Details for: SYK

Gene ID: 6850

Symbol: SYK

Ensembl ID: ENSG00000165025

Description: spleen associated tyrosine kinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 87.1772
    Cell Significance Index: -13.5600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 42.5346
    Cell Significance Index: -17.2800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 35.5084
    Cell Significance Index: -18.2700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 26.2179
    Cell Significance Index: -6.6500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.3610
    Cell Significance Index: -17.5300
  • Cell Name: centroblast (CL0009112)
    Fold Change: 12.2714
    Cell Significance Index: 28.6300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.4359
    Cell Significance Index: -14.1000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.4486
    Cell Significance Index: -17.2800
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 4.8446
    Cell Significance Index: 32.1400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 3.9568
    Cell Significance Index: 32.2700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.7467
    Cell Significance Index: -8.2000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.6796
    Cell Significance Index: -14.5200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.5769
    Cell Significance Index: 66.1100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.2403
    Cell Significance Index: 264.2000
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 2.1007
    Cell Significance Index: 13.4100
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 2.0820
    Cell Significance Index: 5.5800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.0030
    Cell Significance Index: 51.1700
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.9807
    Cell Significance Index: 15.0200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.6156
    Cell Significance Index: 45.1500
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.5315
    Cell Significance Index: 15.4500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.5081
    Cell Significance Index: 90.5400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0174
    Cell Significance Index: 165.4700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0032
    Cell Significance Index: 64.7200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9891
    Cell Significance Index: 893.1000
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.9661
    Cell Significance Index: 7.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4458
    Cell Significance Index: 23.1600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4163
    Cell Significance Index: 5.6800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4068
    Cell Significance Index: 11.7200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3864
    Cell Significance Index: 5.7900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3858
    Cell Significance Index: 69.5400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3829
    Cell Significance Index: 47.0800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3817
    Cell Significance Index: 8.2700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.3740
    Cell Significance Index: 8.6400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.3558
    Cell Significance Index: 3.7800
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.3351
    Cell Significance Index: 3.6600
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.3232
    Cell Significance Index: 4.5400
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.3189
    Cell Significance Index: 3.8300
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.2859
    Cell Significance Index: 2.0600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2160
    Cell Significance Index: 4.6000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2098
    Cell Significance Index: 114.5900
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.1975
    Cell Significance Index: 1.6000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1683
    Cell Significance Index: 7.6300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1431
    Cell Significance Index: 14.1600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1400
    Cell Significance Index: 258.1400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1220
    Cell Significance Index: 2.5300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1078
    Cell Significance Index: 67.3100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0818
    Cell Significance Index: 125.9700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0675
    Cell Significance Index: 11.5200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0617
    Cell Significance Index: 11.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0379
    Cell Significance Index: 1.3300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0297
    Cell Significance Index: 13.1200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0183
    Cell Significance Index: 1.8700
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.0043
    Cell Significance Index: 0.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0009
    Cell Significance Index: -1.1600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0046
    Cell Significance Index: -3.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0056
    Cell Significance Index: -4.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0060
    Cell Significance Index: -11.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0081
    Cell Significance Index: -4.5800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0087
    Cell Significance Index: -6.5800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0126
    Cell Significance Index: -4.5100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0165
    Cell Significance Index: -0.5300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0172
    Cell Significance Index: -3.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0177
    Cell Significance Index: -12.9700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0181
    Cell Significance Index: -0.4900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0248
    Cell Significance Index: -15.7800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0270
    Cell Significance Index: -5.6900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0357
    Cell Significance Index: -16.2000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0374
    Cell Significance Index: -1.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0395
    Cell Significance Index: -7.9200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0420
    Cell Significance Index: -12.0800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0445
    Cell Significance Index: -0.4100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0527
    Cell Significance Index: -6.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0677
    Cell Significance Index: -7.7600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1015
    Cell Significance Index: -13.9400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1017
    Cell Significance Index: -14.7900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1113
    Cell Significance Index: -12.7100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1146
    Cell Significance Index: -5.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1263
    Cell Significance Index: -16.3200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1267
    Cell Significance Index: -9.7300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1342
    Cell Significance Index: -13.9700
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1471
    Cell Significance Index: -1.8200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1588
    Cell Significance Index: -20.3600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1618
    Cell Significance Index: -2.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1703
    Cell Significance Index: -12.6900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1784
    Cell Significance Index: -2.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1914
    Cell Significance Index: -9.0000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2019
    Cell Significance Index: -11.3300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2180
    Cell Significance Index: -17.2700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2199
    Cell Significance Index: -15.5500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2275
    Cell Significance Index: -3.3300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2286
    Cell Significance Index: -14.0200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.2339
    Cell Significance Index: -2.7500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2339
    Cell Significance Index: -15.7300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2456
    Cell Significance Index: -4.1100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2483
    Cell Significance Index: -15.2600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2667
    Cell Significance Index: -16.8100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2705
    Cell Significance Index: -2.8000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2737
    Cell Significance Index: -13.8300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2853
    Cell Significance Index: -14.8600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2946
    Cell Significance Index: -5.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SYK is a non-receptor tyrosine kinase that is activated by the binding of specific ligands to its receptor, FcεRI. This activation leads to the phosphorylation of tyrosine residues on SYK, which in turn recruits and activates downstream signaling molecules. SYK is characterized by its ability to phosphorylate and activate a range of substrates, including adaptor proteins, kinases, and transcription factors. SYK is also known for its involvement in the regulation of immune cell activation, including the activation of B cells, macrophages, and neutrophils. **Pathways and Functions** SYK is involved in a wide range of signaling pathways that regulate immune cell function, including: 1. **Adaptive Immune Response**: SYK is essential for the activation and proliferation of B cells, which is critical for the production of antibodies against pathogens. 2. **Cytokine Signaling**: SYK is involved in the regulation of cytokine production, including the production of IL-2, IL-5, and GM-CSF, which are essential for the activation and proliferation of immune cells. 3. **Leukocyte Activation**: SYK is involved in the activation of leukocytes, including neutrophils, macrophages, and dendritic cells, which is critical for the elimination of pathogens. 4. **Inflammation**: SYK is involved in the regulation of inflammatory responses, including the production of pro-inflammatory cytokines and the activation of immune cells. 5. **Cell Activation**: SYK is involved in the regulation of cell activation, including the activation of B cells, macrophages, and neutrophils, which is critical for the elimination of pathogens. **Clinical Significance** Dysregulation of SYK signaling has been implicated in a range of immune-related disorders, including: 1. **Allergic Diseases**: SYK is involved in the regulation of IgE production and the activation of mast cells, which is critical for the development of allergic diseases. 2. **Autoimmune Diseases**: SYK is involved in the regulation of immune cell activation and the production of autoantibodies, which is critical for the development of autoimmune diseases. 3. **Cancer**: SYK is overexpressed in a range of cancers, including chronic lymphocytic leukemia and lymphoma, and is involved in the regulation of immune cell activation and the production of anti-tumor antibodies. 4. **Infectious Diseases**: SYK is involved in the regulation of immune cell activation and the production of anti-pathogen antibodies, which is critical for the elimination of pathogens. Overall, SYK is a critical regulator of immune cell function and plays a key role in the adaptive immune response. Dysregulation of SYK signaling has been implicated in a range of immune-related disorders, and targeting SYK has emerged as a promising therapeutic strategy for the treatment of these diseases.

Genular Protein ID: 1727247867

Symbol: KSYK_HUMAN

Name: Tyrosine-protein kinase SYK

UniProtKB Accession Codes:

P43405

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CORUM 1 CPTAC 4 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 8 DrugCentral 1 EC 1 ELM 1 EMBL 7 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 100 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 89 PDBsum 89 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 21 RefSeq 6 Rhea 3 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7513161

Title: Cloning of the cDNA for the deleted syk kinase homologous to ZAP-70 from human basophilic leukemia cell line (KU812).

PubMed ID: 7513161

DOI: 10.1006/bbrc.1994.1409

PubMed ID: 8163536

Title: Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex.

PubMed ID: 8163536

DOI: 10.1016/s0021-9258(17)32717-5

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8168854

Title: Molecular cloning of the human homologue to the pig protein-tyrosine kinase syk.

PubMed ID: 8168854

DOI: 10.1007/bf00189234

PubMed ID: 7895172

Title: Integral membrane protein 2 of Epstein-Barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases.

PubMed ID: 7895172

DOI: 10.1016/s1074-7613(95)80040-9

PubMed ID: 8986718

Title: Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product.

PubMed ID: 8986718

DOI: 10.1016/s1074-7613(00)80273-3

PubMed ID: 8657103

Title: Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk.

PubMed ID: 8657103

DOI: 10.1128/mcb.16.4.1305

PubMed ID: 9535867

Title: Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases.

PubMed ID: 9535867

DOI: 10.1074/jbc.273.15.8867

PubMed ID: 9857068

Title: Cbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323.

PubMed ID: 9857068

DOI: 10.1074/jbc.273.52.35273

PubMed ID: 10458769

Title: Dephosphorylation of ZAP-70 and inhibition of T cell activation by activated SHP1.

PubMed ID: 10458769

DOI: 10.1002/(sici)1521-4141(199908)29:08<2539::aid-immu2539>3.0.co;2-m

PubMed ID: 10449770

Title: SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling.

PubMed ID: 10449770

DOI: 10.1073/pnas.96.17.9775

PubMed ID: 11162587

Title: Molecular cloning and characterization of SPAP1, an inhibitory receptor.

PubMed ID: 11162587

DOI: 10.1006/bbrc.2000.4213

PubMed ID: 12456653

Title: BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins.

PubMed ID: 12456653

DOI: 10.1093/emboj/cdf658

PubMed ID: 12387735

Title: ITAM-based interaction of ERM proteins with Syk mediates signaling by the leukocyte adhesion receptor PSGL-1.

PubMed ID: 12387735

DOI: 10.1016/s1074-7613(02)00420-x

PubMed ID: 11940607

Title: Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton.

PubMed ID: 11940607

DOI: 10.1083/jcb.200112113

PubMed ID: 15388330

Title: Association of the Src homology 2 domain-containing leukocyte phosphoprotein of 76 kD (SLP-76) with the p85 subunit of phosphoinositide 3-kinase.

PubMed ID: 15388330

DOI: 10.1016/j.febslet.2004.07.090

PubMed ID: 15123770

Title: Interleukin-15 enhances human neutrophil phagocytosis by a Syk-dependent mechanism: importance of the IL-15Ralpha chain.

PubMed ID: 15123770

DOI: 10.1189/jlb.0605298

PubMed ID: 18369315

Title: The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development.

PubMed ID: 18369315

DOI: 10.1038/emboj.2008.62

PubMed ID: 18818202

Title: Molecular mechanism of the Syk activation switch.

PubMed ID: 18818202

DOI: 10.1074/jbc.m806340200

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 19843936

Title: FCRL3, an autoimmune susceptibility gene, has inhibitory potential on B-cell receptor-mediated signaling.

PubMed ID: 19843936

DOI: 10.4049/jimmunol.0901982

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20154219

Title: CLEC-2 activates Syk through dimerization.

PubMed ID: 20154219

DOI: 10.1182/blood-2009-08-237834

PubMed ID: 19909739

Title: Functional interaction between the ubiquitin-specific protease 25 and the SYK tyrosine kinase.

PubMed ID: 19909739

DOI: 10.1016/j.yexcr.2009.10.023

PubMed ID: 20713593

Title: A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function.

PubMed ID: 20713593

DOI: 10.1084/jem.20100222

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21469132

Title: Complex phosphorylation dynamics control the composition of the Syk interactome in B cells.

PubMed ID: 21469132

DOI: 10.1002/eji.201041326

PubMed ID: 22019427

Title: The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2.

PubMed ID: 22019427

DOI: 10.1016/j.bbamcr.2011.10.001

PubMed ID: 23299888

Title: Germinal centre protein HGAL promotes lymphoid hyperplasia and amyloidosis via BCR-mediated Syk activation.

PubMed ID: 23299888

DOI: 10.1038/ncomms2334

PubMed ID: 34634301

Title: Tyrosine phosphorylation of DEPTOR functions as a molecular switch to activate mTOR signaling.

PubMed ID: 34634301

DOI: 10.1016/j.jbc.2021.101291

PubMed ID: 33782605

Title: Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice.

PubMed ID: 33782605

DOI: 10.1038/s41588-021-00803-4

PubMed ID: 8590001

Title: Solution structure of the C-terminal SH2 domain of the human tyrosine kinase Syk complexed with a phosphotyrosine pentapeptide.

PubMed ID: 8590001

DOI: 10.1016/s0969-2126(01)00242-8

PubMed ID: 9698567

Title: Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide.

PubMed ID: 9698567

DOI: 10.1006/jmbi.1998.1964

Sequence Information:

  • Length: 635
  • Mass: 72066
  • Checksum: EAA6BDE65881FC68
  • Sequence:
    • MASSGMADSA NHLPFFFGNI TREEAEDYLV QGGMSDGLYL LRQSRNYLGG FALSVAHGRK 
AHHYTIEREL NGTYAIAGGR THASPADLCH YHSQESDGLV CLLKKPFNRP QGVQPKTGPF 
EDLKENLIRE YVKQTWNLQG QALEQAIISQ KPQLEKLIAT TAHEKMPWFH GKISREESEQ 
IVLIGSKTNG KFLIRARDNN GSYALCLLHE GKVLHYRIDK DKTGKLSIPE GKKFDTLWQL 
VEHYSYKADG LLRVLTVPCQ KIGTQGNVNF GGRPQLPGSH PATWSAGGII SRIKSYSFPK 
PGHRKSSPAQ GNRQESTVSF NPYEPELAPW AADKGPQREA LPMDTEVYES PYADPEEIRP 
KEVYLDRKLL TLEDKELGSG NFGTVKKGYY QMKKVVKTVA VKILKNEAND PALKDELLAE 
ANVMQQLDNP YIVRMIGICE AESWMLVMEM AELGPLNKYL QQNRHVKDKN IIELVHQVSM 
GMKYLEESNF VHRDLAARNV LLVTQHYAKI SDFGLSKALR ADENYYKAQT HGKWPVKWYA 
PECINYYKFS SKSDVWSFGV LMWEAFSYGQ KPYRGMKGSE VTAMLEKGER MGCPAGCPRE 
MYDLMNLCWT YDVENRPGFA AVELRLRNYY YDVVN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.