Details for: TAF5

Gene ID: 6877

Symbol: TAF5

Ensembl ID: ENSG00000148835

Description: TATA-box binding protein associated factor 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 47.7675
    Cell Significance Index: -7.4300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 34.6550
    Cell Significance Index: -8.7900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 19.6920
    Cell Significance Index: -8.0000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.2874
    Cell Significance Index: -8.9900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.3327
    Cell Significance Index: -9.2100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.8232
    Cell Significance Index: -5.6000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.3662
    Cell Significance Index: -2.9900
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.3390
    Cell Significance Index: 10.1100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.9022
    Cell Significance Index: 19.2200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8462
    Cell Significance Index: 161.0400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5835
    Cell Significance Index: 57.7300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4799
    Cell Significance Index: 28.8100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4210
    Cell Significance Index: 45.7900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3533
    Cell Significance Index: 41.1700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3470
    Cell Significance Index: 56.4300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3414
    Cell Significance Index: 308.2600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2897
    Cell Significance Index: 13.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2003
    Cell Significance Index: 40.1700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1979
    Cell Significance Index: 12.4700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1840
    Cell Significance Index: 12.7300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1744
    Cell Significance Index: 120.6400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1132
    Cell Significance Index: 40.6000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0976
    Cell Significance Index: 2.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0908
    Cell Significance Index: 18.0100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0702
    Cell Significance Index: 8.2800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0688
    Cell Significance Index: 1.4900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0523
    Cell Significance Index: 9.4200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0509
    Cell Significance Index: 22.5000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0486
    Cell Significance Index: 1.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0456
    Cell Significance Index: 6.2600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0396
    Cell Significance Index: 0.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0366
    Cell Significance Index: 20.0000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0341
    Cell Significance Index: 1.7800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0266
    Cell Significance Index: 0.7100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0174
    Cell Significance Index: 2.2300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0157
    Cell Significance Index: 0.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0122
    Cell Significance Index: 1.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0113
    Cell Significance Index: 0.5300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0089
    Cell Significance Index: 0.5500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0067
    Cell Significance Index: 0.1400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0043
    Cell Significance Index: 0.2400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0032
    Cell Significance Index: 0.1100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0023
    Cell Significance Index: 0.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0012
    Cell Significance Index: -2.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0039
    Cell Significance Index: -7.1300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0046
    Cell Significance Index: -2.9500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0047
    Cell Significance Index: -7.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0049
    Cell Significance Index: -6.6300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0051
    Cell Significance Index: -0.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0079
    Cell Significance Index: -0.6100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0081
    Cell Significance Index: -1.3800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0090
    Cell Significance Index: -6.6300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0096
    Cell Significance Index: -7.3000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0096
    Cell Significance Index: -0.2600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0109
    Cell Significance Index: -4.9500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0114
    Cell Significance Index: -8.4700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0153
    Cell Significance Index: -2.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0161
    Cell Significance Index: -9.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0170
    Cell Significance Index: -10.6000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0195
    Cell Significance Index: -0.5000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0205
    Cell Significance Index: -5.9100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0227
    Cell Significance Index: -0.3800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0239
    Cell Significance Index: -1.5400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0309
    Cell Significance Index: -0.5300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0426
    Cell Significance Index: -5.5100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0427
    Cell Significance Index: -4.9000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0438
    Cell Significance Index: -0.9600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0440
    Cell Significance Index: -0.6000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0447
    Cell Significance Index: -2.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0468
    Cell Significance Index: -4.7900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0470
    Cell Significance Index: -1.2600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0495
    Cell Significance Index: -10.4200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0562
    Cell Significance Index: -3.7800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0634
    Cell Significance Index: -2.0300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0699
    Cell Significance Index: -1.8700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0731
    Cell Significance Index: -4.4800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0869
    Cell Significance Index: -9.0500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0875
    Cell Significance Index: -6.5200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0926
    Cell Significance Index: -4.1000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0930
    Cell Significance Index: -4.3700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0941
    Cell Significance Index: -2.4100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0981
    Cell Significance Index: -1.1700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1071
    Cell Significance Index: -8.4800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1132
    Cell Significance Index: -4.2900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1191
    Cell Significance Index: -2.3300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1208
    Cell Significance Index: -1.7300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1230
    Cell Significance Index: -3.5300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1249
    Cell Significance Index: -1.7900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1300
    Cell Significance Index: -6.8300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1334
    Cell Significance Index: -2.1400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1344
    Cell Significance Index: -3.5400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1489
    Cell Significance Index: -2.0900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1492
    Cell Significance Index: -3.1900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1679
    Cell Significance Index: -2.5300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1736
    Cell Significance Index: -1.0300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1850
    Cell Significance Index: -5.4500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1893
    Cell Significance Index: -6.6300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1900
    Cell Significance Index: -6.0500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1961
    Cell Significance Index: -6.4200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1971
    Cell Significance Index: -5.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Transcriptional Regulation**: TAF5 is a key player in the regulation of gene expression, specifically in the initiation of transcription by RNA polymerase II. 2. **TFIID Complex**: TAF5 is a subunit of the TFIID complex, which is responsible for recruiting RNA polymerase II to the promoter region of target genes. 3. **HIV Infection**: TAF5 plays a critical role in the HIV life cycle, particularly in the transcriptional regulation of the HIV genome. 4. **Cell Type-Specific Expression**: TAF5 has been identified in various cell types, including oogonial cells, neural progenitor cells, and intestinal epithelial cells, suggesting its functional significance in different tissues and cell types. **Pathways and Functions** 1. **DNA-templated Transcription Initiation**: TAF5 is involved in the initiation of transcription by RNA polymerase II, facilitating the recruitment of RNA polymerase II to the promoter region of target genes. 2. **Chromatin Remodeling**: TAF5 interacts with chromatin-modifying complexes to facilitate the remodeling of chromatin structure, allowing for the access of RNA polymerase II to the promoter region. 3. **Regulation of Transcription**: TAF5 plays a role in regulating transcription by interacting with transcription factors, such as TP53, to modulate gene expression. 4. **Viral Infection Pathways**: TAF5 is essential for the transcriptional regulation of the HIV genome, facilitating the replication and expression of viral genes. **Clinical Significance** 1. **HIV Infection**: TAF5 is a critical component of the HIV life cycle, and alterations in its expression or function may contribute to the development of HIV-associated diseases. 2. **Cancer**: TAF5 has been implicated in the regulation of gene expression in cancer cells, suggesting its potential role in the development and progression of various cancers. 3. **Neurological Disorders**: TAF5 has been identified in neural progenitor cells, and alterations in its expression may contribute to the development of neurological disorders, such as Alzheimer's disease. 4. **Regenerative Medicine**: TAF5 has been identified in various cell types, including intestinal epithelial cells, suggesting its potential role in regenerative medicine and tissue repair. In conclusion, TAF5 is a crucial component of the transcription initiation complex, playing a pivotal role in regulating gene expression. Its involvement in HIV infection, cancer, and neurological disorders highlights its clinical significance and potential as a therapeutic target. Further research is needed to elucidate the functional significance of TAF5 in different cell types and diseases, and to explore its potential as a therapeutic agent.

Genular Protein ID: 940149131

Symbol: TAF5_HUMAN

Name: Transcription initiation factor TFIID subunit 5

UniProtKB Accession Codes:

Q15542 A8K5B4 B2RMR0 B7ZKJ6 Q53EM4 Q5SYD5 Q86UZ7 Q9Y4K5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 EMDB 29 Ensembl 2 EvolutionaryTrace 1 GO 16 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 31 PDBsum 31 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 10 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8758937

Title: Distinct domains of hTAFII100 are required for functional interaction with transcription factor TFIIF beta (RAP30) and incorporation into the TFIID complex.

PubMed ID: 8758937

DOI: 10.1002/j.1460-2075.1996.tb00740.x

PubMed ID: 8942982

Title: Molecular cloning and analysis of two subunits of the human TFIID complex: hTAFII130 and hTAFII100.

PubMed ID: 8942982

DOI: 10.1073/pnas.93.24.13611

PubMed ID: 9045704

Title: Specific interactions and potential functions of human TAFII100.

PubMed ID: 9045704

DOI: 10.1074/jbc.272.10.6714

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8647434

Title: TAF-like function of SV40 large T antigen.

PubMed ID: 8647434

DOI: 10.1101/gad.10.11.1369

PubMed ID: 10373431

Title: Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction.

PubMed ID: 10373431

DOI: 10.1074/jbc.274.26.18285

PubMed ID: 12601814

Title: Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis.

PubMed ID: 12601814

DOI: 10.1002/pmic.200390030

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 17227857

Title: Structural analysis and dimerization potential of the human TAF5 subunit of TFIID.

PubMed ID: 17227857

DOI: 10.1073/pnas.0610297104

PubMed ID: 33795473

Title: Structural insights into preinitiation complex assembly on core promoters.

PubMed ID: 33795473

DOI: 10.1126/science.aba8490

Sequence Information:

  • Length: 800
  • Mass: 86830
  • Checksum: 87A178BFB7071992
  • Sequence:
    • MAALAEEQTE VAVKLEPEGP PTLLPPQAGD GAGEGSGGTT NNGPNGGGGN VAASSSTGGD 
GGTPKPTVAV SAAAPAGAAP VPAAAPDAGA PHDRQTLLAV LQFLRQSKLR EAEEALRREA 
GLLEEAVAGS GAPGEVDSAG AEVTSALLSR VTASAPGPAA PDPPGTGASG ATVVSGSASG 
PAAPGKVGSV AVEDQPDVSA VLSAYNQQGD PTMYEEYYSG LKHFIECSLD CHRAELSQLF 
YPLFVHMYLE LVYNQHENEA KSFFEKFHGD QECYYQDDLR VLSSLTKKEH MKGNETMLDF 
RTSKFVLRIS RDSYQLLKRH LQEKQNNQIW NIVQEHLYID IFDGMPRSKQ QIDAMVGSLA 
GEAKREANKS KVFFGLLKEP EIEVPLDDED EEGENEEGKP KKKKPKKDSI GSKSKKQDPN 
APPQNRIPLP ELKDSDKLDK IMNMKETTKR VRLGPDCLPS ICFYTFLNAY QGLTAVDVTD 
DSSLIAGGFA DSTVRVWSVT PKKLRSVKQA SDLSLIDKES DDVLERIMDE KTASELKILY 
GHSGPVYGAS FSPDRNYLLS SSEDGTVRLW SLQTFTCLVG YKGHNYPVWD TQFSPYGYYF 
VSGGHDRVAR LWATDHYQPL RIFAGHLADV NCTRFHPNSN YVATGSADRT VRLWDVLNGN 
CVRIFTGHKG PIHSLTFSPN GRFLATGATD GRVLLWDIGH GLMVGELKGH TDTVCSLRFS 
RDGEILASGS MDNTVRLWDA IKAFEDLETD DFTTATGHIN LPENSQELLL GTYMTKSTPV 
VHLHFTRRNL VLAAGAYSPQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.