Details for: SLC1A2

Gene ID: 6506

Symbol: SLC1A2

Ensembl ID: ENSG00000110436

Description: solute carrier family 1 member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 39.7384
    Cell Significance Index: -37.9400
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 17.9112
    Cell Significance Index: 250.4600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 7.6591
    Cell Significance Index: 482.7300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 5.7240
    Cell Significance Index: 44.1200
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 5.1124
    Cell Significance Index: 56.8100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.6340
    Cell Significance Index: 43.3200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.9076
    Cell Significance Index: 195.5100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.1373
    Cell Significance Index: 131.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.0935
    Cell Significance Index: 750.8900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7398
    Cell Significance Index: 349.0100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.7130
    Cell Significance Index: 45.9000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.3835
    Cell Significance Index: 33.1800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.3761
    Cell Significance Index: 39.2700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2802
    Cell Significance Index: 254.0600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.1862
    Cell Significance Index: 20.5100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.7675
    Cell Significance Index: 9.5200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.5338
    Cell Significance Index: 821.7300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2257
    Cell Significance Index: 156.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1362
    Cell Significance Index: 185.2500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1196
    Cell Significance Index: 2.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0705
    Cell Significance Index: 12.0400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0008
    Cell Significance Index: 0.1600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0112
    Cell Significance Index: -20.7400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0157
    Cell Significance Index: -14.1900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0183
    Cell Significance Index: -0.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0230
    Cell Significance Index: -43.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0578
    Cell Significance Index: -42.4200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0623
    Cell Significance Index: -39.5800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0634
    Cell Significance Index: -47.9900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0714
    Cell Significance Index: -31.5700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0717
    Cell Significance Index: -53.1200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0771
    Cell Significance Index: -42.1100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0823
    Cell Significance Index: -51.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0924
    Cell Significance Index: -41.9500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0962
    Cell Significance Index: -54.2400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1166
    Cell Significance Index: -8.9500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1347
    Cell Significance Index: -38.7500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1463
    Cell Significance Index: -20.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1727
    Cell Significance Index: -31.1300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1766
    Cell Significance Index: -28.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2454
    Cell Significance Index: -51.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2651
    Cell Significance Index: -38.5300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2835
    Cell Significance Index: -34.8600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.2959
    Cell Significance Index: -32.1900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3028
    Cell Significance Index: -4.4700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.3108
    Cell Significance Index: -39.8500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3124
    Cell Significance Index: -8.7300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3215
    Cell Significance Index: -41.5400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3284
    Cell Significance Index: -8.7700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.3329
    Cell Significance Index: -32.9300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3419
    Cell Significance Index: -40.3200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3661
    Cell Significance Index: -11.9900
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.3679
    Cell Significance Index: -3.5000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3729
    Cell Significance Index: -43.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3837
    Cell Significance Index: -17.8900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.3952
    Cell Significance Index: -4.7900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.4082
    Cell Significance Index: -41.7000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4206
    Cell Significance Index: -48.1900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4252
    Cell Significance Index: -9.3100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4445
    Cell Significance Index: -46.2800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4571
    Cell Significance Index: -14.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4722
    Cell Significance Index: -28.9500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4763
    Cell Significance Index: -15.1700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.4809
    Cell Significance Index: -5.6100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4891
    Cell Significance Index: -17.1900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.5240
    Cell Significance Index: -36.2400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5269
    Cell Significance Index: -39.2700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5330
    Cell Significance Index: -23.5800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.5377
    Cell Significance Index: -32.2800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.5513
    Cell Significance Index: -24.9900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5753
    Cell Significance Index: -40.6900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5907
    Cell Significance Index: -12.2500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6052
    Cell Significance Index: -12.1500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6359
    Cell Significance Index: -24.0800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6370
    Cell Significance Index: -12.6000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6503
    Cell Significance Index: -36.4900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6790
    Cell Significance Index: -35.6500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.6863
    Cell Significance Index: -11.5600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.6918
    Cell Significance Index: -44.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.7237
    Cell Significance Index: -20.8500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7286
    Cell Significance Index: -37.9500
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.7470
    Cell Significance Index: -10.4700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.7492
    Cell Significance Index: -35.2100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.7660
    Cell Significance Index: -39.7900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.7774
    Cell Significance Index: -8.4700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.8194
    Cell Significance Index: -20.4400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.8858
    Cell Significance Index: -18.8000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.9188
    Cell Significance Index: -19.8500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9226
    Cell Significance Index: -32.3200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.9249
    Cell Significance Index: -13.2500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.9567
    Cell Significance Index: -11.9300
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.9773
    Cell Significance Index: -10.1800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.9822
    Cell Significance Index: -9.3100
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -1.0089
    Cell Significance Index: -12.5400
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -1.1243
    Cell Significance Index: -14.5800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.1569
    Cell Significance Index: -24.7300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.1797
    Cell Significance Index: -29.4900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.2117
    Cell Significance Index: -25.2900
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -1.2338
    Cell Significance Index: -8.9700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.2396
    Cell Significance Index: -26.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **High-affinity glutamate transporter**: SLC1A2 is a high-affinity glutamate transporter that rapidly takes up glutamate from the synaptic cleft, preventing excessive glutamate levels and subsequent excitotoxicity. 2. **Astrocyte-specific expression**: SLC1A2 is predominantly expressed in mature astrocytes, which are involved in maintaining glutamate homeostasis and regulating neuronal activity. 3. **Dual transport function**: SLC1A2 can transport both glutamate and aspartate across the plasma membrane, suggesting a dual role in regulating these amino acids in the CNS. 4. **Regulation of synaptic transmission**: SLC1A2 plays a crucial role in regulating synaptic transmission by controlling glutamate levels and preventing excitotoxicity. **Pathways and Functions:** 1. **Glutamate neurotransmission**: SLC1A2 is involved in regulating glutamate neurotransmission by controlling glutamate levels in the synaptic cleft. 2. **Astrocytic glutamate-glutamine uptake and metabolism**: SLC1A2 is involved in the uptake and metabolism of glutamate and glutamine by astrocytes, which is essential for maintaining glutamate homeostasis. 3. **Cellular response to cocaine**: SLC1A2 is involved in the cellular response to cocaine, which can lead to excessive glutamate release and excitotoxicity. 4. **Neurotransmitter release cycle**: SLC1A2 plays a role in regulating the neurotransmitter release cycle by controlling glutamate levels in the synaptic cleft. **Clinical Significance:** 1. **Neurological disorders**: SLC1A2 has been implicated in various neurological disorders, including schizophrenia, epilepsy, Alzheimer's disease, and Parkinson's disease. 2. **Cognitive impairment**: Alterations in SLC1A2 expression and function have been linked to cognitive impairment in neurological disorders. 3. **Therapeutic potential**: SLC1A2 has been identified as a potential therapeutic target for treating neurological disorders, including schizophrenia and epilepsy. 4. **Neuroprotection**: SLC1A2 may play a role in neuroprotection by regulating glutamate levels and preventing excitotoxicity. In conclusion, SLC1A2 is a crucial gene that plays a pivotal role in regulating glutamate neurotransmission, astrocytic glutamate-glutamine uptake and metabolism, and cellular response to cocaine. Its clinical significance in neurological disorders highlights the importance of further research into the functions and therapeutic potential of this gene.

Genular Protein ID: 735055544

Symbol: EAA2_HUMAN

Name: Glutamate/aspartate transporter II

UniProtKB Accession Codes:

P43004 B4DQE9 Q14417 Q541G6 U3KQQ4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChEBI 22 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 10 EMDB 4 Ensembl 9 ExpressionAtlas 1 GO 41 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 3 Rhea 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7521911

Title: Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex.

PubMed ID: 7521911

DOI: 10.1523/jneurosci.14-09-05559.1994

PubMed ID: 8172925

Title: Molecular cloning of human brain glutamate/aspartate transporter II.

PubMed ID: 8172925

DOI: 10.1016/0005-2736(94)90192-9

PubMed ID: 7522567

Title: Cloning and characterization of a glutamate transporter cDNA from human brain and pancreas.

PubMed ID: 7522567

DOI: 10.1016/0005-2736(94)90026-4

PubMed ID: 9463476

Title: DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters.

PubMed ID: 9463476

DOI: 10.1124/mol.53.2.195

PubMed ID: 12950454

Title: Cloning and characterization of the 3'-untranslated region of the human excitatory amino acid transporter 2 transcript.

PubMed ID: 12950454

DOI: 10.1046/j.1471-4159.2003.01958.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14506254

Title: Glutamate modifies ion conduction and voltage-dependent gating of excitatory amino acid transporter-associated anion channels.

PubMed ID: 14506254

DOI: 10.1074/jbc.m307990200

PubMed ID: 15265858

Title: A trimeric quaternary structure is conserved in bacterial and human glutamate transporters.

PubMed ID: 15265858

DOI: 10.1074/jbc.m408038200

PubMed ID: 15483603

Title: Structure of a glutamate transporter homologue from Pyrococcus horikoshii.

PubMed ID: 15483603

DOI: 10.1038/nature03018

PubMed ID: 20688910

Title: Exon-skipping splice variants of excitatory amino acid transporter-2 (EAAT2) form heteromeric complexes with full-length EAAT2.

PubMed ID: 20688910

DOI: 10.1074/jbc.m110.153494

PubMed ID: 26483543

Title: The Hydroxyl Side Chain of a Highly Conserved Serine Residue Is Required for Cation Selectivity and Substrate Transport in the Glial Glutamate Transporter GLT-1/SLC1A2.

PubMed ID: 26483543

DOI: 10.1074/jbc.m115.689836

PubMed ID: 26690923

Title: Caveolin-1 Sensitivity of Excitatory Amino Acid Transporters EAAT1, EAAT2, EAAT3, and EAAT4.

PubMed ID: 26690923

DOI: 10.1007/s00232-015-9863-0

PubMed ID: 27476654

Title: De novo mutations in SLC1A2 and CACNA1A are important causes of epileptic encephalopathies.

PubMed ID: 27476654

DOI: 10.1016/j.ajhg.2016.06.003

PubMed ID: 28777935

Title: De novo mutations in YWHAG cause early-onset epilepsy.

PubMed ID: 28777935

DOI: 10.1016/j.ajhg.2017.07.004

Sequence Information:

  • Length: 574
  • Mass: 62104
  • Checksum: C8104E6727979435
  • Sequence:
    • MASTEGANNM PKQVEVRMHD SHLGSEEPKH RHLGLRLCDK LGKNLLLTLT VFGVILGAVC 
GGLLRLASPI HPDVVMLIAF PGDILMRMLK MLILPLIISS LITGLSGLDA KASGRLGTRA 
MVYYMSTTII AAVLGVILVL AIHPGNPKLK KQLGPGKKND EVSSLDAFLD LIRNLFPENL 
VQACFQQIQT VTKKVLVAPP PDEEANATSA VVSLLNETVT EVPEETKMVI KKGLEFKDGM 
NVLGLIGFFI AFGIAMGKMG DQAKLMVDFF NILNEIVMKL VIMIMWYSPL GIACLICGKI 
IAIKDLEVVA RQLGMYMVTV IIGLIIHGGI FLPLIYFVVT RKNPFSFFAG IFQAWITALG 
TASSAGTLPV TFRCLEENLG IDKRVTRFVL PVGATINMDG TALYEAVAAI FIAQMNGVVL 
DGGQIVTVSL TATLASVGAA SIPSAGLVTM LLILTAVGLP TEDISLLVAV DWLLDRMRTS 
VNVVGDSFGA GIVYHLSKSE LDTIDSQHRV HEDIEMTKTQ SIYDDMKNHR ESNSNQCVYA 
AHNSVIVDEC KVTLAANGKS ADCSVEEEPW KREK

Genular Protein ID: 1490592963

Symbol: A2A2U1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A2A2U1

Database IDs:

ARBA 7 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 ExpressionAtlas 1 GO 6 Gene3D 1 HOGENOM 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 Pfam 1 RefSeq 4 RuleBase 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 565
  • Mass: 61228
  • Checksum: A7286207F550252F
  • Sequence:
    • MPKQVEVRMH DSHLGSEEPK HRHLGLRLCD KLGKNLLLTL TVFGVILGAV CGGLLRLASP 
IHPDVVMLIA FPGDILMRML KMLILPLIIS SLITGLSGLD AKASGRLGTR AMVYYMSTTI 
IAAVLGVILV LAIHPGNPKL KKQLGPGKKN DEVSSLDAFL DLIRNLFPEN LVQACFQQIQ 
TVTKKVLVAP PPDEEANATS AVVSLLNETV TEVPEETKMV IKKGLEFKDG MNVLGLIGFF 
IAFGIAMGKM GDQAKLMVDF FNILNEIVMK LVIMIMWYSP LGIACLICGK IIAIKDLEVV 
ARQLGMYMVT VIIGLIIHGG IFLPLIYFVV TRKNPFSFFA GIFQAWITAL GTASSAGTLP 
VTFRCLEENL GIDKRVTRFV LPVGATINMD GTALYEAVAA IFIAQMNGVV LDGGQIVTVS 
LTATLASVGA ASIPSAGLVT MLLILTAVGL PTEDISLLVA VDWLLDRMRT SVNVVGDSFG 
AGIVYHLSKS ELDTIDSQHR VHEDIEMTKT QSIYDDMKNH RESNSNQCVY AAHNSVIVDE 
CKVTLAANGK SADCSVEEEP WKREK

Genular Protein ID: 921206659

Symbol: A0A2R8Y860_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A2R8Y860

Database IDs:

ARBA 7 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 579
  • Mass: 62963
  • Checksum: D396011D74660C17
  • Sequence:
    • MKRPKDHIWR SANNMPKQVE VRMHDSHLGS EEPKHRHLGL RLCDKLGKNL LLTLTVFGVI 
LGAVCGGLLR LASPIHPDVV MLIAFPGDIL MRMLKMLILP LIISSLITGL SGLDAKASGR 
LGTRAMVYYM STTIIAAVLG VILVLAIHPG NPKLKKQLGP GKKNDEVSSL DAFLDLIRNL 
FPENLVQACF QQIQTVTKKV LVAPPPDEEA NATSAVVSLL NETVTEVPEE TKMVIKKGLE 
FKDGMNVLGL IGFFIAFGIA MGKMGDQAKL MVDFFNILNE IVMKLVIMIM WYSPLGIACL 
ICGKIIAIKD LEVVARQLGM YMVTVIIGLI IHGGIFLPLI YFVVTRKNPF SFFAGIFQAW 
ITALGTASSA GTLPVTFRCL EENLGIDKRV TRFVLPVGAT INMDGTALYE AVAAIFIAQM 
NGVVLDGGQI VTVSLTATLA SVGAASIPSA GLVTMLLILT AVGLPTEDIS LLVAVDWLLD 
RMRTSVNVVG DSFGAGIVYH LSKSELDTID SQHRVHEDIE MTKTQSIYDD MKNHRESNSN 
QCVYAAHNSV IVDECKVTLA ANGKSADCSV EEEPWKREK

Genular Protein ID: 3208420778

Symbol: A0A2U3TZS7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A2U3TZS7

Database IDs:

ARBA 7 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 570
  • Mass: 61716
  • Checksum: 710719E26F323D97
  • Sequence:
    • MGANNMPKQV EVRMHDSHLG SEEPKHRHLG LRLCDKLGKN LLLTLTVFGV ILGAVCGGLL 
RLASPIHPDV VMLIAFPGDI LMRMLKMLIL PLIISSLITG LSGLDAKASG RLGTRAMVYY 
MSTTIIAAVL GVILVLAIHP GNPKLKKQLG PGKKNDEVSS LDAFLDLIRN LFPENLVQAC 
FQQIQTVTKK VLVAPPPDEE ANATSAVVSL LNETVTEVPE ETKMVIKKGL EFKDGMNVLG 
LIGFFIAFGI AMGKMGDQAK LMVDFFNILN EIVMKLVIMI MWYSPLGIAC LICGKIIAIK 
DLEVVARQLG MYMVTVIIGL IIHGGIFLPL IYFVVTRKNP FSFFAGIFQA WITALGTASS 
AGTLPVTFRC LEENLGIDKR VTRFVLPVGA TINMDGTALY EAVAAIFIAQ MNGVVLDGGQ 
IVTVSLTATL ASVGAASIPS AGLVTMLLIL TAVGLPTEDI SLLVAVDWLL DRMRTSVNVV 
GDSFGAGIVY HLSKSELDTI DSQHRVHEDI EMTKTQSIYD DMKNHRESNS NQCVYAAHNS 
VIVDECKVTL AANGKSADCS VEEEPWKREK

Genular Protein ID: 3270846935

Symbol: A0A2R8YFE3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A2R8YFE3

Database IDs:

ARBA 7 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 496
  • Mass: 53576
  • Checksum: 4DA0215B9C48A4E8
  • Sequence:
    • MASTEGANNM PKQVEVRMHD SHLGSEEPKH RHLGLRLCDK LGKNLLLTLT VFGVILGAVC 
GGLLRLASPI HPDVVMLIAF PGDILMRMLK MLILPLIISS LITGLSGLDA KASGRLGTRA 
MVYYMSTTII AAVLGVILVL AIHPGNPKLK KQLGPGKKND EVSSLDAFLD LIRNLFPENL 
VQACFQQIQT VTKKVLVAPP PDEEANATSA VVSLLNETVT EVPEETKMVI KKGLEFKDGM 
NVLGLIGFFI AFGIAMGKMG DQAKLMVDFF NILNEIVMKL VIMIMCAGTL PVTFRCLEEN 
LGIDKRVTRF VLPVGATINM DGTALYEAVA AIFIAQMNGV VLDGGQIVTV SLTATLASVG 
AASIPSAGLV TMLLILTAVG LPTEDISLLV AVDWLLDRMR TSVNVVGDSF GAGIVYHLSK 
SELDTIDSQH RVHEDIEMTK TQSIYDDMKN HRESNSNQCV YAAHNSVIVD ECKVTLAANG 
KSADCSVEEE PWKREK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.