Details for: SCG5

Gene ID: 6447

Symbol: SCG5

Ensembl ID: ENSG00000166922

Description: secretogranin V

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 264.6176
    Cell Significance Index: -41.1600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 162.3934
    Cell Significance Index: -41.1900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 87.1956
    Cell Significance Index: -35.9200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 33.7578
    Cell Significance Index: -32.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 33.4156
    Cell Significance Index: -41.2000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 5.1791
    Cell Significance Index: 271.9300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 4.7834
    Cell Significance Index: 1376.3200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.8476
    Cell Significance Index: 35.3200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.0741
    Cell Significance Index: 72.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0301
    Cell Significance Index: 407.2400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.2956
    Cell Significance Index: 464.7200
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 1.2105
    Cell Significance Index: 12.6100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.9941
    Cell Significance Index: 26.1400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9787
    Cell Significance Index: 883.7100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.9213
    Cell Significance Index: 40.7500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.8627
    Cell Significance Index: 32.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.7197
    Cell Significance Index: 122.8900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6670
    Cell Significance Index: 65.9800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6120
    Cell Significance Index: 116.4700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5400
    Cell Significance Index: 87.8300
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.5222
    Cell Significance Index: 4.3100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4335
    Cell Significance Index: 47.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3559
    Cell Significance Index: 48.8700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3215
    Cell Significance Index: 7.0400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.2684
    Cell Significance Index: 39.0200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.2538
    Cell Significance Index: 5.4300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2270
    Cell Significance Index: 3.8900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2175
    Cell Significance Index: 43.1700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1828
    Cell Significance Index: 20.8700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1808
    Cell Significance Index: 114.8100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1363
    Cell Significance Index: 8.1800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1198
    Cell Significance Index: 65.4300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0970
    Cell Significance Index: 6.7100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0737
    Cell Significance Index: 32.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0592
    Cell Significance Index: 111.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.0221
    Cell Significance Index: 4.6600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0075
    Cell Significance Index: 5.5300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0009
    Cell Significance Index: 0.0300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0023
    Cell Significance Index: -0.1200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0052
    Cell Significance Index: -0.1500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0175
    Cell Significance Index: -10.9200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0194
    Cell Significance Index: -29.8900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0195
    Cell Significance Index: -36.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0196
    Cell Significance Index: -11.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0207
    Cell Significance Index: -0.9400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0273
    Cell Significance Index: -37.1600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0372
    Cell Significance Index: -1.5300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0479
    Cell Significance Index: -35.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0527
    Cell Significance Index: -39.8900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0563
    Cell Significance Index: -1.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0732
    Cell Significance Index: -33.2300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1210
    Cell Significance Index: -1.5500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1343
    Cell Significance Index: -3.3500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1548
    Cell Significance Index: -27.9000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1594
    Cell Significance Index: -5.2200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1603
    Cell Significance Index: -3.1700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1604
    Cell Significance Index: -18.3800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1894
    Cell Significance Index: -22.0700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1934
    Cell Significance Index: -11.8600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2069
    Cell Significance Index: -11.6100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2229
    Cell Significance Index: -4.7300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2283
    Cell Significance Index: -3.8200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2362
    Cell Significance Index: -7.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2369
    Cell Significance Index: -29.1300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2424
    Cell Significance Index: -31.0800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2465
    Cell Significance Index: -7.8500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2511
    Cell Significance Index: -25.6500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2715
    Cell Significance Index: -5.4500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2749
    Cell Significance Index: -35.5100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3262
    Cell Significance Index: -38.4700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3405
    Cell Significance Index: -35.4600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3570
    Cell Significance Index: -7.4500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3918
    Cell Significance Index: -27.7100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.4431
    Cell Significance Index: -4.2000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4536
    Cell Significance Index: -9.8000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4779
    Cell Significance Index: -35.6200
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.4780
    Cell Significance Index: -3.1100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4941
    Cell Significance Index: -10.2500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5052
    Cell Significance Index: -38.7700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5070
    Cell Significance Index: -14.1700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5172
    Cell Significance Index: -18.1200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5500
    Cell Significance Index: -13.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5653
    Cell Significance Index: -36.4700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.5837
    Cell Significance Index: -9.0300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6156
    Cell Significance Index: -38.8000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6160
    Cell Significance Index: -32.0900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.6172
    Cell Significance Index: -12.9200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.6223
    Cell Significance Index: -7.7600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.6376
    Cell Significance Index: -8.5100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6555
    Cell Significance Index: -13.9600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6715
    Cell Significance Index: -31.5600
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -0.6785
    Cell Significance Index: -3.3000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.6971
    Cell Significance Index: -7.6000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7047
    Cell Significance Index: -20.2000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.7794
    Cell Significance Index: -15.3400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.7998
    Cell Significance Index: -10.1000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.8395
    Cell Significance Index: -43.6100
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.8476
    Cell Significance Index: -8.0700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.8760
    Cell Significance Index: -10.2200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.8996
    Cell Significance Index: -21.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Secretory granule localization**: SCG5 is primarily localized to the secretory granules of enteroendocrine cells, neurons, and other endocrine cells, where it plays a crucial role in regulating hormone secretion. 2. **Neuroendocrine protein**: SCG5 is a member of the secretogranin family, which consists of proteins that regulate the processing and secretion of neuroendocrine hormones. 3. **Enzyme inhibitor activity**: SCG5 has been shown to inhibit the activity of certain enzymes involved in hormone processing and secretion. 4. **GTP binding**: SCG5 contains a GTP-binding domain, which is essential for its function in regulating hormone secretion and cell signaling pathways. 5. **Protein binding**: SCG5 interacts with various proteins, including other secretogranins, to regulate hormone secretion and signal transduction. **Pathways and Functions:** 1. **Neuroendocrine signaling pathway**: SCG5 regulates the secretion of neuroendocrine hormones, such as gastrin and insulin, by interacting with other proteins in the secretory granule complex. 2. **Enzyme regulation**: SCG5 inhibits the activity of certain enzymes involved in hormone processing and secretion, such as carboxypeptidase E and prorenin convertase. 3. **GTP-mediated signaling**: SCG5 uses GTP binding to regulate cell signaling pathways, including the MAPK/ERK pathway and the PI3K/AKT pathway. 4. **Protein transport**: SCG5 regulates the transport of proteins within the secretory granule complex, ensuring proper hormone secretion and cell signaling. 5. **Hormone processing**: SCG5 interacts with other proteins to regulate the processing and secretion of neuroendocrine hormones. **Clinical Significance:** 1. **Diabetes**: Dysregulation of SCG5 has been implicated in the development of diabetes, as it affects the secretion of insulin and other hormones involved in glucose regulation. 2. **Gastric cancer**: SCG5 has been shown to be overexpressed in gastric cancer, suggesting its potential role as a diagnostic marker or therapeutic target. 3. **Neurological disorders**: SCG5 has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy, where it regulates neurotransmitter release and cell signaling. 4. **Endocrine disorders**: SCG5 regulates the secretion of hormones involved in endocrine disorders, such as thyroid disorders and adrenal insufficiency. In conclusion, SCG5 is a critical neuroendocrine protein involved in regulating hormone secretion, cell signaling, and protein transport. Its dysregulation has been implicated in various diseases, including diabetes, gastric cancer, and neurological disorders. Further research is necessary to fully understand the mechanisms of SCG5 and its role in human disease.

Genular Protein ID: 3736493662

Symbol: 7B2_HUMAN

Name: Neuroendocrine protein 7B2

UniProtKB Accession Codes:

P05408 P01164 Q6FHD0 Q9BS38

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 5 ExpressionAtlas 1 GO 11 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3134253

Title: Cloning and sequence analysis of human pituitary cDNA encoding the novel polypeptide 7B2.

PubMed ID: 3134253

DOI: 10.1016/0014-5793(88)81324-3

PubMed ID: 1989596

Title: The production by alternate splicing of two mRNAs differing by one codon could be an intrinsic property of neuroendocrine protein 7B2 gene expression in man.

PubMed ID: 1989596

DOI: 10.1016/0006-291x(91)90499-w

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8617287

Title: Structural organization of the gene encoding the neuroendocrine chaperone 7B2.

PubMed ID: 8617287

DOI: 10.1111/j.1432-1033.1996.00060.x

PubMed ID: 6625600

Title: Isolation and NH2-terminal sequence of a highly conserved human and porcine pituitary protein belonging to a new superfamily. Immunocytochemical localization in pars distalis and pars nervosa of the pituitary and in the supraoptic nucleus of the hypothalamus.

PubMed ID: 6625600

DOI: 10.1016/0003-9861(83)90063-2

PubMed ID: 7913882

Title: 7B2 is a neuroendocrine chaperone that transiently interacts with prohormone convertase PC2 in the secretory pathway.

PubMed ID: 7913882

DOI: 10.1016/0092-8674(94)90296-8

PubMed ID: 11439082

Title: Neuroendocrine secretory protein 7B2: structure, expression and functions.

PubMed ID: 11439082

DOI: 10.1042/0264-6021:3570329

Sequence Information:

  • Length: 212
  • Mass: 23730
  • Checksum: A459702055C0FE84
  • Sequence:
    • MVSRMVSTML SGLLFWLASG WTPAFAYSPR TPDRVSEADI QRLLHGVMEQ LGIARPRVEY 
PAHQAMNLVG PQSIEGGAHE GLQHLGPFGN IPNIVAELTG DNIPKDFSED QGYPDPPNPC 
PVGKTADDGC LENTPDTAEF SREFQLHQHL FDPEHDYPGL GKWNKKLLYE KMKGGERRKR 
RSVNPYLQGQ RLDNVVAKKS VPHFSDEDKD PE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.