Details for: AURKC

Gene ID: 6795

Symbol: AURKC

Ensembl ID: ENSG00000105146

Description: aurora kinase C

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 19.0298
    Cell Significance Index: -2.9600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 11.6699
    Cell Significance Index: -2.9600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.4575
    Cell Significance Index: -3.0300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.7571
    Cell Significance Index: 107.7300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 0.7755
    Cell Significance Index: -3.0600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5433
    Cell Significance Index: 103.4000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3298
    Cell Significance Index: 17.1300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3171
    Cell Significance Index: 31.3700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2753
    Cell Significance Index: 248.5500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2174
    Cell Significance Index: 13.0500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2131
    Cell Significance Index: 23.1800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1735
    Cell Significance Index: 28.2200
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.1410
    Cell Significance Index: 1.0700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.1214
    Cell Significance Index: 2.0000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1064
    Cell Significance Index: 7.3600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.1033
    Cell Significance Index: 1.4800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.1019
    Cell Significance Index: 1.4300
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.0753
    Cell Significance Index: 0.5000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0727
    Cell Significance Index: 8.4700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0609
    Cell Significance Index: 1.6300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0579
    Cell Significance Index: 0.7900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0545
    Cell Significance Index: 1.5700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0466
    Cell Significance Index: 2.9400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0464
    Cell Significance Index: 0.6600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0377
    Cell Significance Index: 7.5600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0326
    Cell Significance Index: 22.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0300
    Cell Significance Index: 8.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0254
    Cell Significance Index: 0.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0113
    Cell Significance Index: 4.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0101
    Cell Significance Index: 1.8200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0101
    Cell Significance Index: 5.5200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0075
    Cell Significance Index: 0.1700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0068
    Cell Significance Index: 0.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0056
    Cell Significance Index: 0.2600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0014
    Cell Significance Index: 0.0300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0014
    Cell Significance Index: 0.6400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0008
    Cell Significance Index: 0.1500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0006
    Cell Significance Index: 0.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0002
    Cell Significance Index: 0.4300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0014
    Cell Significance Index: -2.5100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0017
    Cell Significance Index: -2.5800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0019
    Cell Significance Index: -2.6500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0020
    Cell Significance Index: -1.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0024
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0028
    Cell Significance Index: -2.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0033
    Cell Significance Index: -0.4000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0035
    Cell Significance Index: -2.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0035
    Cell Significance Index: -0.2600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0037
    Cell Significance Index: -0.5400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0037
    Cell Significance Index: -0.3800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0038
    Cell Significance Index: -2.8600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0043
    Cell Significance Index: -2.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0050
    Cell Significance Index: -2.2900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0056
    Cell Significance Index: -3.4900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0057
    Cell Significance Index: -0.6500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0064
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0106
    Cell Significance Index: -1.8100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0110
    Cell Significance Index: -1.4200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0111
    Cell Significance Index: -0.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0117
    Cell Significance Index: -0.4100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0123
    Cell Significance Index: -0.1000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0123
    Cell Significance Index: -1.7000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0149
    Cell Significance Index: -0.3100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0149
    Cell Significance Index: -3.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0171
    Cell Significance Index: -1.3200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0183
    Cell Significance Index: -2.1600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0210
    Cell Significance Index: -1.4900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0211
    Cell Significance Index: -0.6100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0253
    Cell Significance Index: -1.1900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0279
    Cell Significance Index: -2.9000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0279
    Cell Significance Index: -0.7600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0284
    Cell Significance Index: -0.7300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0328
    Cell Significance Index: -2.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0329
    Cell Significance Index: -2.0300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0343
    Cell Significance Index: -2.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0352
    Cell Significance Index: -2.2700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0363
    Cell Significance Index: -0.6100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0368
    Cell Significance Index: -1.1800
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.0417
    Cell Significance Index: -0.4300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0420
    Cell Significance Index: -1.4600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0421
    Cell Significance Index: -2.3600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0432
    Cell Significance Index: -0.6300
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0499
    Cell Significance Index: -0.7000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0525
    Cell Significance Index: -1.3100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0532
    Cell Significance Index: -2.6900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0542
    Cell Significance Index: -0.8700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0565
    Cell Significance Index: -1.9800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0568
    Cell Significance Index: -1.8100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0605
    Cell Significance Index: -0.9600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0610
    Cell Significance Index: -2.7000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0654
    Cell Significance Index: -2.1400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0668
    Cell Significance Index: -2.7400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0674
    Cell Significance Index: -1.8000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0691
    Cell Significance Index: -0.8800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0710
    Cell Significance Index: -2.6900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0711
    Cell Significance Index: -1.5100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0717
    Cell Significance Index: -1.2000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0719
    Cell Significance Index: -0.9700
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0729
    Cell Significance Index: -1.0900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0732
    Cell Significance Index: -1.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** AURKC is a non-receptor tyrosine kinase that belongs to the Aurora kinase family, which consists of three distinct isoforms: AURKA, AURKB, and AURKC. AURKC is specifically expressed in various cell types, including enterocytes, colon goblet cells, and GABAergic interneurons, highlighting its involvement in different tissues and developmental processes. The gene is highly conserved across species, suggesting its vital role in maintaining genome stability. **Pathways and Functions:** AURKC is involved in several key cellular processes, including: 1. **Cell Division:** AURKC regulates the proper segregation of chromosomes during mitosis and meiosis, ensuring accurate genome inheritance. 2. **Chromosome Passenger Complex:** AURKC interacts with the chromosomal passenger complex, a protein complex that regulates the assembly and disassembly of the mitotic spindle. 3. **Cytokinesis:** AURKC regulates the timing and coordination of cytokinesis, ensuring the proper division of the cell into two daughter cells. 4. **Protein Phosphorylation:** AURKC phosphorylates and regulates various proteins, including histone H3, chromatin remodeling proteins, and kinetochore components. **Clinical Significance:** Dysregulation of AURKC has been implicated in various human diseases, including: 1. **Cancer:** Overexpression or mutations in AURKC have been observed in several types of cancer, including breast, lung, and colon cancer, suggesting its potential as a therapeutic target. 2. **Neurological Disorders:** Abnormal expression of AURKC has been linked to neurodevelopmental disorders, such as autism and schizophrenia. 3. **Reproductive Disorders:** AURKC dysregulation has been implicated in infertility and recurrent miscarriage, highlighting its importance in reproductive biology. In conclusion, AURKC is a critical regulator of cell division, chromosome stability, and cytokinesis. Its dysregulation has been implicated in various human diseases, making it a promising target for therapeutic intervention. Further research is needed to fully elucidate the function and clinical significance of AURKC in human health and disease.

Genular Protein ID: 1858682774

Symbol: AURKC_HUMAN

Name: Aurora kinase C

UniProtKB Accession Codes:

Q9UQB9 O60681 O75442 Q6AZY8 Q6DLZ0 Q9UPK5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 12 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 3 EMBL 7 Ensembl 3 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIRSF 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 3 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9809744

Title: Protein kinase profile of sperm and eggs: cloning and characterization of two novel testis-specific protein kinases (AIE1, AIE2) related to yeast and fly chromosome segregation regulators.

PubMed ID: 9809744

DOI: 10.1089/dna.1998.17.823

PubMed ID: 9799611

Title: Cloning of STK13, a third human protein kinase related to Drosophila aurora and budding yeast Ipl1 that maps on chromosome 19q13.3-ter.

PubMed ID: 9799611

DOI: 10.1006/geno.1998.5522

PubMed ID: 10066797

Title: Cell cycle-dependent expression and centrosome localization of a third human Aurora/Ipl1-related protein kinase, AIK3.

PubMed ID: 10066797

DOI: 10.1074/jbc.274.11.7334

PubMed ID: 15670791

Title: Cloning and characterization of a novel human Aurora C splicing variant.

PubMed ID: 15670791

DOI: 10.1016/j.bbrc.2004.12.168

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15499654

Title: Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells.

PubMed ID: 15499654

DOI: 10.1002/cm.20039

PubMed ID: 15316025

Title: Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C.

PubMed ID: 15316025

DOI: 10.1074/jbc.m403029200

PubMed ID: 15938719

Title: Aurora C is directly associated with Survivin and required for cytokinesis.

PubMed ID: 15938719

DOI: 10.1111/j.1365-2443.2005.00863.x

PubMed ID: 17435757

Title: Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility.

PubMed ID: 17435757

DOI: 10.1038/ng2027

PubMed ID: 21531210

Title: Aurora-C interacts with and phosphorylates the transforming acidic coiled-coil 1 protein.

PubMed ID: 21531210

DOI: 10.1016/j.bbrc.2011.04.078

PubMed ID: 21493633

Title: A role for Aurora C in the chromosomal passenger complex during human preimplantation embryo development.

PubMed ID: 21493633

DOI: 10.1093/humrep/der111

PubMed ID: 21733974

Title: A new AURKC mutation causing macrozoospermia: implications for human spermatogenesis and clinical diagnosis.

PubMed ID: 21733974

DOI: 10.1093/molehr/gar050

PubMed ID: 27332895

Title: Aurora-C interactions with survivin and INCENP reveal shared and distinct features compared with Aurora-B chromosome passenger protein complex.

PubMed ID: 27332895

DOI: 10.1371/journal.pone.0157305

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 309
  • Mass: 35591
  • Checksum: 41B7DFCA91704201
  • Sequence:
    • MSSPRAVVQL GKAQPAGEEL ATANQTAQQP SSPAMRRLTV DDFEIGRPLG KGKFGNVYLA 
RLKESHFIVA LKVLFKSQIE KEGLEHQLRR EIEIQAHLQH PNILRLYNYF HDARRVYLIL 
EYAPRGELYK ELQKSEKLDE QRTATIIEEL ADALTYCHDK KVIHRDIKPE NLLLGFRGEV 
KIADFGWSVH TPSLRRKTMC GTLDYLPPEM IEGRTYDEKV DLWCIGVLCY ELLVGYPPFE 
SASHSETYRR ILKVDVRFPL SMPLGARDLI SRLLRYQPLE RLPLAQILKH PWVQAHSRRV 
LPPCAQMAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.