SOD2 | ENSG00000291237 | NCBI 6648

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Pathway Categories (for ONTOLOGY source):

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Node Color (Target Cell CSI, relative to current network):
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- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [SOD2](/details-gene/6648), or Superoxide Dismutase 2, is a critical mitochondrial enzyme that plays a central role in cellular defense against oxidative stress. It functions as a manganese-dependent superoxide dismutase, catalyzing the conversion of superoxide radicals, which are toxic byproducts of mitochondrial respiration, into less harmful molecules ([GO:0004784](https://www.ebi.ac.uk/QuickGO/term/GO:0004784)). Its expression is most significant in cells with high metabolic activity and those involved in inflammatory responses, such as [elicited macrophage](/details-cell/CL0000861), various monocyte subsets, and fibroblasts. This expression pattern underscores its fundamental role in maintaining mitochondrial integrity and cellular homeostasis, particularly under conditions of physiological or pathological stress. Deficiencies in [SOD2](/details-gene/6648) are associated with several clinical conditions, as indicated by its OMIM annotation ([147460](https://omim.org/entry/147460)). ## Cellular Roles and Expression Landscape The expression profile of [SOD2](/details-gene/6648) highlights its indispensable function in the myeloid lineage and in structural cells that form tissue barriers. **Overall**, the gene shows the highest significance in phagocytic cells, including [elicited macrophage](/details-cell/CL0000861) (CSI: 69.54), [CD14-low, CD16-positive monocyte](/details-cell/CL0002396) (CSI: 62.79), and [alternatively activated macrophage](/details-cell/CL0000890) (CSI: 36.32). This is consistent with the high levels of reactive oxygen species (ROS) produced by these cells during processes like phagocytosis and inflammatory signaling, necessitating a robust antioxidant defense system to prevent self-inflicted damage. Beyond the immune system, [SOD2](/details-gene/6648) is also highly significant in various fibroblast populations, including [skin fibroblast](/details-cell/CL0002620) (CSI: 46.86) and [bronchus fibroblast of lung](/details-cell/CL2000093) (CSI: 42.34), as well as in epithelial cells such as [keratinocyte](/details-cell/CL0000312) (CSI: 35.69) and [epithelial cell of lower respiratory tract](/details-cell/CL0002632) (CSI: 43.51). This suggests a broad protective role in maintaining the integrity of tissues frequently exposed to environmental stressors. Conversely, [SOD2](/details-gene/6648) expression is notably low in several specialized cell types. Its lack of significance in various neuronal subtypes, such as [chandelier pvalb GABAergic cortical interneuron](/details-cell/CL4023036) (CSI: -4.73) and [retinal rod cell](/details-cell/CL0000604) (CSI: -4.44), as well as in quiescent lymphocytes like [naive T cell](/details-cell/CL0000898) (CSI: -5.10), defines its functional niche. This pattern suggests that while all cells require some ROS management, the high-level expression of [SOD2](/details-gene/6648) is particularly critical for cells characterized by high rates of mitochondrial respiration or those that utilize ROS for signaling and defense. ## Pathways and Molecular Function [SOD2](/details-gene/6648) encodes an enzyme whose primary molecular function is `Superoxide dismutase activity` ([GO:0004784](https://www.ebi.ac.uk/QuickGO/term/GO:0004784)), which is dependent on `Manganese ion binding` ([GO:0030145](https://www.ebi.ac.uk/QuickGO/term/GO:0030145)). This function is integral to the biological process of `Removal of superoxide radicals` ([GO:0019430](https://www.ebi.ac.uk/QuickGO/term/GO:0019430)). The enzyme is localized to the `Mitochondrial matrix` ([GO:0005759](https://www.ebi.ac.uk/QuickGO/term/GO:0005759)), placing it at the primary site of superoxide production from the `Respiratory electron transport chain` ([GO:0022904](https://www.ebi.ac.uk/QuickGO/term/GO:0022904)). This core function places [SOD2](/details-gene/6648) at the center of the `Cellular response to oxidative stress` ([GO:0034599](https://www.ebi.ac.uk/QuickGO/term/GO:0034599)) and the Reactome pathway for `Detoxification of reactive oxygen species` ([R-HSA-3299685](https://reactome.org/content/detail/R-HSA-3299685)). By controlling mitochondrial ROS levels, [SOD2](/details-gene/6648) influences critical downstream cellular decisions, including the `Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway` ([GO:1902176](https://www.ebi.ac.uk/QuickGO/term/GO:1902176)). This links mitochondrial health directly to cell survival. Furthermore, pathway analysis implicates [SOD2](/details-gene/6648) in broader physiological processes. Its involvement in `Cytokine signaling in immune system` ([R-HSA-1280215](https://reactome.org/content/detail/R-HSA-1280215)) aligns with its high expression in macrophages and monocytes, suggesting that managing oxidative stress is a key checkpoint in modulating immune responses. The gene's connection to pathways associated with `Neurodegenerative diseases` ([R-HSA-8863678](https://reactome.org/content/detail/R-HSA-8863678)) highlights the critical importance of mitochondrial ROS detoxification in maintaining long-term neuronal health. This is supported by early research characterizing the gene's sequence and structure ([Link](https://doi.org/10.1093/nar/15.21.9076), [Link](https://doi.org/10.1089/dna.1994.13.1127)). ## Research Directions The widespread and essential role of [SOD2](/details-gene/6648) in managing mitochondrial oxidative stress suggests several avenues for future research, particularly concerning its role in cellular differentiation and disease pathology. ### Proposed Hypotheses: 1. **Role in Macrophage Polarization:** Given its high significance in both pro-inflammatory ([elicited macrophage](/details-cell/CL0000861)) and anti-inflammatory ([alternatively activated macrophage](/details-cell/CL0000890)) macrophage subtypes, it is plausible that [SOD2](/details-gene/6648) is a critical regulator of macrophage metabolic reprogramming and functional polarization. We hypothesize that the expression level of [SOD2](/details-gene/6648) determines the capacity of a macrophage to sustain the distinct metabolic profiles required for M1 (glycolytic) versus M2 (oxidative) states, thereby acting as a fulcrum in balancing immune responses. 2. **Contribution to Fibroblast Senescence and Tissue Fibrosis:** The high expression of [SOD2](/details-gene/6648) in fibroblasts from tissues like the lung and skin suggests a key role in preventing stress-induced premature senescence. We hypothesize that chronic oxidative stress leading to downregulation or inactivation of [SOD2](/details-gene/6648) in fibroblasts is a key event that triggers their transition into a senescent, pro-fibrotic phenotype, thereby contributing to age-related diseases such as idiopathic pulmonary fibrosis. ### Experimental Approach: To test the hypothesis regarding macrophage polarization, a targeted experiment could be designed. CRISPR-Cas9-mediated knockout of [SOD2](/details-gene/6648) could be performed in primary human monocytes. These modified cells, alongside wild-type controls, would then be differentiated into M1 macrophages (using LPS and IFN-γ) and M2 macrophages (using IL-4 and IL-13). The primary readouts would include: (1) quantification of mitochondrial superoxide levels using MitoSOX Red flow cytometry; (2) assessment of metabolic profiles via Seahorse XF analysis to measure oxygen consumption rate and extracellular acidification rate; and (3) analysis of M1/M2 marker gene and protein expression (e.g., *iNOS*, *ARG1*, *CD206*, *TNF*) by qRT-PCR and western blot to determine if loss of [SOD2](/details-gene/6648) impairs the ability to achieve a stable M2 phenotype. ### Therapeutic Potential: As an intracellular enzyme, [SOD2](/details-gene/6648) is not a conventional target for antibody-based therapies. The therapeutic strategy would likely involve **activation** or functional supplementation rather than inhibition, as loss of function is associated with pathology. Small-molecule mimetics of [SOD2](/details-gene/6648) or compounds that enhance its activity could have significant therapeutic value in a wide range of conditions linked to mitochondrial oxidative stress, including neurodegenerative diseases, cardiovascular disease, and inflammatory disorders. The primary challenge would be ensuring specific delivery to the mitochondria of affected cells to maximize efficacy and minimize potential off-target effects, as systemic modulation of such a fundamental process could be detrimental.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Genular Protein ID: 1122452461

Symbol: SODM_HUMAN

Name: Superoxide dismutase [Mn], mitochondrial

UniProtKB Accession Codes:

P04179 B2R7R1 B3KUK2 B4DL20 B4E3K9 E1P5A9 P78434 Q16792 Q5TCM1 Q96EE6 Q9P2Z3

Database IDs:

Citations:

PubMed ID: 2462451

Title: Synthesis and processing of the precursor for human mangano-superoxide dismutase.

PubMed ID: 2462451

DOI: 10.1016/0167-4838(89)90058-7

PubMed ID: 3684581

Title: Human Mn superoxide dismutase cDNA sequence.

PubMed ID: 3684581

DOI: 10.1093/nar/15.21.9076

PubMed ID: 3399391

Title: Isolation of cDNAs encoding human manganese superoxide dismutase.

PubMed ID: 3399391

DOI: 10.1093/nar/16.13.6224

PubMed ID: 2831093

Title: Isolation and characterization of complementary DNAs encoding human manganese-containing superoxide dismutase.

PubMed ID: 2831093

DOI: 10.1016/0014-5793(88)81136-0

PubMed ID: 1699607

Title: Manganese superoxide dismutase: nucleotide and deduced amino acid sequence of a cDNA encoding a new human transcript.

PubMed ID: 1699607

DOI: 10.1016/0167-4781(90)90213-l

PubMed ID: 1988135

Title: Complementary DNA encoding human colon cancer manganese superoxide dismutase and the expression of its gene in human cells.

PubMed ID: 1988135

PubMed ID: 7702755

Title: Molecular structure and organization of the human manganese superoxide dismutase gene.

PubMed ID: 7702755

DOI: 10.1089/dna.1994.13.1127

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6386798

Title: The primary structure of human liver manganese superoxide dismutase.

PubMed ID: 6386798

DOI: 10.1016/s0021-9258(18)90788-x

PubMed ID: 7895732

Title: The human myocardial two-dimensional gel protein database: update 1994.

PubMed ID: 7895732

DOI: 10.1002/elps.11501501209

PubMed ID: 7498159

Title: The major protein expression profile and two-dimensional protein database of human heart.

PubMed ID: 7498159

DOI: 10.1002/elps.11501601192

PubMed ID: 9150946

Title: Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2.

PubMed ID: 9150946

DOI: 10.1002/elps.1150180342

PubMed ID: 10334867

Title: Tyrosine modifications and inactivation of active site manganese superoxide dismutase mutant (Y34F) by peroxynitrite.

PubMed ID: 10334867

DOI: 10.1006/abbi.1999.1202

PubMed ID: 16399855

Title: Detection of sequence-specific tyrosine nitration of manganese SOD and SERCA in cardiovascular disease and aging.

PubMed ID: 16399855

DOI: 10.1152/ajpheart.01293.2005

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20668652

Title: KRIT1 regulates the homeostasis of intracellular reactive oxygen species.

PubMed ID: 20668652

DOI: 10.1371/journal.pone.0011786

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21268071

Title: Protein stability of mitochondrial superoxide dismutase SOD2 is regulated by USP36.

PubMed ID: 21268071

DOI: 10.1002/jcb.22940

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 1394426

Title: The structure of human mitochondrial manganese superoxide dismutase reveals a novel tetrameric interface of two 4-helix bundles.

PubMed ID: 1394426

DOI: 10.1016/0092-8674(92)90270-m

PubMed ID: 8605177

Title: Human mitochondrial manganese superoxide dismutase polymorphic variant Ile58Thr reduces activity by destabilizing the tetrameric interface.

PubMed ID: 8605177

DOI: 10.1021/bi951892w

PubMed ID: 9537988

Title: Probing the active site of human manganese superoxide dismutase: the role of glutamine 143.

PubMed ID: 9537988

DOI: 10.1021/bi972395d

PubMed ID: 9537987

Title: Crystal structure of Y34F mutant human mitochondrial manganese superoxide dismutase and the functional role of tyrosine 34.

PubMed ID: 9537987

DOI: 10.1021/bi972394l

PubMed ID: 10852710

Title: Multiple replacements of glutamine 143 in human manganese superoxide dismutase: effects on structure, stability, and catalysis.

PubMed ID: 10852710

DOI: 10.1021/bi9929958

PubMed ID: 11580280

Title: Kinetic analysis of product inhibition in human manganese superoxide dismutase.

PubMed ID: 11580280

DOI: 10.1021/bi011047f

PubMed ID: 19265433

Title: Contribution of human manganese superoxide dismutase tyrosine 34 to structure and catalysis.

PubMed ID: 19265433

DOI: 10.1021/bi8023288

PubMed ID: 12624725

Title: The polymorphism of manganese superoxide dismutase is associated with diabetic nephropathy in Japanese type 2 diabetic patients.

PubMed ID: 12624725

DOI: 10.1007/s100380300021

PubMed ID: 18989629

Title: The manganese superoxide dismutase Val16Ala polymorphism is associated with decreased risk of diabetic nephropathy in Chinese patients with type 2 diabetes.

PubMed ID: 18989629

DOI: 10.1007/s11010-008-9943-x

Sequence Information:

Length: 222
Mass: 24750
Checksum: CA047D7900AE5905
Sequence:

MLSRAVCGTS RQLAPVLGYL GSRQKHSLPD LPYDYGALEP HINAQIMQLH HSKHHAAYVN 
NLNVTEEKYQ EALAKGDVTA QIALQPALKF NGGGHINHSI FWTNLSPNGG GEPKGELLEA 
IKRDFGSFDK FKEKLTAASV GVQGSGWGWL GFNKERGHLQ IAACPNQDPL QGTTGLIPLL 
GIDVWEHAYY LQYKNVRPDY LKAIWNVINW ENVTERYMAC KK

Genular Protein ID: 3744830480

Symbol: Q96AM7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96AM7

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 140
Mass: 15745
Checksum: 499AC0467EF5C451
Sequence:

MLSRAVCGTS RQLAPALGYL GSRQKHSLPD LPYDYGALEP HINAQIMQLH HSKHHAAYVN 
NLNVTEEKYQ EALAKGRFQA ERREAVPGRG DPREPGPIRT GLSVEENSLR ICTGSEFSRH 
DSLSFKHMVY LIVEGVPRWV

Genular Protein ID: 2240446820

Symbol: G5E9P6_HUMAN

Name: N/A

UniProtKB Accession Codes:

G5E9P6

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

Length: 140
Mass: 15773
Checksum: 499ADF5676E5D351
Sequence:

MLSRAVCGTS RQLAPVLGYL GSRQKHSLPD LPYDYGALEP HINAQIMQLH HSKHHAAYVN 
NLNVTEEKYQ EALAKGRFQA ERREAVPGRG DPREPGPIRT GLSVEENSLR ICTGSEFSRH 
DSLSFKHMVY LIVEGVPRWV

Genular Protein ID: 4052390520

Symbol: Q9UG59_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9UG59

Database IDs:

Sequence Information:

Length: 76
Mass: 8482
Checksum: 29A1102EC57C3C01
Sequence:

MLSRAVCGTS RQLAPVLGYL GSRQKHSLPD LPYDYGALEP HINAQIMQLH HSKHHAAYVN 
NLNVTEEKYQ EALAKG

	Overall overall
	Acute kidney failure MONDO0002492
	Alzheimer disease MONDO0004975
	Amyotrophic lateral sclerosis MONDO0004976
	Basal cell carcinoma MONDO0020804
	Bipolar disorder MONDO0004985
	Bipolar I disorder MONDO0001866
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Healthy UBERON0000178_PATO0000461
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Brain UBERON0000955
	Breast UBERON0000310
	\|— Breast Healthy UBERON0000310_PATO0000461
	\|— Breast cancer MONDO0007254
	Bronchus UBERON0002185
	Caudate lobe of liver UBERON0001117
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Cerebrospinal fluid UBERON0001359
	Choroid plexus UBERON0001886
	Chronic kidney disease MONDO0005300
	Colon UBERON0001155
	Colorectal cancer MONDO0005575
	Cornea UBERON0000964
	\|— Cornea Healthy UBERON0000964_PATO0000461
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Dementia MONDO0001627
	Dental pulp UBERON0001754
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Bipolar disorder UBERON0009834_MONDO0004985
	\|— Dorsolateral prefrontal cortex Bipolar I disorder UBERON0009834_MONDO0001866
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	\|— Dorsolateral prefrontal cortex Schizophrenia UBERON0009834_MONDO0005090
	\|— Dorsolateral prefrontal cortex Vascular dementia UBERON0009834_MONDO0004648
	Duodenum UBERON0002114
	\|— Duodenum Healthy UBERON0002114_PATO0000461
	Fallopian tube UBERON0003889
	Fovea centralis UBERON0001786
	\|— Fovea centralis Healthy UBERON0001786_PATO0000461
	Frontal cortex UBERON0001870
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileum UBERON0002116
	\|— Ileum Healthy UBERON0002116_PATO0000461
	Islet of Langerhans UBERON0000006
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Leukoencephalopathy, diffuse hereditary, with spheroids 1 MONDO0800027
	Liver UBERON0002107
	\|— Liver Healthy UBERON0002107_PATO0000461
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung Renal cell carcinoma UBERON0002048_MONDO0005086
	\|— Lung adenocarcinoma MONDO0005061
	Lymph node UBERON0000029
	\|— Lymph node Metastatic melanoma UBERON0000029_MONDO0005191
	Malignant ovarian serous tumor MONDO0024885
	Medial orbital frontal cortex UBERON0022352
	Mesenteric lymph node UBERON0002509
	\|— Mesenteric lymph node Healthy UBERON0002509_PATO0000461
	Metastatic melanoma MONDO0005191
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Nasopharynx UBERON0001728
	Occipital cortex UBERON0016540
	Ovary UBERON0000992
	\|— Ovary Healthy UBERON0000992_PATO0000461
	Parkinson disease MONDO0005180
	Peripheral region of retina UBERON0013682
	\|— Peripheral region of retina Healthy UBERON0013682_PATO0000461
	Placenta UBERON0001987
	\|— Placenta Healthy UBERON0001987_PATO0000461
	Pleural effusion UBERON0000175
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Prefrontal cortex UBERON0000451
	Primary motor cortex UBERON0001384
	Prostate gland UBERON0002367
	Renal cell carcinoma MONDO0005086
	Renal medulla UBERON0000362
	\|— Renal medulla Healthy UBERON0000362_PATO0000461
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Schizophrenia MONDO0005090
	Sclera UBERON0001773
	\|— Sclera Healthy UBERON0001773_PATO0000461
	Sigmoid colon UBERON0001159
	Skin of body UBERON0002097
	\|— Skin of body Healthy UBERON0002097_PATO0000461
	Small cell lung carcinoma MONDO0008433
	Spleen UBERON0002106
	\|— Spleen Healthy UBERON0002106_PATO0000461
	Substantia nigra pars compacta UBERON0001965
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	Thymus UBERON0002370
	\|— Thymus Healthy UBERON0002370_PATO0000461
	Trachea UBERON0003126
	Transverse colon UBERON0001157
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Upper lobe of left lung UBERON0008952
	Vascular dementia MONDO0004648

Details for: SOD2

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Synthesis and processing of the precursor for human mangano-superoxide dismutase. PubMed ID: 2462451

Human Mn superoxide dismutase cDNA sequence. PubMed ID: 3684581

Isolation of cDNAs encoding human manganese superoxide dismutase. PubMed ID: 3399391

Isolation and characterization of complementary DNAs encoding human manganese-containing superoxide dismutase. PubMed ID: 2831093

Manganese superoxide dismutase: nucleotide and deduced amino acid sequence of a cDNA encoding a new human transcript. PubMed ID: 1699607

Complementary DNA encoding human colon cancer manganese superoxide dismutase and the expression of its gene in human cells. PubMed ID: 1988135

Molecular structure and organization of the human manganese superoxide dismutase gene. PubMed ID: 7702755

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The primary structure of human liver manganese superoxide dismutase. PubMed ID: 6386798

The human myocardial two-dimensional gel protein database: update 1994. PubMed ID: 7895732

The major protein expression profile and two-dimensional protein database of human heart. PubMed ID: 7498159

Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2. PubMed ID: 9150946

Tyrosine modifications and inactivation of active site manganese superoxide dismutase mutant (Y34F) by peroxynitrite. PubMed ID: 10334867

Detection of sequence-specific tyrosine nitration of manganese SOD and SERCA in cardiovascular disease and aging. PubMed ID: 16399855

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

KRIT1 regulates the homeostasis of intracellular reactive oxygen species. PubMed ID: 20668652

Initial characterization of the human central proteome. PubMed ID: 21269460

Protein stability of mitochondrial superoxide dismutase SOD2 is regulated by USP36. PubMed ID: 21268071

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

The structure of human mitochondrial manganese superoxide dismutase reveals a novel tetrameric interface of two 4-helix bundles. PubMed ID: 1394426

Human mitochondrial manganese superoxide dismutase polymorphic variant Ile58Thr reduces activity by destabilizing the tetrameric interface. PubMed ID: 8605177

Probing the active site of human manganese superoxide dismutase: the role of glutamine 143. PubMed ID: 9537988

Crystal structure of Y34F mutant human mitochondrial manganese superoxide dismutase and the functional role of tyrosine 34. PubMed ID: 9537987

Multiple replacements of glutamine 143 in human manganese superoxide dismutase: effects on structure, stability, and catalysis. PubMed ID: 10852710

Kinetic analysis of product inhibition in human manganese superoxide dismutase. PubMed ID: 11580280

Contribution of human manganese superoxide dismutase tyrosine 34 to structure and catalysis. PubMed ID: 19265433

The polymorphism of manganese superoxide dismutase is associated with diabetic nephropathy in Japanese type 2 diabetic patients. PubMed ID: 12624725

The manganese superoxide dismutase Val16Ala polymorphism is associated with decreased risk of diabetic nephropathy in Chinese patients with type 2 diabetes. PubMed ID: 18989629

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

The sequence of the human genome. PubMed ID: 11181995

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

PubMed ID: 2462451

PubMed ID: 3684581

PubMed ID: 3399391

PubMed ID: 2831093

PubMed ID: 1699607

PubMed ID: 1988135

PubMed ID: 7702755

PubMed ID: 14702039

PubMed ID: 14574404

PubMed ID: 15489334

PubMed ID: 6386798

PubMed ID: 7895732

PubMed ID: 7498159

PubMed ID: 9150946

PubMed ID: 10334867

PubMed ID: 16399855

PubMed ID: 19608861

PubMed ID: 20668652

PubMed ID: 21269460

PubMed ID: 21268071

PubMed ID: 24275569

PubMed ID: 25944712

PubMed ID: 1394426

PubMed ID: 8605177

PubMed ID: 9537988

PubMed ID: 9537987

PubMed ID: 10852710

PubMed ID: 11580280

PubMed ID: 19265433

PubMed ID: 12624725

PubMed ID: 18989629

PubMed ID: 15489334

PubMed ID: 11237011

PubMed ID: 11181995

PubMed ID: 14574404

PubMed ID: 15496913

PubMed ID: 19608861

PubMed ID: 21269460

PubMed ID: 24275569

PubMed ID: 25944712