Details for: SOD2

Gene ID: 6648

Symbol: SOD2

Ensembl ID: ENSG00000291237

Description: superoxide dismutase 2

Associated with

Other Information

Genular Protein ID: 1122452461

Symbol: SODM_HUMAN

Name: Superoxide dismutase [Mn], mitochondrial

UniProtKB Accession Codes:

P04179 B2R7R1 B3KUK2 B4DL20 B4E3K9 E1P5A9 P78434 Q16792 Q5TCM1 Q96EE6 Q9P2Z3

Database IDs:

AGR 1 Allergome 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 ChEBI 9 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DrugBank 6 DrugCentral 1 EC 1 EMBL 18 EPD 1 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 67 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OGP 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 47 PDBsum 34 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 5 RefSeq 8 Rhea 1 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2462451

Title: Synthesis and processing of the precursor for human mangano-superoxide dismutase.

PubMed ID: 2462451

DOI: 10.1016/0167-4838(89)90058-7

PubMed ID: 3684581

Title: Human Mn superoxide dismutase cDNA sequence.

PubMed ID: 3684581

DOI: 10.1093/nar/15.21.9076

PubMed ID: 3399391

Title: Isolation of cDNAs encoding human manganese superoxide dismutase.

PubMed ID: 3399391

DOI: 10.1093/nar/16.13.6224

PubMed ID: 2831093

Title: Isolation and characterization of complementary DNAs encoding human manganese-containing superoxide dismutase.

PubMed ID: 2831093

DOI: 10.1016/0014-5793(88)81136-0

PubMed ID: 1699607

Title: Manganese superoxide dismutase: nucleotide and deduced amino acid sequence of a cDNA encoding a new human transcript.

PubMed ID: 1699607

DOI: 10.1016/0167-4781(90)90213-l

PubMed ID: 1988135

Title: Complementary DNA encoding human colon cancer manganese superoxide dismutase and the expression of its gene in human cells.

PubMed ID: 1988135

PubMed ID: 7702755

Title: Molecular structure and organization of the human manganese superoxide dismutase gene.

PubMed ID: 7702755

DOI: 10.1089/dna.1994.13.1127

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6386798

Title: The primary structure of human liver manganese superoxide dismutase.

PubMed ID: 6386798

DOI: 10.1016/s0021-9258(18)90788-x

PubMed ID: 7895732

Title: The human myocardial two-dimensional gel protein database: update 1994.

PubMed ID: 7895732

DOI: 10.1002/elps.11501501209

PubMed ID: 7498159

Title: The major protein expression profile and two-dimensional protein database of human heart.

PubMed ID: 7498159

DOI: 10.1002/elps.11501601192

PubMed ID: 9150946

Title: Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2.

PubMed ID: 9150946

DOI: 10.1002/elps.1150180342

PubMed ID: 10334867

Title: Tyrosine modifications and inactivation of active site manganese superoxide dismutase mutant (Y34F) by peroxynitrite.

PubMed ID: 10334867

DOI: 10.1006/abbi.1999.1202

PubMed ID: 16399855

Title: Detection of sequence-specific tyrosine nitration of manganese SOD and SERCA in cardiovascular disease and aging.

PubMed ID: 16399855

DOI: 10.1152/ajpheart.01293.2005

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20668652

Title: KRIT1 regulates the homeostasis of intracellular reactive oxygen species.

PubMed ID: 20668652

DOI: 10.1371/journal.pone.0011786

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21268071

Title: Protein stability of mitochondrial superoxide dismutase SOD2 is regulated by USP36.

PubMed ID: 21268071

DOI: 10.1002/jcb.22940

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 1394426

Title: The structure of human mitochondrial manganese superoxide dismutase reveals a novel tetrameric interface of two 4-helix bundles.

PubMed ID: 1394426

DOI: 10.1016/0092-8674(92)90270-m

PubMed ID: 8605177

Title: Human mitochondrial manganese superoxide dismutase polymorphic variant Ile58Thr reduces activity by destabilizing the tetrameric interface.

PubMed ID: 8605177

DOI: 10.1021/bi951892w

PubMed ID: 9537988

Title: Probing the active site of human manganese superoxide dismutase: the role of glutamine 143.

PubMed ID: 9537988

DOI: 10.1021/bi972395d

PubMed ID: 9537987

Title: Crystal structure of Y34F mutant human mitochondrial manganese superoxide dismutase and the functional role of tyrosine 34.

PubMed ID: 9537987

DOI: 10.1021/bi972394l

PubMed ID: 10852710

Title: Multiple replacements of glutamine 143 in human manganese superoxide dismutase: effects on structure, stability, and catalysis.

PubMed ID: 10852710

DOI: 10.1021/bi9929958

PubMed ID: 11580280

Title: Kinetic analysis of product inhibition in human manganese superoxide dismutase.

PubMed ID: 11580280

DOI: 10.1021/bi011047f

PubMed ID: 19265433

Title: Contribution of human manganese superoxide dismutase tyrosine 34 to structure and catalysis.

PubMed ID: 19265433

DOI: 10.1021/bi8023288

PubMed ID: 12624725

Title: The polymorphism of manganese superoxide dismutase is associated with diabetic nephropathy in Japanese type 2 diabetic patients.

PubMed ID: 12624725

DOI: 10.1007/s100380300021

PubMed ID: 18989629

Title: The manganese superoxide dismutase Val16Ala polymorphism is associated with decreased risk of diabetic nephropathy in Chinese patients with type 2 diabetes.

PubMed ID: 18989629

DOI: 10.1007/s11010-008-9943-x

Sequence Information:

  • Length: 222
  • Mass: 24750
  • Checksum: CA047D7900AE5905
  • Sequence:
    • MLSRAVCGTS RQLAPVLGYL GSRQKHSLPD LPYDYGALEP HINAQIMQLH HSKHHAAYVN 
NLNVTEEKYQ EALAKGDVTA QIALQPALKF NGGGHINHSI FWTNLSPNGG GEPKGELLEA 
IKRDFGSFDK FKEKLTAASV GVQGSGWGWL GFNKERGHLQ IAACPNQDPL QGTTGLIPLL 
GIDVWEHAYY LQYKNVRPDY LKAIWNVINW ENVTERYMAC KK

Genular Protein ID: 4052390520

Symbol: Q9UG59_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9UG59

Database IDs:

ARBA 14 AlphaFoldDB 1 BioGRID-ORCS 1 ChEBI 5 DNASU 1 EC 1 EMBL 2 GO 3 Gene3D 1 GenomeRNAi 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 2 RefSeq 1 Rhea 1 SUPFAM 1

Sequence Information:

  • Length: 76
  • Mass: 8482
  • Checksum: 29A1102EC57C3C01
  • Sequence:
    • MLSRAVCGTS RQLAPVLGYL GSRQKHSLPD LPYDYGALEP HINAQIMQLH HSKHHAAYVN 
NLNVTEEKYQ EALAKG

Genular Protein ID: 2240446820

Symbol: G5E9P6_HUMAN

Name: N/A

UniProtKB Accession Codes:

G5E9P6

Database IDs:

ARBA 14 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 ChEBI 5 ChiTaRS 1 DNASU 1 EC 1 EMBL 3 EPD 1 Ensembl 2 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 3 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 1 SAM 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 140
  • Mass: 15773
  • Checksum: 499ADF5676E5D351
  • Sequence:
    • MLSRAVCGTS RQLAPVLGYL GSRQKHSLPD LPYDYGALEP HINAQIMQLH HSKHHAAYVN 
NLNVTEEKYQ EALAKGRFQA ERREAVPGRG DPREPGPIRT GLSVEENSLR ICTGSEFSRH 
DSLSFKHMVY LIVEGVPRWV

Genular Protein ID: 3744830480

Symbol: Q96AM7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96AM7

Database IDs:

ARBA 14 AlphaFoldDB 1 BioGRID-ORCS 1 ChEBI 5 DNASU 1 EC 1 EMBL 2 GO 3 Gene3D 1 GenomeRNAi 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 2 RefSeq 1 Rhea 1 SAM 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 140
  • Mass: 15745
  • Checksum: 499AC0467EF5C451
  • Sequence:
    • MLSRAVCGTS RQLAPALGYL GSRQKHSLPD LPYDYGALEP HINAQIMQLH HSKHHAAYVN 
NLNVTEEKYQ EALAKGRFQA ERREAVPGRG DPREPGPIRT GLSVEENSLR ICTGSEFSRH 
DSLSFKHMVY LIVEGVPRWV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.