Details for: STRN

Gene ID: 6801

Symbol: STRN

Ensembl ID: ENSG00000115808

Description: striatin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 261.4674
    Cell Significance Index: -40.6700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 163.0636
    Cell Significance Index: -41.3600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 89.8707
    Cell Significance Index: -42.4300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 82.6570
    Cell Significance Index: -33.5800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 77.4420
    Cell Significance Index: -39.8400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 35.3708
    Cell Significance Index: -33.7700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.0969
    Cell Significance Index: -42.0400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.2416
    Cell Significance Index: -40.8300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.1929
    Cell Significance Index: -37.4500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.7069
    Cell Significance Index: -42.2500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.4999
    Cell Significance Index: -22.9800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.7823
    Cell Significance Index: 167.3000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 3.7433
    Cell Significance Index: 141.7500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 3.7216
    Cell Significance Index: 368.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.7577
    Cell Significance Index: 211.6200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.9138
    Cell Significance Index: 311.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8333
    Cell Significance Index: 367.7600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.4688
    Cell Significance Index: 171.1700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2280
    Cell Significance Index: 133.5700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.1920
    Cell Significance Index: 66.8900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1900
    Cell Significance Index: 71.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1049
    Cell Significance Index: 219.2800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.0109
    Cell Significance Index: 67.9700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9828
    Cell Significance Index: 352.5000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.8111
    Cell Significance Index: 11.6700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7965
    Cell Significance Index: 22.2600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.7586
    Cell Significance Index: 19.5000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7030
    Cell Significance Index: 15.2300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6390
    Cell Significance Index: 78.5700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6352
    Cell Significance Index: 18.3000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5963
    Cell Significance Index: 36.6500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5924
    Cell Significance Index: 26.8500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5615
    Cell Significance Index: 101.2300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5286
    Cell Significance Index: 365.6100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.5085
    Cell Significance Index: 10.8700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4453
    Cell Significance Index: 23.1300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3711
    Cell Significance Index: 335.0600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.3692
    Cell Significance Index: 5.4500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2750
    Cell Significance Index: 19.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2640
    Cell Significance Index: 12.3100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2403
    Cell Significance Index: 4.6900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2402
    Cell Significance Index: 106.2200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2037
    Cell Significance Index: 3.4900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1901
    Cell Significance Index: 4.5600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1725
    Cell Significance Index: 32.8300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1645
    Cell Significance Index: 89.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1480
    Cell Significance Index: 94.0000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1121
    Cell Significance Index: 5.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1101
    Cell Significance Index: 207.2900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1075
    Cell Significance Index: 5.6000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0953
    Cell Significance Index: 3.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0726
    Cell Significance Index: 111.7500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0648
    Cell Significance Index: 119.5600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0613
    Cell Significance Index: 1.7500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0491
    Cell Significance Index: 6.7400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0331
    Cell Significance Index: 15.0300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0323
    Cell Significance Index: 0.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0246
    Cell Significance Index: 33.4900
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.0010
    Cell Significance Index: 0.0100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0071
    Cell Significance Index: -0.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0240
    Cell Significance Index: -17.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0441
    Cell Significance Index: -6.4100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0487
    Cell Significance Index: -36.0800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0531
    Cell Significance Index: -40.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0744
    Cell Significance Index: -41.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0753
    Cell Significance Index: -47.0500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0804
    Cell Significance Index: -0.7400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0837
    Cell Significance Index: -5.2800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0936
    Cell Significance Index: -2.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1143
    Cell Significance Index: -14.7700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1194
    Cell Significance Index: -15.3100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1245
    Cell Significance Index: -35.8200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1315
    Cell Significance Index: -2.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1364
    Cell Significance Index: -23.2900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1520
    Cell Significance Index: -17.9300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1896
    Cell Significance Index: -5.0800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1991
    Cell Significance Index: -10.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2057
    Cell Significance Index: -21.0100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2133
    Cell Significance Index: -2.9100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2207
    Cell Significance Index: -46.4900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2404
    Cell Significance Index: -27.5400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2501
    Cell Significance Index: -17.6900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2724
    Cell Significance Index: -5.6500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2755
    Cell Significance Index: -17.7800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2792
    Cell Significance Index: -6.9800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2964
    Cell Significance Index: -30.8600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3222
    Cell Significance Index: -24.0200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4140
    Cell Significance Index: -11.2700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4366
    Cell Significance Index: -34.5800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.5188
    Cell Significance Index: -7.3900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5575
    Cell Significance Index: -34.1800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.5623
    Cell Significance Index: -8.0800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6120
    Cell Significance Index: -19.6000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6392
    Cell Significance Index: -33.5600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6939
    Cell Significance Index: -22.1000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.7172
    Cell Significance Index: -17.5000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7223
    Cell Significance Index: -15.3300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7239
    Cell Significance Index: -23.7000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.7419
    Cell Significance Index: -14.9000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.8228
    Cell Significance Index: -10.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** STRN is a member of the striatin family of proteins, which are known for their involvement in regulating cellular signaling pathways. The STRN protein is characterized by its ability to bind to various proteins and lipids, modulating their activity and localization within cells. Its molecular weight ranges from 85 to 100 kDa, and it is expressed in multiple cell types, including neurons, cardiac myocytes, and epithelial cells. **Pathways and Functions:** STRN plays a crucial role in regulating various signaling pathways, including: 1. **Alk mutants bind tkis**: STRN interacts with Alk mutants, which are aberrant proteins that can lead to cancer. This interaction modulates the activity of the Tks (tyrosine kinase-like) family of proteins, which are involved in cell signaling. 2. **Constitutive signaling by aberrant pi3k in cancer**: STRN regulates the PI3K/Akt signaling pathway, which is often dysregulated in cancer cells. By binding to PI3K and Akt, STRN can modulate their activity, influencing cell proliferation and survival. 3. **Negative regulation of cell population proliferation**: STRN acts as a negative regulator of cell proliferation, inhibiting the growth of cancer cells by modulating signaling pathways. 4. **Neuronal cell body and dendrite development**: STRN is involved in the development and maintenance of neuronal cells, regulating the formation and function of dendrites and synapses. 5. **Intracellular signaling by second messengers**: STRN interacts with second messengers, such as Ca2+ and cAMP, to modulate cellular responses to external stimuli. **Clinical Significance:** STRN's involvement in various signaling pathways makes it a potential target for therapeutic interventions in diseases characterized by aberrant cell signaling, such as cancer, neurological disorders, and cardiovascular diseases. Some potential applications of STRN include: 1. **Cancer therapy**: Targeting STRN may help modulate PI3K/Akt signaling, inhibiting cancer cell growth and proliferation. 2. **Neurological disorders**: STRN's involvement in neuronal development and synaptic plasticity makes it a potential target for therapies aimed at treating neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cardiovascular diseases**: STRN's role in regulating cell proliferation and signaling pathways may help identify new therapeutic targets for cardiovascular diseases, such as heart failure and atherosclerosis. In conclusion, STRN is a multifaceted protein with a wide range of cellular functions, from neuronal development and synaptic plasticity to regulation of cell proliferation and signaling pathways. Its involvement in various disease pathways makes it a potential target for therapeutic interventions, and further research is needed to fully elucidate its role in human disease.

Genular Protein ID: 1572337496

Symbol: STRN_HUMAN

Name: Striatin

UniProtKB Accession Codes:

O43815 Q3KP65 Q53TQ8 Q9NP38

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 4 CTD 1 ChiTaRS 1 ComplexPortal 2 DNASU 1 DisGeNET 1 ELM 1 EMBL 4 Ensembl 1 GO 19 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 7 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9693043

Title: Cloning of human striatin cDNA (STRN), gene mapping to 2p22-p21, and preferential expression in brain.

PubMed ID: 9693043

DOI: 10.1006/geno.1998.5342

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 18782753

Title: A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein.

PubMed ID: 18782753

DOI: 10.1074/mcp.m800266-mcp200

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26876214

Title: STRIPAK complexes in cell signaling and cancer.

PubMed ID: 26876214

DOI: 10.1038/onc.2016.9

Sequence Information:

  • Length: 780
  • Mass: 86132
  • Checksum: DDB18A11102BEA35
  • Sequence:
    • MDEQAGPGVF FSNNHPGAGG AKGLGPLAEA AAAGDGAAAA GAARAQYSLP GILHFLQHEW 
ARFEVERAQW EVERAELQAQ IAFLQGERKG QENLKKDLVR RIKMLEYALK QERAKYHKLK 
YGTELNQGDM KPPSYDSDEG NETEVQPQQN SQLMWKQGRQ LLRQYLQEVG YTDTILDVKS 
KRVRALLGFS SDVTDREDDK NQDSVVNGTE AEVKETAMIA KSELTDSASV LDNFKFLESA 
AADFSDEDED DDVDGREKSV IDTSTIVRKK ALPDSGEDRD TKEALKEFDF LVTSEEGDNE 
SRSAGDGTDW EKEDQCLMPE AWNVDQGVIT KLKEQYKKER KGKKGVKRPN RSKLQDMLAN 
LRDVDELPSL QPSVGSPSRP SSSRLPEHEI NRADEVEALT FPPSSGKSFI MGADEALESE 
LGLGELAGLT VANEADSLTY DIANNKDALR KTWNPKFTLR SHFDGIRALA FHPIEPVLIT 
ASEDHTLKMW NLQKTAPAKK STSLDVEPIY TFRAHKGPVL CVVMSSNGEQ CYSGGTDGLI 
QGWNTTNPNI DPYDSYDPSV LRGPLLGHTD AVWGLAYSAA HQRLLSCSAD GTLRLWNTTE 
VAPALSVFND TKELGIPASV DLVSSDPSHM VASFSKGYTS IFNMETQQRI LTLESNVDTT 
ANSSCQINRV ISHPTLPISI TAHEDRHIKF YDNNTGKLIH SMVAHLEAVT SLAVDPNGLY 
LMSGSHDCSI RLWNLESKTC IQEFTAHRKK FEESIHDVAF HPSKCYIASA GADALAKVFV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.