Details for: SSTR1

Gene ID: 6751

Symbol: SSTR1

Ensembl ID: ENSG00000139874

Description: somatostatin receptor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 12.0731
    Cell Significance Index: -5.7000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.4879
    Cell Significance Index: 53.9000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.7603
    Cell Significance Index: 30.0900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2716
    Cell Significance Index: 206.8200
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.1697
    Cell Significance Index: 8.8700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.1507
    Cell Significance Index: 17.3400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.0360
    Cell Significance Index: 13.4100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8992
    Cell Significance Index: 53.9800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8684
    Cell Significance Index: 784.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8005
    Cell Significance Index: 23.0700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7504
    Cell Significance Index: 81.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5270
    Cell Significance Index: 52.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4807
    Cell Significance Index: 21.7900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4235
    Cell Significance Index: 9.0200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4171
    Cell Significance Index: 28.8500
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.4134
    Cell Significance Index: 2.7000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3991
    Cell Significance Index: 5.9800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.3059
    Cell Significance Index: 191.0100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3019
    Cell Significance Index: 35.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2455
    Cell Significance Index: 70.6500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.2118
    Cell Significance Index: 3.4900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1894
    Cell Significance Index: 36.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1247
    Cell Significance Index: 25.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1235
    Cell Significance Index: 4.3400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0704
    Cell Significance Index: 1.7600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0578
    Cell Significance Index: 11.4700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0468
    Cell Significance Index: 0.9700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0416
    Cell Significance Index: 22.7200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0280
    Cell Significance Index: 10.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0177
    Cell Significance Index: 1.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0149
    Cell Significance Index: 2.5400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0146
    Cell Significance Index: 0.3200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0145
    Cell Significance Index: 0.1500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0094
    Cell Significance Index: 0.1400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0068
    Cell Significance Index: 4.7300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0061
    Cell Significance Index: 4.5500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0046
    Cell Significance Index: -0.9800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0049
    Cell Significance Index: -2.7800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0061
    Cell Significance Index: -2.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0062
    Cell Significance Index: -0.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0072
    Cell Significance Index: -5.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0090
    Cell Significance Index: -6.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0142
    Cell Significance Index: -6.4600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0159
    Cell Significance Index: -1.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0216
    Cell Significance Index: -2.4700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0240
    Cell Significance Index: -0.3200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0321
    Cell Significance Index: -5.7900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0332
    Cell Significance Index: -2.0400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0363
    Cell Significance Index: -3.7100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0373
    Cell Significance Index: -0.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0384
    Cell Significance Index: -5.2700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0392
    Cell Significance Index: -2.7700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0450
    Cell Significance Index: -5.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0454
    Cell Significance Index: -2.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0458
    Cell Significance Index: -5.9200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0509
    Cell Significance Index: -2.6700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0569
    Cell Significance Index: -5.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0700
    Cell Significance Index: -5.3700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0792
    Cell Significance Index: -5.9000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0830
    Cell Significance Index: -2.0100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0843
    Cell Significance Index: -6.6800
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: -0.0932
    Cell Significance Index: -0.7600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0980
    Cell Significance Index: -2.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0984
    Cell Significance Index: -5.5200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1128
    Cell Significance Index: -4.9900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1147
    Cell Significance Index: -5.3500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1148
    Cell Significance Index: -2.9500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1185
    Cell Significance Index: -4.1500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1211
    Cell Significance Index: -4.5900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1212
    Cell Significance Index: -6.3200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1243
    Cell Significance Index: -5.8400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1249
    Cell Significance Index: -4.0900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1266
    Cell Significance Index: -1.2000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1309
    Cell Significance Index: -4.1700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1310
    Cell Significance Index: -2.5900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1353
    Cell Significance Index: -3.8600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1380
    Cell Significance Index: -2.7700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1514
    Cell Significance Index: -3.2700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1534
    Cell Significance Index: -3.6800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1539
    Cell Significance Index: -3.9200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1555
    Cell Significance Index: -5.7100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.1559
    Cell Significance Index: -2.0800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1606
    Cell Significance Index: -1.7500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1612
    Cell Significance Index: -4.0200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1642
    Cell Significance Index: -2.8300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1821
    Cell Significance Index: -5.2200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1844
    Cell Significance Index: -5.0200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1847
    Cell Significance Index: -4.9500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1899
    Cell Significance Index: -6.6000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1943
    Cell Significance Index: -5.1100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1957
    Cell Significance Index: -4.8800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2017
    Cell Significance Index: -5.9400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2026
    Cell Significance Index: -4.3000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2042
    Cell Significance Index: -4.1600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2098
    Cell Significance Index: -4.1300
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.2134
    Cell Significance Index: -2.9500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2138
    Cell Significance Index: -5.7100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2162
    Cell Significance Index: -5.4000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2162
    Cell Significance Index: -3.4300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.2220
    Cell Significance Index: -2.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **G-Protein Coupled Receptor**: SSTR1 belongs to the class A/1 (rhodopsin-like receptors) and is a type of G-protein coupled receptor (GPCR) that responds to ligand binding. 2. **Widespread Expression**: SSTR1 is expressed in various cell types, including erythrocytes, double negative thymocytes, megakaryocytes, and hematopoietic stem cells. 3. **Signaling Pathways**: SSTR1 is involved in several signaling pathways, including cellular response to estradiol stimulus, cellular response to leukemia inhibitory factor, and somatostatin signaling pathway. 4. **Negative Regulation of Cell Proliferation**: SSTR1 is known to regulate cell proliferation and differentiation, particularly in hematopoietic stem cells and cardiac endothelial cells. **Pathways and Functions:** 1. **G-Protein Coupled Receptor Signaling Pathway**: SSTR1 activates G-protein coupled receptor signaling pathway, which involves the activation of G-proteins and subsequent activation of downstream effectors. 2. **Somatostatin Signaling Pathway**: SSTR1 is a key component of the somatostatin signaling pathway, which regulates cell proliferation, differentiation, and survival. 3. **Estradiol Response**: SSTR1 is involved in the cellular response to estradiol stimulus, which regulates various physiological processes, including cell growth and differentiation. 4. **Leukemia Inhibitory Factor Response**: SSTR1 is also involved in the cellular response to leukemia inhibitory factor, which regulates cell proliferation and differentiation. **Clinical Significance:** 1. **Cancer Therapy**: SSTR1 has been identified as a potential target for cancer therapy, particularly in the treatment of neuroendocrine tumors. 2. **Neurological Disorders**: SSTR1 has been implicated in various neurological disorders, including Parkinson's disease and Alzheimer's disease, where it regulates dopamine and acetylcholine signaling pathways. 3. **Reproductive Disorders**: SSTR1 has been shown to play a role in reproductive disorders, including endometriosis and infertility, where it regulates estrogen and progesterone signaling pathways. 4. **Cardiovascular Diseases**: SSTR1 has been implicated in cardiovascular diseases, including hypertension and cardiac fibrosis, where it regulates blood pressure and cardiac function. In conclusion, the SSTR1 gene plays a crucial role in various physiological processes, including cell proliferation, differentiation, and survival. Its involvement in several signaling pathways and its expression in various cell types make it a potential target for cancer therapy, neurological disorders, reproductive disorders, and cardiovascular diseases. Further research is needed to fully understand the functions and clinical significance of SSTR1.

Genular Protein ID: 3611338620

Symbol: SSR1_HUMAN

Name: Somatostatin receptor type 1

UniProtKB Accession Codes:

P30872

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EMBL 3 Ensembl 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1346068

Title: Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.

PubMed ID: 1346068

DOI: 10.1073/pnas.89.1.251

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10734105

Title: Interaction of the somatostatin receptor subtype 1 with the human homolog of the Shk1 kinase-binding protein from yeast.

PubMed ID: 10734105

DOI: 10.1074/jbc.275.13.9557

Sequence Information:

  • Length: 391
  • Mass: 42686
  • Checksum: 85C99AFFF339A43D
  • Sequence:
    • MFPNGTASSP SSSPSPSPGS CGEGGGSRGP GAGAADGMEE PGRNASQNGT LSEGQGSAIL 
ISFIYSVVCL VGLCGNSMVI YVILRYAKMK TATNIYILNL AIADELLMLS VPFLVTSTLL 
RHWPFGALLC RLVLSVDAVN MFTSIYCLTV LSVDRYVAVV HPIKAARYRR PTVAKVVNLG 
VWVLSLLVIL PIVVFSRTAA NSDGTVACNM LMPEPAQRWL VGFVLYTFLM GFLLPVGAIC 
LCYVLIIAKM RMVALKAGWQ QRKRSERKIT LMVMMVVMVF VICWMPFYVV QLVNVFAEQD 
DATVSQLSVI LGYANSCANP ILYGFLSDNF KRSFQRILCL SWMDNAAEEP VDYYATALKS 
RAYSVEDFQP ENLESGGVFR NGTCTSRITT L

Genular Protein ID: 1165007676

Symbol: Q86SW9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q86SW9

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PharmGKB 1 RefSeq 1 SAM 1

Sequence Information:

  • Length: 109
  • Mass: 11490
  • Checksum: D49968ABA39A167F
  • Sequence:
    • MAVPCGAPTS WPLLSTVACA RAPRSCKLQS PGNRWAVRPA GAGRSRAPRS GCALPGGAGR 
LWAAGKRSGG EGGRRRRVRE EKAPALAAPL APLSWDVPQW HRLLSFLLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.