Details for: SKIC2

Gene ID: 6499

Symbol: SKIC2

Ensembl ID: ENSG00000204351

Description: SKI2 subunit of superkiller complex

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 67.8902
    Cell Significance Index: -10.5600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 43.2103
    Cell Significance Index: -10.9600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 27.4949
    Cell Significance Index: -11.1700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 11.7728
    Cell Significance Index: -11.2400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.4245
    Cell Significance Index: -11.6200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.1939
    Cell Significance Index: -11.2400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.0119
    Cell Significance Index: -11.8900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.6632
    Cell Significance Index: -8.1800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.1110
    Cell Significance Index: -4.6200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.4301
    Cell Significance Index: 18.0700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.8639
    Cell Significance Index: 13.8600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7602
    Cell Significance Index: 45.6400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7180
    Cell Significance Index: 116.7800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4865
    Cell Significance Index: 439.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4678
    Cell Significance Index: 24.3000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4320
    Cell Significance Index: 29.8800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4035
    Cell Significance Index: 11.6300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3914
    Cell Significance Index: 8.4800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3603
    Cell Significance Index: 71.5100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3345
    Cell Significance Index: 15.1600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3342
    Cell Significance Index: 33.0600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.2903
    Cell Significance Index: 4.2900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2898
    Cell Significance Index: 8.1000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2267
    Cell Significance Index: 43.1400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2092
    Cell Significance Index: 41.9600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2067
    Cell Significance Index: 24.3800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1666
    Cell Significance Index: 2.5100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.1632
    Cell Significance Index: 2.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1552
    Cell Significance Index: 27.9700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1532
    Cell Significance Index: 83.6400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1473
    Cell Significance Index: 20.2300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1298
    Cell Significance Index: 8.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1265
    Cell Significance Index: 5.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1196
    Cell Significance Index: 7.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1118
    Cell Significance Index: 13.7500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0936
    Cell Significance Index: 2.3400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0756
    Cell Significance Index: 9.6900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0733
    Cell Significance Index: 5.4600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0733
    Cell Significance Index: 2.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0710
    Cell Significance Index: 25.4500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0558
    Cell Significance Index: 24.6500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0503
    Cell Significance Index: 2.6200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0378
    Cell Significance Index: 1.9100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0276
    Cell Significance Index: 19.1100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0219
    Cell Significance Index: 0.7700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0203
    Cell Significance Index: 0.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0119
    Cell Significance Index: 2.0300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0102
    Cell Significance Index: 0.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0081
    Cell Significance Index: 15.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0052
    Cell Significance Index: 9.6400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0051
    Cell Significance Index: 0.6700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0035
    Cell Significance Index: 5.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0010
    Cell Significance Index: -0.1200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0034
    Cell Significance Index: -0.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0042
    Cell Significance Index: -5.7500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0043
    Cell Significance Index: -2.7100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0070
    Cell Significance Index: -5.3300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0097
    Cell Significance Index: -7.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0133
    Cell Significance Index: -6.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0133
    Cell Significance Index: -9.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0138
    Cell Significance Index: -1.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0189
    Cell Significance Index: -10.6600
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: -0.0232
    Cell Significance Index: -0.0300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0237
    Cell Significance Index: -14.8300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0265
    Cell Significance Index: -2.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0425
    Cell Significance Index: -12.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0446
    Cell Significance Index: -6.4800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0449
    Cell Significance Index: -1.1800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0501
    Cell Significance Index: -1.0400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0536
    Cell Significance Index: -3.7900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0686
    Cell Significance Index: -14.4500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0690
    Cell Significance Index: -1.4700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0773
    Cell Significance Index: -0.8000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0887
    Cell Significance Index: -2.8400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0907
    Cell Significance Index: -1.0300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0994
    Cell Significance Index: -2.9200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1042
    Cell Significance Index: -4.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1042
    Cell Significance Index: -10.8500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1130
    Cell Significance Index: -6.3400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1166
    Cell Significance Index: -7.1500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1173
    Cell Significance Index: -6.1600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1223
    Cell Significance Index: -2.5600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1239
    Cell Significance Index: -4.6900
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1417
    Cell Significance Index: -2.0300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1471
    Cell Significance Index: -11.6500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1547
    Cell Significance Index: -5.3800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1667
    Cell Significance Index: -4.7800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1715
    Cell Significance Index: -4.3800
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1719
    Cell Significance Index: -2.3900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1873
    Cell Significance Index: -3.1600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1942
    Cell Significance Index: -5.2000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1967
    Cell Significance Index: -5.0600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2005
    Cell Significance Index: -3.7100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2016
    Cell Significance Index: -2.7500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2075
    Cell Significance Index: -7.2700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2170
    Cell Significance Index: -6.9100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2207
    Cell Significance Index: -5.1000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2231
    Cell Significance Index: -8.1900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2276
    Cell Significance Index: -7.4500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2378
    Cell Significance Index: -2.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **RNA Helicase Activity:** SKI2 is a helicase-like protein that exhibits 3'-5' RNA helicase activity, a crucial step in unwinding RNA molecules and facilitating their degradation or processing. 2. **Protein Binding:** SKI2 interacts with various proteins, including those involved in mRNA decay, protein folding, and ribosome rescue, underscoring its role in regulating protein metabolism. 3. **Expression Patterns:** SKI2 is expressed in germ cells, pulmonary interstitial fibroblasts, absorptive cells, intestinal crypt stem cells, and neoplastic cells, indicating its involvement in various cellular processes and disease states. 4. **Functional Implications:** The SKI2 gene's involvement in RNA helicase activity and protein metabolism suggests its potential role in regulating gene expression, maintaining cellular homeostasis, and preventing disease. **Pathways and Functions:** 1. **3'-5' RNA Helicase Activity:** SKI2 participates in the unwinding of RNA molecules, facilitating their degradation or processing through 3'-5' exonucleolytic and nonsense-mediated decay pathways. 2. **Association with Target Proteins:** SKI2 interacts with various proteins, including those involved in mRNA decay, protein folding, and ribosome rescue, highlighting its role in regulating protein metabolism. 3. **Chaperonin-Mediated Protein Folding:** SKI2's involvement in protein folding suggests its potential role in maintaining protein homeostasis and preventing protein misfolding diseases. 4. **RNA Binding:** SKI2's RNA-binding capabilities enable it to regulate RNA metabolism and interact with other RNA-binding proteins. 5. **Metabolism of Proteins and RNAs:** SKI2's involvement in protein and RNA metabolism underscores its role in maintaining cellular homeostasis and regulating gene expression. **Clinical Significance:** 1. **Disease Association:** SKI2's expression in neoplastic cells and its involvement in RNA helicase activity suggest its potential role in cancer development and progression. 2. **RNA-Related Disorders:** SKI2's involvement in RNA metabolism and its interaction with RNA-binding proteins highlight its potential role in disorders related to RNA dysregulation, such as intellectual disability and neurodegenerative diseases. 3. **Therapeutic Targets:** SKI2's role in regulating RNA metabolism and protein metabolism provides a potential target for therapeutic interventions in diseases associated with RNA dysregulation and protein misfolding. In conclusion, the SKI2 gene plays a critical role in regulating RNA metabolism, protein metabolism, and cellular homeostasis. Its involvement in 3'-5' RNA helicase activity, protein binding, and chaperonin-mediated protein folding pathways underscores its significance in maintaining cellular homeostasis and preventing disease. Further research is necessary to fully elucidate the clinical significance of SKI2 and its potential as a therapeutic target for diseases associated with RNA dysregulation and protein misfolding.

Genular Protein ID: 3182671149

Symbol: SKI2_HUMAN

Name: Helicase-like protein

UniProtKB Accession Codes:

Q15477 O15005 Q12902 Q15476 Q5ST66

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEBI 6 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 6 EMDB 8 Ensembl 6 ExpressionAtlas 1 GO 10 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7759100

Title: Identification and characterization of a human cDNA homologous to yeast SKI2.

PubMed ID: 7759100

DOI: 10.1016/0888-7543(95)80008-a

PubMed ID: 7610041

Title: Human helicase gene SKI2W in the HLA class III region exhibits striking structural similarities to the yeast antiviral gene SKI2 and to the human gene KIAA0052: emergence of a new gene family.

PubMed ID: 7610041

DOI: 10.1093/nar/23.12.2120

PubMed ID: 8812450

Title: Localization of eight additional genes in the human major histocompatibility complex, including the gene encoding the casein kinase II beta subunit (CSNK2B).

PubMed ID: 8812450

DOI: 10.1006/geno.1996.0459

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 16024656

Title: The human PAF complex coordinates transcription with events downstream of RNA synthesis.

PubMed ID: 16024656

DOI: 10.1101/gad.1292105

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28204585

Title: A short splicing isoform of HBS1L links the cytoplasmic exosome and SKI complexes in humans.

PubMed ID: 28204585

DOI: 10.1093/nar/gkw862

PubMed ID: 32006463

Title: Extraction of mRNA from stalled ribosomes by the Ski complex.

PubMed ID: 32006463

DOI: 10.1016/j.molcel.2020.01.011

PubMed ID: 35120588

Title: The human SKI complex regulates channeling of ribosome-bound RNA to the exosome via an intrinsic gatekeeping mechanism.

PubMed ID: 35120588

DOI: 10.1016/j.molcel.2022.01.009

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 22444670

Title: SKIV2L mutations cause syndromic diarrhea, or trichohepatoenteric syndrome.

PubMed ID: 22444670

DOI: 10.1016/j.ajhg.2012.02.009

Sequence Information:

  • Length: 1246
  • Mass: 137755
  • Checksum: 9F00097BA83A4AEC
  • Sequence:
    • MMETERLVLP PPDPLDLPLR AVELGCTGHW ELLNLPGAPE SSLPHGLPPC APDLQQEAEQ 
LFLSSPAWLP LHGVEHSARK WQRKTDPWSL LAVLGAPVPS DLQAQRHPTT GQILGYKEVL 
LENTNLSATT SLSLRRPPGP ASQSLWGNPT QYPFWPGGMD EPTITDLNTR EEAEEEIDFE 
KDLLTIPPGF KKGMDFAPKD CPTPAPGLLS LSCMLEPLDL GGGDEDENEA VGQPGGPRGD 
TVSASPCSAP LARASSLEDL VLKEASTAVS TPEAPEPPSQ EQWAIPVDAT SPVGDFYRLI 
PQPAFQWAFE PDVFQKQAIL HLERHDSVFV AAHTSAGKTV VAEYAIALAQ KHMTRTIYTS 
PIKALSNQKF RDFRNTFGDV GLLTGDVQLH PEASCLIMTT EILRSMLYSG SDVIRDLEWV 
IFDEVHYIND VERGVVWEEV LIMLPDHVSI ILLSATVPNA LEFADWIGRL KRRQIYVIST 
VTRPVPLEHY LFTGNSSKTQ GELFLLLDSR GAFHTKGYYA AVEAKKERMS KHAQTFGAKQ 
PTHQGGPAQD RGVYLSLLAS LRTRAQLPVV VFTFSRGRCD EQASGLTSLD LTTSSEKSEI 
HLFLQRCLAR LRGSDRQLPQ VLHMSELLNR GLGVHHSGIL PILKEIVEML FSRGLVKVLF 
ATETFAMGVN MPARTVVFDS MRKHDGSTFR DLLPGEYVQM AGRAGRRGLD PTGTVILLCK 
GRVPEMADLH RMMMGKPSQL QSQFRLTYTM ILNLLRVDAL RVEDMMKRSF SEFPSRKDSK 
AHEQALAELT KRLGALEEPD MTGQLVDLPE YYSWGEELTE TQHMIQRRIM ESVNGLKSLS 
AGRVVVVKNQ EHHNALGVIL QVSSNSTSRV FTTLVLCDKP LSQDPQDRGP ATAEVPYPDD 
LVGFKLFLPE GPCDHTVVKL QPGDMAAITT KVLRVNGEKI LEDFSKRQQP KFKKDPPLAA 
VTTAVQELLR LAQAHPAGPP TLDPVNDLQL KDMSVVEGGL RARKLEELIQ GAQCVHSPRF 
PAQYLKLRER MQIQKEMERL RFLLSDQSLL LLPEYHQRVE VLRTLGYVDE AGTVKLAGRV 
ACAMSSHELL LTELMFDNAL STLRPEEIAA LLSGLVCQSP GDAGDQLPNT LKQGIERVRA 
VAKRIGEVQV ACGLNQTVEE FVGELNFGLV EVVYEWARGM PFSELAGLSG TPEGLVVRCI 
QRLAEMCRSL RGAARLVGEP VLGAKMETAA TLLRRDIVFA ASLYTQ

Genular Protein ID: 2836868894

Symbol: A0A8V8TLC0_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8V8TLC0

Database IDs:

ARBA 4 CDD 2 CTD 1 EMBL 1 Ensembl 2 GO 5 Gene3D 2 GeneTree 1 HGNC 1 InterPro 9 NCBI Taxonomy 1 PANTHER 2 PIRSF 1 PROSITE 4 PeptideAtlas 2 Pfam 5 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 1033
  • Mass: 114054
  • Checksum: C8534F4AF81D8311
  • Sequence:
    • MMETERLVLP PPDPLDLPLR AVELGCTGHW ELLNLPGAPE SSLPHGLPPC APDLQQEAEQ 
LFLSSPAWLP LHGVEHSARK WQRKTDPWSL LAVLGAPVPS DLQAQRHPTT GQILGYKEVL 
LENTNLSATT SLSLRRPPGP ASQSLWGNPT QYPFWPGGMD EPTITDLNTR EEAEEEIDFE 
KDLLTIPPGF KKGMDFAPKD CPTPAPGLLS LSCMLEPLDL GGGDEDENEA VGQPGGPRGD 
TVSASPCSAP LARASSLEDL VLKEASTAVS TPEAPEPPSQ EQWAIPVDAT SPVGDFYRLI 
PQPAFQWAFE PDVFQKQAIL HLERHDSVFV AAHTSAGKTV VAEYAIALAQ KHMTRTIYTS 
PIKALSNQKF RDFRNTFGDV GLLTGDVQLH PEASCLIMTT EILRSMLYSG SDVIRDLEWV 
IFDEVHYIND VERGVVWEEV LIMLPDHVSI ILLSATVPNA LEFADWIGRL KRRQIYVIST 
VTRPVPLEHY LFTGNSSKTQ GELFLLLDSR GAFHTKGYYA AVEAKKERMS KHAQTFGAKQ 
PTHQGGPAQD RGVYLSLLAS LRTRAQLPVV VFTFSRGRCD EQASGLTSLD LTTSSEKSEI 
HLFLQRCLAR LRGSDRQLPQ VLHMSELLNR GLGVHHSGIL PILKEIVEML FSRGLVKVLF 
ATETFAMGVN MPARTVVFDS MRKHDGSTFR DLLPGEYVQM AGRAGRRGLD PTGTVILLCK 
GRVPEMADLH RMMMGKPSQL QSQFRLTYTM ILNLLRVDAL RVEDMMKRSF SEFPSRKDSK 
AHEQALAELT KRLGALEEPD MTGQLVDLPE YYSWGEELTE TQHMIQRRIM ESVNGLKSLS 
AGRVVVVKNQ EHHNALGVIL QVSSNSTSRV FTTLVLCDKP LSQDPQDRGP ATAEVPYPDD 
LVGFKLFLPE GPCDHTVVKL QPGDMAAITT KVLRVNGEKI LEDFSKRQQP KFKKDPPLAA 
VTTAVQELLR LAQAHPAGPP TLDPVNDLQL KDMSVVEGGL RARKLEELIQ GAQCVHSPRF 
PAQCTPAKGQ GEG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.