Details for: XCL2

Gene ID: 6846

Symbol: XCL2

Ensembl ID: ENSG00000143185

Description: X-C motif chemokine ligand 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 38.2436
    Cell Significance Index: 102.4500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 10.9881
    Cell Significance Index: 386.1100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 6.5428
    Cell Significance Index: 135.7300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 4.8715
    Cell Significance Index: 121.7800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 4.7702
    Cell Significance Index: 292.4600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 4.5965
    Cell Significance Index: 132.4400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.7414
    Cell Significance Index: 78.9300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.6774
    Cell Significance Index: 36.3400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2287
    Cell Significance Index: 233.8400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0321
    Cell Significance Index: 102.1000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8046
    Cell Significance Index: 726.5100
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.5320
    Cell Significance Index: 5.6600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.5282
    Cell Significance Index: 7.9600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4812
    Cell Significance Index: 78.2700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3556
    Cell Significance Index: 38.6800
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: 0.1953
    Cell Significance Index: 0.5000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1615
    Cell Significance Index: 11.1700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1105
    Cell Significance Index: 1.7100
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.0617
    Cell Significance Index: 0.6400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0477
    Cell Significance Index: 1.0200
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.0320
    Cell Significance Index: 0.2300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0003
    Cell Significance Index: -0.0200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0004
    Cell Significance Index: -0.0200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0016
    Cell Significance Index: -0.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0064
    Cell Significance Index: -4.8200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0073
    Cell Significance Index: -13.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0087
    Cell Significance Index: -13.3700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0179
    Cell Significance Index: -13.2300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0201
    Cell Significance Index: -14.7100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0223
    Cell Significance Index: -14.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0244
    Cell Significance Index: -13.7500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0284
    Cell Significance Index: -1.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0288
    Cell Significance Index: -13.0600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0325
    Cell Significance Index: -1.9500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0455
    Cell Significance Index: -9.0200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0521
    Cell Significance Index: -1.6700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0630
    Cell Significance Index: -13.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0673
    Cell Significance Index: -13.5100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0736
    Cell Significance Index: -9.4300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0747
    Cell Significance Index: -13.4700
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0786
    Cell Significance Index: -1.1500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0790
    Cell Significance Index: -10.8500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0805
    Cell Significance Index: -13.7500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0977
    Cell Significance Index: -14.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0998
    Cell Significance Index: -12.2700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1007
    Cell Significance Index: -1.7100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1044
    Cell Significance Index: -1.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1065
    Cell Significance Index: -5.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1140
    Cell Significance Index: -14.7300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1149
    Cell Significance Index: -13.1600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1221
    Cell Significance Index: -14.4000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1233
    Cell Significance Index: -12.5900
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.1756
    Cell Significance Index: -1.8200
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1847
    Cell Significance Index: -1.8000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1994
    Cell Significance Index: -14.8600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1997
    Cell Significance Index: -13.4300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.2078
    Cell Significance Index: -1.9700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2127
    Cell Significance Index: -5.6900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2143
    Cell Significance Index: -13.1700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2286
    Cell Significance Index: -14.7500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2397
    Cell Significance Index: -6.7000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2407
    Cell Significance Index: -15.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2456
    Cell Significance Index: -12.7600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2622
    Cell Significance Index: -6.5400
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.2727
    Cell Significance Index: -4.6900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2885
    Cell Significance Index: -13.4500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3179
    Cell Significance Index: -7.7000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.3252
    Cell Significance Index: -3.8400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3263
    Cell Significance Index: -11.9800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.3323
    Cell Significance Index: -6.5400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.3584
    Cell Significance Index: -3.9700
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: -0.3587
    Cell Significance Index: -2.0800
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.3853
    Cell Significance Index: -3.4300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3971
    Cell Significance Index: -13.0000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4047
    Cell Significance Index: -8.4700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4076
    Cell Significance Index: -12.9800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4349
    Cell Significance Index: -11.1100
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: -0.4373
    Cell Significance Index: -1.8200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4437
    Cell Significance Index: -13.0300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4548
    Cell Significance Index: -11.9600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.4580
    Cell Significance Index: -11.4400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4712
    Cell Significance Index: -12.8300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4812
    Cell Significance Index: -12.8500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4919
    Cell Significance Index: -14.4900
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.4942
    Cell Significance Index: -7.0300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.4955
    Cell Significance Index: -7.9500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5114
    Cell Significance Index: -14.6600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5138
    Cell Significance Index: -11.8700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.5212
    Cell Significance Index: -13.2800
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.5308
    Cell Significance Index: -5.5100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.5325
    Cell Significance Index: -13.2800
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.5517
    Cell Significance Index: -4.7000
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: -0.5547
    Cell Significance Index: -3.5300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5583
    Cell Significance Index: -13.3900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.5628
    Cell Significance Index: -6.7300
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.5742
    Cell Significance Index: -7.9400
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.5946
    Cell Significance Index: -6.7000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6040
    Cell Significance Index: -12.8200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.6091
    Cell Significance Index: -13.1600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.6242
    Cell Significance Index: -10.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** XCL2 is a small, secreted chemokine that exhibits a unique structure, consisting of two alpha-helical regions flanked by a disulfide bond. This structure allows it to bind to its receptor, CXCR6, with high affinity. XCL2 is predominantly expressed in various immune cells, including decidual natural killer cells, CD56-positive and CD161-positive immature natural killer cells, and gamma-delta intraepithelial T cells. Its expression is also detected in human tissues, such as the colon and epithelium of the large intestine. **Pathways and Functions** XCL2 plays a crucial role in the chemotaxis of immune cells, particularly in the recruitment of T cells, natural killer cells, and other immune cells to sites of inflammation and infection. Its signaling pathway involves the binding of XCL2 to its receptor, CXCR6, which activates a G-protein coupled receptor (GPCR) signaling cascade. This cascade leads to the activation of various downstream signaling pathways, including the ERK1/2 cascade, which is involved in the regulation of T cell activation and proliferation. In addition to its role in chemotaxis, XCL2 has been shown to regulate the activity of immune cells, including the activation of T cells, natural killer cells, and other immune cells. Its expression is also linked to the regulation of various immune responses, including the inflammatory response, lymphocyte chemotaxis, and monocyte chemotaxis. **Clinical Significance** XCL2 has been implicated in various diseases, including cancer, autoimmune disorders, and inflammatory conditions. Its expression has been detected in the tumor microenvironment, where it may contribute to the recruitment of immune cells to tumor sites, leading to the activation of anti-tumor immune responses. In autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis, XCL2 has been shown to play a role in the recruitment of immune cells to sites of inflammation, leading to the activation of disease-promoting immune responses. Furthermore, XCL2 has been implicated in the regulation of immune responses in the context of infectious diseases, such as HIV and tuberculosis. Its expression has been detected in the respiratory tract of HIV-infected individuals, where it may contribute to the recruitment of immune cells to sites of inflammation, leading to the activation of anti-viral immune responses. In conclusion, XCL2 is a key player in the regulation of immune responses, particularly in the recruitment of immune cells to sites of inflammation and infection. Its expression has been implicated in various diseases, including cancer, autoimmune disorders, and infectious diseases, highlighting its potential as a therapeutic target for the treatment of these conditions. **Proteins and Signaling Pathways** XCL2 interacts with its receptor, CXCR6, to activate a G-protein coupled receptor (GPCR) signaling cascade. This cascade leads to the activation of various downstream signaling pathways, including the ERK1/2 cascade, which is involved in the regulation of T cell activation and proliferation. The signaling pathway of XCL2 involves the following key molecules: * CXCR6: The receptor for XCL2, which binds to the chemokine and activates a G-protein coupled receptor (GPCR) signaling cascade. * G-proteins: The G-proteins are activated by the binding of XCL2 to CXCR6, leading to the activation of downstream signaling pathways. * ERK1/2 cascade: The ERK1/2 cascade is involved in the regulation of T cell activation and proliferation, and is activated by the signaling pathway of XCL2. * NF-kB: NF-kB is a transcription factor that is involved in the regulation of immune responses, and is activated by the signaling pathway of XCL2. Overall, the signaling pathway of XCL2 involves a complex interplay between various molecules, including CXCR6, G-proteins, ERK1/2 cascade, and NF-kB, which leads to the activation of immune responses and the regulation of immune cell activity.

Genular Protein ID: 2355153298

Symbol: XCL2_HUMAN

Name: Cytokine SCM-1 beta

UniProtKB Accession Codes:

Q9UBD3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8849694

Title: Structure and expression of two highly related genes encoding SCM-1/human lymphotactin.

PubMed ID: 8849694

DOI: 10.1016/0014-5793(96)01004-6

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

Sequence Information:

  • Length: 114
  • Mass: 12567
  • Checksum: E7F3C283F02D6D9D
  • Sequence:
    • MRLLILALLG ICSLTAYIVE GVGSEVSHRR TCVSLTTQRL PVSRIKTYTI TEGSLRAVIF 
ITKRGLKVCA DPQATWVRDV VRSMDRKSNT RNNMIQTKPT GTQQSTNTAV TLTG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.