Details for: VAMP1

Gene ID: 6843

Symbol: VAMP1

Ensembl ID: ENSG00000139190

Description: vesicle associated membrane protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 52.1392
    Cell Significance Index: -8.1100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 31.5403
    Cell Significance Index: -8.0000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 17.6437
    Cell Significance Index: -8.3300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.9264
    Cell Significance Index: -8.5400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.0349
    Cell Significance Index: -8.1300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.5623
    Cell Significance Index: -7.8700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.1794
    Cell Significance Index: -8.6000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.7774
    Cell Significance Index: -3.8900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7503
    Cell Significance Index: 142.8000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.6318
    Cell Significance Index: 4.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5368
    Cell Significance Index: 53.1100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4514
    Cell Significance Index: 29.1200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4460
    Cell Significance Index: 12.8500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4185
    Cell Significance Index: 377.8400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3552
    Cell Significance Index: 71.2600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3522
    Cell Significance Index: 41.5400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3092
    Cell Significance Index: 50.2900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2914
    Cell Significance Index: 31.7000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2544
    Cell Significance Index: 11.5300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2276
    Cell Significance Index: 11.9500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2266
    Cell Significance Index: 4.9100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1898
    Cell Significance Index: 11.4000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1447
    Cell Significance Index: 9.1200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1361
    Cell Significance Index: 9.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1194
    Cell Significance Index: 8.0300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1177
    Cell Significance Index: 3.2900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1129
    Cell Significance Index: 40.4800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0995
    Cell Significance Index: 11.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0914
    Cell Significance Index: 3.2100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0865
    Cell Significance Index: 1.1800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0642
    Cell Significance Index: 44.4300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0557
    Cell Significance Index: 7.1400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0549
    Cell Significance Index: 9.8900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0528
    Cell Significance Index: 1.3200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0518
    Cell Significance Index: 1.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0414
    Cell Significance Index: 8.2100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0352
    Cell Significance Index: 19.2500
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.0300
    Cell Significance Index: 0.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0135
    Cell Significance Index: 25.4100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0113
    Cell Significance Index: 0.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0107
    Cell Significance Index: 1.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0104
    Cell Significance Index: 19.1400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0097
    Cell Significance Index: 14.9800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0078
    Cell Significance Index: 3.5400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0064
    Cell Significance Index: 2.8500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0016
    Cell Significance Index: 2.2100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0007
    Cell Significance Index: 0.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0028
    Cell Significance Index: -1.7700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0032
    Cell Significance Index: -0.0400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0043
    Cell Significance Index: -0.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0086
    Cell Significance Index: -1.1800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0097
    Cell Significance Index: -7.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0101
    Cell Significance Index: -7.6500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0110
    Cell Significance Index: -8.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0145
    Cell Significance Index: -8.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0147
    Cell Significance Index: -1.1300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0209
    Cell Significance Index: -6.0200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0222
    Cell Significance Index: -0.6000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0249
    Cell Significance Index: -0.3500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0273
    Cell Significance Index: -4.6700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0279
    Cell Significance Index: -0.4600
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0307
    Cell Significance Index: -0.2700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0326
    Cell Significance Index: -3.3300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0392
    Cell Significance Index: -1.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0411
    Cell Significance Index: -1.8200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0427
    Cell Significance Index: -9.0000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0471
    Cell Significance Index: -6.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0496
    Cell Significance Index: -3.0500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0516
    Cell Significance Index: -1.5200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0536
    Cell Significance Index: -2.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0544
    Cell Significance Index: -6.2300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0578
    Cell Significance Index: -4.3100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0610
    Cell Significance Index: -3.7400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0639
    Cell Significance Index: -3.3200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0677
    Cell Significance Index: -7.0500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0678
    Cell Significance Index: -1.3400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0682
    Cell Significance Index: -1.3700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0724
    Cell Significance Index: -4.0600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0784
    Cell Significance Index: -0.9900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0834
    Cell Significance Index: -3.8900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0854
    Cell Significance Index: -1.4300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0867
    Cell Significance Index: -2.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0932
    Cell Significance Index: -4.3800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0960
    Cell Significance Index: -2.0800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0973
    Cell Significance Index: -6.8800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1002
    Cell Significance Index: -2.6800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1024
    Cell Significance Index: -2.4600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1028
    Cell Significance Index: -5.2000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1058
    Cell Significance Index: -1.5200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1082
    Cell Significance Index: -1.2900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1153
    Cell Significance Index: -1.4300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1214
    Cell Significance Index: -2.6000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1220
    Cell Significance Index: -3.2700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1265
    Cell Significance Index: -1.8100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1299
    Cell Significance Index: -4.5500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1362
    Cell Significance Index: -4.4600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1378
    Cell Significance Index: -3.5200
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.1630
    Cell Significance Index: -2.4800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1720
    Cell Significance Index: -4.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Structural homology**: VAMP1 shares structural homology with VAMP2, another member of the VAMP family, which suggests a conserved evolutionary history. 2. **Snare complex assembly**: VAMP1 is involved in the assembly of the SNARE complex, a protein complex required for vesicle fusion and neurotransmitter release. 3. **Protein binding**: VAMP1 interacts with various proteins, including syntaxin, SNAP-25, and synaptobrevin, to regulate vesicle fusion and neurotransmitter release. 4. **Cellular localization**: VAMP1 is primarily localized to the plasma membrane, synaptic vesicles, and azurophil granules, indicating its role in various cellular processes. **Pathways and Functions** 1. **Vesicle fusion**: VAMP1 regulates the fusion of vesicles with membranes, including synaptic vesicles, azurophil granules, and mitochondrial outer membranes. 2. **Neurotransmission**: VAMP1 plays a critical role in neurotransmission, particularly in the release of neurotransmitters such as glutamate and GABA. 3. **Immune response**: VAMP1 is involved in the regulation of immune responses, including the uptake and actions of bacterial toxins. 4. **Cellular homeostasis**: VAMP1 maintains cellular homeostasis by regulating the fusion of vesicles with membranes, which is essential for cellular growth, differentiation, and survival. **Clinical Significance** 1. **Neurodegenerative diseases**: VAMP1 has been implicated in various neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Autoimmune disorders**: VAMP1 has been linked to autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis, where immune responses are dysregulated. 3. **Infectious diseases**: VAMP1 plays a role in the regulation of immune responses to bacterial toxins, highlighting its potential as a target for therapeutic interventions against infectious diseases. 4. **Cancer**: VAMP1 has been implicated in cancer progression, where its dysregulation contributes to the development and metastasis of tumors. In conclusion, VAMP1 is a critical regulator of vesicle fusion and immune function, with far-reaching implications for various cellular processes and diseases. Further research is necessary to fully elucidate the complexities of VAMP1 and its role in human health and disease.

Genular Protein ID: 3772015989

Symbol: VAMP1_HUMAN

Name: Vesicle-associated membrane protein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1976629

Title: Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2.

PubMed ID: 1976629

DOI: 10.1016/s0021-9258(17)44898-8

PubMed ID: 9658161

Title: A splice-isoform of vesicle-associated membrane protein-1 (VAMP-1) contains a mitochondrial targeting signal.

PubMed ID: 9658161

DOI: 10.1091/mbc.9.7.1649

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22958904

Title: VAMP1 mutation causes dominant hereditary spastic ataxia in Newfoundland families.

PubMed ID: 22958904

DOI: 10.1016/j.ajhg.2012.07.018

PubMed ID: 22289120

Title: Specificity of botulinum protease for human VAMP family proteins.

PubMed ID: 22289120

DOI: 10.1111/j.1348-0421.2012.00434.x

PubMed ID: 28168212

Title: Novel synaptobrevin-1 mutation causes fatal congenital myasthenic syndrome.

PubMed ID: 28168212

DOI: 10.1002/acn3.387

PubMed ID: 28253535

Title: Homozygous mutations in VAMP1 cause a presynaptic congenital myasthenic syndrome.

PubMed ID: 28253535

DOI: 10.1002/ana.24905

PubMed ID: 28600779

Title: The landscape of genetic diseases in Saudi Arabia based on the first 1000 diagnostic panels and exomes.

PubMed ID: 28600779

DOI: 10.1007/s00439-017-1821-8

PubMed ID: 29540745

Title: Structural characterisation of the catalytic domain of botulinum neurotoxin X - high activity and unique substrate specificity.

PubMed ID: 29540745

DOI: 10.1038/s41598-018-22842-4

Sequence Information:

  • Length: 118
  • Mass: 12902
  • Checksum: 64CE9615447B686B
  • Sequence:
  • MSAPAQPPAE GTEGTAPGGG PPGPPPNMTS NRRLQQTQAQ VEEVVDIIRV NVDKVLERDQ 
    KLSELDDRAD ALQAGASQFE SSAAKLKRKY WWKNCKMMIM LGAICAIIVV VIVIYFFT

Genular Protein ID: 3302157323

Symbol: F5GZV7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

Sequence Information:

  • Length: 116
  • Mass: 12600
  • Checksum: 97AA002B686B1AE6
  • Sequence:
  • MSAPAQPPAE GTEGTAPGGG PPGPPPNMTS NRRLQQTQAQ VEEVVDIIRV NVDKVLERDQ 
    KLSELDDRAD ALQAGASQFE SSAAKLKRKY WWKNCKMMIM LGAICAIIVV VIVRRG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.