Details for: STAT1

Gene ID: 6772

Symbol: STAT1

Ensembl ID: ENSG00000115415

Description: signal transducer and activator of transcription 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 260.4387
    Cell Significance Index: -40.5100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 152.4976
    Cell Significance Index: -38.6800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 104.5028
    Cell Significance Index: -42.4600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 94.8800
    Cell Significance Index: -44.8000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 88.3968
    Cell Significance Index: -45.4700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 44.9126
    Cell Significance Index: -42.8800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.4295
    Cell Significance Index: -42.4500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.1889
    Cell Significance Index: -38.0100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.9198
    Cell Significance Index: -43.0900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.8357
    Cell Significance Index: -30.2100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.8224
    Cell Significance Index: -17.1200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.6728
    Cell Significance Index: 49.4000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.5782
    Cell Significance Index: 75.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.9161
    Cell Significance Index: 2605.3500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4657
    Cell Significance Index: 159.4300
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.3034
    Cell Significance Index: 11.2000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2699
    Cell Significance Index: 76.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.0757
    Cell Significance Index: 125.3600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.0426
    Cell Significance Index: 54.3100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9915
    Cell Significance Index: 196.7700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8627
    Cell Significance Index: 140.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8441
    Cell Significance Index: 23.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7687
    Cell Significance Index: 39.9300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.7267
    Cell Significance Index: 1118.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6516
    Cell Significance Index: 80.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5846
    Cell Significance Index: 105.3900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5040
    Cell Significance Index: 69.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.4668
    Cell Significance Index: 860.8100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4536
    Cell Significance Index: 91.0000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4396
    Cell Significance Index: 240.0800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4343
    Cell Significance Index: 55.6700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4320
    Cell Significance Index: 190.9900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3946
    Cell Significance Index: 27.2900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3736
    Cell Significance Index: 9.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3697
    Cell Significance Index: 696.0800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3046
    Cell Significance Index: 109.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2142
    Cell Significance Index: 136.0100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1864
    Cell Significance Index: 35.4800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1735
    Cell Significance Index: 5.0000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1696
    Cell Significance Index: 16.7800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1365
    Cell Significance Index: 6.3700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1162
    Cell Significance Index: 52.7300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1104
    Cell Significance Index: 76.3600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1037
    Cell Significance Index: 4.7000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0356
    Cell Significance Index: 1.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0279
    Cell Significance Index: 4.7600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0212
    Cell Significance Index: 1.5000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0148
    Cell Significance Index: 2.1500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0129
    Cell Significance Index: 0.6500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0079
    Cell Significance Index: -4.9300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0145
    Cell Significance Index: -10.7100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0208
    Cell Significance Index: -15.7400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0258
    Cell Significance Index: -0.6900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0295
    Cell Significance Index: -3.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0340
    Cell Significance Index: -19.1500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0391
    Cell Significance Index: -28.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0393
    Cell Significance Index: -4.0900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0679
    Cell Significance Index: -1.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0708
    Cell Significance Index: -4.5700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0804
    Cell Significance Index: -9.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0989
    Cell Significance Index: -4.6500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1038
    Cell Significance Index: -21.8600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1058
    Cell Significance Index: -6.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1199
    Cell Significance Index: -34.4900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1356
    Cell Significance Index: -15.5300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1902
    Cell Significance Index: -24.5700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2094
    Cell Significance Index: -14.0800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2274
    Cell Significance Index: -16.9500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2444
    Cell Significance Index: -18.7600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3000
    Cell Significance Index: -34.2400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3242
    Cell Significance Index: -6.7300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3250
    Cell Significance Index: -7.0400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3709
    Cell Significance Index: -5.0600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3779
    Cell Significance Index: -10.2900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4202
    Cell Significance Index: -11.2400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.4274
    Cell Significance Index: -7.2000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4424
    Cell Significance Index: -10.2200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4681
    Cell Significance Index: -26.2700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4685
    Cell Significance Index: -13.4300
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.4910
    Cell Significance Index: -7.4700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4947
    Cell Significance Index: -30.4100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5282
    Cell Significance Index: -27.7300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5317
    Cell Significance Index: -42.1100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5626
    Cell Significance Index: -15.0800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5841
    Cell Significance Index: -11.4000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5885
    Cell Significance Index: -26.0300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5898
    Cell Significance Index: -9.8700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5907
    Cell Significance Index: -15.0900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6052
    Cell Significance Index: -12.8900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6561
    Cell Significance Index: -21.0200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6996
    Cell Significance Index: -14.9600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.7141
    Cell Significance Index: -10.5400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7231
    Cell Significance Index: -44.3300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7363
    Cell Significance Index: -27.8800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7785
    Cell Significance Index: -22.9300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.8017
    Cell Significance Index: -7.3800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.8063
    Cell Significance Index: -11.4800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8786
    Cell Significance Index: -30.5300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.8902
    Cell Significance Index: -28.1600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.8908
    Cell Significance Index: -25.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** STAT1 is a cytoplasmic protein that, upon activation by interferons (IFNs) and other cytokines, translocates to the nucleus, where it regulates gene expression by binding to specific DNA sequences. It is a member of the STAT family of transcription factors, which are characterized by their ability to dimerize and bind to IFN-stimulated genes (ISGs). STAT1 is also involved in the regulation of cell growth, differentiation, and survival. **Pathways and Functions:** STAT1 is activated by IFNs, particularly IFN-α/β and IFN-γ, which induce its phosphorylation and nuclear translocation. Once in the nucleus, STAT1 regulates the expression of ISGs, which are involved in the antiviral response, immune cell activation, and the production of cytokines and chemokines. STAT1 also interacts with other transcription factors, such as NF-κB and AP-1, to modulate the expression of genes involved in inflammation and immune response. STAT1 plays a critical role in various biological processes, including: 1. **Antiviral Response:** STAT1 regulates the expression of ISGs that encode proteins involved in the antiviral response, such as protein kinase R (PKR) and 2',5'-oligoadenylate synthetase (OAS). 2. **Immune Cell Activation:** STAT1 is required for the activation of immune cells, including natural killer (NK) cells and T cells, which are essential for the elimination of pathogens. 3. **Inflammation:** STAT1 regulates the expression of genes involved in inflammation, such as cytokines and chemokines, which are essential for the recruitment of immune cells to sites of infection. 4. **Cell Growth and Differentiation:** STAT1 is involved in the regulation of cell growth and differentiation, particularly in the context of cancer. **Clinical Significance:** Dysregulation of STAT1 has been implicated in various diseases, including: 1. **Cancer:** STAT1 is often overexpressed in cancer cells, leading to enhanced proliferation and survival. 2. **Autoimmune Disorders:** STAT1 is involved in the regulation of immune responses, and dysregulation has been implicated in autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis. 3. **Infectious Diseases:** STAT1 plays a critical role in the antiviral response, and dysregulation has been implicated in viral infections, such as HIV and influenza. 4. **Neurological Disorders:** STAT1 has been implicated in the regulation of immune responses in the nervous system, and dysregulation has been implicated in neurological disorders, such as multiple sclerosis and Alzheimer's disease. In conclusion, STAT1 is a critical component of the interferon signaling pathway, playing a pivotal role in the regulation of immune responses and the modulation of gene expression. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding the mechanisms of STAT1 signaling in the context of human disease.

Genular Protein ID: 101010464

Symbol: STAT1_HUMAN

Name: Signal transducer and activator of transcription 1-alpha/beta

UniProtKB Accession Codes:

P42224 A8K989 B2RCA0 D2KFR8 D3DPI7 Q53S88 Q53XW4 Q68D00 Q9UDL5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CORUM 1 CPTAC 3 CPTC 1 CTD 1 CarbonylDB 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 4 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugCentral 1 EMBL 23 Ensembl 9 EvolutionaryTrace 1 ExpressionAtlas 1 GO 77 Gene3D 6 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 14 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 28 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1502203

Title: Proteins of transcription factor ISGF-3: one gene encodes the 91- and 84-kDa ISGF-3 proteins that are activated by interferon alpha.

PubMed ID: 1502203

DOI: 10.1073/pnas.89.16.7836

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7885841

Title: The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2.

PubMed ID: 7885841

DOI: 10.1093/nar/23.3.459

PubMed ID: 1638633

Title: A transcription factor with SH2 and SH3 domains is directly activated by an interferon alpha-induced cytoplasmic protein tyrosine kinase(s).

PubMed ID: 1638633

DOI: 10.1016/0092-8674(92)90106-m

PubMed ID: 8156998

Title: Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91).

PubMed ID: 8156998

DOI: 10.1002/j.1460-2075.1994.tb06422.x

PubMed ID: 7543024

Title: Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation.

PubMed ID: 7543024

DOI: 10.1016/0092-8674(95)90311-9

PubMed ID: 7657660

Title: Phosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptor.

PubMed ID: 7657660

DOI: 10.1074/jbc.270.35.20775

PubMed ID: 8605877

Title: The SH2 domains of Stat1 and Stat2 mediate multiple interactions in the transduction of IFN-alpha signals.

PubMed ID: 8605877

DOI: 10.1002/j.1460-2075.1996.tb00445.x

PubMed ID: 9121453

Title: Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling.

PubMed ID: 9121453

DOI: 10.1128/mcb.17.4.2048

PubMed ID: 9724754

Title: Inhibition of Stat1-mediated gene activation by PIAS1.

PubMed ID: 9724754

DOI: 10.1073/pnas.95.18.10626

PubMed ID: 9989503

Title: Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling.

PubMed ID: 9989503

DOI: 10.1016/s0092-8674(00)80965-4

PubMed ID: 10702714

Title: Viral inhibition of interferon signal transduction.

PubMed ID: 10702714

DOI: 10.1159/000053968

PubMed ID: 11442634

Title: Sendai virus C protein physically associates with Stat1.

PubMed ID: 11442634

DOI: 10.1046/j.1365-2443.2001.00442.x

PubMed ID: 11278462

Title: Focal adhesion kinase activates Stat1 in integrin-mediated cell migration and adhesion.

PubMed ID: 11278462

DOI: 10.1074/jbc.m009063200

PubMed ID: 12138178

Title: Identification of a nuclear Stat1 protein tyrosine phosphatase.

PubMed ID: 12138178

DOI: 10.1128/mcb.22.16.5662-5668.2002

PubMed ID: 11972023

Title: Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma.

PubMed ID: 11972023

DOI: 10.1073/pnas.052159099

PubMed ID: 12855578

Title: PIAS proteins promote SUMO-1 conjugation to STAT1.

PubMed ID: 12855578

DOI: 10.1182/blood-2002-12-3816

PubMed ID: 12764129

Title: SUMO modification of STAT1 and its role in PIAS-mediated inhibition of gene activation.

PubMed ID: 12764129

DOI: 10.1074/jbc.m301344200

PubMed ID: 15526160

Title: Signal transduction via the stem cell factor receptor/c-Kit.

PubMed ID: 15526160

DOI: 10.1007/s00018-004-4189-6

PubMed ID: 15322115

Title: Protein kinase Cdelta regulates apoptosis via activation of STAT1.

PubMed ID: 15322115

DOI: 10.1074/jbc.m407448200

PubMed ID: 15140960

Title: Nipah virus V and W proteins have a common STAT1-binding domain yet inhibit STAT1 activation from the cytoplasmic and nuclear compartments, respectively.

PubMed ID: 15140960

DOI: 10.1128/jvi.78.11.5633-5641.2004

PubMed ID: 16139798

Title: Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.

PubMed ID: 16139798

DOI: 10.1016/j.bbrc.2005.08.132

PubMed ID: 15825084

Title: Hepatitis C virus expression suppresses interferon signaling by degrading STAT1.

PubMed ID: 15825084

DOI: 10.1053/j.gastro.2005.02.006

PubMed ID: 16257975

Title: The conserved Leu-724 residue is required for both serine phosphorylation and co-activator recruitment for Stat1-mediated transcription activation in response to interferon-gamma.

PubMed ID: 16257975

DOI: 10.1074/jbc.m505797200

PubMed ID: 16799645

Title: Serine-phosphorylated STAT1 is a prosurvival factor in Wilms' tumor pathogenesis.

PubMed ID: 16799645

DOI: 10.1038/sj.onc.1209742

PubMed ID: 17561467

Title: Sustained phosphorylation of mutated FGFR3 is a crucial feature of genetic dwarfism and induces apoptosis in the ATDC5 chondrogenic cell line via PLCgamma-activated STAT1.

PubMed ID: 17561467

DOI: 10.1016/j.bone.2006.11.030

PubMed ID: 17311277

Title: Fibroblast growth factor receptor-induced phosphorylation of STAT1 at the Golgi apparatus without translocation to the nucleus.

PubMed ID: 17311277

DOI: 10.1002/jcp.21014

PubMed ID: 17897103

Title: MAPK-induced Ser727 phosphorylation promotes SUMOylation of STAT1.

PubMed ID: 17897103

DOI: 10.1042/bj20070620

PubMed ID: 18721752

Title: System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties.

PubMed ID: 18721752

DOI: 10.1016/j.chembiol.2008.07.006

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19088846

Title: Analysis of STAT1 activation by six FGFR3 mutants associated with skeletal dysplasia undermines dominant role of STAT1 in FGFR3 signaling in cartilage.

PubMed ID: 19088846

DOI: 10.1371/journal.pone.0003961

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19136629

Title: PRMT1-mediated arginine methylation of PIAS1 regulates STAT1 signaling.

PubMed ID: 19136629

DOI: 10.1101/gad.489409

PubMed ID: 21724836

Title: Retraction. PRMT1-mediated arginine methylation of PIAS1 regulates STAT1 signaling.

PubMed ID: 21724836

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21135090

Title: Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells.

PubMed ID: 21135090

DOI: 10.1074/jbc.m110.182642

PubMed ID: 22065572

Title: Inhibitor of kappaB kinase epsilon (IKK(epsilon)), STAT1, and IFIT2 proteins define novel innate immune effector pathway against West Nile virus infection.

PubMed ID: 22065572

DOI: 10.1074/jbc.m111.285205

PubMed ID: 22383882

Title: The ebola virus interferon antagonist VP24 directly binds STAT1 and has a novel, pyramidal fold.

PubMed ID: 22383882

DOI: 10.1371/journal.ppat.1002550

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23940278

Title: Ubiquitin-specific protease 13 regulates IFN signaling by stabilizing STAT1.

PubMed ID: 23940278

DOI: 10.4049/jimmunol.1300225

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 26479788

Title: PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection.

PubMed ID: 26479788

DOI: 10.1038/ni.3279

PubMed ID: 27796300

Title: PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation.

PubMed ID: 27796300

DOI: 10.1038/ncomms12849

PubMed ID: 28753426

Title: Methyltransferase SETD2-mediated methylation of STAT1 is critical for interferon antiviral activity.

PubMed ID: 28753426

DOI: 10.1016/j.cell.2017.06.042

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 29858569

Title: On the role of STAT1 and STAT6 ADP-ribosylation in the regulation of macrophage activation.

PubMed ID: 29858569

DOI: 10.1038/s41467-018-04522-z

PubMed ID: 32699158

Title: Herpes Simplex Virus Type 2 Inhibits Type I IFN Signaling Mediated by the Novel E3 Ubiquitin Protein Ligase Activity of Viral Protein ICP22.

PubMed ID: 32699158

DOI: 10.4049/jimmunol.2000418

PubMed ID: 32209697

Title: Noncanonical STAT1 phosphorylation expands its transcriptional activity into promoting LPS-induced IL-6 and IL-12p40 production.

PubMed ID: 32209697

DOI: 10.1126/scisignal.aay0574

PubMed ID: 34508746

Title: Interleukin-35 inhibits lipopolysaccharide-induced endothelial cell activation by downregulating inflammation and apoptosis.

PubMed ID: 34508746

DOI: 10.1016/j.yexcr.2021.112784

PubMed ID: 34319780

Title: Suppression of JAK-STAT Signaling by Epstein-Barr Virus Tegument Protein BGLF2 through Recruitment of SHP1 Phosphatase and Promotion of STAT2 Degradation.

PubMed ID: 34319780

DOI: 10.1128/jvi.01027-21

PubMed ID: 35568036

Title: A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling.

PubMed ID: 35568036

DOI: 10.1016/j.cell.2022.04.028

PubMed ID: 38621137

Title: Threonine phosphorylation of STAT1 restricts interferon signaling and promotes innate inflammatory responses.

PubMed ID: 38621137

DOI: 10.1073/pnas.2402226121

PubMed ID: 9630226

Title: Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA.

PubMed ID: 9630226

DOI: 10.1016/s0092-8674(00)81443-9

PubMed ID: 11452125

Title: Impairment of mycobacterial but not viral immunity by a germline human STAT1 mutation.

PubMed ID: 11452125

DOI: 10.1126/science.1061154

PubMed ID: 12590259

Title: Impaired response to interferon-alpha/beta and lethal viral disease in human STAT1 deficiency.

PubMed ID: 12590259

DOI: 10.1038/ng1097

PubMed ID: 16934001

Title: Novel STAT1 alleles in otherwise healthy patients with mycobacterial disease.

PubMed ID: 16934001

DOI: 10.1371/journal.pgen.0020131

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 20841510

Title: A novel form of human STAT1 deficiency impairing early but not late responses to interferons.

PubMed ID: 20841510

DOI: 10.1182/blood-2010-04-280586

PubMed ID: 21727188

Title: Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis.

PubMed ID: 21727188

DOI: 10.1084/jem.20110958

PubMed ID: 21714643

Title: STAT1 mutations in autosomal dominant chronic mucocutaneous candidiasis.

PubMed ID: 21714643

DOI: 10.1056/nejmoa1100102

PubMed ID: 22573496

Title: Dominant-negative STAT1 SH2 domain mutations in unrelated patients with Mendelian susceptibility to mycobacterial disease.

PubMed ID: 22573496

DOI: 10.1002/humu.22113

PubMed ID: 23709754

Title: New and recurrent gain-of-function STAT1 mutations in patients with chronic mucocutaneous candidiasis from Eastern and Central Europe.

PubMed ID: 23709754

DOI: 10.1136/jmedgenet-2013-101570

PubMed ID: 25288569

Title: Two novel gain-of-function mutations of STAT1 responsible for chronic mucocutaneous candidiasis disease: impaired production of IL-17A and IL-22, and the presence of anti-IL-17F autoantibody.

PubMed ID: 25288569

DOI: 10.4049/jimmunol.1401467

PubMed ID: 26514428

Title: A novel gain-of-function STAT1 mutation resulting in basal phosphorylation of STAT1 and increased distal IFN-gamma-mediated responses in chronic mucocutaneous candidiasis.

PubMed ID: 26514428

DOI: 10.1016/j.molimm.2015.09.014

Sequence Information:

  • Length: 750
  • Mass: 87335
  • Checksum: 054A813522364BA6
  • Sequence:
    • MSQWYELQQL DSKFLEQVHQ LYDDSFPMEI RQYLAQWLEK QDWEHAANDV SFATIRFHDL 
LSQLDDQYSR FSLENNFLLQ HNIRKSKRNL QDNFQEDPIQ MSMIIYSCLK EERKILENAQ 
RFNQAQSGNI QSTVMLDKQK ELDSKVRNVK DKVMCIEHEI KSLEDLQDEY DFKCKTLQNR 
EHETNGVAKS DQKQEQLLLK KMYLMLDNKR KEVVHKIIEL LNVTELTQNA LINDELVEWK 
RRQQSACIGG PPNACLDQLQ NWFTIVAESL QQVRQQLKKL EELEQKYTYE HDPITKNKQV 
LWDRTFSLFQ QLIQSSFVVE RQPCMPTHPQ RPLVLKTGVQ FTVKLRLLVK LQELNYNLKV 
KVLFDKDVNE RNTVKGFRKF NILGTHTKVM NMEESTNGSL AAEFRHLQLK EQKNAGTRTN 
EGPLIVTEEL HSLSFETQLC QPGLVIDLET TSLPVVVISN VSQLPSGWAS ILWYNMLVAE 
PRNLSFFLTP PCARWAQLSE VLSWQFSSVT KRGLNVDQLN MLGEKLLGPN ASPDGLIPWT 
RFCKENINDK NFPFWLWIES ILELIKKHLL PLWNDGCIMG FISKERERAL LKDQQPGTFL 
LRFSESSREG AITFTWVERS QNGGEPDFHA VEPYTKKELS AVTFPDIIRN YKVMAAENIP 
ENPLKYLYPN IDKDHAFGKY YSRPKEAPEP MELDGPKGTG YIKTELISVS EVHPSRLQTT 
DNLLPMSPEE FDEVSRIVGS VEFDSMMNTV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.