Details for: SPAG4

Gene ID: 6676

Symbol: SPAG4

Ensembl ID: ENSG00000061656

Description: sperm associated antigen 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 35.9381
    Cell Significance Index: -5.5900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 22.1965
    Cell Significance Index: -5.6300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 13.1198
    Cell Significance Index: -5.3300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 5.5617
    Cell Significance Index: -5.3100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.5906
    Cell Significance Index: -5.6600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.9582
    Cell Significance Index: 344.7500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.5735
    Cell Significance Index: 81.7400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.4546
    Cell Significance Index: -5.7400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.9030
    Cell Significance Index: 12.9400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7283
    Cell Significance Index: 19.5200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4684
    Cell Significance Index: 9.9800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4144
    Cell Significance Index: 41.0000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3964
    Cell Significance Index: 3.6500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3895
    Cell Significance Index: 212.7000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.3641
    Cell Significance Index: 3.1000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2311
    Cell Significance Index: 208.6400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2139
    Cell Significance Index: 23.2700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2129
    Cell Significance Index: 12.7800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2043
    Cell Significance Index: 33.2300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.1972
    Cell Significance Index: 3.2500
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.1629
    Cell Significance Index: 2.2600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1209
    Cell Significance Index: 20.6400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0969
    Cell Significance Index: 17.4600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0903
    Cell Significance Index: 6.2500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0892
    Cell Significance Index: 2.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0889
    Cell Significance Index: 10.9300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0696
    Cell Significance Index: 13.2400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0671
    Cell Significance Index: 3.1300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0524
    Cell Significance Index: 0.8400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0483
    Cell Significance Index: 1.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0446
    Cell Significance Index: 2.3400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0435
    Cell Significance Index: 0.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0311
    Cell Significance Index: 4.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0273
    Cell Significance Index: 5.4800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0221
    Cell Significance Index: 0.3500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0216
    Cell Significance Index: 2.7800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0132
    Cell Significance Index: 9.1600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0113
    Cell Significance Index: 0.5100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0107
    Cell Significance Index: 20.1100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0097
    Cell Significance Index: 0.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0076
    Cell Significance Index: 11.6300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0062
    Cell Significance Index: 0.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0041
    Cell Significance Index: 0.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0037
    Cell Significance Index: 1.3200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0028
    Cell Significance Index: 5.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0017
    Cell Significance Index: 0.0600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0004
    Cell Significance Index: 0.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0001
    Cell Significance Index: 0.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0009
    Cell Significance Index: -1.1600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0016
    Cell Significance Index: -0.0400
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0044
    Cell Significance Index: -0.0500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0060
    Cell Significance Index: -2.6400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0062
    Cell Significance Index: -4.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0064
    Cell Significance Index: -0.6500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0066
    Cell Significance Index: -4.8800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0080
    Cell Significance Index: -5.8900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0085
    Cell Significance Index: -4.8200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0094
    Cell Significance Index: -5.8700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0099
    Cell Significance Index: -4.5100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0100
    Cell Significance Index: -1.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0155
    Cell Significance Index: -4.4600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0182
    Cell Significance Index: -0.5100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0187
    Cell Significance Index: -0.2900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0237
    Cell Significance Index: -0.3400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0264
    Cell Significance Index: -0.3000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0285
    Cell Significance Index: -6.0000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0322
    Cell Significance Index: -0.5500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0366
    Cell Significance Index: -0.7600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0405
    Cell Significance Index: -5.2300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0421
    Cell Significance Index: -2.5800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0446
    Cell Significance Index: -5.2600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0451
    Cell Significance Index: -0.2800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0479
    Cell Significance Index: -3.3900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0479
    Cell Significance Index: -2.4200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0499
    Cell Significance Index: -2.0400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0516
    Cell Significance Index: -5.3800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0540
    Cell Significance Index: -3.4100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0555
    Cell Significance Index: -4.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0605
    Cell Significance Index: -4.6400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0636
    Cell Significance Index: -2.9900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0670
    Cell Significance Index: -2.1500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0781
    Cell Significance Index: -5.0400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0811
    Cell Significance Index: -5.4500
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0859
    Cell Significance Index: -0.4500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0917
    Cell Significance Index: -5.1500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0954
    Cell Significance Index: -5.8700
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0964
    Cell Significance Index: -0.6400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0986
    Cell Significance Index: -0.7600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0989
    Cell Significance Index: -5.1500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1042
    Cell Significance Index: -0.8500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1096
    Cell Significance Index: -3.8400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1121
    Cell Significance Index: -3.5700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1129
    Cell Significance Index: -2.9700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1138
    Cell Significance Index: -5.0400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1249
    Cell Significance Index: -4.0900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1272
    Cell Significance Index: -3.2700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1284
    Cell Significance Index: -2.1600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1301
    Cell Significance Index: -1.9600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1310
    Cell Significance Index: -4.9600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1350
    Cell Significance Index: -4.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SPAG4 is a highly conserved protein, with high sequence similarity across species. It belongs to the SPAG family of proteins, which are known for their involvement in cell cycle regulation, cytoskeleton organization, and cell differentiation. SPAG4 is characterized by its ability to interact with various proteins, including those involved in the cytoskeleton, nuclear envelope, and meiotic nuclear membrane microtubule tethering complex. Its expression is often associated with the presence of microtubules, which are essential for maintaining cell shape and organizing the cytoskeleton. **Pathways and Functions** SPAG4 is involved in several cellular pathways, including: 1. **Cytoskeleton organization**: SPAG4 interacts with actin and microtubule-associated proteins to regulate cytoskeleton organization and cell shape. 2. **Cell differentiation**: SPAG4 is involved in the differentiation of various cell types, including spermatogenesis, epithelial cells, and immune cells. 3. **Spermatogenesis**: SPAG4 plays a critical role in the regulation of spermatogenesis, including the organization of the meiotic nuclear membrane microtubule tethering complex. 4. **Protein-membrane adaptor activity**: SPAG4 acts as a protein-membrane adaptor, facilitating the interaction between proteins and membranes. 5. **Nuclear envelope organization**: SPAG4 is involved in the organization of the nuclear envelope and the regulation of nuclear pore complexes. **Clinical Significance** Dysregulation of SPAG4 has been implicated in various diseases, including: 1. **Infertility**: Abnormal expression of SPAG4 has been linked to infertility in males, suggesting its role in spermatogenesis. 2. **Cancer**: SPAG4 has been identified as a potential oncogene in various types of cancer, including breast, lung, and colon cancer. 3. **Neurological disorders**: Abnormal expression of SPAG4 has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Immune system disorders**: SPAG4 has been implicated in immune system disorders, including autoimmune diseases and immunodeficiency diseases. In conclusion, SPAG4 is a multifunctional protein that plays a critical role in various cellular processes, including cell differentiation, cytoskeleton organization, and spermatogenesis. Its dysregulation has been implicated in various diseases, highlighting the importance of further research on this protein.

Genular Protein ID: 295195431

Symbol: SPAG4_HUMAN

Name: Sperm-associated antigen 4 protein

UniProtKB Accession Codes:

Q9NPE6 O43648

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14614621

Title: Human sperm associated antigen 4 (SPAG4) is a potential cancer marker.

PubMed ID: 14614621

DOI: 10.1007/s00441-003-0821-2

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 9691178

Title: A novel testis-specific gene, SPAG4, whose product interacts specifically with outer dense fiber protein ODF27, maps to human chromosome 20q11.2.

PubMed ID: 9691178

DOI: 10.1159/000014990

PubMed ID: 25775403

Title: SEPT12/SPAG4/LAMINB1 complexes are required for maintaining the integrity of the nuclear envelope in postmeiotic male germ cells.

PubMed ID: 25775403

DOI: 10.1371/journal.pone.0120722

Sequence Information:

  • Length: 437
  • Mass: 48165
  • Checksum: 5D1E3BCAEEE8B702
  • Sequence:
    • MRRSSRPGSA SSSRKHTPNF FSENSSMSIT SEDSKGLRSA EPGPGEPEGR RARGPSCGEP 
ALSAGVPGGT TWAGSSQQKP APRSHNWQTA CGAATVRGGA SEPTGSPVVS EEPLDLLPTL 
DLRQEMPPPR VFKSFLSLLF QGLSVLLSLA GDVLVSMYRE VCSIRFLFTA VSLLSLFLSA 
FWLGLLYLVS PLENEPKEML TLSEYHERVR SQGQQLQQLQ AELDKLHKEV STVRAANSER 
VAKLVFQRLN EDFVRKPDYA LSSVGASIDL QKTSHDYADR NTAYFWNRFS FWNYARPPTV 
ILEPHVFPGN CWAFEGDQGQ VVIQLPGRVQ LSDITLQHPP PSVEHTGGAN SAPRDFAVFG 
LQVYDETEVS LGKFTFDVEK SEIQTFHLQN DPPAAFPKVK IQILSNWGHP RFTCLYRVRA 
HGVRTSEGAE GSAQGPH

Genular Protein ID: 2760533959

Symbol: A0A7P0Z4G5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A7P0Z4G5

Database IDs:

ARBA 3 AlphaFoldDB 1 Bgee 1 CTD 1 DisGeNET 1 EMBL 1 Ensembl 2 GO 1 Gene3D 1 GeneTree 1 HGNC 1 InterPro 2 NCBI Taxonomy 1 PANTHER 2 PROSITE 2 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 3 SMR 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 360
  • Mass: 40398
  • Checksum: 17C3355FD6925588
  • Sequence:
    • MGRKLSAEAS ASEPQLADSL WRGNQPTGSP VVSEEPLDLL PTLDLRQEMP PPRVFKSFLS 
LLFQGLSVLL SLAGDVLVSM YREVCSIRFL FTAVSLLSLF LSAFWLGLLY LVSPLENEPK 
EMLTLSEYHE RVRSQGQQLQ QLQAELDKLH KEVSTVRAAN SERVAKLVFQ RLNEDFVRKP 
DYALSSVGAS IDLQKTSHDY ADRNTAYFWN RFSFWNYARP PTVILEPHVF PGNCWAFEGD 
QGQVVIQLPG RVQLSDITLQ HPPPSVEHTG GANSAPRDFA VFGLQVYDET EVSLGKFTFD 
VEKSEIQTFH LQNDPPAAFP KVKIQILSNW GHPRFTCLYR VRAHGVRTSE GAEGSAQGPH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.