Details for: SNAPC1

Gene ID: 6617

Symbol: SNAPC1

Ensembl ID: ENSG00000023608

Description: small nuclear RNA activating complex polypeptide 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 168.5040
    Cell Significance Index: -26.2100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 97.6765
    Cell Significance Index: -24.7800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 68.0912
    Cell Significance Index: -28.0500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 63.2039
    Cell Significance Index: -29.8400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 58.2636
    Cell Significance Index: -23.6700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 25.0224
    Cell Significance Index: -23.8900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.2879
    Cell Significance Index: -27.4800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.0472
    Cell Significance Index: -26.9200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.0450
    Cell Significance Index: -27.8000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.0493
    Cell Significance Index: -18.5800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.1770
    Cell Significance Index: 253.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.9819
    Cell Significance Index: 377.1800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.6756
    Cell Significance Index: 45.6100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.9730
    Cell Significance Index: 25.5900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9109
    Cell Significance Index: 112.0000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8549
    Cell Significance Index: 154.1200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7318
    Cell Significance Index: 399.6300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6805
    Cell Significance Index: 614.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5580
    Cell Significance Index: 71.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5139
    Cell Significance Index: 103.0800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4963
    Cell Significance Index: 25.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4423
    Cell Significance Index: 60.7500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4283
    Cell Significance Index: 11.9700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4270
    Cell Significance Index: 42.2400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4204
    Cell Significance Index: 68.3800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4165
    Cell Significance Index: 45.3000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3490
    Cell Significance Index: 5.2300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3466
    Cell Significance Index: 153.2500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3419
    Cell Significance Index: 67.8500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3334
    Cell Significance Index: 18.7100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3227
    Cell Significance Index: 24.7700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3178
    Cell Significance Index: 19.0800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3056
    Cell Significance Index: 4.1700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2124
    Cell Significance Index: 15.0200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2110
    Cell Significance Index: 24.8800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1750
    Cell Significance Index: 12.1000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1644
    Cell Significance Index: 4.1100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1637
    Cell Significance Index: 5.6900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1592
    Cell Significance Index: 110.1300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1462
    Cell Significance Index: 52.4300
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.1285
    Cell Significance Index: 0.9700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1230
    Cell Significance Index: 3.3000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1124
    Cell Significance Index: 173.0000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0909
    Cell Significance Index: 4.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0751
    Cell Significance Index: 102.0600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0674
    Cell Significance Index: 1.4600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0578
    Cell Significance Index: 106.5600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0568
    Cell Significance Index: 106.9400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0513
    Cell Significance Index: 0.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0351
    Cell Significance Index: 2.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0311
    Cell Significance Index: 1.4100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0268
    Cell Significance Index: 0.5600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0207
    Cell Significance Index: 0.3200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0109
    Cell Significance Index: 0.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0105
    Cell Significance Index: 0.2800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0094
    Cell Significance Index: 0.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0024
    Cell Significance Index: -1.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0101
    Cell Significance Index: -7.4900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0104
    Cell Significance Index: -0.2400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0114
    Cell Significance Index: -7.1000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0181
    Cell Significance Index: -8.2200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0184
    Cell Significance Index: -13.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0222
    Cell Significance Index: -12.5000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0226
    Cell Significance Index: -17.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0346
    Cell Significance Index: -5.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0445
    Cell Significance Index: -9.3800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0507
    Cell Significance Index: -5.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0535
    Cell Significance Index: -7.7700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0564
    Cell Significance Index: -0.4600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0626
    Cell Significance Index: -2.7700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0738
    Cell Significance Index: -8.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0752
    Cell Significance Index: -21.6400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0893
    Cell Significance Index: -3.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0940
    Cell Significance Index: -6.3200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0961
    Cell Significance Index: -6.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1002
    Cell Significance Index: -5.2600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1094
    Cell Significance Index: -14.1400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1096
    Cell Significance Index: -5.7100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1224
    Cell Significance Index: -3.2800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1270
    Cell Significance Index: -2.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1419
    Cell Significance Index: -8.7200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1587
    Cell Significance Index: -8.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1602
    Cell Significance Index: -18.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1716
    Cell Significance Index: -12.7900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1729
    Cell Significance Index: -1.8800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1738
    Cell Significance Index: -5.0100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2176
    Cell Significance Index: -22.6600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2232
    Cell Significance Index: -7.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2435
    Cell Significance Index: -14.9300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2658
    Cell Significance Index: -5.6600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2828
    Cell Significance Index: -7.2700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3128
    Cell Significance Index: -24.7700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3431
    Cell Significance Index: -4.0900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3504
    Cell Significance Index: -7.4900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3597
    Cell Significance Index: -10.3100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3841
    Cell Significance Index: -5.6700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3925
    Cell Significance Index: -11.5600
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.3983
    Cell Significance Index: -6.0600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4539
    Cell Significance Index: -11.6000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4604
    Cell Significance Index: -4.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNAPC1 is a polypeptide subunit of the snRNA-activating complex, which is a complex of proteins that facilitate the transcription of snRNA genes. The SNAPC1 protein is characterized by its ability to bind to specific DNA sequences and recruit RNA polymerase II and III to the transcription initiation site. This complex is essential for the regulation of gene expression, particularly in the context of snRNA transcription. **Pathways and Functions:** The SNAPC1 protein is involved in several transcriptional pathways, including those mediated by RNA polymerase II and III. The gene expression pathways associated with SNAPC1 include: 1. **RNA polymerase II general transcription initiation factor activity:** SNAPC1 is involved in the recruitment of RNA polymerase II to the transcription initiation site, allowing for the transcription of snRNA genes. 2. **RNA polymerase III abortive and retractive initiation:** SNAPC1 also plays a role in the initiation of transcription by RNA polymerase III, a non-canonical pathway involved in the transcription of some snRNA genes. 3. **Sequence-specific DNA binding:** SNAPC1 is capable of binding to specific DNA sequences, allowing for the recruitment of RNA polymerase II and III to the transcription initiation site. 4. **SnRNA transcription by RNA polymerase II and III:** SNAPC1 is essential for the transcription of snRNA genes by both RNA polymerase II and III. **Clinical Significance:** The SNAPC1 gene has been identified in various cell types, including oogonial cells, corneal endothelial cells, and male germ cells. The clinical significance of SNAPC1 is multifaceted: 1. **Regulation of gene expression:** SNAPC1 plays a crucial role in regulating gene expression, particularly in the context of snRNA transcription. Dysregulation of SNAPC1 has been implicated in various diseases, including cancer and neurological disorders. 2. **Developmental biology:** SNAPC1 is essential for the development of oogonial cells and male germ cells, highlighting its importance in reproductive biology. 3. **Disease association:** SNAPC1 has been associated with various diseases, including cancer, where it is often overexpressed. Its role in disease pathogenesis is still being investigated. In conclusion, SNAPC1 is a critical component of the snRNA-activating complex, playing a vital role in regulating gene expression. Its involvement in various transcriptional pathways, including those mediated by RNA polymerase II and III, highlights its importance in cellular processes. Further research is needed to fully understand the clinical significance of SNAPC1 and its role in disease pathogenesis.

Genular Protein ID: 3779097250

Symbol: SNPC1_HUMAN

Name: snRNA-activating protein complex subunit 1

UniProtKB Accession Codes:

Q16533

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EMDB 9 Ensembl 1 GO 8 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7715707

Title: A TBP-TAF complex required for transcription of human snRNA genes by RNA polymerase II and III.

PubMed ID: 7715707

DOI: 10.1038/374653a0

PubMed ID: 8524284

Title: Cloning of two proximal sequence element-binding transcription factor subunits (gamma and delta) that are required for transcription of small nuclear RNA genes by RNA polymerases II and III and interact with the TATA-binding protein.

PubMed ID: 8524284

DOI: 10.1128/mcb.16.1.1

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11056176

Title: A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc.

PubMed ID: 11056176

DOI: 10.1074/jbc.m009301200

PubMed ID: 12621023

Title: The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition.

PubMed ID: 12621023

DOI: 10.1074/jbc.m204247200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

Sequence Information:

  • Length: 368
  • Mass: 42994
  • Checksum: 324E89CF8B540C32
  • Sequence:
    • MGTPPGLQTD CEALLSRFQE TDSVRFEDFT ELWRNMKFGT IFCGRMRNLE KNMFTKEALA 
LAWRYFLPPY TFQIRVGALY LLYGLYNTQL CQPKQKIRVA LKDWDEVLKF QQDLVNAQHF 
DAAYIFRKLR LDRAFHFTAM PKLLSYRMKK KIHRAEVTEE FKDPSDRVMK LITSDVLEEM 
LNVHDHYQNM KHVISVDKSK PDKALSLIKD DFFDNIKNIV LEHQQWHKDR KNPSLKSKTN 
DGEEKMEGNS QETERCERAE SLAKIKSKAF SVVIQASKSR RHRQVKLDSS DSDSASGQGQ 
VKATRKKEKK ERLKPAGRKM SLRNKGNVQN IHKEDKPLSL SMPVITEEEE NESLSGTEFT 
ASKKRRKH

Genular Protein ID: 360844937

Symbol: B2RC42_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2RC42

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 InterPro 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1

Sequence Information:

  • Length: 368
  • Mass: 42966
  • Checksum: 4EDE4282701727C6
  • Sequence:
    • MGTPPGLQTD CEALLSRFQE TDSVRFEDFT ELWKNMKFGT IFCGRMRNLE KNMFTKEALA 
LAWRYFLPPY TFQIRVGALY LLYGLYNTQL CQPKQKIRVA LKDWDEVLKF QQDLVNAQHF 
DAAYIFRKLR LDRAFHFTAM PKLLSYRMKK KIHRAEVTEE FKDPSDRVMK LITSDVLEEM 
LNVHDHYQNM KHVISVDKSK PDKALSLIKD DFFDNIKNIV LEHQQWHKDR KNPSLKSKTN 
DGEEKMEGNS QETERCERAE SLAKIKSKAF SVVIQASKSR RHRQVKLDSS DSDSASGQGQ 
VKATRKKEKK ERLKPAGRKM SLRNKGNVQN IHKEDKPLSL SMPVITEEEE NESLSGTEFT 
ASKKRRKH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.