Details for: SOX3

Gene ID: 6658

Symbol: SOX3

Ensembl ID: ENSG00000134595

Description: SRY-box transcription factor 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.9273
    Cell Significance Index: 67.6300
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 2.3047
    Cell Significance Index: 13.1000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.5783
    Cell Significance Index: 26.9800
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.1681
    Cell Significance Index: 1.6700
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.1541
    Cell Significance Index: 1.1200
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.0741
    Cell Significance Index: 0.4400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0717
    Cell Significance Index: 1.1100
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: 0.0044
    Cell Significance Index: 0.0400
  • Cell Name: glioblast (CL0000030)
    Fold Change: 0.0016
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0035
    Cell Significance Index: -6.5000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0053
    Cell Significance Index: -9.7500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0058
    Cell Significance Index: -7.8800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0062
    Cell Significance Index: -9.6100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0087
    Cell Significance Index: -6.4700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0097
    Cell Significance Index: -6.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0099
    Cell Significance Index: -7.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0113
    Cell Significance Index: -6.3800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0128
    Cell Significance Index: -7.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0144
    Cell Significance Index: -6.5300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0180
    Cell Significance Index: -6.4700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0225
    Cell Significance Index: -6.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0375
    Cell Significance Index: -7.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0451
    Cell Significance Index: -6.5600
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0461
    Cell Significance Index: -0.3200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0506
    Cell Significance Index: -1.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0519
    Cell Significance Index: -7.1300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0535
    Cell Significance Index: -6.2400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0566
    Cell Significance Index: -9.6700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0586
    Cell Significance Index: -0.8000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0617
    Cell Significance Index: -7.0700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0642
    Cell Significance Index: -6.6900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0665
    Cell Significance Index: -8.5900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0806
    Cell Significance Index: -0.9800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0812
    Cell Significance Index: -5.1200
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.0882
    Cell Significance Index: -1.2000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0975
    Cell Significance Index: -5.9900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0996
    Cell Significance Index: -6.7000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1016
    Cell Significance Index: -5.7000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1038
    Cell Significance Index: -3.8100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1095
    Cell Significance Index: -1.1900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1096
    Cell Significance Index: -8.1700
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.1103
    Cell Significance Index: -1.0800
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.1216
    Cell Significance Index: -1.1800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1290
    Cell Significance Index: -2.0900
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.1325
    Cell Significance Index: -1.8100
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1395
    Cell Significance Index: -1.3800
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.1400
    Cell Significance Index: -1.4100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1432
    Cell Significance Index: -1.8500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1440
    Cell Significance Index: -7.5600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1495
    Cell Significance Index: -2.0500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1623
    Cell Significance Index: -7.1800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1669
    Cell Significance Index: -8.4400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1719
    Cell Significance Index: -4.5200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1830
    Cell Significance Index: -8.6000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.1855
    Cell Significance Index: -1.4300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1899
    Cell Significance Index: -6.6000
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.1943
    Cell Significance Index: -1.1900
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.1998
    Cell Significance Index: -1.3000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2002
    Cell Significance Index: -7.5800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2015
    Cell Significance Index: -7.0600
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.2027
    Cell Significance Index: -1.1900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2095
    Cell Significance Index: -6.8600
  • Cell Name: articular chondrocyte (CL1001607)
    Fold Change: -0.2196
    Cell Significance Index: -1.1900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2200
    Cell Significance Index: -6.4800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2226
    Cell Significance Index: -7.0900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2362
    Cell Significance Index: -6.7400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2366
    Cell Significance Index: -6.3400
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.2514
    Cell Significance Index: -3.4200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2695
    Cell Significance Index: -5.9000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2948
    Cell Significance Index: -8.4500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2979
    Cell Significance Index: -7.5900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2999
    Cell Significance Index: -7.4800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3021
    Cell Significance Index: -7.2500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.3086
    Cell Significance Index: -4.4800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3130
    Cell Significance Index: -9.9000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.3143
    Cell Significance Index: -2.6400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3289
    Cell Significance Index: -6.9800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.3356
    Cell Significance Index: -4.2400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.3389
    Cell Significance Index: -6.6700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3463
    Cell Significance Index: -8.6500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3522
    Cell Significance Index: -7.6100
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.3564
    Cell Significance Index: -4.2000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3587
    Cell Significance Index: -5.6900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3591
    Cell Significance Index: -7.1000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3603
    Cell Significance Index: -8.7900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3641
    Cell Significance Index: -7.6000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.3653
    Cell Significance Index: -6.0200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3771
    Cell Significance Index: -7.5700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3800
    Cell Significance Index: -5.6100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3828
    Cell Significance Index: -6.5600
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.3840
    Cell Significance Index: -4.4800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3882
    Cell Significance Index: -6.5300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3901
    Cell Significance Index: -10.4200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3902
    Cell Significance Index: -6.5300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.4027
    Cell Significance Index: -8.0300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.4061
    Cell Significance Index: -5.8200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.4074
    Cell Significance Index: -5.6500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.4101
    Cell Significance Index: -7.0900
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: -0.4226
    Cell Significance Index: -3.9900
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.4229
    Cell Significance Index: -5.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional regulation:** SOX3 is a transcription factor that binds to specific DNA sequences, thereby regulating the expression of target genes. 2. **Dual functionality:** SOX3 exhibits both transcriptional activator and repressor activities, depending on the context in which it is expressed. 3. **Cell-type specificity:** SOX3 is significantly expressed in various cell types, including hematopoietic stem cells, T cells, plasma cells, and cerebral cortex GABAergic interneurons. 4. **Developmental involvement:** SOX3 is crucial for regulating development in the brain, central nervous system, and other tissues, including the pituitary gland and sensory organs. **Pathways and Functions:** 1. **Brain development:** SOX3 regulates the expression of genes involved in brain development, including those involved in neuronal differentiation and patterning. 2. **Central nervous system development:** SOX3 plays a role in regulating the development of the central nervous system, including the formation of the cerebral cortex and hypothalamus. 3. **Chromatin regulation:** SOX3 interacts with chromatin remodeling complexes to regulate the accessibility of target genes to transcriptional machinery. 4. **Neuron differentiation:** SOX3 inhibits the differentiation of neurons, thereby regulating the balance between neuronal and non-neuronal cell fates. 5. **Hypothalamic development:** SOX3 is involved in regulating the development of the hypothalamus, a critical region for regulating body temperature, hunger, and thirst. 6. **Sex determination:** SOX3 plays a role in regulating sex determination, particularly in the context of the Wnt signaling pathway. **Clinical Significance:** 1. **Neurological disorders:** Alterations in SOX3 expression have been implicated in various neurological disorders, including autism spectrum disorder, schizophrenia, and Alzheimer's disease. 2. **Cancer:** SOX3 has been identified as a tumor suppressor gene in certain types of cancer, including glioblastoma and colorectal cancer. 3. **Immunological disorders:** SOX3 plays a role in regulating the function of immune cells, including T cells and plasma cells, which are critical for immune responses. 4. **Hematological disorders:** SOX3 is involved in regulating the development and function of hematopoietic stem cells, which are essential for producing blood cells. In conclusion, SOX3 is a multifunctional transcription factor that plays a crucial role in regulating development, differentiation, and function in various tissues. Its dysregulation has been implicated in various neurological, immunological, and hematological disorders, highlighting the importance of SOX3 in maintaining tissue homeostasis and preventing disease. Further research is needed to fully elucidate the mechanisms by which SOX3 regulates gene expression and to explore its therapeutic potential in treating human diseases.

Genular Protein ID: 1485621247

Symbol: SOX3_HUMAN

Name: Transcription factor SOX-3

UniProtKB Accession Codes:

P41225 P35714 Q5JWI3 Q9NP49

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 GO 19 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 9 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 5 OrthoDB 1 PANTHER 2 PIR 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8111369

Title: SOX3 is an X-linked gene related to SRY.

PubMed ID: 8111369

DOI: 10.1093/hmg/2.12.2013

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1614875

Title: A conserved family of genes related to the testis determining gene, SRY.

PubMed ID: 1614875

DOI: 10.1093/nar/20.11.2887

PubMed ID: 21183788

Title: Identification of SOX3 as an XX male sex reversal gene in mice and humans.

PubMed ID: 21183788

DOI: 10.1172/jci42580

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 34342803

Title: The 9aaTAD Activation Domains in the Yamanaka Transcription Factors Oct4, Sox2, Myc, and Klf4.

PubMed ID: 34342803

DOI: 10.1007/s12015-021-10225-8

PubMed ID: 12428212

Title: Transcription factor SOX3 is involved in X-linked mental retardation with growth hormone deficiency.

PubMed ID: 12428212

DOI: 10.1086/344661

PubMed ID: 15800844

Title: Over- and underdosage of SOX3 is associated with infundibular hypoplasia and hypopituitarism.

PubMed ID: 15800844

DOI: 10.1086/430134

PubMed ID: 16167084

Title: An interstitial deletion-insertion involving chromosomes 2p25.3 and Xq27.1, near SOX3, causes X-linked recessive hypoparathyroidism.

PubMed ID: 16167084

DOI: 10.1172/jci24156

Sequence Information:

  • Length: 446
  • Mass: 45210
  • Checksum: F79E79C2D16BB929
  • Sequence:
    • MRPVRENSSG ARSPRVPADL ARSILISLPF PPDSLAHRPP SSAPTESQGL FTVAAPAPGA 
PSPPATLAHL LPAPAMYSLL ETELKNPVGT PTQAAGTGGP AAPGGAGKSS ANAAGGANSG 
GGSSGGASGG GGGTDQDRVK RPMNAFMVWS RGQRRKMALE NPKMHNSEIS KRLGADWKLL 
TDAEKRPFID EAKRLRAVHM KEYPDYKYRP RRKTKTLLKK DKYSLPSGLL PPGAAAAAAA 
AAAAAAAASS PVGVGQRLDT YTHVNGWANG AYSLVQEQLG YAQPPSMSSP PPPPALPPMH 
RYDMAGLQYS PMMPPGAQSY MNVAAAAAAA SGYGGMAPSA TAAAAAAYGQ QPATAAAAAA 
AAAAMSLGPM GSVVKSEPSS PPPAIASHSQ RACLGDLRDM ISMYLPPGGD AADAASPLPG 
GRLHGVHQHY QGAGTAVNGT VPLTHI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.