Details for: STX5

Gene ID: 6811

Symbol: STX5

Ensembl ID: ENSG00000162236

Description: syntaxin 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 234.2084
    Cell Significance Index: -36.4300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 139.4478
    Cell Significance Index: -35.3700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 91.9777
    Cell Significance Index: -37.8900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 85.3698
    Cell Significance Index: -40.3100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 84.9954
    Cell Significance Index: -34.5300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 76.2658
    Cell Significance Index: -39.2300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 60.2588
    Cell Significance Index: -40.4400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.5989
    Cell Significance Index: -38.9600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.4941
    Cell Significance Index: -33.4700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.1494
    Cell Significance Index: -40.0500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.8831
    Cell Significance Index: -21.6300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.1064
    Cell Significance Index: -27.9700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3970
    Cell Significance Index: 19.0600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1745
    Cell Significance Index: 116.1800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.1097
    Cell Significance Index: 29.6300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.0875
    Cell Significance Index: 29.6000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0524
    Cell Significance Index: 63.1800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9981
    Cell Significance Index: 108.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9540
    Cell Significance Index: 44.4800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.9306
    Cell Significance Index: 69.3600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.9214
    Cell Significance Index: 119.0400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8429
    Cell Significance Index: 137.0900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8153
    Cell Significance Index: 161.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7984
    Cell Significance Index: 160.1500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7124
    Cell Significance Index: 33.4800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6953
    Cell Significance Index: 95.4800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6882
    Cell Significance Index: 14.9100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6679
    Cell Significance Index: 13.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5923
    Cell Significance Index: 17.0700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5551
    Cell Significance Index: 35.8200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.5299
    Cell Significance Index: 15.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5129
    Cell Significance Index: 23.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4226
    Cell Significance Index: 51.9600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4186
    Cell Significance Index: 228.5900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3990
    Cell Significance Index: 20.9500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3888
    Cell Significance Index: 139.4600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3725
    Cell Significance Index: 164.6700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3269
    Cell Significance Index: 38.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2994
    Cell Significance Index: 22.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2985
    Cell Significance Index: 53.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2963
    Cell Significance Index: 15.3900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2864
    Cell Significance Index: 198.1000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2841
    Cell Significance Index: 36.4200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2315
    Cell Significance Index: 5.9500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2069
    Cell Significance Index: 39.3800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1633
    Cell Significance Index: 8.5100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1556
    Cell Significance Index: 10.7600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1302
    Cell Significance Index: 9.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1248
    Cell Significance Index: 21.3100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1205
    Cell Significance Index: 4.2400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0984
    Cell Significance Index: 2.7500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0485
    Cell Significance Index: 91.4000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0430
    Cell Significance Index: 0.8400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0267
    Cell Significance Index: 0.4000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0252
    Cell Significance Index: 16.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0222
    Cell Significance Index: 34.2500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0182
    Cell Significance Index: 33.6000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0149
    Cell Significance Index: 0.2500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0004
    Cell Significance Index: -0.5000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0034
    Cell Significance Index: -1.5600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0048
    Cell Significance Index: -3.6700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0184
    Cell Significance Index: -0.3200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0345
    Cell Significance Index: -25.2900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0402
    Cell Significance Index: -5.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0448
    Cell Significance Index: -33.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0490
    Cell Significance Index: -5.0100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0551
    Cell Significance Index: -1.4500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0676
    Cell Significance Index: -38.1300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0689
    Cell Significance Index: -43.0100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1086
    Cell Significance Index: -6.8500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1136
    Cell Significance Index: -32.7000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1193
    Cell Significance Index: -2.5400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1461
    Cell Significance Index: -3.9100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1544
    Cell Significance Index: -4.9500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1565
    Cell Significance Index: -5.4400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1620
    Cell Significance Index: -2.4600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1806
    Cell Significance Index: -5.3100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1896
    Cell Significance Index: -10.6400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2099
    Cell Significance Index: -44.2100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2222
    Cell Significance Index: -25.8900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2455
    Cell Significance Index: -28.1300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2985
    Cell Significance Index: -20.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3103
    Cell Significance Index: -19.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3403
    Cell Significance Index: -35.4300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3805
    Cell Significance Index: -9.7200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4264
    Cell Significance Index: -18.8600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4409
    Cell Significance Index: -34.9200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4989
    Cell Significance Index: -30.5900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5633
    Cell Significance Index: -21.3300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5765
    Cell Significance Index: -9.8800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.5810
    Cell Significance Index: -5.3500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5912
    Cell Significance Index: -15.8200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6288
    Cell Significance Index: -13.4400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.6503
    Cell Significance Index: -7.0700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6717
    Cell Significance Index: -16.7900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.7164
    Cell Significance Index: -36.2000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.7282
    Cell Significance Index: -8.6800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.7502
    Cell Significance Index: -11.0800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.8040
    Cell Significance Index: -14.8600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.8237
    Cell Significance Index: -19.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** STX5 is a transmembrane protein that belongs to the syntaxin family, known for its involvement in vesicle fusion and membrane trafficking. It shares structural homology with other syntaxins, such as STX1A and STX2, but exhibits distinct differences in its expression pattern and functional roles. STX5 is primarily expressed in germ cells, pancreatic A cells, and progenitor cells of mammary luminal epithelium, highlighting its involvement in cellular differentiation and development. **Pathways and Functions:** STX5 is involved in various cellular processes, including: 1. **Vesicle-mediated transport:** STX5 regulates the fusion of vesicles with the endoplasmic reticulum (ER) and Golgi apparatus, ensuring the proper trafficking of proteins and lipids. 2. **Cargo concentration in the ER:** STX5 facilitates the concentration of cargo proteins in the ER, allowing for efficient loading and transport of vesicles. 3. **Copii-mediated anterograde transport:** STX5 interacts with the Copii complex, a vesicle transport machinery that mediates the anterograde transport of proteins from the ER to the Golgi apparatus. 4. **Cargo concentration in the Golgi:** STX5 regulates the concentration of cargo proteins in the Golgi apparatus, ensuring the proper modification and sorting of proteins. 5. **Intra-golgi and retrograde golgi-to-ER traffic:** STX5 is involved in the regulation of intra-golgi and retrograde golgi-to-ER traffic, ensuring the proper trafficking of proteins and lipids. **Clinical Significance:** STX5 has been implicated in various immunological disorders, including: 1. **Autoimmune diseases:** STX5 has been shown to be overexpressed in autoimmune diseases, such as rheumatoid arthritis and lupus, suggesting its potential role in the pathogenesis of these diseases. 2. **Cancer:** STX5 has been found to be overexpressed in various types of cancer, including breast and prostate cancer, highlighting its potential role in tumorigenesis. 3. **Neurological disorders:** STX5 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, suggesting its potential role in the pathogenesis of these diseases. In conclusion, STX5 plays a crucial role in regulating membrane trafficking and vesicle fusion in various cell types, including immune cells. Its significant expression in immune cells and its involvement in various immunological disorders make it an attractive target for therapeutic intervention. Further studies are needed to elucidate the mechanisms by which STX5 regulates membrane trafficking and its role in immunological disorders.

Genular Protein ID: 2993981762

Symbol: STX5_HUMAN

Name: Syntaxin-5

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9188044

Title: Cloning and identification of human syntaxin 5 as a synaptobrevin/VAMP binding protein.

PubMed ID: 9188044

DOI: 10.1007/bf02736780

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19536132

Title: Direct interaction between the COG complex and the SM protein, Sly1, is required for Golgi SNARE pairing.

PubMed ID: 19536132

DOI: 10.1038/emboj.2009.168

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23701949

Title: Stx5 is a novel interactor of VLDL-R to affect its intracellular trafficking and processing.

PubMed ID: 23701949

DOI: 10.1016/j.yexcr.2013.05.010

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27795424

Title: Potent Inhibition of Human Cytomegalovirus by Modulation of Cellular SNARE Syntaxin 5.

PubMed ID: 27795424

DOI: 10.1128/jvi.01637-16

PubMed ID: 34779586

Title: BET1 variants establish impaired vesicular transport as a cause for muscular dystrophy with epilepsy.

PubMed ID: 34779586

DOI: 10.15252/emmm.202013787

PubMed ID: 18843296

Title: Structural basis of cargo membrane protein discrimination by the human COPII coat machinery.

PubMed ID: 18843296

DOI: 10.1038/emboj.2008.208

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 29463886

Title: A set of regulatory genes co-expressed in embryonic human brain is implicated in disrupted speech development.

PubMed ID: 29463886

DOI: 10.1038/s41380-018-0020-x

PubMed ID: 34711829

Title: Congenital disorder of glycosylation caused by starting site-specific variant in syntaxin-5.

PubMed ID: 34711829

DOI: 10.1038/s41467-021-26534-y

Sequence Information:

  • Length: 355
  • Mass: 39673
  • Checksum: EE8616A226888501
  • Sequence:
  • MIPRKRYGSK NTDQGVYLGL SKTQVLSPAT AGSSSSDIAP LPPPVTLVPP PPDTMSCRDR 
    TQEFLSACKS LQTRQNGIQT NKPALRAVRQ RSEFTLMAKR IGKDLSNTFA KLEKLTILAK 
    RKSLFDDKAV EIEELTYIIK QDINSLNKQI AQLQDFVRAK GSQSGRHLQT HSNTIVVSLQ 
    SKLASMSNDF KSVLEVRTEN LKQQRSRREQ FSRAPVSALP LAPNHLGGGA VVLGAESHAS 
    KDVAIDMMDS RTSQQLQLID EQDSYIQSRA DTMQNIESTI VELGSIFQQL AHMVKEQEET 
    IQRIDENVLG AQLDVEAAHS EILKYFQSVT SNRWLMVKIF LILIVFFIIF VVFLA

Genular Protein ID: 2876114290

Symbol: B4DKR0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 259
  • Mass: 29234
  • Checksum: A68A11B6122D7950
  • Sequence:
  • MAKRIGKDLS NTFAKLEKLT ILAKRKSLFD DKAVEIEELT YIIKQDINSL NKQIAQLQDF 
    VRAKGSQSGR HLQTHSNTIV VSLQSKLASM SNDFKSVLEV RTENLKQQRS RREQFSRAPV 
    SALPLAPNHL GGGAVVLGAE SHASKDVAID MMDSRTSQQL QLIDEQDSYI QSRADTMQNI 
    ESTIVELGSI FQQLAHMVKE QEETIQRIDE NVLGAQLDVE AAHSEILKYF QSVTSNRWLM 
    VKIFLILIVF FIIFVVFLA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.