45%

PRS 81.89
cerebral cortex GABAergic interneuron CL0010011

CSI 7.29

rCSI 21.52%

PRS 89.58
retinal bipolar neuron CL0000748

CSI 7.01

rCSI 13.13%

PRS 80.33
fallopian tube secretory epithelial cell CL4030006

CSI 6.94

rCSI 6.68%

PRS 87.99
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 6.89

rCSI 12.16%

PRS 74.96
Cajal-Retzius cell CL0000695

CSI 6.87

rCSI 53.87%

PRS 91.25
stem cell CL0000034

CSI 6.66

rCSI 6.42%

PRS 84.96
sst GABAergic cortical interneuron CL4023017

CSI 6.66

rCSI 8.58%

PRS 76.63
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 6.59

rCSI 16.02%

PRS 73.22
GABAergic amacrine cell CL4030027

CSI 6.55

rCSI 22.43%

PRS 76.51
Mueller cell CL0000636

CSI 6.37

rCSI 14.53%

PRS 82.44
ciliated epithelial cell CL0000067

CSI 6.31

rCSI 5.55%

PRS 80.49
cerebellar granule cell CL0001031

CSI 6.31

rCSI 9.28%

PRS 83.83
neuroendocrine cell CL0000165

CSI 6.1

rCSI 23.61%

PRS 92.81
neuron CL0000540

CSI 5.86

rCSI 15.6%

PRS 77.15
retinal ganglion cell CL0000740

CSI 5.66

rCSI 12.5%

PRS 78.25
pancreatic stellate cell CL0002410

CSI 5.59

rCSI 32.55%

PRS 90.97
L6b glutamatergic cortical neuron CL4023038

CSI 5.29

rCSI 16.53%

PRS 76.85
enteric smooth muscle cell CL0002504

CSI 5.14

rCSI 7.33%

PRS 89.54
sncg GABAergic cortical interneuron CL4023015

CSI 5.04

rCSI 8.1%

PRS 76.58
pancreatic acinar cell CL0002064

CSI 4.98

rCSI 6.62%

PRS 92.36
lamp5 GABAergic cortical interneuron CL4023011

CSI 4.83

rCSI 8.1%

PRS 75.47
mesenchymal cell CL0008019

CSI 4.76

rCSI 12.08%

PRS 84.07
glutamatergic neuron CL0000679

CSI 4.65

rCSI 9.55%

PRS 77.46
rod bipolar cell CL0000751

CSI 4.59

rCSI 8.24%

PRS 84.06
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 4.54

rCSI 16.34%

PRS 73.43
pancreatic ductal cell CL0002079

CSI 4.53

rCSI 8.82%

PRS 91
GABAergic neuron CL0000617

CSI 4.46

rCSI 14.93%

PRS 75.56
forebrain radial glial cell CL0013000

CSI 4.12

rCSI 13.22%

PRS 89.18
basal cell CL0000646

CSI 4.04

rCSI 5.4%

PRS 86.69
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 3.86

rCSI 22.75%

PRS 75.96
near-projecting glutamatergic cortical neuron CL4023012

CSI 3.82

rCSI 14.46%

PRS 75.71
astrocyte of the cerebral cortex CL0002605

CSI 3.68

rCSI 8.24%

PRS 75.94
amacrine cell CL0000561

CSI 3.16

rCSI 9.15%

PRS 80.6
retinal pigment epithelial cell CL0002586

CSI 3.14

rCSI 6.24%

PRS 85.57
cerebral cortex pyramidal neuron CL4023111

CSI 2.98

rCSI 18.34%

PRS 90.58
L2/3 intratelencephalic projecting glutamatergic neuron CL4030059

CSI 2.94

rCSI 6.38%

PRS 78.01
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 2.55

rCSI 7.96%

PRS 78.74
direct pathway medium spiny neuron CL4023026

CSI 2.54

rCSI 60.87%

PRS 73.22
OFF-bipolar cell CL0000750

CSI 2.51

rCSI 3.43%

PRS 88.44
indirect pathway medium spiny neuron CL4023029

CSI 2.48

rCSI 59.72%

PRS 73.49
mesodermal cell CL0000222

CSI 2.45

rCSI 2.95%

PRS 88.01
L5/6 near-projecting glutamatergic neuron CL4030067

CSI 2.39

rCSI 7.86%

PRS 77.35
endocrine cell CL0000163

CSI 2.33

rCSI 11.97%

PRS 95.92
glycinergic amacrine cell CL4030028

CSI 2.27

rCSI 5.92%

PRS 83.43
Bergmann glial cell CL0000644

CSI 2.24

rCSI 3.07%

PRS 81.44
Purkinje cell CL0000121

CSI 2.23

rCSI 29.12%

PRS 90.23
central nervous system neuron CL2000029

CSI 2.21

rCSI 16.22%

PRS 80.26
midbrain dopaminergic neuron CL2000097

CSI 2.02

rCSI 12.96%

PRS 83.92
enteric neuron CL0007011

CSI 1.98

rCSI 29.31%

PRS 91.27
neuroplacodal cell CL0000032

CSI 1.77

rCSI 16.37%

PRS 87.25
retinal cone cell CL0000573

CSI 1.55

rCSI 2.5%

PRS 81.35
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 1.55

rCSI 3.7%

PRS 78.37
macroglial cell CL0000126

CSI 1.49

rCSI 3.83%

PRS 85.27
ON parasol ganglion cell CL4033052

CSI 1.45

rCSI 20.57%

PRS 81.4
neural progenitor cell CL0011020

CSI 1.3

rCSI 5.74%

PRS 78.61
fibroblast of breast CL4006000

CSI 1.12

rCSI 4.72%

PRS 91.58
OFF midget ganglion cell CL4033047

CSI 0.86

rCSI 17.52%

PRS 81.12
ON midget ganglion cell CL4033046

CSI 0.68

rCSI 13.78%

PRS 80.37
pluripotent stem cell CL0002248

CSI 0.49

rCSI 14.84%

PRS 94.3

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [SCG5](/details-gene/6447), or Secretogranin V, encodes the neuroendocrine protein 7B2. This protein functions as a crucial molecular chaperone and temporary inhibitor for prohormone convertase 2 (PC2), an enzyme essential for the processing of various peptide hormones and neuropeptides. The expression profile of [SCG5](/details-gene/6447) is highly specific to neuroendocrine tissues, with particularly significant expression in the endocrine cells of the pancreas and gastrointestinal tract. Its fundamental role in peptide hormone maturation implicates it in the regulation of numerous physiological processes, and its dysfunction may be associated with endocrine disorders, as suggested by its OMIM entry [173120](https://omim.org/entry/173120). Foundational research has elucidated its sequence, structure, and function as a chaperone ([Link](https://doi.org/10.1016/0014-5793(88)81324-3), [Link](https://doi.org/10.1111/j.1432-1033.1996.00060.x), [Link](https://doi.org/10.1016/0092-8674(94)90296-8)). ## Cellular Roles and Expression Landscape The expression pattern of [SCG5](/details-gene/6447) firmly establishes it as a key component of the neuroendocrine system. **Overall**, the gene shows its most profound significance in hormone-secreting cells of the pancreas, including [pancreatic A cell](/details-cell/CL0000171) (CSI: 62.02), [pancreatic D cell](/details-cell/CL0000173) (CSI: 56.60), and [type B pancreatic cell](/details-cell/CL0000169) (CSI: 31.58). This highlights its critical involvement in the regulation of glucose homeostasis through the processing of pro-glucagon, pro-somatostatin, and pro-insulin, respectively. Beyond the pancreas, [SCG5](/details-gene/6447) is also a significant marker for various [enteroendocrine cell](/details-cell/CL0000164) populations, such as [type L enteroendocrine cell](/details-cell/CL0002279) (CSI: 34.32), which are responsible for gut hormone production. Its expression in [peripheral nervous system neuron](/details-cell/CL2000032)s (CSI: 21.69) and [interneuron](/details-cell/CL0000099)s (CSI: 14.04) is consistent with its role in processing neuropeptides. The broad but specific expression across these diverse neuroendocrine cell types underscores its conserved and fundamental function in the secretory pathway of cells that release peptide-based signaling molecules. ## Pathways and Molecular Function Functionally, [SCG5](/details-gene/6447) is primarily associated with the post-translational modification and transport of proteins within the secretory pathway. Its gene ontology annotations point to roles in [peptide hormone processing](/details-go/GO:0016486), the [neuropeptide signaling pathway](/details-go/GO:0007218), and [intracellular protein transport](/details-go/GO:0006886). The protein product localizes to the [secretory granule](/details-go/GO:0030141), the site of final hormone maturation and storage before release. The molecular function of the 7B2 protein is best characterized by its [enzyme inhibitor activity](/details-go/GO:0004857) and its role as an [unfolded protein binding](/details-go/GO:0051082) chaperone. Seminal work has demonstrated that 7B2 binds to proPC2 in the endoplasmic reticulum, facilitating its proper folding and transport to the trans-Golgi network, while simultaneously inhibiting its enzymatic activity until it reaches the appropriate acidic environment of the secretory granules ([Link](https://doi.org/10.1016/0092-8674(94)90296-8), [Link](https://doi.org/10.1042/0264-6021:3570329)). This dual function ensures that prohormone processing is both efficient and tightly regulated. ## Research Directions Based on its specific expression and critical function, [SCG5](/details-gene/6447) presents several avenues for further investigation, particularly in the context of metabolic and neuroendocrine diseases. **Proposed Hypotheses:** 1. Given its high significance in pancreatic alpha, beta, and delta cells, genetic variants or altered expression of [SCG5](/details-gene/6447) may impair the coordinated processing of pro-glucagon, pro-insulin, and pro-somatostatin, contributing to the pathophysiology of type 2 diabetes by disrupting islet cell function and hormonal crosstalk. 2. The expression of [SCG5](/details-gene/6447) in neuroendocrine cell types suggests it could serve as a specific biomarker for neuroendocrine tumors (NETs). Furthermore, dysregulation of [SCG5](/details-gene/6447) in these tumors may alter neuropeptide production, contributing to the clinical symptoms of carcinoid syndrome. **Experimental Approach:** To test the hypothesis linking [SCG5](/details-gene/6447) to pancreatic islet dysfunction, a targeted approach could be employed. A conditional knockout of [SCG5](/details-gene/6447) in mouse pancreatic islet cells (e.g., using a Pdx1-Cre driver) would allow for a detailed investigation of its role *in vivo*. These mice could be subjected to metabolic stressors like a high-fat diet, followed by analysis of glucose tolerance, insulin sensitivity, and direct measurement of circulating processed and unprocessed hormones (e.g., insulin, C-peptide, glucagon). Single-cell RNA-sequencing of the islets from knockout and control animals would further reveal compensatory changes and cellular stress responses resulting from the loss of [SCG5](/details-gene/6447). **Therapeutic Potential:** As an intracellular chaperone, [SCG5](/details-gene/6447) is not an easily "druggable" target for conventional small molecule inhibitors. Its essential role in normal endocrine function suggests that systemic inhibition would likely lead to significant adverse effects. However, its high specificity for neuroendocrine cells could make it a potential target for diagnostic imaging or a payload target for therapies directed at neuroendocrine tumors. In disease states characterized by insufficient hormone processing, strategies to enhance [SCG5](/details-gene/6447) expression or function could be a potential therapeutic avenue, though this would require sophisticated gene or protein-based delivery systems.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Neuroendocrine protein 7B2

Genular Protein ID: 3736493662

Symbol: 7B2_HUMAN

Name: Neuroendocrine protein 7B2

UniProtKB Accession Codes:

P05408 P01164 Q6FHD0 Q9BS38

Database IDs:

Citations:

PubMed ID: 3134253

Title: Cloning and sequence analysis of human pituitary cDNA encoding the novel polypeptide 7B2.

PubMed ID: 3134253

DOI: 10.1016/0014-5793(88)81324-3

PubMed ID: 1989596

Title: The production by alternate splicing of two mRNAs differing by one codon could be an intrinsic property of neuroendocrine protein 7B2 gene expression in man.

PubMed ID: 1989596

DOI: 10.1016/0006-291x(91)90499-w

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8617287

Title: Structural organization of the gene encoding the neuroendocrine chaperone 7B2.

PubMed ID: 8617287

DOI: 10.1111/j.1432-1033.1996.00060.x

PubMed ID: 6625600

Title: Isolation and NH2-terminal sequence of a highly conserved human and porcine pituitary protein belonging to a new superfamily. Immunocytochemical localization in pars distalis and pars nervosa of the pituitary and in the supraoptic nucleus of the hypothalamus.

PubMed ID: 6625600

DOI: 10.1016/0003-9861(83)90063-2

PubMed ID: 7913882

Title: 7B2 is a neuroendocrine chaperone that transiently interacts with prohormone convertase PC2 in the secretory pathway.

PubMed ID: 7913882

DOI: 10.1016/0092-8674(94)90296-8

PubMed ID: 11439082

Title: Neuroendocrine secretory protein 7B2: structure, expression and functions.

PubMed ID: 11439082

DOI: 10.1042/0264-6021:3570329

Sequence Information:

Length: 212
Mass: 23730
Checksum: A459702055C0FE84
Sequence:

MVSRMVSTML SGLLFWLASG WTPAFAYSPR TPDRVSEADI QRLLHGVMEQ LGIARPRVEY 
PAHQAMNLVG PQSIEGGAHE GLQHLGPFGN IPNIVAELTG DNIPKDFSED QGYPDPPNPC 
PVGKTADDGC LENTPDTAEF SREFQLHQHL FDPEHDYPGL GKWNKKLLYE KMKGGERRKR 
RSVNPYLQGQ RLDNVVAKKS VPHFSDEDKD PE

Details for: SCG5

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Cloning and sequence analysis of human pituitary cDNA encoding the novel polypeptide 7B2. PubMed ID: 3134253

The production by alternate splicing of two mRNAs differing by one codon could be an intrinsic property of neuroendocrine protein 7B2 gene expression in man. PubMed ID: 1989596

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Structural organization of the gene encoding the neuroendocrine chaperone 7B2. PubMed ID: 8617287

Isolation and NH2-terminal sequence of a highly conserved human and porcine pituitary protein belonging to a new superfamily. Immunocytochemical localization in pars distalis and pars nervosa of the pituitary and in the supraoptic nucleus of the hypothalamus. PubMed ID: 6625600

7B2 is a neuroendocrine chaperone that transiently interacts with prohormone convertase PC2 in the secretory pathway. PubMed ID: 7913882