Details for: SULT1A1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 138.5449
Cell Significance Index: -21.5500 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 71.9908
Cell Significance Index: -18.2600 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 49.9437
Cell Significance Index: -20.2900 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 43.9457
Cell Significance Index: -22.6100 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 33.9035
Cell Significance Index: -22.7500 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 21.2832
Cell Significance Index: -20.3200 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 17.7946
Cell Significance Index: -21.9400 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 8.2255
Cell Significance Index: -22.0400 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 6.2186
Cell Significance Index: -19.1000 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 5.6462
Cell Significance Index: -22.2800 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.9982
Cell Significance Index: 324.9800 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.5558
Cell Significance Index: 28.7600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.4284
Cell Significance Index: 286.5400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.3628
Cell Significance Index: 392.1100 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 1.2294
Cell Significance Index: 26.9200 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.9385
Cell Significance Index: 64.9100 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.9197
Cell Significance Index: 40.6800 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.8607
Cell Significance Index: 7.2300 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.8556
Cell Significance Index: 32.4000 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.7958
Cell Significance Index: 285.4500 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.7348
Cell Significance Index: 11.0100 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7300
Cell Significance Index: 659.1200 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.6943
Cell Significance Index: 125.1600 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.6490
Cell Significance Index: 354.4600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.6396
Cell Significance Index: 43.0100 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.6222
Cell Significance Index: 28.2000 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.5977
Cell Significance Index: 16.0200 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4672
Cell Significance Index: 46.2200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.4560
Cell Significance Index: 23.7500 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.4377
Cell Significance Index: 12.4900 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.4104
Cell Significance Index: 5.0900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.3479
Cell Significance Index: 50.5700 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.3278
Cell Significance Index: 65.0600 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.3271
Cell Significance Index: 35.5800 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.2959
Cell Significance Index: 8.2700 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.2952
Cell Significance Index: 7.3800 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.2916
Cell Significance Index: 37.3800 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.2897
Cell Significance Index: 15.0500 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.2661
Cell Significance Index: 13.9700 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.2563
Cell Significance Index: 8.9100 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.2258
Cell Significance Index: 14.5700 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2222
Cell Significance Index: 42.2900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.1460
Cell Significance Index: 11.2000 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.1391
Cell Significance Index: 3.7200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1341
Cell Significance Index: 16.4900 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.1240
Cell Significance Index: 3.9700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1148
Cell Significance Index: 15.7600 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0939
Cell Significance Index: 2.0000 - Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 0.0866
Cell Significance Index: 0.9200 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0615
Cell Significance Index: 2.1600 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0516
Cell Significance Index: 32.7900 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0411
Cell Significance Index: 77.4200 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.0381
Cell Significance Index: 2.1400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0286
Cell Significance Index: 20.9900 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0218
Cell Significance Index: 16.4900 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0158
Cell Significance Index: 0.2700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.0150
Cell Significance Index: 1.7200 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0061
Cell Significance Index: 1.0400 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0021
Cell Significance Index: 3.2300 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0008
Cell Significance Index: 0.3700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0074
Cell Significance Index: -13.6200 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0082
Cell Significance Index: -5.1100 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0109
Cell Significance Index: -14.8300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0113
Cell Significance Index: -5.1300 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0120
Cell Significance Index: -8.8900 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0166
Cell Significance Index: -9.3400 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0242
Cell Significance Index: -2.4700 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0281
Cell Significance Index: -0.7400 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0317
Cell Significance Index: -1.4800 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0473
Cell Significance Index: -9.9600 - Cell Name: keratocyte (CL0002363)
Fold Change: -0.0605
Cell Significance Index: -0.9600 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0676
Cell Significance Index: -7.9700 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0677
Cell Significance Index: -4.1600 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0739
Cell Significance Index: -5.5100 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -0.0828
Cell Significance Index: -0.5400 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0855
Cell Significance Index: -9.9600 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1034
Cell Significance Index: -13.3600 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1284
Cell Significance Index: -9.0800 - Cell Name: peg cell (CL4033014)
Fold Change: -0.1329
Cell Significance Index: -3.0700 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.1419
Cell Significance Index: -2.3900 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.1616
Cell Significance Index: -3.5000 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1772
Cell Significance Index: -20.2300 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1781
Cell Significance Index: -4.5500 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1810
Cell Significance Index: -3.0300 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.1817
Cell Significance Index: -4.9500 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1848
Cell Significance Index: -14.6400 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1851
Cell Significance Index: -8.7000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2011
Cell Significance Index: -20.9400 - Cell Name: colonocyte (CL1000347)
Fold Change: -0.2233
Cell Significance Index: -1.3800 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.2266
Cell Significance Index: -4.8100 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.2473
Cell Significance Index: -2.5600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2593
Cell Significance Index: -15.9000 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2827
Cell Significance Index: -9.0100 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2862
Cell Significance Index: -9.3700 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.3001
Cell Significance Index: -4.4300 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.3071
Cell Significance Index: -5.3100 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.3094
Cell Significance Index: -7.4200 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.3141
Cell Significance Index: -6.3100 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.3223
Cell Significance Index: -6.2900 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.3232
Cell Significance Index: -20.3700
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3034548866
Symbol: ST1A1_HUMAN
Name: Sulfotransferase 1A1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8363592
Title: Identification of two human brain aryl sulfotransferase cDNAs.
PubMed ID: 8363592
PubMed ID: 8484775
Title: Molecular characterisation of a human aryl sulfotransferase cDNA.
PubMed ID: 8484775
PubMed ID: 8423770
Title: Sequence analysis and expression of the cDNA for the phenol-sulfating form of human liver phenol sulfotransferase.
PubMed ID: 8423770
PubMed ID: 8033246
Title: Structural similarity and diversity of sulfotransferases.
PubMed ID: 8033246
PubMed ID: 7864863
Title: Molecular cloning of an isoform of phenol sulfotransferase from human brain hippocampus.
PubMed ID: 7864863
PubMed ID: 7695643
Title: Human platelet phenolsulfotransferases: cDNA cloning, stable expression in V79 cells and identification of a novel allelic variant of the phenol-sulfating form.
PubMed ID: 7695643
PubMed ID: 7581483
Title: Primary structures and properties of two related forms of aryl sulfotransferases in human liver.
PubMed ID: 7581483
PubMed ID: 8912648
Title: Genomic organization and DNA sequences of two human phenol sulfotransferase genes (STP1 and STP2) on the short arm of chromosome 16.
PubMed ID: 8912648
PubMed ID: 8924211
Title: Human phenol sulfotransferase gene contains two alternative promoters: structure and expression of the gene.
PubMed ID: 8924211
PubMed ID: 9855620
Title: A single amino acid, Glu146, governs the substrate specificity of a human dopamine sulfotransferase, SULT1A3.
PubMed ID: 9855620
DOI: 10.1124/mol.54.6.942
PubMed ID: 15616553
Title: The sequence and analysis of duplication-rich human chromosome 16.
PubMed ID: 15616553
DOI: 10.1038/nature03187
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8288252
Title: Mapping of the phenol sulfotransferase gene (STP) to human chromosome 16p12.1-p11.2 and to mouse chromosome 7.
PubMed ID: 8288252
PubMed ID: 8093002
Title: Functional characterization of two human sulphotransferase cDNAs that encode monoamine- and phenol-sulphating forms of phenol sulphotransferase: substrate kinetics, thermal-stability and inhibitor-sensitivity studies.
PubMed ID: 8093002
DOI: 10.1042/bj3020497
PubMed ID: 8033270
Title: Characterization of expressed human phenol-sulfating phenol sulfotransferase: effect of mutating cys70 on activity and thermostability.
PubMed ID: 8033270
PubMed ID: 7834621
Title: Metabolic activation of N-hydroxy arylamines and N-hydroxy heterocyclic amines by human sulfotransferase(s).
PubMed ID: 7834621
PubMed ID: 10199779
Title: Characterization of human iodothyronine sulfotransferases.
PubMed ID: 10199779
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 35165440
Title: A gut-derived metabolite alters brain activity and anxiety behaviour in mice.
PubMed ID: 35165440
PubMed ID: 12471039
Title: Structure of a human carcinogen-converting enzyme, SULT1A1. Structural and kinetic implications of substrate inhibition.
PubMed ID: 12471039
PubMed ID: 16221673
Title: The structure of human SULT1A1 crystallized with estradiol. An insight into active site plasticity and substrate inhibition with multi-ring substrates.
PubMed ID: 16221673
PubMed ID: 20417180
Title: Crystal structures of SULT1A2 and SULT1A1 *3: insights into the substrate inhibition and the role of Tyr149 in SULT1A2.
PubMed ID: 20417180
PubMed ID: 21723874
Title: Directed evolution of sulfotransferases and paraoxonases by ancestral libraries.
PubMed ID: 21723874
PubMed ID: 22069470
Title: The molecular basis for the broad substrate specificity of human sulfotransferase 1A1.
PubMed ID: 22069470
PubMed ID: 9345314
Title: Phenol sulfotransferase pharmacogenetics in humans: association of common SULT1A1 alleles with TS PST phenotype.
PubMed ID: 9345314
PubMed ID: 10762004
Title: Association between functional genetic polymorphisms of human sulfotransferases 1A1 and 1A2.
PubMed ID: 10762004
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
Sequence Information:
- Length: 295
- Mass: 34165
- Checksum: 7D4362A603A29176
- Sequence:
MELIQDTSRP PLEYVKGVPL IKYFAEALGP LQSFQARPDD LLISTYPKSG TTWVSQILDM IYQGGDLEKC HRAPIFMRVP FLEFKAPGIP SGMETLKDTP APRLLKTHLP LALLPQTLLD QKVKVVYVAR NAKDVAVSYY HFYHMAKVHP EPGTWDSFLE KFMVGEVSYG SWYQHVQEWW ELSRTHPVLY LFYEDMKENP KREIQKILEF VGRSLPEETV DFVVQHTSFK EMKKNPMTNY TTVPQEFMDH SISPFMRKGM AGDWKTTFTV AQNERFDADY AEKMAGCSLS FRSEL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.