STAT5B | ENSG00000173757 | NCBI 6777

Details for: STAT5B

Gene ID: 6777

Symbol: STAT5B

Ensembl ID: ENSG00000173757

Description: signal transducer and activator of transcription 5B

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downstream signal transduction
(R-HSA-186763)
Erythropoietin activates stat5
(R-HSA-9027283)
Fgfr1 mutant receptor activation
(R-HSA-1839124)
Flt3 signaling
(R-HSA-9607240)
Flt3 signaling in disease
(R-HSA-9682385)
Growth hormone receptor signaling
(R-HSA-982772)
Immune system
(R-HSA-168256)
Inactivation of csf3 (g-csf) signaling
(R-HSA-9705462)
Interleukin-2 family signaling
(R-HSA-451927)
Interleukin-2 signaling
(R-HSA-9020558)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-HSA-512988)
Interleukin-7 signaling
(R-HSA-1266695)
Interleukin-9 signaling
(R-HSA-8985947)
Interleukin-15 signaling
(R-HSA-8983432)
Interleukin-20 family signaling
(R-HSA-8854691)
Interleukin-21 signaling
(R-HSA-9020958)
Prolactin receptor signaling
(R-HSA-1170546)
Signaling by csf3 (g-csf)
(R-HSA-9674555)
Signaling by cytosolic fgfr1 fusion mutants
(R-HSA-1839117)
Signaling by erythropoietin
(R-HSA-9006335)
Signaling by fgfr1 in disease
(R-HSA-5655302)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by flt3 fusion proteins
(R-HSA-9703465)
Signaling by flt3 itd and tkd mutants
(R-HSA-9703648)
Signaling by interleukins
(R-HSA-449147)
Signaling by kit in disease
(R-HSA-9669938)
Signaling by leptin
(R-HSA-2586552)
Signaling by pdgf
(R-HSA-186797)
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain kit mutants
(R-HSA-9670439)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by scf-kit
(R-HSA-1433557)
Signal transduction
(R-HSA-162582)
Stat5 activation
(R-HSA-9645135)
Stat5 activation downstream of flt3 itd mutants
(R-HSA-9702518)
Activated t cell proliferation
(GO:0050798)
B cell differentiation
(GO:0030183)
Cell surface receptor signaling pathway via jak-stat
(GO:0007259)
Cellular response to hormone stimulus
(GO:0032870)
Chromatin binding
(GO:0003682)
Cytokine-mediated signaling pathway
(GO:0019221)
Defense response
(GO:0006952)
Development of secondary female sexual characteristics
(GO:0046543)
Development of secondary male sexual characteristics
(GO:0046544)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Erythrocyte differentiation
(GO:0030218)
Erythropoietin-mediated signaling pathway
(GO:0038162)
Female pregnancy
(GO:0007565)
Gamma-delta t cell differentiation
(GO:0042492)
Growth hormone receptor signaling pathway via jak-stat
(GO:0060397)
Identical protein binding
(GO:0042802)
Lactation
(GO:0007595)
Lipid storage
(GO:0019915)
Luteinization
(GO:0001553)
Mitotic cell cycle
(GO:0000278)
Myeloid cell apoptotic process
(GO:0033028)
Natural killer cell differentiation
(GO:0001779)
Natural killer cell mediated cytotoxicity
(GO:0042267)
Natural killer cell proliferation
(GO:0001787)
Negative regulation of erythrocyte differentiation
(GO:0045647)
Negative regulation of myeloid cell apoptotic process
(GO:0033033)
Nuclear glucocorticoid receptor binding
(GO:0035259)
Peyer's patch development
(GO:0048541)
Positive regulation of activated t cell proliferation
(GO:0042104)
Positive regulation of b cell differentiation
(GO:0045579)
Positive regulation of erythrocyte differentiation
(GO:0045648)
Positive regulation of gamma-delta t cell differentiation
(GO:0045588)
Positive regulation of inflammatory response
(GO:0050729)
Positive regulation of interleukin-2 production
(GO:0032743)
Positive regulation of mitotic cell cycle
(GO:0045931)
Positive regulation of multicellular organism growth
(GO:0040018)
Positive regulation of natural killer cell differentiation
(GO:0032825)
Positive regulation of natural killer cell mediated cytotoxicity
(GO:0045954)
Positive regulation of natural killer cell proliferation
(GO:0032819)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Progesterone metabolic process
(GO:0042448)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Protein homodimerization activity
(GO:0042803)
Regulation of cell population proliferation
(GO:0042127)
Regulation of epithelial cell differentiation
(GO:0030856)
Regulation of multicellular organism growth
(GO:0040014)
Regulation of steroid metabolic process
(GO:0019218)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to estradiol
(GO:0032355)
Response to interleukin-2
(GO:0070669)
Response to interleukin-4
(GO:0070670)
Response to peptide hormone
(GO:0043434)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Taurine metabolic process
(GO:0019530)
T cell differentiation in thymus
(GO:0033077)
T cell homeostasis
(GO:0043029)
Transcription by rna polymerase ii
(GO:0006366)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 240.8303
Cell Significance Index: -37.4600
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 148.0819
Cell Significance Index: -37.5600
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 82.4109
Cell Significance Index: -33.4800
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 75.2354
Cell Significance Index: -38.7000
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 35.1168
Cell Significance Index: -33.5300
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 31.8097
Cell Significance Index: -39.2200
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 14.4408
Cell Significance Index: -38.6900
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 11.7564
Cell Significance Index: -25.7300
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 10.3078
Cell Significance Index: -31.6600
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 10.1063
Cell Significance Index: -39.8800
Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.1821
Cell Significance Index: 433.0400
Cell Name: adipocyte of breast (CL0002617)
Fold Change: 1.3449
Cell Significance Index: 16.9400
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.3211
Cell Significance Index: 473.8500
Cell Name: cortical interneuron (CL0008031)
Fold Change: 1.2605
Cell Significance Index: 30.2300
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 1.2397
Cell Significance Index: 76.2000
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.1221
Cell Significance Index: 182.5000
Cell Name: preadipocyte (CL0002334)
Fold Change: 1.0642
Cell Significance Index: 20.7700
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.0467
Cell Significance Index: 209.9600
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.9998
Cell Significance Index: 98.9000
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.9579
Cell Significance Index: 53.7500
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.8381
Cell Significance Index: 579.6800
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.5943
Cell Significance Index: 15.9300
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.5554
Cell Significance Index: 60.4100
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.5529
Cell Significance Index: 13.8200
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.4464
Cell Significance Index: 6.4200
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.4397
Cell Significance Index: 33.7400
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.3304
Cell Significance Index: 45.3800
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.3160
Cell Significance Index: 18.9700
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.3149
Cell Significance Index: 8.8000
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.3027
Cell Significance Index: 7.7800
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.2730
Cell Significance Index: 123.9000
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.2516
Cell Significance Index: 11.1300
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2507
Cell Significance Index: 226.3900
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.1964
Cell Significance Index: 2.8200
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1917
Cell Significance Index: 13.2600
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.1906
Cell Significance Index: 8.9600
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.1738
Cell Significance Index: 6.5800
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1693
Cell Significance Index: 318.7300
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1647
Cell Significance Index: 4.7500
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1512
Cell Significance Index: 18.5900
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.1470
Cell Significance Index: 3.1900
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1443
Cell Significance Index: 26.0100
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1427
Cell Significance Index: 90.6100
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.1243
Cell Significance Index: 2.1300
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0710
Cell Significance Index: 38.7900
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0609
Cell Significance Index: 112.2500
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0530
Cell Significance Index: 6.2500
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0507
Cell Significance Index: 78.0900
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0439
Cell Significance Index: 19.4300
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0166
Cell Significance Index: 22.5500
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0137
Cell Significance Index: -2.3400
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0159
Cell Significance Index: -9.9300
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0242
Cell Significance Index: -17.9300
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0253
Cell Significance Index: -18.5800
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0393
Cell Significance Index: -1.0500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0401
Cell Significance Index: -1.4100
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0441
Cell Significance Index: -24.8500
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0495
Cell Significance Index: -37.5000
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0521
Cell Significance Index: -3.5000
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0622
Cell Significance Index: -2.8200
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: -0.0671
Cell Significance Index: -12.7800
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0761
Cell Significance Index: -9.7500
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0989
Cell Significance Index: -4.6100
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1166
Cell Significance Index: -12.1400
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1169
Cell Significance Index: -15.1100
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1171
Cell Significance Index: -33.7000
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1238
Cell Significance Index: -26.0800
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1368
Cell Significance Index: -19.8900
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1591
Cell Significance Index: -18.5400
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.1685
Cell Significance Index: -3.6900
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.1857
Cell Significance Index: -3.0600
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.2085
Cell Significance Index: -1.2600
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2136
Cell Significance Index: -15.9200
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.2179
Cell Significance Index: -22.2600
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.2326
Cell Significance Index: -15.0100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2442
Cell Significance Index: -27.9800
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.2562
Cell Significance Index: -6.2500
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3040
Cell Significance Index: -18.6400
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.3084
Cell Significance Index: -3.8300
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3095
Cell Significance Index: -35.3300
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.3695
Cell Significance Index: -26.1300
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.3769
Cell Significance Index: -19.5800
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.3796
Cell Significance Index: -8.0800
Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: -0.4043
Cell Significance Index: -1.7600
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.4052
Cell Significance Index: -25.5400
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4232
Cell Significance Index: -33.5200
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.4558
Cell Significance Index: -23.9300
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.4782
Cell Significance Index: -9.9200
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.5352
Cell Significance Index: -11.3600
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.5396
Cell Significance Index: -10.6700
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.5470
Cell Significance Index: -28.4900
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.6295
Cell Significance Index: -13.4600
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.6639
Cell Significance Index: -19.0300
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.6871
Cell Significance Index: -20.1800
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.6907
Cell Significance Index: -4.6800
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.6924
Cell Significance Index: -13.9000
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.6984
Cell Significance Index: -22.3700
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.7296
Cell Significance Index: -20.8200
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.7925
Cell Significance Index: -25.2400
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.8118
Cell Significance Index: -26.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** STAT5B is a cytoplasmic protein that undergoes phosphorylation and dimerization upon activation by cytokines or growth factors. It contains two SH2 domains and a DNA-binding domain, which enable it to interact with specific DNA sequences and regulate gene expression. STAT5B is highly expressed in hematopoietic cells, particularly in T cells, B cells, and myeloid cells. It is also present in other cell types, including epithelial cells, smooth muscle cells, and neurons. **Pathways and Functions** STAT5B is involved in various signaling pathways, including: 1. **Cytokine signaling**: STAT5B is activated by cytokines such as IL-2, IL-4, IL-7, and IL-15, which regulate immune responses, cell proliferation, and differentiation. 2. **Growth factor signaling**: STAT5B is activated by growth factors such as erythropoietin, which regulates erythropoiesis and red blood cell production. 3. **Hormone signaling**: STAT5B is activated by hormones such as prolactin, which regulates lactation and breast development. 4. **Receptor tyrosine kinase signaling**: STAT5B is activated by receptor tyrosine kinases such as Flt3, which regulates hematopoiesis and immune responses. STAT5B regulates gene expression by binding to specific DNA sequences, known as gamma-activated sites (GAS). It recruits coactivators and corepressors to modulate gene expression, leading to the transcription of target genes involved in cell proliferation, differentiation, and survival. **Clinical Significance** Dysregulation of STAT5B has been implicated in various diseases, including: 1. **Cancer**: STAT5B is often overexpressed in cancer cells, leading to enhanced cell proliferation and survival. 2. **Autoimmune disorders**: STAT5B is involved in autoimmune responses, and its dysregulation can lead to diseases such as rheumatoid arthritis and lupus. 3. **Developmental abnormalities**: STAT5B is essential for normal development, and its dysregulation can lead to abnormalities such as thrombocytopenia and aplastic anemia. 4. **Neurological disorders**: STAT5B is involved in neuronal development and function, and its dysregulation can lead to diseases such as Parkinson's disease and Alzheimer's disease. In conclusion, STAT5B is a critical transcription factor involved in various cellular processes, including cell proliferation, differentiation, survival, and immune response. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its mechanisms of action and regulation.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Signal transducer and activator of transcription 5B

Genular Protein ID: 2854661808

Symbol: STA5B_HUMAN

Name: Signal transducer and activator of transcription 5B

UniProtKB Accession Codes:

P51692 Q8WWS8

Database IDs:

Citations:

PubMed ID: 8732682

Title: Characterization and cloning of STAT5 from IM-9 cells and its activation by growth hormone.

PubMed ID: 8732682

DOI: 10.1210/mend.10.5.8732682

PubMed ID: 8631883

Title: Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells.

PubMed ID: 8631883

DOI: 10.1074/jbc.271.18.10738

PubMed ID: 12039059

Title: The structure of human STAT5A and B genes reveals two regions of nearly identical sequence and an alternative tissue specific STAT5B promoter.

PubMed ID: 12039059

DOI: 10.1016/s0378-1119(02)00421-3

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9428692

Title: Identification of Stat 5B as a substrate of the insulin receptor.

PubMed ID: 9428692

DOI: 10.1111/j.1432-1033.1997.0411a.x

PubMed ID: 9989503

Title: Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling.

PubMed ID: 9989503

DOI: 10.1016/s0092-8674(00)80965-4

PubMed ID: 12411494

Title: The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells.

PubMed ID: 12411494

DOI: 10.1093/emboj/cdf562

PubMed ID: 11773439

Title: A nuclear protein tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated signaling pathway: dephosphorylation and deactivation of signal transducer and activator of transcription 5a and 5b by TC-PTP in nucleus.

PubMed ID: 11773439

DOI: 10.1210/mend.16.1.0761

PubMed ID: 24319783

Title: Retraction.

PubMed ID: 24319783

DOI: 10.1210/me.2013-1264

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 12954634

Title: NCoA-1/SRC-1 is an essential coactivator of STAT5 that binds to the FDL motif in the alpha-helical region of the STAT5 transactivation domain.

PubMed ID: 12954634

DOI: 10.1074/jbc.m303644200

PubMed ID: 14504097

Title: FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy.

PubMed ID: 14504097

DOI: 10.1182/blood-2003-02-0418

PubMed ID: 15526160

Title: Signal transduction via the stem cell factor receptor/c-Kit.

PubMed ID: 15526160

DOI: 10.1007/s00018-004-4189-6

PubMed ID: 15121872

Title: Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta.

PubMed ID: 15121872

DOI: 10.1128/mcb.24.10.4557-4570.2004

PubMed ID: 15677474

Title: Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation.

PubMed ID: 15677474

DOI: 10.1074/jbc.m411596200

PubMed ID: 15827093

Title: Severe growth hormone insensitivity resulting from total absence of signal transducer and activator of transcription 5b.

PubMed ID: 15827093

DOI: 10.1210/jc.2005-0515

PubMed ID: 17997837

Title: Signal transducer and activator of transcription 5b: a new target of breast tumor kinase/protein tyrosine kinase 6.

PubMed ID: 17997837

DOI: 10.1186/bcr1794

PubMed ID: 20702587

Title: ZFP36L1 negatively regulates erythroid differentiation of CD34+ hematopoietic stem cells by interfering with the Stat5b pathway.

PubMed ID: 20702587

DOI: 10.1091/mbc.e10-01-0040

PubMed ID: 20639532

Title: A novel role of CPEB3 in regulating EGFR gene transcription via association with Stat5b in neurons.

PubMed ID: 20639532

DOI: 10.1093/nar/gkq634

PubMed ID: 21135090

Title: Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells.

PubMed ID: 21135090

DOI: 10.1074/jbc.m110.182642

PubMed ID: 29844444

Title: Dominant-negative STAT5B mutations cause growth hormone insensitivity with short stature and mild immune dysregulation.

PubMed ID: 29844444

DOI: 10.1038/s41467-018-04521-0

PubMed ID: 13679528

Title: Growth hormone insensitivity associated with a STAT5b mutation.

PubMed ID: 13679528

DOI: 10.1056/nejmoa022926

PubMed ID: 22419735

Title: A Novel Missense Mutation in the SH2 Domain of the STAT5B Gene Results in a transcriptionally inactive STAT5b associated with severe IGF-I deficiency, immune dysfunction, and lack of pulmonary disease.

PubMed ID: 22419735

DOI: 10.1210/jc.2011-2554

Sequence Information:

Length: 787
Mass: 89866
Checksum: AA2F1CAB20955ACA
Sequence:

MAVWIQAQQL QGEALHQMQA LYGQHFPIEV RHYLSQWIES QAWDSVDLDN PQENIKATQL 
LEGLVQELQK KAEHQVGEDG FLLKIKLGHY ATQLQNTYDR CPMELVRCIR HILYNEQRLV 
REANNGSSPA GSLADAMSQK HLQINQTFEE LRLVTQDTEN ELKKLQQTQE YFIIQYQESL 
RIQAQFGPLA QLSPQERLSR ETALQQKQVS LEAWLQREAQ TLQQYRVELA EKHQKTLQLL 
RKQQTIILDD ELIQWKRRQQ LAGNGGPPEG SLDVLQSWCE KLAEIIWQNR QQIRRAEHLC 
QQLPIPGPVE EMLAEVNATI TDIISALVTS TFIIEKQPPQ VLKTQTKFAA TVRLLVGGKL 
NVHMNPPQVK ATIISEQQAK SLLKNENTRN DYSGEILNNC CVMEYHQATG TLSAHFRNMS 
LKRIKRSDRR GAESVTEEKF TILFESQFSV GGNELVFQVK TLSLPVVVIV HGSQDNNATA 
TVLWDNAFAE PGRVPFAVPD KVLWPQLCEA LNMKFKAEVQ SNRGLTKENL VFLAQKLFNN 
SSSHLEDYSG LSVSWSQFNR ENLPGRNYTF WQWFDGVMEV LKKHLKPHWN DGAILGFVNK 
QQAHDLLINK PDGTFLLRFS DSEIGGITIA WKFDSQERMF WNLMPFTTRD FSIRSLADRL 
GDLNYLIYVF PDRPKDEVYS KYYTPVPCES ATAKAVDGYV KPQIKQVVPE FVNASADAGG 
GSATYMDQAP SPAVCPQAHY NMYPQNPDSV LDTDGDFDLE DTMDVARRVE ELLGRPMDSQ 
WIPHAQS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: STAT5B

Associated with

Cells (max top 100)

Other Information

Characterization and cloning of STAT5 from IM-9 cells and its activation by growth hormone. PubMed ID: 8732682

Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells. PubMed ID: 8631883

The structure of human STAT5A and B genes reveals two regions of nearly identical sequence and an alternative tissue specific STAT5B promoter. PubMed ID: 12039059

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of Stat 5B as a substrate of the insulin receptor. PubMed ID: 9428692

Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling. PubMed ID: 9989503

The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells. PubMed ID: 12411494

A nuclear protein tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated signaling pathway: dephosphorylation and deactivation of signal transducer and activator of transcription 5a and 5b by TC-PTP in nucleus. PubMed ID: 11773439

Retraction. PubMed ID: 24319783

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

NCoA-1/SRC-1 is an essential coactivator of STAT5 that binds to the FDL motif in the alpha-helical region of the STAT5 transactivation domain. PubMed ID: 12954634

FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy. PubMed ID: 14504097

Signal transduction via the stem cell factor receptor/c-Kit. PubMed ID: 15526160

Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta. PubMed ID: 15121872

Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation. PubMed ID: 15677474

Severe growth hormone insensitivity resulting from total absence of signal transducer and activator of transcription 5b. PubMed ID: 15827093

Signal transducer and activator of transcription 5b: a new target of breast tumor kinase/protein tyrosine kinase 6. PubMed ID: 17997837

ZFP36L1 negatively regulates erythroid differentiation of CD34+ hematopoietic stem cells by interfering with the Stat5b pathway. PubMed ID: 20702587

A novel role of CPEB3 in regulating EGFR gene transcription via association with Stat5b in neurons. PubMed ID: 20639532

Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells. PubMed ID: 21135090

Dominant-negative STAT5B mutations cause growth hormone insensitivity with short stature and mild immune dysregulation. PubMed ID: 29844444

Growth hormone insensitivity associated with a STAT5b mutation. PubMed ID: 13679528

A Novel Missense Mutation in the SH2 Domain of the STAT5B Gene Results in a transcriptionally inactive STAT5b associated with severe IGF-I deficiency, immune dysfunction, and lack of pulmonary disease. PubMed ID: 22419735