Details for: VAMP1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 52.1392
Cell Significance Index: -8.1100 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 31.5403
Cell Significance Index: -8.0000 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 17.6437
Cell Significance Index: -8.3300 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 6.9264
Cell Significance Index: -8.5400 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 3.0349
Cell Significance Index: -8.1300 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 2.5623
Cell Significance Index: -7.8700 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 2.1794
Cell Significance Index: -8.6000 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 1.7774
Cell Significance Index: -3.8900 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.7503
Cell Significance Index: 142.8000 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 0.6318
Cell Significance Index: 4.8700 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5368
Cell Significance Index: 53.1100 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.4514
Cell Significance Index: 29.1200 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.4460
Cell Significance Index: 12.8500 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4185
Cell Significance Index: 377.8400 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.3552
Cell Significance Index: 71.2600 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.3522
Cell Significance Index: 41.5400 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3092
Cell Significance Index: 50.2900 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2914
Cell Significance Index: 31.7000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2544
Cell Significance Index: 11.5300 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.2276
Cell Significance Index: 11.9500 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2266
Cell Significance Index: 4.9100 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.1898
Cell Significance Index: 11.4000 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.1447
Cell Significance Index: 9.1200 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1361
Cell Significance Index: 9.4100 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.1194
Cell Significance Index: 8.0300 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1177
Cell Significance Index: 3.2900 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1129
Cell Significance Index: 40.4800 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.0995
Cell Significance Index: 11.5900 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0914
Cell Significance Index: 3.2100 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.0865
Cell Significance Index: 1.1800 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0642
Cell Significance Index: 44.4300 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0557
Cell Significance Index: 7.1400 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0549
Cell Significance Index: 9.8900 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0528
Cell Significance Index: 1.3200 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.0518
Cell Significance Index: 1.1000 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0414
Cell Significance Index: 8.2100 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0352
Cell Significance Index: 19.2500 - Cell Name: centroblast (CL0009112)
Fold Change: 0.0300
Cell Significance Index: 0.0700 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0135
Cell Significance Index: 25.4100 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0113
Cell Significance Index: 0.2400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0107
Cell Significance Index: 1.3100 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0104
Cell Significance Index: 19.1400 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0097
Cell Significance Index: 14.9800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0078
Cell Significance Index: 3.5400 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0064
Cell Significance Index: 2.8500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0016
Cell Significance Index: 2.2100 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.0007
Cell Significance Index: 0.0100 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.0000
Cell Significance Index: 0.0000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0028
Cell Significance Index: -1.7700 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.0032
Cell Significance Index: -0.0400 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0043
Cell Significance Index: -0.0900 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0086
Cell Significance Index: -1.1800 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0097
Cell Significance Index: -7.0900 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0101
Cell Significance Index: -7.6500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0110
Cell Significance Index: -8.1600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0145
Cell Significance Index: -8.1600 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0147
Cell Significance Index: -1.1300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0209
Cell Significance Index: -6.0200 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0222
Cell Significance Index: -0.6000 - Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.0249
Cell Significance Index: -0.3500 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0273
Cell Significance Index: -4.6700 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.0279
Cell Significance Index: -0.4600 - Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: -0.0307
Cell Significance Index: -0.2700 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0326
Cell Significance Index: -3.3300 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0392
Cell Significance Index: -1.1200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0411
Cell Significance Index: -1.8200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0427
Cell Significance Index: -9.0000 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0471
Cell Significance Index: -6.0900 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0496
Cell Significance Index: -3.0500 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.0516
Cell Significance Index: -1.5200 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0536
Cell Significance Index: -2.0300 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0544
Cell Significance Index: -6.2300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0578
Cell Significance Index: -4.3100 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0610
Cell Significance Index: -3.7400 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0639
Cell Significance Index: -3.3200 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0677
Cell Significance Index: -7.0500 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0678
Cell Significance Index: -1.3400 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.0682
Cell Significance Index: -1.3700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0724
Cell Significance Index: -4.0600 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.0784
Cell Significance Index: -0.9900 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0834
Cell Significance Index: -3.8900 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0854
Cell Significance Index: -1.4300 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0867
Cell Significance Index: -2.7600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0932
Cell Significance Index: -4.3800 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0960
Cell Significance Index: -2.0800 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0973
Cell Significance Index: -6.8800 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.1002
Cell Significance Index: -2.6800 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.1024
Cell Significance Index: -2.4600 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.1028
Cell Significance Index: -5.2000 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.1058
Cell Significance Index: -1.5200 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.1082
Cell Significance Index: -1.2900 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.1153
Cell Significance Index: -1.4300 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.1214
Cell Significance Index: -2.6000 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.1220
Cell Significance Index: -3.2700 - Cell Name: proerythroblast (CL0000547)
Fold Change: -0.1265
Cell Significance Index: -1.8100 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1299
Cell Significance Index: -4.5500 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1362
Cell Significance Index: -4.4600 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1378
Cell Significance Index: -3.5200 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: -0.1630
Cell Significance Index: -2.4800 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.1720
Cell Significance Index: -4.2900
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3772015989
Symbol: VAMP1_HUMAN
Name: Vesicle-associated membrane protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1976629
Title: Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2.
PubMed ID: 1976629
PubMed ID: 9658161
Title: A splice-isoform of vesicle-associated membrane protein-1 (VAMP-1) contains a mitochondrial targeting signal.
PubMed ID: 9658161
DOI: 10.1091/mbc.9.7.1649
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 16541075
Title: The finished DNA sequence of human chromosome 12.
PubMed ID: 16541075
DOI: 10.1038/nature04569
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 22958904
Title: VAMP1 mutation causes dominant hereditary spastic ataxia in Newfoundland families.
PubMed ID: 22958904
PubMed ID: 22289120
Title: Specificity of botulinum protease for human VAMP family proteins.
PubMed ID: 22289120
PubMed ID: 28168212
Title: Novel synaptobrevin-1 mutation causes fatal congenital myasthenic syndrome.
PubMed ID: 28168212
DOI: 10.1002/acn3.387
PubMed ID: 28253535
Title: Homozygous mutations in VAMP1 cause a presynaptic congenital myasthenic syndrome.
PubMed ID: 28253535
DOI: 10.1002/ana.24905
PubMed ID: 28600779
Title: The landscape of genetic diseases in Saudi Arabia based on the first 1000 diagnostic panels and exomes.
PubMed ID: 28600779
PubMed ID: 29540745
Title: Structural characterisation of the catalytic domain of botulinum neurotoxin X - high activity and unique substrate specificity.
PubMed ID: 29540745
Sequence Information:
- Length: 118
- Mass: 12902
- Checksum: 64CE9615447B686B
- Sequence:
MSAPAQPPAE GTEGTAPGGG PPGPPPNMTS NRRLQQTQAQ VEEVVDIIRV NVDKVLERDQ KLSELDDRAD ALQAGASQFE SSAAKLKRKY WWKNCKMMIM LGAICAIIVV VIVIYFFT
Genular Protein ID: 3302157323
Symbol: F5GZV7_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16541075
Title: The finished DNA sequence of human chromosome 12.
PubMed ID: 16541075
DOI: 10.1038/nature04569
Sequence Information:
- Length: 116
- Mass: 12600
- Checksum: 97AA002B686B1AE6
- Sequence:
MSAPAQPPAE GTEGTAPGGG PPGPPPNMTS NRRLQQTQAQ VEEVVDIIRV NVDKVLERDQ KLSELDDRAD ALQAGASQFE SSAAKLKRKY WWKNCKMMIM LGAICAIIVV VIVRRG
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.