Details for: STK11

Gene ID: 6794

Symbol: STK11

Ensembl ID: ENSG00000118046

Description: serine/threonine kinase 11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 131.7302
    Cell Significance Index: -20.4900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 93.6748
    Cell Significance Index: -23.7600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 53.4607
    Cell Significance Index: -25.2400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 45.5377
    Cell Significance Index: -18.5000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 37.5546
    Cell Significance Index: -25.2000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.6184
    Cell Significance Index: -20.6400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.7436
    Cell Significance Index: -23.1100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.2689
    Cell Significance Index: -24.8300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.2113
    Cell Significance Index: -24.5100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.6618
    Cell Significance Index: -17.3900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.1951
    Cell Significance Index: -11.3700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.7770
    Cell Significance Index: 196.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.2864
    Cell Significance Index: 266.4600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.6321
    Cell Significance Index: 177.5300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.5472
    Cell Significance Index: 21.1100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4185
    Cell Significance Index: 85.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2944
    Cell Significance Index: 37.3000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1962
    Cell Significance Index: 1080.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0204
    Cell Significance Index: 46.2500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9184
    Cell Significance Index: 47.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9181
    Cell Significance Index: 19.8900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8520
    Cell Significance Index: 23.8100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6723
    Cell Significance Index: 46.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5971
    Cell Significance Index: 107.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5465
    Cell Significance Index: 108.4500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5049
    Cell Significance Index: 62.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4885
    Cell Significance Index: 98.0000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3928
    Cell Significance Index: 214.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3925
    Cell Significance Index: 18.3000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3564
    Cell Significance Index: 48.9500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3337
    Cell Significance Index: 5.0000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3170
    Cell Significance Index: 8.5000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2875
    Cell Significance Index: 46.7600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2744
    Cell Significance Index: 17.7100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2439
    Cell Significance Index: 87.4700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2388
    Cell Significance Index: 5.9700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2341
    Cell Significance Index: 103.4800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2059
    Cell Significance Index: 39.1800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1892
    Cell Significance Index: 4.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1619
    Cell Significance Index: 7.6100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1603
    Cell Significance Index: 15.8600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1560
    Cell Significance Index: 11.9800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.1524
    Cell Significance Index: 1.2800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1503
    Cell Significance Index: 103.9800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1277
    Cell Significance Index: 8.0500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1202
    Cell Significance Index: 3.1600
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.1065
    Cell Significance Index: 0.2400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0795
    Cell Significance Index: 2.2800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0581
    Cell Significance Index: 1.0000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0576
    Cell Significance Index: 0.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0383
    Cell Significance Index: 72.1400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0324
    Cell Significance Index: 1.1400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0215
    Cell Significance Index: 33.0400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0191
    Cell Significance Index: 0.5200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0173
    Cell Significance Index: 1.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0107
    Cell Significance Index: 19.7100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0071
    Cell Significance Index: 4.4800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0064
    Cell Significance Index: 1.1000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0034
    Cell Significance Index: 1.5400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0030
    Cell Significance Index: 0.3800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0016
    Cell Significance Index: 2.1200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0024
    Cell Significance Index: -1.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0173
    Cell Significance Index: -13.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0198
    Cell Significance Index: -0.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0295
    Cell Significance Index: -21.8600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0428
    Cell Significance Index: -24.1300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0433
    Cell Significance Index: -27.0100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0510
    Cell Significance Index: -6.0100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0553
    Cell Significance Index: -5.6500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0684
    Cell Significance Index: -19.6700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0759
    Cell Significance Index: -2.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0841
    Cell Significance Index: -12.2300
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0890
    Cell Significance Index: -0.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0933
    Cell Significance Index: -12.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1162
    Cell Significance Index: -7.8100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1328
    Cell Significance Index: -27.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1344
    Cell Significance Index: -15.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1401
    Cell Significance Index: -10.4400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1455
    Cell Significance Index: -8.9500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1847
    Cell Significance Index: -5.9200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1888
    Cell Significance Index: -19.6600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2026
    Cell Significance Index: -4.6800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2221
    Cell Significance Index: -5.7100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2282
    Cell Significance Index: -18.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2315
    Cell Significance Index: -12.9900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2535
    Cell Significance Index: -13.3100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2631
    Cell Significance Index: -3.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2814
    Cell Significance Index: -12.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3150
    Cell Significance Index: -19.3100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3299
    Cell Significance Index: -4.8700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3531
    Cell Significance Index: -13.3700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3869
    Cell Significance Index: -11.0400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4018
    Cell Significance Index: -6.7300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4382
    Cell Significance Index: -8.1000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4814
    Cell Significance Index: -16.7300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5249
    Cell Significance Index: -18.3900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.5365
    Cell Significance Index: -13.0900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5439
    Cell Significance Index: -5.6300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5488
    Cell Significance Index: -17.4800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5499
    Cell Significance Index: -18.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** STK11 is a serine/threonine kinase that belongs to the LKB1 family of kinases. The gene is composed of 11 exons and encodes a protein of approximately 1,000 amino acids. STK11 is characterized by its ability to phosphorylate and activate AMPK, a key regulator of energy metabolism in cells. The gene is also involved in the regulation of protein kinase activity, cell growth, and apoptosis. STK11 is a tumor suppressor gene, and mutations in the gene have been identified in several cancer types, including PJS, pancreatic cancer, and colorectal cancer. **Pathways and Functions** STK11 is involved in several key cellular pathways, including: 1. **AMPK signaling pathway**: STK11 phosphorylates and activates AMPK, which is a key regulator of energy metabolism in cells. AMPK activation leads to the inhibition of glucose uptake, fatty acid synthesis, and protein synthesis, and the activation of glucose and lipid metabolism. 2. **Cell cycle regulation**: STK11 regulates cell cycle progression by inhibiting the activity of cyclin-dependent kinases and promoting the activity of cyclin-dependent kinase inhibitors. 3. **Apoptosis regulation**: STK11 regulates apoptosis by phosphorylating and activating pro-apoptotic proteins and inhibiting anti-apoptotic proteins. 4. **Autophagy regulation**: STK11 regulates autophagy by phosphorylating and activating autophagy-related proteins. 5. **Wnt signaling pathway**: STK11 regulates Wnt signaling by phosphorylating and activating Wnt receptors, which leads to the inhibition of Wnt-dependent transcriptional activity. **Clinical Significance** Mutations in the STK11 gene have been identified in several tumor types, including: 1. **Peutz-Jeghers syndrome (PJS)**: STK11 mutations are a common cause of PJS, a rare genetic disorder characterized by the development of hamartomatous polyps in the gastrointestinal tract and an increased risk of cancer. 2. **Pancreatic cancer**: STK11 mutations have been identified in a subset of pancreatic cancer cases, suggesting that STK11 may play a role in the development of this cancer type. 3. **Colorectal cancer**: STK11 mutations have been identified in a subset of colorectal cancer cases, suggesting that STK11 may play a role in the development of this cancer type. 4. **Other cancers**: STK11 mutations have also been identified in other cancer types, including prostate cancer, breast cancer, and lung cancer. Overall, STK11 is a critical regulator of energy metabolism, cell growth, and apoptosis, and its dysfunction has been implicated in several tumor types. Further research is needed to fully understand the role of STK11 in human disease and to develop effective therapeutic strategies for the treatment of STK11-related cancers.

Genular Protein ID: 591389115

Symbol: STK11_HUMAN

Name: Liver kinase B1

UniProtKB Accession Codes:

Q15831 B2RBX7 E7EW76

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 2 CPTC 1 CTD 1 ChEBI 14 ChEMBL 1 ChiTaRS 1 ComplexPortal 4 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 2 EMBL 17 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 65 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 4 RefSeq 2 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9425897

Title: Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase.

PubMed ID: 9425897

DOI: 10.1038/ng0198-38

PubMed ID: 9537235

Title: Low frequency of somatic mutations in the LKB1/Peutz-Jeghers syndrome gene in sporadic breast cancer.

PubMed ID: 9537235

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10508479

Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.

PubMed ID: 10508479

DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5

PubMed ID: 11212897

Title: Frequent loss of heterozygosity at the 19p13.3 locus without LKB1/STK11 mutations in human carcinoma metastases to the brain.

PubMed ID: 11212897

DOI: 10.1023/a:1006442024874

PubMed ID: 11741830

Title: LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1.

PubMed ID: 11741830

DOI: 10.1093/hmg/10.25.2869

PubMed ID: 11430832

Title: The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death.

PubMed ID: 11430832

DOI: 10.1016/s1097-2765(01)00258-1

PubMed ID: 12097271

Title: Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung.

PubMed ID: 12097271

PubMed ID: 12805220

Title: Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD.

PubMed ID: 12805220

DOI: 10.1093/emboj/cdg292

PubMed ID: 14517248

Title: MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm.

PubMed ID: 14517248

DOI: 10.1093/emboj/cdg490

PubMed ID: 15016379

Title: Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD.

PubMed ID: 15016379

DOI: 10.1016/s0092-8674(04)00114-x

PubMed ID: 14976552

Title: LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.

PubMed ID: 14976552

DOI: 10.1038/sj.emboj.7600110

PubMed ID: 15021901

Title: Novel and natural knockout lung cancer cell lines for the LKB1/STK11 tumor suppressor gene.

PubMed ID: 15021901

DOI: 10.1038/sj.onc.1207502

PubMed ID: 15733851

Title: Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate.

PubMed ID: 15733851

DOI: 10.1016/j.febslet.2005.01.042

PubMed ID: 15987703

Title: LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes.

PubMed ID: 15987703

DOI: 10.1093/hmg/ddi225

PubMed ID: 17108107

Title: LKB1 is recruited to the p21/WAF1 promoter by p53 to mediate transcriptional activation.

PubMed ID: 17108107

DOI: 10.1158/0008-5472.can-06-0999

PubMed ID: 17216128

Title: Association of LKB1 with a WD-repeat protein WDR6 is implicated in cell growth arrest and p27(Kip1) induction.

PubMed ID: 17216128

DOI: 10.1007/s11010-006-9402-5

PubMed ID: 17711506

Title: LKB1 gene mutations in Japanese lung cancer patients.

PubMed ID: 17711506

DOI: 10.1111/j.1349-7006.2007.00585.x

PubMed ID: 17676035

Title: LKB1 modulates lung cancer differentiation and metastasis.

PubMed ID: 17676035

DOI: 10.1038/nature06030

PubMed ID: 17384680

Title: Prevalence and specificity of LKB1 genetic alterations in lung cancers.

PubMed ID: 17384680

DOI: 10.1038/sj.onc.1210418

PubMed ID: 18594528

Title: Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patients.

PubMed ID: 18594528

DOI: 10.1038/sj.bjc.6604469

PubMed ID: 18321849

Title: Protein kinase Czeta-dependent LKB1 serine 428 phosphorylation increases LKB1 nucleus export and apoptosis in endothelial cells.

PubMed ID: 18321849

DOI: 10.1074/jbc.m708208200

PubMed ID: 31519760

Title: Withdrawal: Protein kinase Czeta-dependent LKB1 serine 428 phosphorylation increases LKB1 nucleus export and apoptosis in endothelial cells.

PubMed ID: 31519760

DOI: 10.1074/jbc.w119.010661

PubMed ID: 18687677

Title: SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation.

PubMed ID: 18687677

DOI: 10.1074/jbc.m805711200

PubMed ID: 18854309

Title: Characterization of an alternative splice variant of LKB1.

PubMed ID: 18854309

DOI: 10.1074/jbc.m806153200

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20559149

Title: Spectrum of LKB1, EGFR, and KRAS mutations in Chinese lung adenocarcinomas.

PubMed ID: 20559149

DOI: 10.1097/jto.0b013e3181e05016

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21317932

Title: A new role of NUAK1: directly phosphorylating p53 and regulating cell proliferation.

PubMed ID: 21317932

DOI: 10.1038/onc.2011.19

PubMed ID: 21396365

Title: The role of LKB1 and AMPK in cellular responses to stress and damage.

PubMed ID: 21396365

DOI: 10.1016/j.febslet.2011.03.010

PubMed ID: 21380642

Title: LKB1 in lung cancerigenesis: a serine/threonine kinase as tumor suppressor.

PubMed ID: 21380642

DOI: 10.1007/s13238-011-1021-6

PubMed ID: 22983157

Title: The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK.

PubMed ID: 22983157

DOI: 10.1038/nchembio.1069

PubMed ID: 23572524

Title: Integrin-binding protein nischarin interacts with tumor suppressor liver kinase B1 (LKB1) to regulate cell migration of breast epithelial cells.

PubMed ID: 23572524

DOI: 10.1074/jbc.m112.418103

PubMed ID: 23612973

Title: Phosphorylation of serine 399 in LKB1 protein short form by protein kinase Czeta is required for its nucleocytoplasmic transport and consequent AMP-activated protein kinase (AMPK) activation.

PubMed ID: 23612973

DOI: 10.1074/jbc.m112.443580

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25329316

Title: A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation.

PubMed ID: 25329316

DOI: 10.1371/journal.pgen.1004721

PubMed ID: 19892943

Title: Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation.

PubMed ID: 19892943

DOI: 10.1126/science.1178377

PubMed ID: 9837816

Title: Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity.

PubMed ID: 9837816

DOI: 10.1086/302159

PubMed ID: 9605748

Title: Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumors.

PubMed ID: 9605748

PubMed ID: 9731485

Title: Frequent somatic mutations in serine/threonine kinase 11/Peutz-Jeghers syndrome gene in left-sided colon cancer.

PubMed ID: 9731485

PubMed ID: 9809980

Title: STK11 mutations in Peutz-Jeghers syndrome and sporadic colon cancer.

PubMed ID: 9809980

PubMed ID: 9760200

Title: Nine novel germline mutations of STK11 in ten families with Peutz-Jeghers syndrome.

PubMed ID: 9760200

DOI: 10.1007/s004390050801

PubMed ID: 9683800

Title: Mutations of the STK11 gene in sporadic gastric carcinoma.

PubMed ID: 9683800

PubMed ID: 9428765

Title: A serine/threonine kinase gene defective in Peutz-Jeghers syndrome.

PubMed ID: 9428765

DOI: 10.1038/34432

PubMed ID: 10079245

Title: LKB1 somatic mutations in sporadic cancers.

PubMed ID: 10079245

DOI: 10.1016/s0002-9440(10)65314-x

PubMed ID: 10408777

Title: Novel mutations in the LKB1/STK11 gene in Dutch Peutz-Jeghers families.

PubMed ID: 10408777

DOI: 10.1002/(sici)1098-1004(1999)13:6<476::aid-humu7>3.0.co;2-2

PubMed ID: 9887330

Title: Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer.

PubMed ID: 9887330

DOI: 10.1093/hmg/8.1.45

PubMed ID: 10429654

Title: Mutational analysis of STK11 gene in ovarian carcinomas.

PubMed ID: 10429654

DOI: 10.1111/j.1349-7006.1999.tb00793.x

PubMed ID: 10201537

Title: Somatic mutations in the Peutz-Jeghers (LKB1/STKII) gene in sporadic malignant melanomas.

PubMed ID: 10201537

DOI: 10.1046/j.1523-1747.1999.00551.x

PubMed ID: 10208439

Title: Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma.

PubMed ID: 10208439

DOI: 10.1038/sj.onc.1202486

PubMed ID: 12372054

Title: Mutation analysis of the STK11/LKB1 gene and clinical characteristics of an Australian series of Peutz-Jeghers syndrome patients.

PubMed ID: 12372054

DOI: 10.1034/j.1399-0004.2002.620405.x

PubMed ID: 12533684

Title: Mutations in the STK11 gene characterize minimal deviation adenocarcinoma of the uterine cervix.

PubMed ID: 12533684

DOI: 10.1097/01.lab.0000049821.16698.d0

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 21411391

Title: A novel de novo mutation in LKB1 gene in a Chinese Peutz Jeghers syndrome patient significantly diminished p53 activity.

PubMed ID: 21411391

DOI: 10.1016/j.clinre.2010.11.008

Sequence Information:

  • Length: 433
  • Mass: 48636
  • Checksum: 6DF4C37AB7A89569
  • Sequence:
    • MEVVDPQQLG MFTEGELMSV GMDTFIHRID STEVIYQPRR KRAKLIGKYL MGDLLGEGSY 
GKVKEVLDSE TLCRRAVKIL KKKKLRRIPN GEANVKKEIQ LLRRLRHKNV IQLVDVLYNE 
EKQKMYMVME YCVCGMQEML DSVPEKRFPV CQAHGYFCQL IDGLEYLHSQ GIVHKDIKPG 
NLLLTTGGTL KISDLGVAEA LHPFAADDTC RTSQGSPAFQ PPEIANGLDT FSGFKVDIWS 
AGVTLYNITT GLYPFEGDNI YKLFENIGKG SYAIPGDCGP PLSDLLKGML EYEPAKRFSI 
RQIRQHSWFR KKHPPAEAPV PIPPSPDTKD RWRSMTVVPY LEDLHGADED EDLFDIEDDI 
IYTQDFTVPG QVPEEEASHN GQRRGLPKAV CMNGTEAAQL STKSRAEGRA PNPARKACSA 
SSKIRRLSAC KQQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.