Details for: TAP2

Gene ID: 6891

Symbol: TAP2

Ensembl ID: ENSG00000204267

Description: transporter 2, ATP binding cassette subfamily B member

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 34.5850
    Cell Significance Index: -17.7900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.8939
    Cell Significance Index: -13.1100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.0828
    Cell Significance Index: -12.5400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3284
    Cell Significance Index: 1199.4600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9917
    Cell Significance Index: 107.8700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9199
    Cell Significance Index: 149.6100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8957
    Cell Significance Index: 53.7700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5360
    Cell Significance Index: 37.0700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4956
    Cell Significance Index: 5.6300
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.4678
    Cell Significance Index: 3.3600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4556
    Cell Significance Index: 29.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4194
    Cell Significance Index: 48.8800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4152
    Cell Significance Index: 19.5200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4143
    Cell Significance Index: 40.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3987
    Cell Significance Index: 20.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3328
    Cell Significance Index: 7.2100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3039
    Cell Significance Index: 38.9600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2391
    Cell Significance Index: 6.8900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.2157
    Cell Significance Index: 3.9900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.2060
    Cell Significance Index: 3.6400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2042
    Cell Significance Index: 90.3000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1753
    Cell Significance Index: 33.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1563
    Cell Significance Index: 56.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1519
    Cell Significance Index: 19.6300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1486
    Cell Significance Index: 29.8100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1256
    Cell Significance Index: 3.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1210
    Cell Significance Index: 14.8800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1143
    Cell Significance Index: 15.6900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1085
    Cell Significance Index: 19.5600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0893
    Cell Significance Index: 10.5300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0793
    Cell Significance Index: 2.1200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0715
    Cell Significance Index: 39.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0682
    Cell Significance Index: 7.8100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0445
    Cell Significance Index: 0.6400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0356
    Cell Significance Index: 1.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0336
    Cell Significance Index: 1.1800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0162
    Cell Significance Index: 0.8200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0095
    Cell Significance Index: 0.2200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0021
    Cell Significance Index: -1.6100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0087
    Cell Significance Index: -1.4900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0157
    Cell Significance Index: -1.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0182
    Cell Significance Index: -13.4600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0195
    Cell Significance Index: -14.2800
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0207
    Cell Significance Index: -0.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0263
    Cell Significance Index: -16.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0264
    Cell Significance Index: -14.8800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0301
    Cell Significance Index: -0.6400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0305
    Cell Significance Index: -19.0800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0314
    Cell Significance Index: -3.2100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0382
    Cell Significance Index: -1.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0668
    Cell Significance Index: -3.0300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0807
    Cell Significance Index: -17.0000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0826
    Cell Significance Index: -2.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1049
    Cell Significance Index: -4.8900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1101
    Cell Significance Index: -16.0100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1106
    Cell Significance Index: -8.2400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.1127
    Cell Significance Index: -0.7000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1147
    Cell Significance Index: -6.0200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1287
    Cell Significance Index: -8.1100
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.1503
    Cell Significance Index: -1.7400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1564
    Cell Significance Index: -12.0000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1698
    Cell Significance Index: -5.4400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1852
    Cell Significance Index: -2.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1884
    Cell Significance Index: -10.5700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1907
    Cell Significance Index: -11.6900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1986
    Cell Significance Index: -8.1400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2117
    Cell Significance Index: -16.7700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2196
    Cell Significance Index: -3.2900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2356
    Cell Significance Index: -6.9200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2480
    Cell Significance Index: -10.9700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2640
    Cell Significance Index: -9.2500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2829
    Cell Significance Index: -3.8600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2887
    Cell Significance Index: -4.3500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2991
    Cell Significance Index: -10.9800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2997
    Cell Significance Index: -11.3500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3003
    Cell Significance Index: -2.7700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3041
    Cell Significance Index: -6.5700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3143
    Cell Significance Index: -6.6700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3173
    Cell Significance Index: -5.3100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3234
    Cell Significance Index: -6.7500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3314
    Cell Significance Index: -10.8500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3343
    Cell Significance Index: -5.7800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3734
    Cell Significance Index: -9.9700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.3870
    Cell Significance Index: -7.8800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3890
    Cell Significance Index: -8.0700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3981
    Cell Significance Index: -12.6800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.4008
    Cell Significance Index: -6.9100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4135
    Cell Significance Index: -12.1800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4400
    Cell Significance Index: -11.5700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4443
    Cell Significance Index: -8.9200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.4469
    Cell Significance Index: -3.8400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4506
    Cell Significance Index: -11.2400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4629
    Cell Significance Index: -16.0900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.4632
    Cell Significance Index: -11.5700
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.4638
    Cell Significance Index: -4.6500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4864
    Cell Significance Index: -8.3400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4885
    Cell Significance Index: -9.6600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.4898
    Cell Significance Index: -6.9600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.4928
    Cell Significance Index: -8.1200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.4969
    Cell Significance Index: -21.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TAP2 is a transmembrane protein with 12 transmembrane domains, which form a hydrophobic pore that allows the transport of peptides across the ER membrane. The protein is composed of two subunits, TAP1 and TAP2, which work together to form a heterodimeric complex. TAP2 is specifically involved in the transport of peptides from the cytosol to the ER, whereas TAP1 is involved in the transport of peptides from the ER to the Golgi apparatus. TAP2 is also capable of binding to metal ions, which are essential for its function. **Pathways and Functions** TAP2 is involved in several key pathways, including: 1. **Antigen processing and presentation**: TAP2 is responsible for the transport of peptides from the cytosol to the ER, where they are loaded onto MHC-I molecules for presentation to cytotoxic T cells. 2. **Class I MHC-mediated antigen processing and presentation**: TAP2 is involved in the transport of peptides from the cytosol to the ER, where they are loaded onto MHC-I molecules for presentation to cytotoxic T cells. 3. **Endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC) pathway**: TAP2 is involved in the transport of peptides from the ER to the Golgi apparatus via the ERGIC pathway. 4. **Tap-dependent antigen processing and presentation**: TAP2 is involved in the transport of peptides from the cytosol to the ER, where they are loaded onto MHC-I molecules for presentation to cytotoxic T cells. **Clinical Significance** Dysregulation of TAP2 has been implicated in several diseases, including: 1. **Multiple sclerosis**: TAP2 has been shown to be involved in the processing and presentation of myelin basic protein, a major antigen in multiple sclerosis. 2. **Lupus**: TAP2 has been shown to be involved in the processing and presentation of nuclear antigens, which are targets of autoantibodies in systemic lupus erythematosus. 3. **Cancer**: TAP2 has been shown to be involved in the processing and presentation of tumor antigens, which can be recognized by cytotoxic T cells. 4. **Viral infections**: TAP2 has been shown to be involved in the processing and presentation of viral antigens, which can be recognized by cytotoxic T cells. In summary, TAP2 is a critical protein involved in the processing and presentation of antigens to the immune system. Its dysregulation has been implicated in several diseases, highlighting its importance in immune function and disease pathogenesis.

Genular Protein ID: 2379391309

Symbol: TAP2_HUMAN

Name: Antigen peptide transporter 2

UniProtKB Accession Codes:

Q03519 B0V2J8 O95410 Q53FI6 Q5HY71 Q96PT8 Q9UQ83

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CPTAC 1 CPTC 1 CTD 1 ChEBI 8 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EC 1 EMBL 21 EMDB 2 Ensembl 14 ExpressionAtlas 1 GO 28 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 Rhea 3 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1453454

Title: DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing.

PubMed ID: 1453454

DOI: 10.1016/0022-2836(92)90832-5

PubMed ID: 1741401

Title: Polymorphism in a second ABC transporter gene located within the class II region of the human major histocompatibility complex.

PubMed ID: 1741401

DOI: 10.1073/pnas.89.4.1463

PubMed ID: 1946428

Title: Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region.

PubMed ID: 1946428

DOI: 10.1073/pnas.88.22.10094

PubMed ID: 8428770

Title: Alleles and haplotypes of the MHC-encoded ABC transporters TAP1 and TAP2.

PubMed ID: 8428770

DOI: 10.1007/bf00216802

PubMed ID: 9324024

Title: Association of a new allele of the TAP2 gene, TAP2*Bky2 (Val577), with susceptibility to Sjogren's syndrome.

PubMed ID: 9324024

DOI: 10.1002/art.1780400919

PubMed ID: 9916708

Title: Novel splicing of the human MHC-encoded peptide transporter confers unique properties.

PubMed ID: 9916708

PubMed ID: 8568858

Title: Evolutionary dynamics of non-coding sequences within the class II region of the human MHC.

PubMed ID: 8568858

DOI: 10.1006/jmbi.1996.0001

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7792761

Title: Novel human TAP2*103 allele shows further polymorphism in the ATP-binding domain.

PubMed ID: 7792761

DOI: 10.1111/j.1399-0039.1995.tb02431.x

PubMed ID: 9672156

Title: New TAP2 polymorphisms in Africans.

PubMed ID: 9672156

DOI: 10.1111/j.1399-0039.1998.tb02992.x

PubMed ID: 8162639

Title: Polymorphisms in the TAP2 gene and their association with rheumatoid arthritis.

PubMed ID: 8162639

PubMed ID: 1589036

Title: Location of MHC-encoded transporters in the endoplasmic reticulum and cis-Golgi.

PubMed ID: 1589036

DOI: 10.1038/357342a0

PubMed ID: 1538751

Title: Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex.

PubMed ID: 1538751

DOI: 10.1038/355641a0

PubMed ID: 7500034

Title: The peptide-binding motif for the human transporter associated with antigen processing.

PubMed ID: 7500034

DOI: 10.1084/jem.182.6.1883

PubMed ID: 7760936

Title: A viral inhibitor of peptide transporters for antigen presentation.

PubMed ID: 7760936

DOI: 10.1038/375415a0

PubMed ID: 8805302

Title: Point mutations in the alpha 2 domain of HLA-A2.1 define a functionally relevant interaction with TAP.

PubMed ID: 8805302

DOI: 10.1016/s0960-9822(02)00611-5

PubMed ID: 8630735

Title: A point mutation in HLA-A*0201 results in failure to bind the TAP complex and to present virus-derived peptides to CTL.

PubMed ID: 8630735

DOI: 10.1016/s1074-7613(00)80416-1

PubMed ID: 8955196

Title: Multiple regions of the transporter associated with antigen processing (TAP) contribute to its peptide binding site.

PubMed ID: 8955196

PubMed ID: 8670825

Title: Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47.

PubMed ID: 8670825

DOI: 10.1002/j.1460-2075.1996.tb00689.x

PubMed ID: 9175839

Title: The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP.

PubMed ID: 9175839

DOI: 10.1016/s1074-7613(00)80349-0

PubMed ID: 9256420

Title: Recognition principle of the TAP transporter disclosed by combinatorial peptide libraries.

PubMed ID: 9256420

DOI: 10.1073/pnas.94.17.8976

PubMed ID: 9427624

Title: TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide.

PubMed ID: 9427624

DOI: 10.1016/s0960-9822(98)70014-4

PubMed ID: 11157746

Title: The human cytomegalovirus gene product US6 inhibits ATP binding by TAP.

PubMed ID: 11157746

DOI: 10.1093/emboj/20.3.387

PubMed ID: 10227971

Title: Adenovirus E19 has two mechanisms for affecting class I MHC expression.

PubMed ID: 10227971

PubMed ID: 10605026

Title: HLA-F is a predominantly empty, intracellular, TAP-associated MHC class Ib protein with a restricted expression pattern.

PubMed ID: 10605026

DOI: 10.4049/jimmunol.164.1.319

PubMed ID: 11274390

Title: Allosteric crosstalk between peptide-binding, transport, and ATP hydrolysis of the ABC transporter TAP.

PubMed ID: 11274390

DOI: 10.1073/pnas.061467898

PubMed ID: 19201886

Title: Specific targeting of the EBV lytic phase protein BNLF2a to the transporter associated with antigen processing results in impairment of HLA class I-restricted antigen presentation.

PubMed ID: 19201886

DOI: 10.4049/jimmunol.0803218

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22638925

Title: Direct evidence that the N-terminal extensions of the TAP complex act as autonomous interaction scaffolds for the assembly of the MHC I peptide-loading complex.

PubMed ID: 22638925

DOI: 10.1007/s00018-012-1005-6

PubMed ID: 25377891

Title: Mechanistic determinants of the directionality and energetics of active export by a heterodimeric ABC transporter.

PubMed ID: 25377891

DOI: 10.1038/ncomms6419

PubMed ID: 25656091

Title: Ultrasensitive quantification of TAP-dependent antigen compartmentalization in scarce primary immune cell subsets.

PubMed ID: 25656091

DOI: 10.1038/ncomms7199

PubMed ID: 26611325

Title: Assembly of the MHC I peptide-loading complex determined by a conserved ionic lock-switch.

PubMed ID: 26611325

DOI: 10.1038/srep17341

PubMed ID: 1570316

Title: Allelic variants of the human putative peptide transporter involved in antigen processing.

PubMed ID: 1570316

DOI: 10.1073/pnas.89.9.3932

PubMed ID: 7517574

Title: Homozygous human TAP peptide transporter mutation in HLA class I deficiency.

PubMed ID: 7517574

DOI: 10.1126/science.7517574

PubMed ID: 11294565

Title: Genotyping TAP2 variants in North American Caucasians, Brazilians, and Africans.

PubMed ID: 11294565

DOI: 10.1038/sj.gene.6363731

Sequence Information:

  • Length: 686
  • Mass: 75664
  • Checksum: E7E4A7F6A2A3B48B
  • Sequence:
    • MRLPDLRPWT SLLLVDAALL WLLQGPLGTL LPQGLPGLWL EGTLRLGGLW GLLKLRGLLG 
FVGTLLLPLC LATPLTVSLR ALVAGASRAP PARVASAPWS WLLVGYGAAG LSWSLWAVLS 
PPGAQEKEQD QVNNKVLMWR LLKLSRPDLP LLVAAFFFLV LAVLGETLIP HYSGRVIDIL 
GGDFDPHAFA SAIFFMCLFS FGSSLSAGCR GGCFTYTMSR INLRIREQLF SSLLRQDLGF 
FQETKTGELN SRLSSDTTLM SNWLPLNANV LLRSLVKVVG LYGFMLSISP RLTLLSLLHM 
PFTIAAEKVY NTRHQEVLRE IQDAVARAGQ VVREAVGGLQ TVRSFGAEEH EVCRYKEALE 
QCRQLYWRRD LERALYLLVR RVLHLGVQML MLSCGLQQMQ DGELTQGSLL SFMIYQESVG 
SYVQTLVYIY GDMLSNVGAA EKVFSYMDRQ PNLPSPGTLA PTTLQGVVKF QDVSFAYPNR 
PDRPVLKGLT FTLRPGEVTA LVGPNGSGKS TVAALLQNLY QPTGGQVLLD EKPISQYEHC 
YLHSQVVSVG QEPVLFSGSV RNNIAYGLQS CEDDKVMAAA QAAHADDFIQ EMEHGIYTDV 
GEKGSQLAAG QKQRLAIARA LVRDPRVLIL DEATSALDVQ CEQALQDWNS RGDRTVLVIA 
HRLQTVQRAH QILVLQEGKL QKLAQL

Genular Protein ID: 3440259897

Symbol: X5CMH5_HUMAN

Name: N/A

UniProtKB Accession Codes:

X5CMH5

Database IDs:

ARBA 10 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 6 DNASU 1 DisGeNET 1 EC 1 EMBL 9 Ensembl 4 GO 7 Gene3D 2 HGNC 1 IntAct 1 InterPro 9 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PROSITE 5 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 3 SAM 1 SMART 1 SUPFAM 2 UCSC 1

Citations:

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 703
  • Mass: 77695
  • Checksum: 2C7803EF0DF0FECB
  • Sequence:
    • MRLPDLRPWT SLLLVDAALL WLLQGPLGTL LPQGLPGLWL EGTLRLGGLW GLLKLRGLLG 
FVGTLLLPLC LATPLTVSLR ALVAGASRAP PARVASAPWS WLLVGYGAAG LSWSLWAVLS 
PPGAQEKEQD QVNNKVLMWR LLKLSRPDLP LLVAAFFFLV LAVLGETLIP HYSGRVIDIL 
GGDFDPHAFA SAIFFMCLFS FGSSLSAGCR GGCFTYTMSR INLRIREQLF SSLLRQDLGF 
FQETKTGELN SRLSSDTTLM SNWLPLNANV LLRSLVKVVG LYGFMLSISP RLTLLSLLHM 
PFTIAAEKVY NTRHQEVLRE IQDAVARAGQ VVREAVGGLQ TVRSFGAEEH EVCRYKEALE 
QCRQLYWRRD LERALYLLVR RVLHLGVQML MLSCGLQQMQ DGELTQGSLL SFMIYQESVG 
SYVQTLVYIY GDMLSNVGAA EKVFSYMDRQ PNLPSPGTLA PTTLQGVVKF QDVSFAYPNR 
PDRPVLKGLT FTLRPGEVTA LVGPNGSGKS TVAALLQNLY QPTGGQVLLD EKPISQYEHC 
YLHSQVVSVG QEPVLFSGSV RNNIAYGLQS CEDDKVMAAA QAAHADDFIQ EMEHGIYTDV 
GEKGSQLAAG QKQRLAIARA LVRDPRVLIL DEATSALDVQ CEQALQDWNS RGDRTVLVIA 
HRLQAVQRAH QILVLQEGKL QKLAQLQEGQ DLYSRLVQQR LMD

Genular Protein ID: 2389374403

Symbol: Q9UP03_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9UP03

Database IDs:

ARBA 10 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 6 DNASU 1 DisGeNET 1 EC 1 EMBL 4 ExpressionAtlas 1 GO 10 Gene3D 2 InterPro 9 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 5 Pfam 2 PharmGKB 1 RefSeq 1 Rhea 3 SAM 1 SMART 1 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 653
  • Mass: 72003
  • Checksum: AA79C3E9C6FE31AB
  • Sequence:
    • MRLPDLRPWT SLLLVDAALL WLLQGPLGTL LPQGLPGLWL EGTLRLGGLW GLLKLRGLLG 
FVGTLLLPLC LATPLTVSLR ALVAGASRAP PARVASAPWS WLLVGYGAAG LSWSLWAVLS 
PPGAQEKEQD QVNNKVLMWR LLKLSRPDLP LLVAAFFFLV LAVLGETLIP HYSGRVIDIL 
GGDFDPHAFA SAIFFMCLFS FGSSLSAGCR GGCFTYTMSR INLRIREQLF SSLLRQDLGF 
FQETKTGELN SRLSSDTTLM SNWLPLNANV LLRSLVKVVG LYGFMLSISP RLTLLSLLHM 
PFTIAAEKVY NTRHQEVLRE IQDAVARAGQ VVREAVGGLQ TVRSFGAEEH EVCRYKEALE 
QCRQLYWRRD LERALYLLVR RVLHLGVQML MLSCGLQQMQ DGELTQGSLL SFMIYQESVG 
SYVQTLVYIY GDMLSNVGAA EKVFSYMDRQ PNLPSPGTLA PTTLQGVVKF QDVSFAYPNR 
PDRPVLKGLT FTLRPGEVTA LVGPNGSGKS TVAALLQNLY QPTGGQVLLD EKPISQYEHC 
YLHSQVVSVG QEPVLFSGSV RNNIAYGLQS CEDDKVMAAA QAAHADDFIQ EMEHGIYTDV 
GEKGSQLAAG QKQRLAIARA LVRDPRVLIL DEATSALDVQ CEQAKTLWKF MIF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.