Details for: TAF9

Gene ID: 6880

Symbol: TAF9

Ensembl ID: ENSG00000273841

Description: TATA-box binding protein associated factor 9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 81.5880
    Cell Significance Index: -33.6100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 74.7475
    Cell Significance Index: -35.2900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 67.0704
    Cell Significance Index: -34.5000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 52.6063
    Cell Significance Index: -35.3000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 9.8001
    Cell Significance Index: 101.4500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.4695
    Cell Significance Index: -29.0900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.2270
    Cell Significance Index: -19.3600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.1382
    Cell Significance Index: 58.2000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 2.0912
    Cell Significance Index: 213.6200
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.5775
    Cell Significance Index: 12.2600
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.3846
    Cell Significance Index: 10.4600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.2898
    Cell Significance Index: 83.2100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.2774
    Cell Significance Index: 33.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2074
    Cell Significance Index: 62.7200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.1970
    Cell Significance Index: 154.6500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.1652
    Cell Significance Index: 20.5900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.1399
    Cell Significance Index: 23.8600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.1020
    Cell Significance Index: 11.9800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0874
    Cell Significance Index: 149.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.0574
    Cell Significance Index: 78.8100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.0545
    Cell Significance Index: 11.9800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.0513
    Cell Significance Index: 72.7000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9994
    Cell Significance Index: 117.8600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9827
    Cell Significance Index: 120.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.9499
    Cell Significance Index: 44.6500
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.8987
    Cell Significance Index: 5.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8744
    Cell Significance Index: 477.5100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8233
    Cell Significance Index: 364.0200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8177
    Cell Significance Index: 738.3600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.8044
    Cell Significance Index: 56.8900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7894
    Cell Significance Index: 22.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7878
    Cell Significance Index: 128.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7708
    Cell Significance Index: 138.9500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7692
    Cell Significance Index: 48.4800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7541
    Cell Significance Index: 35.1600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.6391
    Cell Significance Index: 5.8900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.6112
    Cell Significance Index: 32.0900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5094
    Cell Significance Index: 23.0900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.5036
    Cell Significance Index: 4.2300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.4796
    Cell Significance Index: 7.0800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4265
    Cell Significance Index: 14.8200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.4042
    Cell Significance Index: 7.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3462
    Cell Significance Index: 69.4500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.2949
    Cell Significance Index: 4.9600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2481
    Cell Significance Index: 31.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2196
    Cell Significance Index: 37.5000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1472
    Cell Significance Index: 3.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1073
    Cell Significance Index: 38.5000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0903
    Cell Significance Index: 10.3100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0459
    Cell Significance Index: 4.5500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0451
    Cell Significance Index: 0.9600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0448
    Cell Significance Index: 8.5200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0420
    Cell Significance Index: 31.8100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0006
    Cell Significance Index: 0.3700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0114
    Cell Significance Index: -0.3600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0121
    Cell Significance Index: -0.6100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0123
    Cell Significance Index: -9.1200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0171
    Cell Significance Index: -12.5200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0178
    Cell Significance Index: -33.5100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0237
    Cell Significance Index: -43.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0283
    Cell Significance Index: -43.5900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0287
    Cell Significance Index: -6.0500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0302
    Cell Significance Index: -0.5200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0321
    Cell Significance Index: -43.6600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0379
    Cell Significance Index: -21.3600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0512
    Cell Significance Index: -32.5100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0523
    Cell Significance Index: -0.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0594
    Cell Significance Index: -6.8000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0609
    Cell Significance Index: -2.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0797
    Cell Significance Index: -36.1700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1279
    Cell Significance Index: -5.2400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1442
    Cell Significance Index: -3.8500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1491
    Cell Significance Index: -3.8100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1542
    Cell Significance Index: -2.5800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1805
    Cell Significance Index: -21.0300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2280
    Cell Significance Index: -4.9400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2365
    Cell Significance Index: -34.3800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2382
    Cell Significance Index: -3.2500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.2605
    Cell Significance Index: -2.0800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2966
    Cell Significance Index: -8.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3401
    Cell Significance Index: -26.1000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3448
    Cell Significance Index: -27.3100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3796
    Cell Significance Index: -23.2700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3919
    Cell Significance Index: -21.9900
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.3927
    Cell Significance Index: -2.5600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.4313
    Cell Significance Index: -2.6800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5449
    Cell Significance Index: -13.6200
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.5718
    Cell Significance Index: -8.0200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6298
    Cell Significance Index: -18.5500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6386
    Cell Significance Index: -22.3700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6600
    Cell Significance Index: -21.6100
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.6716
    Cell Significance Index: -6.3900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7039
    Cell Significance Index: -25.8400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.7266
    Cell Significance Index: -15.1700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7369
    Cell Significance Index: -23.4700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.7424
    Cell Significance Index: -7.7500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7552
    Cell Significance Index: -20.2000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.7558
    Cell Significance Index: -9.0100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.9345
    Cell Significance Index: -16.1100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.9497
    Cell Significance Index: -12.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulation:** TAF9 is a multifunctional protein that participates in various transcriptional processes, including the regulation of viral gene expression, DNA damage response, and immune response. 2. **Subunit of TFIID:** TAF9 is a subunit of the transcription initiation factor TFIID, which is essential for the recruitment of RNA polymerase II to specific genomic regions. 3. **DNA-binding Domain:** TAF9 contains a C2H2 zinc finger domain, which allows it to bind to specific DNA sequences and regulate gene expression. 4. **Histone Acetylation:** TAF9 is also involved in histone acetylation, which is a key epigenetic mechanism that regulates chromatin structure and gene expression. **Pathways and Functions:** 1. **RNA Polymerase II Transcription:** TAF9 plays a crucial role in the recruitment of RNA polymerase II to specific genomic regions, facilitating the transcription of genes involved in various cellular processes. 2. **Viral Gene Expression:** TAF9 is essential for the transcription of viral genes, particularly in the context of HIV infection. 3. **DNA Damage Response:** TAF9 is involved in the regulation of DNA damage response, including the recruitment of proteins involved in nucleotide excision repair and homologous recombination. 4. **Immune Response:** TAF9 is also involved in the regulation of immune response, particularly in the context of HIV infection, where it plays a crucial role in the transcriptional regulation of genes involved in immune evasion. **Clinical Significance:** 1. **HIV Infection:** TAF9 is essential for the transcriptional regulation of HIV genes, particularly in the context of viral replication and immune evasion. 2. **Cancer:** TAF9 has been implicated in the regulation of gene expression in various cancers, including breast cancer and leukemia. 3. **Autoimmune Diseases:** TAF9 has been implicated in the regulation of immune response in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 4. **Neurological Disorders:** TAF9 has been implicated in the regulation of gene expression in various neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, TAF9 is a crucial component in the regulation of gene expression, particularly in the context of viral infections, DNA damage response, and immune response. Its dysregulation has been implicated in various diseases, including cancer, autoimmune diseases, and neurological disorders. Further research is needed to fully understand the role of TAF9 in these diseases and to develop therapeutic strategies to target its dysregulation.

Genular Protein ID: 2214890362

Symbol: TAF9_HUMAN

Name: Transcription initiation factor TFIID subunit 9

UniProtKB Accession Codes:

Q16594 D3DWA3 Q5U0D1 Q9BTS1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ComplexPortal 6 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EMDB 30 Ensembl 19 ExpressionAtlas 1 GO 35 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 31 PDBsum 31 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 11 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7761466

Title: Human TAFII31 protein is a transcriptional coactivator of the p53 protein.

PubMed ID: 7761466

DOI: 10.1073/pnas.92.11.5154

PubMed ID: 7597030

Title: Molecular cloning and expression of the 32-kDa subunit of human TFIID reveals interactions with VP16 and TFIIB that mediate transcriptional activation.

PubMed ID: 7597030

DOI: 10.1073/pnas.92.13.5788

PubMed ID: 7667268

Title: Evolutionary conservation of human TATA-binding-polypeptide-associated factors TAFII31 and TAFII80 and interactions of TAFII80 with other TAFs and with general transcription factors.

PubMed ID: 7667268

DOI: 10.1073/pnas.92.18.8195

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9674425

Title: Histone-like TAFs within the PCAF histone acetylase complex.

PubMed ID: 9674425

DOI: 10.1016/s0092-8674(00)81219-2

PubMed ID: 11564863

Title: Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo.

PubMed ID: 11564863

DOI: 10.1128/mcb.21.20.6782-6795.2001

PubMed ID: 9885574

Title: The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily.

PubMed ID: 9885574

DOI: 10.1016/s1097-2765(00)80301-9

PubMed ID: 15960975

Title: Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.

PubMed ID: 15960975

DOI: 10.1016/j.cell.2005.04.031

PubMed ID: 16079131

Title: Characterization of hCINAP, a novel coilin-interacting protein encoded by a transcript from the transcription factor TAFIID32 locus.

PubMed ID: 16079131

DOI: 10.1074/jbc.m501982200

PubMed ID: 15601843

Title: Core promoter binding by histone-like TAF complexes.

PubMed ID: 15601843

DOI: 10.1128/mcb.25.1.206-219.2005

PubMed ID: 15899866

Title: TAF9b (formerly TAF9L) is a bona fide TAF that has unique and overlapping roles with TAF9.

PubMed ID: 15899866

DOI: 10.1128/mcb.25.11.4638-4649.2005

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 33795473

Title: Structural insights into preinitiation complex assembly on core promoters.

PubMed ID: 33795473

DOI: 10.1126/science.aba8490

Sequence Information:

  • Length: 264
  • Mass: 28974
  • Checksum: 1925AEC65D6C84C7
  • Sequence:
    • MESGKTASPK SMPKDAQMMA QILKDMGITE YEPRVINQML EFAFRYVTTI LDDAKIYSSH 
AKKATVDADD VRLAIQCRAD QSFTSPPPRD FLLDIARQRN QTPLPLIKPY SGPRLPPDRY 
CLTAPNYRLK SLQKKASTSA GRITVPRLSV GSVTSRPSTP TLGTPTPQTM SVSTKVGTPM 
SLTGQRFTVQ MPTSQSPAVK ASIPATSAVQ NVLINPSLIG SKNILITTNM MSSQNTANES 
SNALKRKRED DDDDDDDDDD YDNL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.