Details for: SOX12

Gene ID: 6666

Symbol: SOX12

Ensembl ID: ENSG00000177732

Description: SRY-box transcription factor 12

Associated with

  • Brain development
    (GO:0007420)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neuron differentiation
    (GO:0030182)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of regulatory t cell differentiation
    (GO:0045591)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein-dna complex
    (GO:0032993)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Spinal cord development
    (GO:0021510)
  • Transcription cis-regulatory region binding
    (GO:0000976)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 90.0060
    Cell Significance Index: -14.0000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 51.7262
    Cell Significance Index: -13.1200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.5981
    Cell Significance Index: -14.3000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.4621
    Cell Significance Index: -3.2000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.1768
    Cell Significance Index: 74.1700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8279
    Cell Significance Index: 81.9000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6578
    Cell Significance Index: 593.9700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.5695
    Cell Significance Index: 4.3900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.5590
    Cell Significance Index: 12.2400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4830
    Cell Significance Index: 95.8500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4367
    Cell Significance Index: 47.5100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4309
    Cell Significance Index: 70.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3902
    Cell Significance Index: 53.5900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3791
    Cell Significance Index: 22.7600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.3699
    Cell Significance Index: 4.4100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3500
    Cell Significance Index: 9.7800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3078
    Cell Significance Index: 13.9500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2931
    Cell Significance Index: 58.7900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2902
    Cell Significance Index: 3.9600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2777
    Cell Significance Index: 151.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2744
    Cell Significance Index: 78.9500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2665
    Cell Significance Index: 13.9900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2633
    Cell Significance Index: 14.7800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.2517
    Cell Significance Index: 3.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2480
    Cell Significance Index: 47.1900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.2451
    Cell Significance Index: 7.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2408
    Cell Significance Index: 86.3800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2129
    Cell Significance Index: 14.7300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1956
    Cell Significance Index: 12.0200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1731
    Cell Significance Index: 4.6300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1702
    Cell Significance Index: 4.5600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1563
    Cell Significance Index: 5.4300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1228
    Cell Significance Index: 2.5700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1225
    Cell Significance Index: 3.2200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1069
    Cell Significance Index: 3.0800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0959
    Cell Significance Index: 6.7800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0927
    Cell Significance Index: 40.9800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0871
    Cell Significance Index: 1.0800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0780
    Cell Significance Index: 1.6900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0453
    Cell Significance Index: 2.9200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0367
    Cell Significance Index: 4.7100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0189
    Cell Significance Index: 35.6700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0136
    Cell Significance Index: 2.4600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0111
    Cell Significance Index: 17.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0105
    Cell Significance Index: 19.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0095
    Cell Significance Index: 12.9300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0026
    Cell Significance Index: 1.8800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0002
    Cell Significance Index: 0.1400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0016
    Cell Significance Index: -0.0200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0038
    Cell Significance Index: -0.0700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0078
    Cell Significance Index: -5.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0105
    Cell Significance Index: -7.9200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0132
    Cell Significance Index: -1.9200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0153
    Cell Significance Index: -11.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0224
    Cell Significance Index: -12.6300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0247
    Cell Significance Index: -11.1900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0251
    Cell Significance Index: -0.4200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0254
    Cell Significance Index: -15.8500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0271
    Cell Significance Index: -0.6500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0304
    Cell Significance Index: -3.7400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0316
    Cell Significance Index: -1.9400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0327
    Cell Significance Index: -1.1500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0331
    Cell Significance Index: -1.0600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0347
    Cell Significance Index: -1.8000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0378
    Cell Significance Index: -0.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0411
    Cell Significance Index: -7.0100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0474
    Cell Significance Index: -5.5200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0488
    Cell Significance Index: -4.9900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0643
    Cell Significance Index: -4.9400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0712
    Cell Significance Index: -1.7800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0734
    Cell Significance Index: -9.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0739
    Cell Significance Index: -15.5700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0804
    Cell Significance Index: -1.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0810
    Cell Significance Index: -9.2800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0931
    Cell Significance Index: -2.5400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0970
    Cell Significance Index: -11.4400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1021
    Cell Significance Index: -1.1100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1169
    Cell Significance Index: -1.2100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1187
    Cell Significance Index: -1.7000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1231
    Cell Significance Index: -12.8200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1242
    Cell Significance Index: -8.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1365
    Cell Significance Index: -10.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1417
    Cell Significance Index: -6.6600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1439
    Cell Significance Index: -11.4000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1463
    Cell Significance Index: -3.7600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1675
    Cell Significance Index: -3.8700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1743
    Cell Significance Index: -7.7100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2090
    Cell Significance Index: -1.2400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2121
    Cell Significance Index: -8.0300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2205
    Cell Significance Index: -4.6800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.2300
    Cell Significance Index: -3.6900
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.2659
    Cell Significance Index: -1.6700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2755
    Cell Significance Index: -9.0200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.2843
    Cell Significance Index: -2.2700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2881
    Cell Significance Index: -4.5700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2928
    Cell Significance Index: -5.7900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2949
    Cell Significance Index: -3.3500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3018
    Cell Significance Index: -7.7100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3046
    Cell Significance Index: -10.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulation:** SOX12 is a transcription factor that regulates the expression of target genes through direct binding to specific DNA sequences. 2. **DNA Binding:** SOX12 exhibits sequence-specific DNA binding properties, allowing it to bind to specific regions of the genome and modulate gene expression. 3. **Cell-Type Specificity:** SOX12 is expressed in various cell types, including neural cells, immune cells, and epithelial cells, suggesting a cell-type specific role in developmental and immune processes. 4. **Dimerization:** SOX12 can dimerize with other SOX transcription factors, such as SOX3, to form heterodimers that regulate gene expression. **Pathways and Functions:** 1. **Brain Development:** SOX12 is involved in the regulation of neural cell differentiation and the development of the brain. 2. **Chromatin Remodeling:** SOX12 interacts with chromatin-modifying enzymes to regulate chromatin structure and gene expression. 3. **Immune Cell Differentiation:** SOX12 is required for the differentiation of immune cells, including regulatory T cells and GABAergic interneurons. 4. **Epithelial Cell Function:** SOX12 regulates the expression of genes involved in epithelial cell function, including ion transport and cell proliferation. **Clinical Significance:** 1. **Cancer:** SOX12 is frequently overexpressed in various types of cancer, including leukemia, lymphoma, and melanoma, suggesting its potential as a diagnostic biomarker and therapeutic target. 2. **Neurological Disorders:** SOX12 mutations have been implicated in neurological disorders, such as epilepsy and schizophrenia, highlighting its role in brain development and function. 3. **Immunological Disorders:** SOX12 is involved in the regulation of immune cell function, and its dysregulation may contribute to immunological disorders, such as autoimmune diseases. In conclusion, SOX12 is a multifunctional transcription factor that plays a critical role in developmental and immune processes. Its dysregulation has been implicated in various diseases, including cancer and neurological disorders, highlighting the importance of SOX12 in human health and disease. Further studies are needed to fully elucidate the functional mechanisms of SOX12 and its clinical significance.

Genular Protein ID: 936681620

Symbol: SOX12_HUMAN

Name: Transcription factor SOX-12

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9215677

Title: SOX22 is a new member of the SOX gene family, mainly expressed in human nervous tissue.

PubMed ID: 9215677

DOI: 10.1093/hmg/6.7.1069

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 315
  • Mass: 34122
  • Checksum: A5BF539AC505942D
  • Sequence:
  • MVQQRGARAK RDGGPPPPGP GPAEEGAREP GWCKTPSGHI KRPMNAFMVW SQHERRKIMD 
    QWPDMHNAEI SKRLGRRWQL LQDSEKIPFV REAERLRLKH MADYPDYKYR PRKKSKGAPA 
    KARPRPPGGS GGGSRLKPGP QLPGRGGRRA AGGPLGGGAA APEDDDEDDD EELLEVRLVE 
    TPGRELWRMV PAGRAARGQA ERAQGPSGEG AAAAAAASPT PSEDEEPEEE EEEAAAAEEG 
    EEETVASGEE SLGFLSRLPP GPAGLDCSAL DRDPDLQPPS GTSHFEFPDY CTPEVTEMIA 
    GDWRPSSIAD LVFTY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.