Details for: SULT1A1

Gene ID: 6817

Symbol: SULT1A1

Ensembl ID: ENSG00000196502

Description: sulfotransferase family 1A member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 138.5449
    Cell Significance Index: -21.5500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 71.9908
    Cell Significance Index: -18.2600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 49.9437
    Cell Significance Index: -20.2900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 43.9457
    Cell Significance Index: -22.6100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 33.9035
    Cell Significance Index: -22.7500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.2832
    Cell Significance Index: -20.3200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.7946
    Cell Significance Index: -21.9400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.2255
    Cell Significance Index: -22.0400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.2186
    Cell Significance Index: -19.1000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.6462
    Cell Significance Index: -22.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.9982
    Cell Significance Index: 324.9800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.5558
    Cell Significance Index: 28.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4284
    Cell Significance Index: 286.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.3628
    Cell Significance Index: 392.1100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.2294
    Cell Significance Index: 26.9200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9385
    Cell Significance Index: 64.9100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.9197
    Cell Significance Index: 40.6800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.8607
    Cell Significance Index: 7.2300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.8556
    Cell Significance Index: 32.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7958
    Cell Significance Index: 285.4500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.7348
    Cell Significance Index: 11.0100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7300
    Cell Significance Index: 659.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6943
    Cell Significance Index: 125.1600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6490
    Cell Significance Index: 354.4600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.6396
    Cell Significance Index: 43.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6222
    Cell Significance Index: 28.2000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5977
    Cell Significance Index: 16.0200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4672
    Cell Significance Index: 46.2200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4560
    Cell Significance Index: 23.7500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.4377
    Cell Significance Index: 12.4900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.4104
    Cell Significance Index: 5.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.3479
    Cell Significance Index: 50.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3278
    Cell Significance Index: 65.0600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3271
    Cell Significance Index: 35.5800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2959
    Cell Significance Index: 8.2700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2952
    Cell Significance Index: 7.3800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2916
    Cell Significance Index: 37.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2897
    Cell Significance Index: 15.0500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2661
    Cell Significance Index: 13.9700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2563
    Cell Significance Index: 8.9100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2258
    Cell Significance Index: 14.5700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2222
    Cell Significance Index: 42.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1460
    Cell Significance Index: 11.2000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1391
    Cell Significance Index: 3.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1341
    Cell Significance Index: 16.4900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1240
    Cell Significance Index: 3.9700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1148
    Cell Significance Index: 15.7600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0939
    Cell Significance Index: 2.0000
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.0866
    Cell Significance Index: 0.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0615
    Cell Significance Index: 2.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0516
    Cell Significance Index: 32.7900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0411
    Cell Significance Index: 77.4200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0381
    Cell Significance Index: 2.1400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0286
    Cell Significance Index: 20.9900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0218
    Cell Significance Index: 16.4900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0158
    Cell Significance Index: 0.2700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0150
    Cell Significance Index: 1.7200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0061
    Cell Significance Index: 1.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0021
    Cell Significance Index: 3.2300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0008
    Cell Significance Index: 0.3700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0074
    Cell Significance Index: -13.6200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0082
    Cell Significance Index: -5.1100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0109
    Cell Significance Index: -14.8300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0113
    Cell Significance Index: -5.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0120
    Cell Significance Index: -8.8900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0166
    Cell Significance Index: -9.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0242
    Cell Significance Index: -2.4700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0281
    Cell Significance Index: -0.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0317
    Cell Significance Index: -1.4800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0473
    Cell Significance Index: -9.9600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0605
    Cell Significance Index: -0.9600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0676
    Cell Significance Index: -7.9700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0677
    Cell Significance Index: -4.1600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0739
    Cell Significance Index: -5.5100
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0828
    Cell Significance Index: -0.5400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0855
    Cell Significance Index: -9.9600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1034
    Cell Significance Index: -13.3600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1284
    Cell Significance Index: -9.0800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1329
    Cell Significance Index: -3.0700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1419
    Cell Significance Index: -2.3900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1616
    Cell Significance Index: -3.5000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1772
    Cell Significance Index: -20.2300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1781
    Cell Significance Index: -4.5500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1810
    Cell Significance Index: -3.0300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1817
    Cell Significance Index: -4.9500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1848
    Cell Significance Index: -14.6400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1851
    Cell Significance Index: -8.7000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2011
    Cell Significance Index: -20.9400
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.2233
    Cell Significance Index: -1.3800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2266
    Cell Significance Index: -4.8100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2473
    Cell Significance Index: -2.5600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2593
    Cell Significance Index: -15.9000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2827
    Cell Significance Index: -9.0100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2862
    Cell Significance Index: -9.3700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3001
    Cell Significance Index: -4.4300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3071
    Cell Significance Index: -5.3100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3094
    Cell Significance Index: -7.4200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3141
    Cell Significance Index: -6.3100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3223
    Cell Significance Index: -6.2900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3232
    Cell Significance Index: -20.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SULT1A1 is a cytosolic enzyme that exhibits high specificity for sulfonation reactions. It is a member of the sulfotransferase family 1A, which is characterized by its ability to catalyze the transfer of a sulfonate group from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to a wide range of substrates. The enzyme is highly regulated, with its expression and activity influenced by various factors, including cellular stress, inflammation, and hormonal signals. **Pathways and Functions** SULT1A1 is involved in the sulfonation of several key compounds, including: 1. **Xenobiotics**: SULT1A1 plays a crucial role in the metabolism and elimination of xenobiotics, including drugs, environmental pollutants, and endogenous compounds such as ethanol and paracetamol. 2. **Hormones**: The enzyme is involved in the sulfonation of hormones, including estrogen and catecholamines, which regulates their activity and availability. 3. **Flavonoids**: SULT1A1 catalyzes the sulfonation of flavonoids, which is essential for their antioxidant and anti-inflammatory activities. 4. **Amine metabolic process**: The enzyme is also involved in the sulfonation of amines, which is a key step in their degradation and elimination from the body. **Clinical Significance** Dysregulation of SULT1A1 has been implicated in various diseases and disorders, including: 1. **Cancer**: Altered expression and activity of SULT1A1 have been observed in several types of cancer, including colon, breast, and prostate cancer. 2. **Neurological disorders**: SULT1A1 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. 3. **Metabolic disorders**: The enzyme is involved in the metabolism of certain drugs and endogenous compounds, and dysregulation of SULT1A1 has been linked to metabolic disorders, including diabetes and obesity. 4. **Toxicity**: Altered expression and activity of SULT1A1 have been observed in individuals exposed to certain environmental toxins, such as pesticides and heavy metals. In conclusion, SULT1A1 is a critical enzyme involved in the sulfonation of various compounds, including xenobiotics, hormones, and flavonoids. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of this enzyme in maintaining normal physiological processes and preventing disease.

Genular Protein ID: 3034548866

Symbol: ST1A1_HUMAN

Name: Sulfotransferase 1A1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8363592

Title: Identification of two human brain aryl sulfotransferase cDNAs.

PubMed ID: 8363592

DOI: 10.1006/bbrc.1993.2018

PubMed ID: 8484775

Title: Molecular characterisation of a human aryl sulfotransferase cDNA.

PubMed ID: 8484775

DOI: 10.1006/bbrc.1993.1467

PubMed ID: 8423770

Title: Sequence analysis and expression of the cDNA for the phenol-sulfating form of human liver phenol sulfotransferase.

PubMed ID: 8423770

PubMed ID: 8033246

Title: Structural similarity and diversity of sulfotransferases.

PubMed ID: 8033246

DOI: 10.1016/0009-2797(94)90057-4

PubMed ID: 7864863

Title: Molecular cloning of an isoform of phenol sulfotransferase from human brain hippocampus.

PubMed ID: 7864863

DOI: 10.1006/bbrc.1995.1244

PubMed ID: 7695643

Title: Human platelet phenolsulfotransferases: cDNA cloning, stable expression in V79 cells and identification of a novel allelic variant of the phenol-sulfating form.

PubMed ID: 7695643

DOI: 10.1006/bbrc.1995.1414

PubMed ID: 7581483

Title: Primary structures and properties of two related forms of aryl sulfotransferases in human liver.

PubMed ID: 7581483

DOI: 10.1097/00008571-199512001-00015

PubMed ID: 8912648

Title: Genomic organization and DNA sequences of two human phenol sulfotransferase genes (STP1 and STP2) on the short arm of chromosome 16.

PubMed ID: 8912648

DOI: 10.1006/bbrc.1996.1628

PubMed ID: 8924211

Title: Human phenol sulfotransferase gene contains two alternative promoters: structure and expression of the gene.

PubMed ID: 8924211

DOI: 10.1089/dna.1996.15.367

PubMed ID: 9855620

Title: A single amino acid, Glu146, governs the substrate specificity of a human dopamine sulfotransferase, SULT1A3.

PubMed ID: 9855620

DOI: 10.1124/mol.54.6.942

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8288252

Title: Mapping of the phenol sulfotransferase gene (STP) to human chromosome 16p12.1-p11.2 and to mouse chromosome 7.

PubMed ID: 8288252

DOI: 10.1006/geno.1993.1494

PubMed ID: 8093002

Title: Functional characterization of two human sulphotransferase cDNAs that encode monoamine- and phenol-sulphating forms of phenol sulphotransferase: substrate kinetics, thermal-stability and inhibitor-sensitivity studies.

PubMed ID: 8093002

DOI: 10.1042/bj3020497

PubMed ID: 8033270

Title: Characterization of expressed human phenol-sulfating phenol sulfotransferase: effect of mutating cys70 on activity and thermostability.

PubMed ID: 8033270

DOI: 10.1016/0009-2797(94)90053-1

PubMed ID: 7834621

Title: Metabolic activation of N-hydroxy arylamines and N-hydroxy heterocyclic amines by human sulfotransferase(s).

PubMed ID: 7834621

PubMed ID: 10199779

Title: Characterization of human iodothyronine sulfotransferases.

PubMed ID: 10199779

DOI: 10.1210/jcem.84.4.5590

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 35165440

Title: A gut-derived metabolite alters brain activity and anxiety behaviour in mice.

PubMed ID: 35165440

DOI: 10.1038/s41586-022-04396-8

PubMed ID: 12471039

Title: Structure of a human carcinogen-converting enzyme, SULT1A1. Structural and kinetic implications of substrate inhibition.

PubMed ID: 12471039

DOI: 10.1074/jbc.m207246200

PubMed ID: 16221673

Title: The structure of human SULT1A1 crystallized with estradiol. An insight into active site plasticity and substrate inhibition with multi-ring substrates.

PubMed ID: 16221673

DOI: 10.1074/jbc.m508289200

PubMed ID: 20417180

Title: Crystal structures of SULT1A2 and SULT1A1 *3: insights into the substrate inhibition and the role of Tyr149 in SULT1A2.

PubMed ID: 20417180

DOI: 10.1016/j.bbrc.2010.04.109

PubMed ID: 21723874

Title: Directed evolution of sulfotransferases and paraoxonases by ancestral libraries.

PubMed ID: 21723874

DOI: 10.1016/j.jmb.2011.06.037

PubMed ID: 22069470

Title: The molecular basis for the broad substrate specificity of human sulfotransferase 1A1.

PubMed ID: 22069470

DOI: 10.1371/journal.pone.0026794

PubMed ID: 9345314

Title: Phenol sulfotransferase pharmacogenetics in humans: association of common SULT1A1 alleles with TS PST phenotype.

PubMed ID: 9345314

DOI: 10.1006/bbrc.1997.7466

PubMed ID: 10762004

Title: Association between functional genetic polymorphisms of human sulfotransferases 1A1 and 1A2.

PubMed ID: 10762004

DOI: 10.1097/00008571-200003000-00008

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 295
  • Mass: 34165
  • Checksum: 7D4362A603A29176
  • Sequence:
  • MELIQDTSRP PLEYVKGVPL IKYFAEALGP LQSFQARPDD LLISTYPKSG TTWVSQILDM 
    IYQGGDLEKC HRAPIFMRVP FLEFKAPGIP SGMETLKDTP APRLLKTHLP LALLPQTLLD 
    QKVKVVYVAR NAKDVAVSYY HFYHMAKVHP EPGTWDSFLE KFMVGEVSYG SWYQHVQEWW 
    ELSRTHPVLY LFYEDMKENP KREIQKILEF VGRSLPEETV DFVVQHTSFK EMKKNPMTNY 
    TTVPQEFMDH SISPFMRKGM AGDWKTTFTV AQNERFDADY AEKMAGCSLS FRSEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.