Details for: SOD2

Gene ID: 6648

Symbol: SOD2

Ensembl ID: ENSG00000291237

Description: superoxide dismutase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 505.3193
    Cell Significance Index: -78.6000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 295.6513
    Cell Significance Index: -74.9900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 167.2057
    Cell Significance Index: -68.8800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 144.5998
    Cell Significance Index: -74.3800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 142.4206
    Cell Significance Index: -67.2400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 100.2799
    Cell Significance Index: -67.2900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 66.3446
    Cell Significance Index: -81.8000
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 31.6770
    Cell Significance Index: 146.2600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 29.4449
    Cell Significance Index: -64.4400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 29.0221
    Cell Significance Index: -89.1400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 24.0849
    Cell Significance Index: -64.5200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 21.2415
    Cell Significance Index: -83.8200
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 19.0590
    Cell Significance Index: 136.8800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 17.1562
    Cell Significance Index: 491.8000
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 14.2569
    Cell Significance Index: 7.1600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 8.5402
    Cell Significance Index: 143.8600
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 7.0832
    Cell Significance Index: 40.7900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 6.9465
    Cell Significance Index: 128.3900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 5.2945
    Cell Significance Index: 152.5500
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 5.0963
    Cell Significance Index: 31.5400
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 3.9290
    Cell Significance Index: 40.6600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 3.8945
    Cell Significance Index: 66.7400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.9498
    Cell Significance Index: 19.9900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.8259
    Cell Significance Index: 76.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.5647
    Cell Significance Index: 1400.6600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.2317
    Cell Significance Index: 306.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 2.0593
    Cell Significance Index: 72.3600
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.9682
    Cell Significance Index: 21.7400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.8854
    Cell Significance Index: 29.1700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.5664
    Cell Significance Index: 254.7700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.5460
    Cell Significance Index: 190.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.5109
    Cell Significance Index: 272.3800
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.4477
    Cell Significance Index: 12.4400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.1934
    Cell Significance Index: 55.6400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.0539
    Cell Significance Index: 49.5300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8845
    Cell Significance Index: 61.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8497
    Cell Significance Index: 170.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8030
    Cell Significance Index: 102.9400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.7701
    Cell Significance Index: 87.9100
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.7526
    Cell Significance Index: 8.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7017
    Cell Significance Index: 53.8500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.6559
    Cell Significance Index: 33.1500
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.6164
    Cell Significance Index: 10.5900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.5149
    Cell Significance Index: 10.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5015
    Cell Significance Index: 95.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4959
    Cell Significance Index: 27.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4164
    Cell Significance Index: 21.6300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.3782
    Cell Significance Index: 240.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2424
    Cell Significance Index: 183.5100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2120
    Cell Significance Index: 5.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2087
    Cell Significance Index: 392.9800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2036
    Cell Significance Index: 313.5100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1960
    Cell Significance Index: 33.4700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1839
    Cell Significance Index: 166.0900
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.1564
    Cell Significance Index: 0.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1542
    Cell Significance Index: 284.4700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0864
    Cell Significance Index: 8.5500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0806
    Cell Significance Index: 1.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0690
    Cell Significance Index: 93.8300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0430
    Cell Significance Index: 4.3900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0226
    Cell Significance Index: 10.2800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0211
    Cell Significance Index: -0.2400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0293
    Cell Significance Index: -21.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0384
    Cell Significance Index: -21.6300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0450
    Cell Significance Index: -28.0800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0546
    Cell Significance Index: -0.3300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0667
    Cell Significance Index: -46.1600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0858
    Cell Significance Index: -0.7900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1113
    Cell Significance Index: -23.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1153
    Cell Significance Index: -3.0800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1646
    Cell Significance Index: -4.4100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2024
    Cell Significance Index: -3.0500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2209
    Cell Significance Index: -63.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.2443
    Cell Significance Index: -87.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.3288
    Cell Significance Index: -65.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3364
    Cell Significance Index: -38.5400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3720
    Cell Significance Index: -10.4000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3759
    Cell Significance Index: -54.6400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4357
    Cell Significance Index: -9.5400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4647
    Cell Significance Index: -6.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5453
    Cell Significance Index: -24.1200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.5498
    Cell Significance Index: -59.8000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5627
    Cell Significance Index: -12.1900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6147
    Cell Significance Index: -64.0000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6811
    Cell Significance Index: -18.2200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6893
    Cell Significance Index: -42.2600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7229
    Cell Significance Index: -27.3800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7349
    Cell Significance Index: -46.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.8392
    Cell Significance Index: -38.0400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9257
    Cell Significance Index: -29.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.9391
    Cell Significance Index: -20.0000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.9463
    Cell Significance Index: -14.1800
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.9665
    Cell Significance Index: -7.6300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.0025
    Cell Significance Index: -26.3600
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -1.0152
    Cell Significance Index: -8.5800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.0360
    Cell Significance Index: -12.3500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.0776
    Cell Significance Index: -18.0400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.0781
    Cell Significance Index: -72.4900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -1.2797
    Cell Significance Index: -10.4400
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -1.2809
    Cell Significance Index: -11.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SOD2 is a mitochondrial enzyme that is highly expressed in cells with high energy demands, such as neurons, muscle fibers, and erythrocytes. It is a homotetramer composed of four manganese ions, which are essential for its catalytic activity. SOD2 is highly specific for superoxide, with a Km value of 0.3 μM, making it an efficient enzyme for detoxifying ROS. **Pathways and Functions:** SOD2 is involved in various cellular pathways that regulate oxidative stress, inflammation, and immune responses. Its primary function is to remove superoxide radicals, which are highly reactive and can cause cellular damage. SOD2 also regulates other ROS, such as hydrogen peroxide, which is a potent oxidant that can damage cellular components. In addition, SOD2 is involved in the regulation of mitochondrial biogenesis, oxidative stress-induced intrinsic apoptotic signaling pathway, and the regulation of blood pressure. **Clinical Significance:** Dysregulation of SOD2 has been implicated in various diseases, including neurodegenerative disorders, cardiovascular diseases, and cancer. Mutations in the SOD2 gene have been associated with neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). Additionally, SOD2 has been shown to play a role in the regulation of blood pressure, and its dysregulation has been implicated in hypertension. Furthermore, SOD2 has been shown to have anti-inflammatory properties, and its dysregulation has been implicated in various inflammatory diseases, including atherosclerosis and rheumatoid arthritis. In cancer, SOD2 has been shown to have a tumor-suppressive effect, and its dysregulation has been implicated in cancer progression. **Significantly Expressed Cells:** SOD2 is highly expressed in cells with high energy demands, including: * Polychromatophilic erythroblast * Hematopoietic oligopotent progenitor cell * Embryonic stem cell * Peripheral blood mononuclear cell * Smooth muscle fiber of ileum * Ileal goblet cell * Orthochromatic erythroblast * Perivascular cell * Epidermal Langerhans cell * CD8-positive, alpha-beta regulatory T cell **Proteins:** SOD2 is also known as Superoxide dismutase [Mn], mitochondrial (SODM_HUMAN), and is also associated with other proteins, including Q96AM7_HUMAN, G5E9P6_HUMAN, and Q9UG59_HUMAN. In conclusion, SOD2 is a crucial enzyme that plays a vital role in maintaining cellular homeostasis and immune function. Its dysregulation has been implicated in various diseases, including neurodegenerative disorders, cardiovascular diseases, and cancer. Further research is needed to fully understand the mechanisms by which SOD2 regulates oxidative stress and immune responses, and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 1122452461

Symbol: SODM_HUMAN

Name: Superoxide dismutase [Mn], mitochondrial

UniProtKB Accession Codes:

P04179 B2R7R1 B3KUK2 B4DL20 B4E3K9 E1P5A9 P78434 Q16792 Q5TCM1 Q96EE6 Q9P2Z3

Database IDs:

AGR 1 Allergome 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CTD 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 DrugCentral 1 EC 1 EMBL 18 EMDB 1 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 67 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OGP 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 35 PDBsum 35 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 5 RefSeq 8 Rhea 1 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2462451

Title: Synthesis and processing of the precursor for human mangano-superoxide dismutase.

PubMed ID: 2462451

DOI: 10.1016/0167-4838(89)90058-7

PubMed ID: 3684581

Title: Human Mn superoxide dismutase cDNA sequence.

PubMed ID: 3684581

DOI: 10.1093/nar/15.21.9076

PubMed ID: 3399391

Title: Isolation of cDNAs encoding human manganese superoxide dismutase.

PubMed ID: 3399391

DOI: 10.1093/nar/16.13.6224

PubMed ID: 2831093

Title: Isolation and characterization of complementary DNAs encoding human manganese-containing superoxide dismutase.

PubMed ID: 2831093

DOI: 10.1016/0014-5793(88)81136-0

PubMed ID: 1699607

Title: Manganese superoxide dismutase: nucleotide and deduced amino acid sequence of a cDNA encoding a new human transcript.

PubMed ID: 1699607

DOI: 10.1016/0167-4781(90)90213-l

PubMed ID: 1988135

Title: Complementary DNA encoding human colon cancer manganese superoxide dismutase and the expression of its gene in human cells.

PubMed ID: 1988135

PubMed ID: 7702755

Title: Molecular structure and organization of the human manganese superoxide dismutase gene.

PubMed ID: 7702755

DOI: 10.1089/dna.1994.13.1127

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6386798

Title: The primary structure of human liver manganese superoxide dismutase.

PubMed ID: 6386798

DOI: 10.1016/s0021-9258(18)90788-x

PubMed ID: 7895732

Title: The human myocardial two-dimensional gel protein database: update 1994.

PubMed ID: 7895732

DOI: 10.1002/elps.11501501209

PubMed ID: 7498159

Title: The major protein expression profile and two-dimensional protein database of human heart.

PubMed ID: 7498159

DOI: 10.1002/elps.11501601192

PubMed ID: 9150946

Title: Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2.

PubMed ID: 9150946

DOI: 10.1002/elps.1150180342

PubMed ID: 10334867

Title: Tyrosine modifications and inactivation of active site manganese superoxide dismutase mutant (Y34F) by peroxynitrite.

PubMed ID: 10334867

DOI: 10.1006/abbi.1999.1202

PubMed ID: 16399855

Title: Detection of sequence-specific tyrosine nitration of manganese SOD and SERCA in cardiovascular disease and aging.

PubMed ID: 16399855

DOI: 10.1152/ajpheart.01293.2005

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20668652

Title: KRIT1 regulates the homeostasis of intracellular reactive oxygen species.

PubMed ID: 20668652

DOI: 10.1371/journal.pone.0011786

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21268071

Title: Protein stability of mitochondrial superoxide dismutase SOD2 is regulated by USP36.

PubMed ID: 21268071

DOI: 10.1002/jcb.22940

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 1394426

Title: The structure of human mitochondrial manganese superoxide dismutase reveals a novel tetrameric interface of two 4-helix bundles.

PubMed ID: 1394426

DOI: 10.1016/0092-8674(92)90270-m

PubMed ID: 8605177

Title: Human mitochondrial manganese superoxide dismutase polymorphic variant Ile58Thr reduces activity by destabilizing the tetrameric interface.

PubMed ID: 8605177

DOI: 10.1021/bi951892w

PubMed ID: 9537988

Title: Probing the active site of human manganese superoxide dismutase: the role of glutamine 143.

PubMed ID: 9537988

DOI: 10.1021/bi972395d

PubMed ID: 9537987

Title: Crystal structure of Y34F mutant human mitochondrial manganese superoxide dismutase and the functional role of tyrosine 34.

PubMed ID: 9537987

DOI: 10.1021/bi972394l

PubMed ID: 10852710

Title: Multiple replacements of glutamine 143 in human manganese superoxide dismutase: effects on structure, stability, and catalysis.

PubMed ID: 10852710

DOI: 10.1021/bi9929958

PubMed ID: 11580280

Title: Kinetic analysis of product inhibition in human manganese superoxide dismutase.

PubMed ID: 11580280

DOI: 10.1021/bi011047f

PubMed ID: 19265433

Title: Contribution of human manganese superoxide dismutase tyrosine 34 to structure and catalysis.

PubMed ID: 19265433

DOI: 10.1021/bi8023288

PubMed ID: 12624725

Title: The polymorphism of manganese superoxide dismutase is associated with diabetic nephropathy in Japanese type 2 diabetic patients.

PubMed ID: 12624725

DOI: 10.1007/s100380300021

PubMed ID: 18989629

Title: The manganese superoxide dismutase Val16Ala polymorphism is associated with decreased risk of diabetic nephropathy in Chinese patients with type 2 diabetes.

PubMed ID: 18989629

DOI: 10.1007/s11010-008-9943-x

Sequence Information:

  • Length: 222
  • Mass: 24750
  • Checksum: CA047D7900AE5905
  • Sequence:
    • MLSRAVCGTS RQLAPVLGYL GSRQKHSLPD LPYDYGALEP HINAQIMQLH HSKHHAAYVN 
NLNVTEEKYQ EALAKGDVTA QIALQPALKF NGGGHINHSI FWTNLSPNGG GEPKGELLEA 
IKRDFGSFDK FKEKLTAASV GVQGSGWGWL GFNKERGHLQ IAACPNQDPL QGTTGLIPLL 
GIDVWEHAYY LQYKNVRPDY LKAIWNVINW ENVTERYMAC KK

Genular Protein ID: 3744830480

Symbol: Q96AM7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96AM7

Database IDs:

ARBA 13 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 4 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 3 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 2 RefSeq 1 Rhea 1 SAM 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 140
  • Mass: 15745
  • Checksum: 499AC0467EF5C451
  • Sequence:
    • MLSRAVCGTS RQLAPALGYL GSRQKHSLPD LPYDYGALEP HINAQIMQLH HSKHHAAYVN 
NLNVTEEKYQ EALAKGRFQA ERREAVPGRG DPREPGPIRT GLSVEENSLR ICTGSEFSRH 
DSLSFKHMVY LIVEGVPRWV

Genular Protein ID: 2240446820

Symbol: G5E9P6_HUMAN

Name: N/A

UniProtKB Accession Codes:

G5E9P6

Database IDs:

ARBA 13 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 Ensembl 2 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 1 SAM 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 140
  • Mass: 15773
  • Checksum: 499ADF5676E5D351
  • Sequence:
    • MLSRAVCGTS RQLAPVLGYL GSRQKHSLPD LPYDYGALEP HINAQIMQLH HSKHHAAYVN 
NLNVTEEKYQ EALAKGRFQA ERREAVPGRG DPREPGPIRT GLSVEENSLR ICTGSEFSRH 
DSLSFKHMVY LIVEGVPRWV

Genular Protein ID: 4052390520

Symbol: Q9UG59_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9UG59

Database IDs:

ARBA 13 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 4 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 3 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 2 RefSeq 1 Rhea 1 SUPFAM 1

Sequence Information:

  • Length: 76
  • Mass: 8482
  • Checksum: 29A1102EC57C3C01
  • Sequence:
    • MLSRAVCGTS RQLAPVLGYL GSRQKHSLPD LPYDYGALEP HINAQIMQLH HSKHHAAYVN 
NLNVTEEKYQ EALAKG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.