Details for: ITSN1

Gene ID: 6453

Symbol: ITSN1

Ensembl ID: ENSG00000205726

Description: intersectin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 436.0468
    Cell Significance Index: -67.8300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 285.8738
    Cell Significance Index: -72.5100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 157.6709
    Cell Significance Index: -74.4400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 149.9543
    Cell Significance Index: -60.9200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 63.8182
    Cell Significance Index: -60.9300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 55.7157
    Cell Significance Index: -68.7000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 26.3582
    Cell Significance Index: -70.6100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 18.2993
    Cell Significance Index: -72.2100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 5.2879
    Cell Significance Index: 63.0400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 4.2974
    Cell Significance Index: 72.3900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 3.5260
    Cell Significance Index: 44.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.7280
    Cell Significance Index: 978.5000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 2.5006
    Cell Significance Index: 59.9700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.4250
    Cell Significance Index: 149.0600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.4015
    Cell Significance Index: 46.8700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.3543
    Cell Significance Index: 472.2700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.0150
    Cell Significance Index: 113.0700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.6105
    Cell Significance Index: 123.5900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.5795
    Cell Significance Index: 1092.4600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5233
    Cell Significance Index: 302.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.3733
    Cell Significance Index: 38.3800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.2771
    Cell Significance Index: 56.4900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.1876
    Cell Significance Index: 74.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.1366
    Cell Significance Index: 43.0400
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.8247
    Cell Significance Index: 3.5900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.7742
    Cell Significance Index: 52.0600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7230
    Cell Significance Index: 652.8300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.6853
    Cell Significance Index: 931.8000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5525
    Cell Significance Index: 75.8700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5493
    Cell Significance Index: 28.8400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4669
    Cell Significance Index: 11.6700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3958
    Cell Significance Index: 11.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3662
    Cell Significance Index: 563.8100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3338
    Cell Significance Index: 5.7200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3249
    Cell Significance Index: 611.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3095
    Cell Significance Index: 50.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2139
    Cell Significance Index: 135.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2036
    Cell Significance Index: 375.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1953
    Cell Significance Index: 35.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1684
    Cell Significance Index: 20.7100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1565
    Cell Significance Index: 71.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0903
    Cell Significance Index: 49.3100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0635
    Cell Significance Index: 2.8800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0098
    Cell Significance Index: 4.3400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0030
    Cell Significance Index: -0.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0048
    Cell Significance Index: -0.9100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0070
    Cell Significance Index: -0.6900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0133
    Cell Significance Index: -0.3800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0221
    Cell Significance Index: -0.1800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0461
    Cell Significance Index: -5.9100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0580
    Cell Significance Index: -36.2400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0647
    Cell Significance Index: -47.4600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0664
    Cell Significance Index: -49.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0733
    Cell Significance Index: -41.3300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0985
    Cell Significance Index: -74.5400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2102
    Cell Significance Index: -12.6200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2117
    Cell Significance Index: -3.1300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2210
    Cell Significance Index: -63.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2465
    Cell Significance Index: -8.6600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2467
    Cell Significance Index: -35.8600
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.2610
    Cell Significance Index: -3.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2792
    Cell Significance Index: -28.5200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2964
    Cell Significance Index: -50.6200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3030
    Cell Significance Index: -63.8300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3830
    Cell Significance Index: -44.6300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4069
    Cell Significance Index: -8.9100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4528
    Cell Significance Index: -47.1500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.4623
    Cell Significance Index: -59.7300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4898
    Cell Significance Index: -55.9100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5246
    Cell Significance Index: -60.1000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5550
    Cell Significance Index: -28.8300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.6008
    Cell Significance Index: -70.8500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.6739
    Cell Significance Index: -31.4200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.6815
    Cell Significance Index: -48.2000
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.7000
    Cell Significance Index: -10.6500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.7139
    Cell Significance Index: -10.5400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.7330
    Cell Significance Index: -9.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.7750
    Cell Significance Index: -57.7600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8062
    Cell Significance Index: -49.4300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.8062
    Cell Significance Index: -17.1100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8115
    Cell Significance Index: -64.2700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.8595
    Cell Significance Index: -40.4000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.9083
    Cell Significance Index: -17.9600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.9235
    Cell Significance Index: -59.5800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.9502
    Cell Significance Index: -19.7100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.9622
    Cell Significance Index: -13.7800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.9623
    Cell Significance Index: -50.1300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.9785
    Cell Significance Index: -12.3500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.0007
    Cell Significance Index: -21.6800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.0059
    Cell Significance Index: -16.8400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.0622
    Cell Significance Index: -33.8300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.1100
    Cell Significance Index: -36.3400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.1150
    Cell Significance Index: -38.7500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.1238
    Cell Significance Index: -19.4300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.1326
    Cell Significance Index: -24.2100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -1.1407
    Cell Significance Index: -16.3800
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -1.2710
    Cell Significance Index: -13.2400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.3382
    Cell Significance Index: -42.8600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.3887
    Cell Significance Index: -27.8800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.4282
    Cell Significance Index: -38.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Adaptor Function:** ITS N1 acts as a molecular adaptor, bridging signaling molecules and cytoskeletal components to regulate various cellular processes. 2. **Cargo Recognition:** ITS N1 recognizes and binds to specific cargo proteins, facilitating clathrin-mediated endocytosis and regulating membrane trafficking. 3. **Calcium Ion Binding:** ITS N1 interacts with calcium ions, modulating signaling pathways involved in cell death and development. 4. **Signaling Pathways:** ITS N1 is involved in multiple signaling pathways, including those regulated by G-proteins, Rho GTPases, and Death Receptor Signaling. **Pathways and Functions:** 1. **Axon Guidance:** ITS N1 regulates axon guidance by interacting with cytoskeletal components and signaling molecules, influencing the formation and maintenance of neuronal connections. 2. **Clathrin-Mediated Endocytosis:** ITS N1 recognizes and binds to specific cargo proteins, facilitating clathrin-mediated endocytosis and regulating membrane trafficking. 3. **Cell Death Signaling:** ITS N1 modulates signaling pathways involved in cell death, including those regulated by Death Receptor Signaling and the JNK pathway. 4. **Developmental Biology:** ITS N1 is involved in the regulation of developmental processes, including nervous system development and cell fate determination. 5. **Intracellular Transport:** ITS N1 regulates intracellular transport by interacting with motor proteins and cargo proteins, influencing the movement of vesicles and organelles. **Clinical Significance:** Dysregulation of ITS N1 has been implicated in several diseases, including: 1. **Neurological Disorders:** ITS N1 has been linked to neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Cancer:** ITS N1 has been implicated in the regulation of cancer cell growth, migration, and invasion. 3. **Metabolic Disorders:** ITS N1 has been linked to metabolic disorders, including obesity and insulin resistance. In summary, ITS N1 is a multifunctional adaptor protein that plays a crucial role in various cellular processes, including axon guidance, clathrin-mediated endocytosis, and signaling pathways involved in cell death and development. Its dysregulation has been implicated in several diseases, highlighting the importance of ITS N1 in maintaining cellular homeostasis. Further research is needed to fully elucidate the role of ITS N1 in human disease and to develop therapeutic strategies targeting this protein.

Genular Protein ID: 4150454920

Symbol: ITSN1_HUMAN

Name: SH3P17

UniProtKB Accession Codes:

Q15811 A7Y322 A8CTX8 A8CTY3 A8CTY7 A8D7D0 A8DCP3 B4DTM2 E7ERJ1 E9PE44 E9PG01 E9PHV2 O95216 Q0PW94 Q0PW95 Q0PW97 Q14BD3 Q1ED40 Q20BK3 Q9UET5 Q9UK60 Q9UNK1 Q9UNK2 Q9UQ92

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CDD 9 CTD 1 ChEBI 14 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 29 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 15 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 11 PRINTS 2 PRO 1 PROSITE 8 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 8 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 10 Pumba 1 RNAct 1 Reactome 8 RefSeq 12 SIGNOR 1 SMART 6 SMR 1 STRING 1 SUPFAM 5 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9799604

Title: Two isoforms of a human intersectin (ITSN) protein are produced by brain-specific alternative splicing in a stop codon.

PubMed ID: 9799604

DOI: 10.1006/geno.1998.5521

PubMed ID: 10482960

Title: Alu-splice cloning of human intersectin (ITSN), a putative multivalent binding protein expressed in proliferating and differentiating neurons and overexpressed in Down syndrome.

PubMed ID: 10482960

DOI: 10.1038/sj.ejhg.5200356

PubMed ID: 19777371

Title: Structural diversity and differential expression of novel human intersectin 1 isoforms.

PubMed ID: 19777371

DOI: 10.1007/s11033-009-9824-8

PubMed ID: 21712076

Title: Identification and characterization of a novel mammalian isoform of the endocytic adaptor ITSN1.

PubMed ID: 21712076

DOI: 10.1016/j.gene.2011.06.021

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9630982

Title: Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins.

PubMed ID: 9630982

DOI: 10.1038/nbt0696-741

PubMed ID: 11690630

Title: The human intersectin genes and their spliced variants are differentially expressed.

PubMed ID: 11690630

DOI: 10.1016/s0167-4781(01)00276-7

PubMed ID: 9465890

Title: The SH3D1A gene maps to human chromosome 21q22.1-->q22.2.

PubMed ID: 9465890

DOI: 10.1159/000134659

PubMed ID: 11584276

Title: Endocytic protein intersectin-l regulates actin assembly via Cdc42 and N-WASP.

PubMed ID: 11584276

DOI: 10.1038/ncb1001-927

PubMed ID: 11744688

Title: The activity of the GTPase-activating protein CdGAP is regulated by the endocytic protein intersectin.

PubMed ID: 11744688

DOI: 10.1074/jbc.m105516200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19718658

Title: Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins.

PubMed ID: 19718658

DOI: 10.1002/jcb.22317

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20946875

Title: Intersectin 1 forms complexes with SGIP1 and Reps1 in clathrin-coated pits.

PubMed ID: 20946875

DOI: 10.1016/j.bbrc.2010.10.045

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 20448150

Title: FCHo proteins are nucleators of clathrin-mediated endocytosis.

PubMed ID: 20448150

DOI: 10.1126/science.1188462

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22648170

Title: The clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin beta1 endocytosis.

PubMed ID: 22648170

DOI: 10.1091/mbc.e11-12-1007

PubMed ID: 22484487

Title: Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning.

PubMed ID: 22484487

DOI: 10.1038/ncb2473

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27670116

Title: NPF motifs in the vaccinia virus protein A36 recruit intersectin-1 to promote Cdc42:N-WASP-mediated viral release from infected cells.

PubMed ID: 27670116

DOI: 10.1038/nmicrobiol.2016.141

PubMed ID: 29030480

Title: Intersectin-s interaction with DENND2B facilitates recycling of epidermal growth factor receptor.

PubMed ID: 29030480

DOI: 10.15252/embr.201744034

PubMed ID: 29599122

Title: Intersectin goes nuclear: secret life of an endocytic protein.

PubMed ID: 29599122

DOI: 10.1042/bcj20170897

PubMed ID: 32315611

Title: A DNM2 Centronuclear Myopathy Mutation Reveals a Link between Recycling Endosome Scission and Autophagy.

PubMed ID: 32315611

DOI: 10.1016/j.devcel.2020.03.018

PubMed ID: 12006984

Title: Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.

PubMed ID: 12006984

DOI: 10.1038/nsb796

PubMed ID: 29887380

Title: A Flat BAR Protein Promotes Actin Polymerization at the Base of Clathrin-Coated Pits.

PubMed ID: 29887380

DOI: 10.1016/j.cell.2018.05.020

Sequence Information:

  • Length: 1721
  • Mass: 195422
  • Checksum: FC4DE644D8BEA2BE
  • Sequence:
    • MAQFPTPFGG SLDIWAITVE ERAKHDQQFH SLKPISGFIT GDQARNFFFQ SGLPQPVLAQ 
IWALADMNND GRMDQVEFSI AMKLIKLKLQ GYQLPSALPP VMKQQPVAIS SAPAFGMGGI 
ASMPPLTAVA PVPMGSIPVV GMSPTLVSSV PTAAVPPLAN GAPPVIQPLP AFAHPAATLP 
KSSSFSRSGP GSQLNTKLQK AQSFDVASVP PVAEWAVPQS SRLKYRQLFN SHDKTMSGHL 
TGPQARTILM QSSLPQAQLA SIWNLSDIDQ DGKLTAEEFI LAMHLIDVAM SGQPLPPVLP 
PEYIPPSFRR VRSGSGISVI SSTSVDQRLP EEPVLEDEQQ QLEKKLPVTF EDKKRENFER 
GNLELEKRRQ ALLEQQRKEQ ERLAQLERAE QERKERERQE QERKRQLELE KQLEKQRELE 
RQREEERRKE IERREAAKRE LERQRQLEWE RNRRQELLNQ RNKEQEDIVV LKAKKKTLEF 
ELEALNDKKH QLEGKLQDIR CRLTTQRQEI ESTNKSRELR IAEITHLQQQ LQESQQMLGR 
LIPEKQILND QLKQVQQNSL HRDSLVTLKR ALEAKELARQ HLRDQLDEVE KETRSKLQEI 
DIFNNQLKEL REIHNKQQLQ KQKSMEAERL KQKEQERKII ELEKQKEEAQ RRAQERDKQW 
LEHVQQEDEH QRPRKLHEEE KLKREESVKK KDGEEKGKQE AQDKLGRLFH QHQEPAKPAV 
QAPWSTAEKG PLTISAQENV KVVYYRALYP FESRSHDEIT IQPGDIVMVK GEWVDESQTG 
EPGWLGGELK GKTGWFPANY AEKIPENEVP APVKPVTDST SAPAPKLALR ETPAPLAVTS 
SEPSTTPNNW ADFSSTWPTS TNEKPETDNW DAWAAQPSLT VPSAGQLRQR SAFTPATATG 
SSPSPVLGQG EKVEGLQAQA LYPWRAKKDN HLNFNKNDVI TVLEQQDMWW FGEVQGQKGW 
FPKSYVKLIS GPIRKSTSMD SGSSESPASL KRVASPAAKP VVSGEEFIAM YTYESSEQGD 
LTFQQGDVIL VTKKDGDWWT GTVGDKAGVF PSNYVRLKDS EGSGTAGKTG SLGKKPEIAQ 
VIASYTATGP EQLTLAPGQL ILIRKKNPGG WWEGELQARG KKRQIGWFPA NYVKLLSPGT 
SKITPTEPPK STALAAVCQV IGMYDYTAQN DDELAFNKGQ IINVLNKEDP DWWKGEVNGQ 
VGLFPSNYVK LTTDMDPSQQ WCSDLHLLDM LTPTERKRQG YIHELIVTEE NYVNDLQLVT 
EIFQKPLMES ELLTEKEVAM IFVNWKELIM CNIKLLKALR VRKKMSGEKM PVKMIGDILS 
AQLPHMQPYI RFCSRQLNGA ALIQQKTDEA PDFKEFVKRL AMDPRCKGMP LSSFILKPMQ 
RVTRYPLIIK NILENTPENH PDHSHLKHAL EKAEELCSQV NEGVREKENS DRLEWIQAHV 
QCEGLSEQLV FNSVTNCLGP RKFLHSGKLY KAKSNKELYG FLFNDFLLLT QITKPLGSSG 
TDKVFSPKSN LQYKMYKTPI FLNEVLVKLP TDPSGDEPIF HISHIDRVYT LRAESINERT 
AWVQKIKAAS ELYIETEKKK REKAYLVRSQ RATGIGRLMV NVVEGIELKP CRSHGKSNPY 
CEVTMGSQCH ITKTIQDTLN PKWNSNCQFF IRDLEQEVLC ITVFERDQFS PDDFLGRTEI 
RVADIKKDQG SKGPVTKCLL LHEVPTGEIV VRLDLQLFDE P

Genular Protein ID: 3134968291

Symbol: Q6PD56_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6PD56

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 5 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 2 SAM 2 SMART 2 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 634
  • Mass: 72700
  • Checksum: B2EF2F26D316710A
  • Sequence:
    • MAQFPTPFGG SLDIWAITVE ERAKHDQQFH SLKPISGFIT GDQARNFFFQ SGLPQPVLAQ 
IWALADMNND GRMDQVEFSI AMKLIKLKLQ GYQLPSALPP VMKQQPVAIS SAPAFGMGGI 
ASMPPLTAVA PVPMGSIPVV GMSPTLVSSV PTAAVPPLAN GAPPVIQPLP AFAHPAATLP 
KSSSFSRSGP GSQLNTKLQK AQSFDVASVP PVAEWAVPQS SRLKYRQLFN SHDKTMSGHL 
TGPQARTILM QSSLPQAQLA SIWNLSDIDQ DGKLTAEEFI LAMHLIDVAM SGQPLPPVLP 
PEYIPPSFRR VRSGSGISVI SSTSVDQRLP EEPVLEDEQQ QLEKKLPVTF EDKKRENFER 
GNLELEKRRQ ALLEQQRKEQ ERLAQLERAE QERKERERQE QERKRQLELE KQLEKQRELE 
RQREEERRKE IERREAAKRE LERQRQLEWE RNRRQELLNQ RNKEQEDIVV LKAKKKTLEF 
ELEALNDKKH QLEGKLQDIR CRLTTQRQEI ESTNKSRELR IAEITHLQQQ LQESQQMLGR 
LIPEKQILND QLKQVQQNSL HRDSLVTLKR ALEAKELARQ HLRDQLDEVE KETRSKLQEI 
DIFNNQLKEL REIHNKQQLQ KQKSMEAERL KKKK

Genular Protein ID: 2792080890

Symbol: F8W7U0_HUMAN

Name: N/A

UniProtKB Accession Codes:

F8W7U0

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 2 GeneTree 1 HGNC 1 InterPro 7 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 7 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 5 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 2 SMART 3 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 1149
  • Mass: 130015
  • Checksum: AE3F610AED36186D
  • Sequence:
    • MAQFPTPFGG SLDIWAITVE ERAKHDQQFH SLKPISGFIT GDQARNFFFQ SGLPQPVLAQ 
IWALADMNND GRMDQVEFSI AMKLIKLKLQ GYQLPSALPP VMKQQPVAIS SAPAFGMGGI 
ASMPPLTAVA PVPMGSIPVV GMSPTLVSSV PTAAVPPLAN GAPPVIQPLP AFAHPAATLP 
KSSSFSRSGP GSQLNTKLQK AQSFDVASVP PVAEWAVPQS SRLKYRQLFN SHDKTMSGHL 
TGPQARTILM QSSLPQAQLA SIWNLSDIDQ DGKLTAEEFI LAMHLIDVAM SGQPLPPVLP 
PEYIPPSFRR VRSGSGISVI SSTSVDQRLP EEPVLEDEQQ QLEKKLPVTF EDKKRENFER 
GNLELEKRRQ ALLEQQRKEQ ERLAQLERAE QERKERERQE QERKRQLELE KQLEKQRELE 
RQREEERRKE IERREAAKRE LERQRQLEWE RNRRQELLNQ RNKEQEDIVV LKAKKKTLEF 
ELEALNDKKH QLEGKLQDIR CRLTTQRQEI ESTNKSRELR IAEITHLQQQ LQESQQMLGR 
LIPEKQILND QLKQVQQNSL HRDSLVTLKR ALEAKELARQ HLRDQLDEVE KETRSKLQEI 
DIFNNQLKEL REIHNKQQLQ KQKSMEAERL KQKEQERKII ELEKQKEEAQ RRAQERDKQW 
LEHVQQEDEH QRPRKLHEEE KLKREESVKK KDGEEKGKQE AQDKLGRLFH QHQEPAKPAV 
QAPWSTAEKG PLTISAQENV KVVYYRALYP FESRSHDEIT IQPGDIVMVK GEWVDESQTG 
EPGWLGGELK GKTGWFPANY AEKIPENEVP APVKPVTDST SAPAPKLALR ETPAPLAVTS 
SEPSTTPNNW ADFSSTWPTS TNEKPETDNW DAWAAQPSLT VPSAGQLRQR SAFTPATATG 
SSPSPVLGQG EKVEGLQAQA LYPWRAKKDN HLNFNKNDVI TVLEQQDMWW FGEVQGQKGW 
FPKSYVKLIS GPIRKSTSMD SGSSESPASL KRVASPAAKP VVSGEEIAQV IASYTATGPE 
QLTLAPGQLI LIRKKNPGGW WEGELQARGK KRQIGWFPAN YVKLLSPGTS KITPTEPPKS 
TALAAVCQVI GMYDYTAQND DELAFNKGQI INVLNKEDPD WWKGEVNGQV GLFPSNYVKL 
TTDMDPSQQ

Genular Protein ID: 1837609489

Symbol: A7XZY7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A7XZY7

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 2 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 7 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 5 RefSeq 1 SAM 2 SMART 3 SUPFAM 2

Citations:

PubMed ID: 19777371

Title: Structural diversity and differential expression of novel human intersectin 1 isoforms.

PubMed ID: 19777371

DOI: 10.1007/s11033-009-9824-8

Sequence Information:

  • Length: 1183
  • Mass: 134159
  • Checksum: 8A762140D073A09C
  • Sequence:
    • MAQFPTPFGG SLDIWAITVE ERAKHDQQFH SLKPISGFIT GDQARNFFFQ SGLPQPVLAQ 
IWALADMNND GRMDQVEFSI AMKLIKLKLQ GYQLPSALPP VMKQQPVAIS SAPAFAAVPP 
LANGAPPVIQ PLPAFAHPAA TLPKSSSFSR SGPGSQLNTK LQKAQSFDVA SVPPVAEWAV 
PQSSRLKYRQ LFNSHDKTMS GHLTGPQART ILMQSSLPQA QLASIWNLSD IDQDGKLTAE 
EFILAMHLID VAMSGQPLPP VLPPEYIPPS FRRVRSGSGI SVISSTSVDQ RLPEEPVLED 
EQQQLEKKLP VTFEDKKREN FERGNLELEK RRQALLEQQR KEQERLAQLE RAEQERKERE 
RQEQERKRQL ELEKQLEKQR ELERQREEER RKEIERREAA KRELERQRQL EWERNRRQEL 
LNQRNKEQED IVVLKAKKKT LEFELEALND KKHQLEGKLQ DIRCRLTTQR QEIESTNKSR 
ELRIAEITHL QQQLQESQQM LGRLIPEKQI LNDQLKQVQQ NSLHRDSLVT LKRALEAKEL 
ARQHLRDQLD EVEKETRSKL QEIDIFNNQL KELREIHNKQ QLQKQKSMEA ERLKQKEQER 
KIIELEKQKE EAQRRAQERD KQWLEHVQQE DEHQRPRKLH EEEKLKREES VKKKDGEEKG 
KQEAQDKLGR LFHQHQEPAK PAVQAPWSTA EKGPLTISAQ ENVKVVYYRA LYPFESRSHD 
EITIQPGDIV MVKGEWVDES QTGEPGWLGG ELKGKTGWFP ANYAEKIPEN EVPAPVKPVT 
DSTSAPAPKL ALRETPAPLA VTSSEPSTTP NNWADFSSTW PTSTNEKPET DNWDAWAAQP 
SLTVPSAGQL RQRSAFTPAT ATGSSPSPVL GQGEKVEGLQ AQALYPWRAK KDNHLNFNKN 
DVITVLEQQD MWWFGEVQGQ KGWFPKSYVK LISGPIRKST SMDSGSSESP ASLKRVASPA 
AKPVVSGEEF IAMYTYESSE QGDLTFQQGD VILVTKKDGD WWTGTVGDKA GVFPSNYVRL 
KDSEGSGTAG KTGSLGKKPE IAQVIASYTA TGPEQLTLAP GQLILIRKKN PGGWWEGELQ 
ARGKKRQIGW FPANYVKLLS PGTSKITPTE PPKSTALAAV CQVIGMYDYT AQNDDELAFN 
KGQIINVLNK EDPDWWKGEV NGQVGLFPSN YVKLTTDMDP SQQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.