Details for: SLC20A1

Gene ID: 6574

Symbol: SLC20A1

Ensembl ID: ENSG00000144136

Description: solute carrier family 20 member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 220.6432
    Cell Significance Index: -34.3200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 161.2500
    Cell Significance Index: -40.9000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 104.1637
    Cell Significance Index: -42.9100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 95.5790
    Cell Significance Index: -45.1300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 88.9831
    Cell Significance Index: -36.1500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 82.5451
    Cell Significance Index: -42.4600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 67.3003
    Cell Significance Index: -45.1600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 38.0731
    Cell Significance Index: -36.3500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 33.9915
    Cell Significance Index: -41.9100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.4655
    Cell Significance Index: -41.4300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.9211
    Cell Significance Index: -43.1000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.0148
    Cell Significance Index: -30.7600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 6.5649
    Cell Significance Index: 89.5700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.9536
    Cell Significance Index: -13.0300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 5.2080
    Cell Significance Index: 270.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.4336
    Cell Significance Index: 98.9300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 3.0640
    Cell Significance Index: 66.3800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 3.0299
    Cell Significance Index: 45.4000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.2704
    Cell Significance Index: 32.3200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.9541
    Cell Significance Index: 18.0000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.5572
    Cell Significance Index: 41.5800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.4199
    Cell Significance Index: 255.9700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2248
    Cell Significance Index: 245.6900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1209
    Cell Significance Index: 30.5100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0847
    Cell Significance Index: 133.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0581
    Cell Significance Index: 47.9600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7883
    Cell Significance Index: 128.2200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6027
    Cell Significance Index: 544.1600
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.5234
    Cell Significance Index: 1.1800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.5170
    Cell Significance Index: 14.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.5065
    Cell Significance Index: 953.5900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5023
    Cell Significance Index: 99.6800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4864
    Cell Significance Index: 12.1600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.4803
    Cell Significance Index: 5.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4452
    Cell Significance Index: 243.1400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4243
    Cell Significance Index: 23.8100
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.3688
    Cell Significance Index: 5.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3038
    Cell Significance Index: 108.9900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2890
    Cell Significance Index: 10.1600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2589
    Cell Significance Index: 28.1600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2569
    Cell Significance Index: 7.1800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.2523
    Cell Significance Index: 4.2500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2504
    Cell Significance Index: 32.1000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2496
    Cell Significance Index: 29.4300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2370
    Cell Significance Index: 163.8900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2019
    Cell Significance Index: 89.2800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1684
    Cell Significance Index: 10.1100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1093
    Cell Significance Index: 20.8000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0928
    Cell Significance Index: 5.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0868
    Cell Significance Index: 8.5900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0777
    Cell Significance Index: 119.6200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0665
    Cell Significance Index: 42.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0583
    Cell Significance Index: 8.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0367
    Cell Significance Index: 67.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0149
    Cell Significance Index: 0.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0010
    Cell Significance Index: 0.1700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0068
    Cell Significance Index: -3.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0109
    Cell Significance Index: -14.7700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0220
    Cell Significance Index: -16.3200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0267
    Cell Significance Index: -16.7000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0317
    Cell Significance Index: -23.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0325
    Cell Significance Index: -4.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0345
    Cell Significance Index: -26.0900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0449
    Cell Significance Index: -25.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0727
    Cell Significance Index: -3.4200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0822
    Cell Significance Index: -1.7500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0847
    Cell Significance Index: -8.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0934
    Cell Significance Index: -7.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1067
    Cell Significance Index: -7.9500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1088
    Cell Significance Index: -22.9100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1169
    Cell Significance Index: -33.6400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1237
    Cell Significance Index: -3.1800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1285
    Cell Significance Index: -9.0900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1394
    Cell Significance Index: -9.3700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1486
    Cell Significance Index: -17.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1519
    Cell Significance Index: -19.6200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.1570
    Cell Significance Index: -1.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2236
    Cell Significance Index: -25.6200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2282
    Cell Significance Index: -26.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2690
    Cell Significance Index: -12.5400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2697
    Cell Significance Index: -4.9900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3060
    Cell Significance Index: -21.1600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3066
    Cell Significance Index: -31.9200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3845
    Cell Significance Index: -20.0300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3937
    Cell Significance Index: -20.6700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4124
    Cell Significance Index: -14.3300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4282
    Cell Significance Index: -6.3200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4366
    Cell Significance Index: -4.9600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4628
    Cell Significance Index: -28.4500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4751
    Cell Significance Index: -10.1600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4903
    Cell Significance Index: -38.8300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4961
    Cell Significance Index: -13.2700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4978
    Cell Significance Index: -30.5200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5090
    Cell Significance Index: -14.9500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5451
    Cell Significance Index: -17.4600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5925
    Cell Significance Index: -3.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5988
    Cell Significance Index: -26.4900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6755
    Cell Significance Index: -11.3100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7044
    Cell Significance Index: -26.6800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7340
    Cell Significance Index: -19.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Sodium-dependent phosphate transporter**: SLC20A1 is a sodium-dependent transporter that facilitates the transport of inorganic phosphate across cell membranes. 2. **Expressed in various cell types**: SLC20A1 is expressed in corneal endothelial cells, bladder urothelial cells, corneal epithelial cells, colon epithelial cells, Paneth cells, conjunctival epithelial cells, pigmented epithelial cells, germ cells, enterocytes, and enterocytes of the large intestine. 3. **Regulation of phosphate homeostasis**: SLC20A1 plays a crucial role in regulating phosphate homeostasis by controlling the transport of inorganic phosphate into cells. 4. **Cell proliferation and differentiation**: SLC20A1 is involved in regulating cell proliferation and differentiation by controlling the availability of phosphate ions. **Pathways and Functions:** 1. **Biomineral tissue development**: SLC20A1 is involved in the development of biomineral tissues, such as bone and teeth, by regulating the availability of phosphate ions. 2. **Cell population proliferation**: SLC20A1 regulates cell population proliferation by controlling the transport of inorganic phosphate into cells. 3. **High-affinity inorganic phosphate:sodium symporter activity**: SLC20A1 exhibits high-affinity inorganic phosphate:sodium symporter activity, which allows for efficient transport of phosphate ions into cells. 4. **Inorganic phosphate transmembrane transporter activity**: SLC20A1 exhibits inorganic phosphate transmembrane transporter activity, which enables the transport of phosphate ions across cell membranes. 5. **Phosphate-containing compound metabolic process**: SLC20A1 is involved in the metabolic process of phosphate-containing compounds, such as nucleotides and phospholipids. **Clinical Significance:** 1. **Phosphate metabolism disorders**: Mutations in the SLC20A1 gene have been associated with phosphate metabolism disorders, such as kidney disease and osteoporosis. 2. **Cancer research**: SLC20A1 is overexpressed in various types of cancer, including breast, lung, and colon cancer, and has been implicated in cancer progression and metastasis. 3. **Neurological disorders**: SLC20A1 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where phosphate homeostasis is disrupted. 4. **Ophthalmological disorders**: SLC20A1 has been implicated in ophthalmological disorders, such as glaucoma and cataracts, where phosphate homeostasis is disrupted. In conclusion, the SLC20A1 gene plays a crucial role in regulating phosphate homeostasis, cell proliferation, and differentiation. Its dysregulation has been implicated in various diseases, including phosphate metabolism disorders, cancer, neurological disorders, and ophthalmological disorders. Further research is needed to fully understand the mechanisms by which SLC20A1 regulates phosphate homeostasis and its clinical significance.

Genular Protein ID: 2720872629

Symbol: S20A1_HUMAN

Name: Sodium-dependent phosphate transporter 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2078500

Title: Characterization of a human gene conferring sensitivity to infection by gibbon ape leukemia virus.

PubMed ID: 2078500

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9889306

Title: Characterization of the human Glvr-1 phosphate transporter/retrovirus receptor gene and promoter region.

PubMed ID: 9889306

DOI: 10.1016/s0378-1119(98)00572-1

PubMed ID: 1309898

Title: Feline leukemia virus subgroup B uses the same cell surface receptor as gibbon ape leukemia virus.

PubMed ID: 1309898

DOI: 10.1128/jvi.66.2.1219-1222.1992

PubMed ID: 1531369

Title: GLVR1, a receptor for gibbon ape leukemia virus, is homologous to a phosphate permease of Neurospora crassa and is expressed at high levels in the brain and thymus.

PubMed ID: 1531369

DOI: 10.1128/jvi.66.3.1635-1640.1992

PubMed ID: 8411375

Title: Definition of a domain of GLVR1 which is necessary for infection by gibbon ape leukemia virus and which is highly polymorphic between species.

PubMed ID: 8411375

DOI: 10.1128/jvi.67.11.6733-6736.1993

PubMed ID: 7929240

Title: The cellular receptor for gibbon ape leukemia virus is a novel high affinity sodium-dependent phosphate transporter.

PubMed ID: 7929240

DOI: 10.1016/s0021-9258(18)47267-5

PubMed ID: 7966619

Title: A family of retroviruses that utilize related phosphate transporters for cell entry.

PubMed ID: 7966619

DOI: 10.1128/jvi.68.12.8270-8276.1994

PubMed ID: 8041748

Title: Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters.

PubMed ID: 8041748

DOI: 10.1073/pnas.91.15.7071

PubMed ID: 11009570

Title: Phosphate regulation of vascular smooth muscle cell calcification.

PubMed ID: 11009570

DOI: 10.1161/01.res.87.7.e10

PubMed ID: 12097582

Title: Reassessing the role of region A in Pit1-mediated viral entry.

PubMed ID: 12097582

DOI: 10.1128/jvi.76.15.7683-7693.2002

PubMed ID: 15641067

Title: Role of interleukin-8 in PiT-1 expression and CXCR1-mediated inorganic phosphate uptake in chondrocytes.

PubMed ID: 15641067

DOI: 10.1002/art.20748

PubMed ID: 16790504

Title: Characterization of transport mechanisms and determinants critical for Na+-dependent Pi symport of the PiT family paralogs human PiT1 and PiT2.

PubMed ID: 16790504

DOI: 10.1152/ajpcell.00015.2006

PubMed ID: 17494632

Title: Deciphering PiT transport kinetics and substrate specificity using electrophysiology and flux measurements.

PubMed ID: 17494632

DOI: 10.1152/ajpcell.00064.2007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19726692

Title: Identification of a novel function of PiT1 critical for cell proliferation and independent of its phosphate transport activity.

PubMed ID: 19726692

DOI: 10.1074/jbc.m109.053132

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 679
  • Mass: 73700
  • Checksum: 5545F6E6DC8F5EA8
  • Sequence:
  • MATLITSTTA ATAASGPLVD YLWMLILGFI IAFVLAFSVG ANDVANSFGT AVGSGVVTLK 
    QACILASIFE TVGSVLLGAK VSETIRKGLI DVEMYNSTQG LLMAGSVSAM FGSAVWQLVA 
    SFLKLPISGT HCIVGATIGF SLVAKGQEGV KWSELIKIVM SWFVSPLLSG IMSGILFFLV 
    RAFILHKADP VPNGLRALPV FYACTVGINL FSIMYTGAPL LGFDKLPLWG TILISVGCAV 
    FCALIVWFFV CPRMKRKIER EIKCSPSESP LMEKKNSLKE DHEETKLSVG DIENKHPVSE 
    VGPATVPLQA VVEERTVSFK LGDLEEAPER ERLPSVDLKE ETSIDSTVNG AVQLPNGNLV 
    QFSQAVSNQI NSSGHYQYHT VHKDSGLYKE LLHKLHLAKV GDCMGDSGDK PLRRNNSYTS 
    YTMAICGMPL DSFRAKEGEQ KGEEMEKLTW PNADSKKRIR MDSYTSYCNA VSDLHSASEI 
    DMSVKAEMGL GDRKGSNGSL EEWYDQDKPE VSLLFQFLQI LTACFGSFAH GGNDVSNAIG 
    PLVALYLVYD TGDVSSKVAT PIWLLLYGGV GICVGLWVWG RRVIQTMGKD LTPITPSSGF 
    SIELASALTV VIASNIGLPI STTHCKVGSV VSVGWLRSKK AVDWRLFRNI FMAWFVTVPI 
    SGVISAAIMA IFRYVILRM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.