Details for: SUOX

Gene ID: 6821

Symbol: SUOX

Ensembl ID: ENSG00000139531

Description: sulfite oxidase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 81.7769
    Cell Significance Index: -12.7200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 46.8768
    Cell Significance Index: -11.8900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.4546
    Cell Significance Index: -12.8900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.2854
    Cell Significance Index: -11.4800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.2970
    Cell Significance Index: -13.0100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.7317
    Cell Significance Index: -3.7900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.2167
    Cell Significance Index: 16.6000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.0901
    Cell Significance Index: 75.3900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9088
    Cell Significance Index: 89.9000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8687
    Cell Significance Index: 141.2900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8000
    Cell Significance Index: 41.5600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6889
    Cell Significance Index: 622.0600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5890
    Cell Significance Index: 35.3600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5546
    Cell Significance Index: 14.8600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5524
    Cell Significance Index: 60.0800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5202
    Cell Significance Index: 4.7900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4906
    Cell Significance Index: 97.3700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.4616
    Cell Significance Index: 7.4100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3851
    Cell Significance Index: 69.4300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3397
    Cell Significance Index: 21.4100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2518
    Cell Significance Index: 7.2600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2473
    Cell Significance Index: 28.8200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.2463
    Cell Significance Index: 3.5000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2203
    Cell Significance Index: 27.0900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2184
    Cell Significance Index: 41.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1404
    Cell Significance Index: 28.1700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1389
    Cell Significance Index: 17.8100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1376
    Cell Significance Index: 3.4400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1291
    Cell Significance Index: 6.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1198
    Cell Significance Index: 5.4300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1115
    Cell Significance Index: 3.1200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1030
    Cell Significance Index: 56.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0738
    Cell Significance Index: 26.4800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0711
    Cell Significance Index: 9.7700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0522
    Cell Significance Index: 1.1300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0511
    Cell Significance Index: 3.9300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0404
    Cell Significance Index: 1.0800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0394
    Cell Significance Index: 17.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0305
    Cell Significance Index: 0.8300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0283
    Cell Significance Index: 1.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0083
    Cell Significance Index: 15.6900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0062
    Cell Significance Index: 4.5700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0000
    Cell Significance Index: -0.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0017
    Cell Significance Index: -3.1900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0022
    Cell Significance Index: -0.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0036
    Cell Significance Index: -5.4900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0060
    Cell Significance Index: -4.5500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0062
    Cell Significance Index: -0.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0062
    Cell Significance Index: -8.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0123
    Cell Significance Index: -5.5800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0133
    Cell Significance Index: -9.8300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0192
    Cell Significance Index: -10.8400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0230
    Cell Significance Index: -1.6300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0232
    Cell Significance Index: -14.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0235
    Cell Significance Index: -6.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0245
    Cell Significance Index: -2.5000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0275
    Cell Significance Index: -4.0000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0276
    Cell Significance Index: -4.7100
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0281
    Cell Significance Index: -0.4200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0537
    Cell Significance Index: -3.2900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0545
    Cell Significance Index: -1.1600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0558
    Cell Significance Index: -7.2100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0598
    Cell Significance Index: -1.2400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0644
    Cell Significance Index: -13.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0654
    Cell Significance Index: -7.4900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0729
    Cell Significance Index: -1.2200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0780
    Cell Significance Index: -1.0000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0816
    Cell Significance Index: -6.0800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0823
    Cell Significance Index: -9.7000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0879
    Cell Significance Index: -2.2600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0927
    Cell Significance Index: -1.9400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0952
    Cell Significance Index: -2.2000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0981
    Cell Significance Index: -3.4100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1028
    Cell Significance Index: -6.3200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1040
    Cell Significance Index: -8.2400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1136
    Cell Significance Index: -7.6400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1136
    Cell Significance Index: -11.8300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1324
    Cell Significance Index: -2.9000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1334
    Cell Significance Index: -6.2700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1453
    Cell Significance Index: -3.8200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1455
    Cell Significance Index: -9.3900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1497
    Cell Significance Index: -7.8600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1815
    Cell Significance Index: -1.2300
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.2004
    Cell Significance Index: -1.2400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2044
    Cell Significance Index: -10.3300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2121
    Cell Significance Index: -2.4100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2212
    Cell Significance Index: -5.6500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2261
    Cell Significance Index: -2.9000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2275
    Cell Significance Index: -4.4400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2371
    Cell Significance Index: -3.5000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2378
    Cell Significance Index: -10.5200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2568
    Cell Significance Index: -6.8700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2615
    Cell Significance Index: -4.4100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2648
    Cell Significance Index: -7.8000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2709
    Cell Significance Index: -3.8800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2798
    Cell Significance Index: -10.6000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2807
    Cell Significance Index: -4.8100
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2905
    Cell Significance Index: -4.0300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2910
    Cell Significance Index: -8.3100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2932
    Cell Significance Index: -10.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SUOX is a molybdenum-dependent enzyme that catalyzes the oxidation of sulfite to sulfate, with the concomitant reduction of molybdenum. This reaction is crucial for the removal of excess sulfite, which can be toxic to cells, and for the production of sulfate, a key intermediate in the synthesis of amino acids, nucleotides, and other biomolecules. SUOX is primarily expressed in the brain, kidneys, and liver, where it is involved in the metabolism of sulfur-containing compounds. **Pathways and Functions:** SUOX is involved in several key pathways, including: 1. **Degradation of cysteine and homocysteine:** SUOX catalyzes the oxidation of cysteine and homocysteine to cysteine sulfinic acid and homocysteine thiolactate, respectively, which are then further metabolized to produce sulfate and other biomolecules. 2. **Metabolism of sulfur-containing compounds:** SUOX is involved in the metabolism of various sulfur-containing compounds, including sulfite, cysteine, and homocysteine. 3. **Heme binding:** SUOX is also involved in the binding of heme, which is a critical component of various proteins involved in oxygen transport and storage. 4. **Molybdenum ion binding:** SUOX binds to molybdenum ions, which are essential cofactors for the enzyme's catalytic activity. **Clinical Significance:** Dysregulation of SUOX has been implicated in various human diseases, including: 1. **Neurodegenerative disorders:** Mutations in the SUOX gene have been associated with neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). 2. **Cancer:** Abnormal expression of SUOX has been observed in various types of cancer, including colon and lung cancer. 3. **Neurodevelopmental disorders:** SUOX has been implicated in the development of neurodevelopmental disorders, such as autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD). 4. **Metabolic disorders:** SUOX is involved in the metabolism of sulfur-containing compounds, which are essential for various bodily functions. Abnormal expression of SUOX has been observed in metabolic disorders, such as homocystinuria. In conclusion, SUOX is a critical enzyme that plays a vital role in the degradation of cysteine and homocysteine, as well as the metabolism of sulfur-containing compounds. Its dysregulation has been implicated in various human diseases, highlighting the importance of SUOX in human health. Further research is needed to fully understand the mechanisms by which SUOX regulates sulfur metabolism and to identify potential therapeutic targets for the treatment of SUOX-related disorders.

Genular Protein ID: 3982877297

Symbol: SUOX_HUMAN

Name: N/A

UniProtKB Accession Codes:

P51687

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 20 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 3 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 5 Rhea 2 SABIO-RK 1 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7599189

Title: Molecular cloning of human liver sulfite oxidase.

PubMed ID: 7599189

DOI: 10.1016/0167-4781(95)00068-r

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 12832761

Title: The 1.2 A structure of the human sulfite oxidase cytochrome b(5) domain.

PubMed ID: 12832761

DOI: 10.1107/s0907444903009934

PubMed ID: 9428520

Title: Molecular basis of sulfite oxidase deficiency from the structure of sulfite oxidase.

PubMed ID: 9428520

DOI: 10.1016/s0092-8674(00)80488-2

PubMed ID: 9600976

Title: Human sulfite oxidase R160Q: identification of the mutation in a sulfite oxidase-deficient patient and expression and characterization of the mutant enzyme.

PubMed ID: 9600976

DOI: 10.1073/pnas.95.11.6394

PubMed ID: 10519592

Title: Isolated sulfite oxidase deficiency: review of two cases in one family.

PubMed ID: 10519592

DOI: 10.1016/s0161-6420(99)90408-6

PubMed ID: 12112661

Title: Isolated sulfite oxidase deficiency: identification of 12 novel SUOX mutations in 10 patients.

PubMed ID: 12112661

DOI: 10.1002/humu.9038

PubMed ID: 12368985

Title: A novel mutation in neonatal isolated sulphite oxidase deficiency.

PubMed ID: 12368985

DOI: 10.1055/s-2002-34491

Sequence Information:

  • Length: 545
  • Mass: 60283
  • Checksum: 39B842C55D39E11F
  • Sequence:
    • MLLLHRAVVL RLQQACRLKS IPSRICIQAC STNDSFQPQR PSLTFSGDNS STQGWRVMGT 
LLGLGAVLAY QDHRCRAAQE STHIYTKEEV SSHTSPETGI WVTLGSEVFD VTEFVDLHPG 
GPSKLMLAAG GPLEPFWALY AVHNQSHVRE LLAQYKIGEL NPEDKVAPTV ETSDPYADDP 
VRHPALKVNS QRPFNAEPPP ELLTENYITP NPIFFTRNHL PVPNLDPDTY RLHVVGAPGG 
QSLSLSLDDL HNFPRYEITV TLQCAGNRRS EMTQVKEVKG LEWRTGAIST ARWAGARLCD 
VLAQAGHQLC ETEAHVCFEG LDSDPTGTAY GASIPLARAM DPEAEVLLAY EMNGQPLPRD 
HGFPVRVVVP GVVGARHVKW LGRVSVQPEE SYSHWQRRDY KGFSPSVDWE TVDFDSAPSI 
QELPVQSAIT EPRDGETVES GEVTIKGYAW SGGGRAVIRV DVSLDGGLTW QVAKLDGEEQ 
RPRKAWAWRL WQLKAPVPAG QKELNIVCKA VDDGYNVQPD TVAPIWNLRG VLSNAWHRVH 
VYVSP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.