Details for: TAP2

Gene ID: 6891

Symbol: TAP2

Ensembl ID: ENSG00000204267

Description: transporter 2, ATP binding cassette subfamily B member

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 2.87
    Marker Score: 8118
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.71
    Marker Score: 1915
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 2.28
    Marker Score: 1381
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.15
    Marker Score: 10558
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2
    Marker Score: 1782
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.51
    Marker Score: 2183
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.47
    Marker Score: 3044.5
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.33
    Marker Score: 3265
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.18
    Marker Score: 3316
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.04
    Marker Score: 2648
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30396
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.97
    Marker Score: 664
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2396
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476.5
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 431
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2702
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5104.5
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.88
    Marker Score: 1058.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5276
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 306
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.85
    Marker Score: 4059.5
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.83
    Marker Score: 601.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1253
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.77
    Marker Score: 1539.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 576
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.75
    Marker Score: 450
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 298
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.74
    Marker Score: 412
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.74
    Marker Score: 167
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.72
    Marker Score: 1119
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.72
    Marker Score: 252
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.71
    Marker Score: 718
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.71
    Marker Score: 410
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.71
    Marker Score: 1959
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.69
    Marker Score: 261
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 624
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.68
    Marker Score: 236
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2858
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.68
    Marker Score: 153
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.68
    Marker Score: 5847
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.68
    Marker Score: 239
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.67
    Marker Score: 2893
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.67
    Marker Score: 394
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.67
    Marker Score: 261
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.66
    Marker Score: 234.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.66
    Marker Score: 394
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.66
    Marker Score: 660
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.66
    Marker Score: 565
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.65
    Marker Score: 434
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.65
    Marker Score: 209
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.65
    Marker Score: 2711
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.64
    Marker Score: 541
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.64
    Marker Score: 201
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.64
    Marker Score: 6494
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.64
    Marker Score: 148
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.64
    Marker Score: 647
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.63
    Marker Score: 2733
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.63
    Marker Score: 620
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.6
    Marker Score: 122
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.6
    Marker Score: 400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.6
    Marker Score: 594
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.6
    Marker Score: 5930
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.6
    Marker Score: 15304
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.6
    Marker Score: 497
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.59
    Marker Score: 143
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.59
    Marker Score: 2433
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.58
    Marker Score: 543.5
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.58
    Marker Score: 113.5
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.58
    Marker Score: 381
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.57
    Marker Score: 594
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.57
    Marker Score: 197
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.57
    Marker Score: 31646
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.56
    Marker Score: 124
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.56
    Marker Score: 127
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.56
    Marker Score: 411
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.56
    Marker Score: 1633
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.56
    Marker Score: 233
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.56
    Marker Score: 377
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.56
    Marker Score: 183
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.55
    Marker Score: 229
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.55
    Marker Score: 227
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.55
    Marker Score: 589
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.55
    Marker Score: 803
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.54
    Marker Score: 488
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.54
    Marker Score: 2217
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.54
    Marker Score: 914
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 429
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.54
    Marker Score: 268
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.54
    Marker Score: 343
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.53
    Marker Score: 131
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.53
    Marker Score: 555.5
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.53
    Marker Score: 388
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.52
    Marker Score: 214
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.52
    Marker Score: 467
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.52
    Marker Score: 315
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.52
    Marker Score: 5805
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.51
    Marker Score: 503
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.51
    Marker Score: 17479
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.51
    Marker Score: 7670

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Other Information

**Key Characteristics** TAP2 is a transmembrane protein with 12 transmembrane domains, which form a hydrophobic pore that allows the transport of peptides across the ER membrane. The protein is composed of two subunits, TAP1 and TAP2, which work together to form a heterodimeric complex. TAP2 is specifically involved in the transport of peptides from the cytosol to the ER, whereas TAP1 is involved in the transport of peptides from the ER to the Golgi apparatus. TAP2 is also capable of binding to metal ions, which are essential for its function. **Pathways and Functions** TAP2 is involved in several key pathways, including: 1. **Antigen processing and presentation**: TAP2 is responsible for the transport of peptides from the cytosol to the ER, where they are loaded onto MHC-I molecules for presentation to cytotoxic T cells. 2. **Class I MHC-mediated antigen processing and presentation**: TAP2 is involved in the transport of peptides from the cytosol to the ER, where they are loaded onto MHC-I molecules for presentation to cytotoxic T cells. 3. **Endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC) pathway**: TAP2 is involved in the transport of peptides from the ER to the Golgi apparatus via the ERGIC pathway. 4. **Tap-dependent antigen processing and presentation**: TAP2 is involved in the transport of peptides from the cytosol to the ER, where they are loaded onto MHC-I molecules for presentation to cytotoxic T cells. **Clinical Significance** Dysregulation of TAP2 has been implicated in several diseases, including: 1. **Multiple sclerosis**: TAP2 has been shown to be involved in the processing and presentation of myelin basic protein, a major antigen in multiple sclerosis. 2. **Lupus**: TAP2 has been shown to be involved in the processing and presentation of nuclear antigens, which are targets of autoantibodies in systemic lupus erythematosus. 3. **Cancer**: TAP2 has been shown to be involved in the processing and presentation of tumor antigens, which can be recognized by cytotoxic T cells. 4. **Viral infections**: TAP2 has been shown to be involved in the processing and presentation of viral antigens, which can be recognized by cytotoxic T cells. In summary, TAP2 is a critical protein involved in the processing and presentation of antigens to the immune system. Its dysregulation has been implicated in several diseases, highlighting its importance in immune function and disease pathogenesis.

Genular Protein ID: 2379391309

Symbol: TAP2_HUMAN

Name: Antigen peptide transporter 2

UniProtKB Accession Codes:

Q03519 B0V2J8 O95410 Q53FI6 Q5HY71 Q96PT8 Q9UQ83

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CPTAC 1 CPTC 1 CTD 1 ChEBI 8 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EC 1 EMBL 21 EPD 1 Ensembl 14 ExpressionAtlas 1 GO 28 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 Rhea 3 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1453454

Title: DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing.

PubMed ID: 1453454

DOI: 10.1016/0022-2836(92)90832-5

PubMed ID: 1741401

Title: Polymorphism in a second ABC transporter gene located within the class II region of the human major histocompatibility complex.

PubMed ID: 1741401

DOI: 10.1073/pnas.89.4.1463

PubMed ID: 1946428

Title: Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region.

PubMed ID: 1946428

DOI: 10.1073/pnas.88.22.10094

PubMed ID: 8428770

Title: Alleles and haplotypes of the MHC-encoded ABC transporters TAP1 and TAP2.

PubMed ID: 8428770

DOI: 10.1007/bf00216802

PubMed ID: 9324024

Title: Association of a new allele of the TAP2 gene, TAP2*Bky2 (Val577), with susceptibility to Sjogren's syndrome.

PubMed ID: 9324024

DOI: 10.1002/art.1780400919

PubMed ID: 9916708

Title: Novel splicing of the human MHC-encoded peptide transporter confers unique properties.

PubMed ID: 9916708

PubMed ID: 8568858

Title: Evolutionary dynamics of non-coding sequences within the class II region of the human MHC.

PubMed ID: 8568858

DOI: 10.1006/jmbi.1996.0001

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7792761

Title: Novel human TAP2*103 allele shows further polymorphism in the ATP-binding domain.

PubMed ID: 7792761

DOI: 10.1111/j.1399-0039.1995.tb02431.x

PubMed ID: 9672156

Title: New TAP2 polymorphisms in Africans.

PubMed ID: 9672156

DOI: 10.1111/j.1399-0039.1998.tb02992.x

PubMed ID: 8162639

Title: Polymorphisms in the TAP2 gene and their association with rheumatoid arthritis.

PubMed ID: 8162639

PubMed ID: 1589036

Title: Location of MHC-encoded transporters in the endoplasmic reticulum and cis-Golgi.

PubMed ID: 1589036

DOI: 10.1038/357342a0

PubMed ID: 1538751

Title: Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex.

PubMed ID: 1538751

DOI: 10.1038/355641a0

PubMed ID: 7500034

Title: The peptide-binding motif for the human transporter associated with antigen processing.

PubMed ID: 7500034

DOI: 10.1084/jem.182.6.1883

PubMed ID: 7760936

Title: A viral inhibitor of peptide transporters for antigen presentation.

PubMed ID: 7760936

DOI: 10.1038/375415a0

PubMed ID: 8805302

Title: Point mutations in the alpha 2 domain of HLA-A2.1 define a functionally relevant interaction with TAP.

PubMed ID: 8805302

DOI: 10.1016/s0960-9822(02)00611-5

PubMed ID: 8630735

Title: A point mutation in HLA-A*0201 results in failure to bind the TAP complex and to present virus-derived peptides to CTL.

PubMed ID: 8630735

DOI: 10.1016/s1074-7613(00)80416-1

PubMed ID: 8955196

Title: Multiple regions of the transporter associated with antigen processing (TAP) contribute to its peptide binding site.

PubMed ID: 8955196

PubMed ID: 8670825

Title: Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47.

PubMed ID: 8670825

DOI: 10.1002/j.1460-2075.1996.tb00689.x

PubMed ID: 9175839

Title: The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP.

PubMed ID: 9175839

DOI: 10.1016/s1074-7613(00)80349-0

PubMed ID: 9256420

Title: Recognition principle of the TAP transporter disclosed by combinatorial peptide libraries.

PubMed ID: 9256420

DOI: 10.1073/pnas.94.17.8976

PubMed ID: 9427624

Title: TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide.

PubMed ID: 9427624

DOI: 10.1016/s0960-9822(98)70014-4

PubMed ID: 11157746

Title: The human cytomegalovirus gene product US6 inhibits ATP binding by TAP.

PubMed ID: 11157746

DOI: 10.1093/emboj/20.3.387

PubMed ID: 10227971

Title: Adenovirus E19 has two mechanisms for affecting class I MHC expression.

PubMed ID: 10227971

PubMed ID: 10605026

Title: HLA-F is a predominantly empty, intracellular, TAP-associated MHC class Ib protein with a restricted expression pattern.

PubMed ID: 10605026

DOI: 10.4049/jimmunol.164.1.319

PubMed ID: 11274390

Title: Allosteric crosstalk between peptide-binding, transport, and ATP hydrolysis of the ABC transporter TAP.

PubMed ID: 11274390

DOI: 10.1073/pnas.061467898

PubMed ID: 19201886

Title: Specific targeting of the EBV lytic phase protein BNLF2a to the transporter associated with antigen processing results in impairment of HLA class I-restricted antigen presentation.

PubMed ID: 19201886

DOI: 10.4049/jimmunol.0803218

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22638925

Title: Direct evidence that the N-terminal extensions of the TAP complex act as autonomous interaction scaffolds for the assembly of the MHC I peptide-loading complex.

PubMed ID: 22638925

DOI: 10.1007/s00018-012-1005-6

PubMed ID: 25377891

Title: Mechanistic determinants of the directionality and energetics of active export by a heterodimeric ABC transporter.

PubMed ID: 25377891

DOI: 10.1038/ncomms6419

PubMed ID: 25656091

Title: Ultrasensitive quantification of TAP-dependent antigen compartmentalization in scarce primary immune cell subsets.

PubMed ID: 25656091

DOI: 10.1038/ncomms7199

PubMed ID: 26611325

Title: Assembly of the MHC I peptide-loading complex determined by a conserved ionic lock-switch.

PubMed ID: 26611325

DOI: 10.1038/srep17341

PubMed ID: 1570316

Title: Allelic variants of the human putative peptide transporter involved in antigen processing.

PubMed ID: 1570316

DOI: 10.1073/pnas.89.9.3932

PubMed ID: 7517574

Title: Homozygous human TAP peptide transporter mutation in HLA class I deficiency.

PubMed ID: 7517574

DOI: 10.1126/science.7517574

PubMed ID: 11294565

Title: Genotyping TAP2 variants in North American Caucasians, Brazilians, and Africans.

PubMed ID: 11294565

DOI: 10.1038/sj.gene.6363731

Sequence Information:

  • Length: 686
  • Mass: 75664
  • Checksum: E7E4A7F6A2A3B48B
  • Sequence:
    • MRLPDLRPWT SLLLVDAALL WLLQGPLGTL LPQGLPGLWL EGTLRLGGLW GLLKLRGLLG 
FVGTLLLPLC LATPLTVSLR ALVAGASRAP PARVASAPWS WLLVGYGAAG LSWSLWAVLS 
PPGAQEKEQD QVNNKVLMWR LLKLSRPDLP LLVAAFFFLV LAVLGETLIP HYSGRVIDIL 
GGDFDPHAFA SAIFFMCLFS FGSSLSAGCR GGCFTYTMSR INLRIREQLF SSLLRQDLGF 
FQETKTGELN SRLSSDTTLM SNWLPLNANV LLRSLVKVVG LYGFMLSISP RLTLLSLLHM 
PFTIAAEKVY NTRHQEVLRE IQDAVARAGQ VVREAVGGLQ TVRSFGAEEH EVCRYKEALE 
QCRQLYWRRD LERALYLLVR RVLHLGVQML MLSCGLQQMQ DGELTQGSLL SFMIYQESVG 
SYVQTLVYIY GDMLSNVGAA EKVFSYMDRQ PNLPSPGTLA PTTLQGVVKF QDVSFAYPNR 
PDRPVLKGLT FTLRPGEVTA LVGPNGSGKS TVAALLQNLY QPTGGQVLLD EKPISQYEHC 
YLHSQVVSVG QEPVLFSGSV RNNIAYGLQS CEDDKVMAAA QAAHADDFIQ EMEHGIYTDV 
GEKGSQLAAG QKQRLAIARA LVRDPRVLIL DEATSALDVQ CEQALQDWNS RGDRTVLVIA 
HRLQTVQRAH QILVLQEGKL QKLAQL

Genular Protein ID: 3440259897

Symbol: X5CMH5_HUMAN

Name: N/A

UniProtKB Accession Codes:

X5CMH5

Database IDs:

ARBA 13 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 7 DNASU 1 EC 1 EMBL 13 EPD 1 Ensembl 4 GO 7 Gene3D 2 GenomeRNAi 1 HGNC 1 IntAct 1 InterPro 9 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PROSITE 5 Pfam 2 Proteomes 2 RefSeq 1 Rhea 3 SAM 1 SMART 1 SMR 1 SUPFAM 2 UCSC 1

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 703
  • Mass: 77695
  • Checksum: 2C7803EF0DF0FECB
  • Sequence:
    • MRLPDLRPWT SLLLVDAALL WLLQGPLGTL LPQGLPGLWL EGTLRLGGLW GLLKLRGLLG 
FVGTLLLPLC LATPLTVSLR ALVAGASRAP PARVASAPWS WLLVGYGAAG LSWSLWAVLS 
PPGAQEKEQD QVNNKVLMWR LLKLSRPDLP LLVAAFFFLV LAVLGETLIP HYSGRVIDIL 
GGDFDPHAFA SAIFFMCLFS FGSSLSAGCR GGCFTYTMSR INLRIREQLF SSLLRQDLGF 
FQETKTGELN SRLSSDTTLM SNWLPLNANV LLRSLVKVVG LYGFMLSISP RLTLLSLLHM 
PFTIAAEKVY NTRHQEVLRE IQDAVARAGQ VVREAVGGLQ TVRSFGAEEH EVCRYKEALE 
QCRQLYWRRD LERALYLLVR RVLHLGVQML MLSCGLQQMQ DGELTQGSLL SFMIYQESVG 
SYVQTLVYIY GDMLSNVGAA EKVFSYMDRQ PNLPSPGTLA PTTLQGVVKF QDVSFAYPNR 
PDRPVLKGLT FTLRPGEVTA LVGPNGSGKS TVAALLQNLY QPTGGQVLLD EKPISQYEHC 
YLHSQVVSVG QEPVLFSGSV RNNIAYGLQS CEDDKVMAAA QAAHADDFIQ EMEHGIYTDV 
GEKGSQLAAG QKQRLAIARA LVRDPRVLIL DEATSALDVQ CEQALQDWNS RGDRTVLVIA 
HRLQAVQRAH QILVLQEGKL QKLAQLQEGQ DLYSRLVQQR LMD

Genular Protein ID: 2389374403

Symbol: Q9UP03_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9UP03

Database IDs:

ARBA 13 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 7 DNASU 1 EC 1 EMBL 4 ExpressionAtlas 1 GO 10 Gene3D 2 GenomeRNAi 1 InterPro 9 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 5 Pfam 2 PharmGKB 1 RefSeq 1 Rhea 3 SAM 1 SMART 1 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 653
  • Mass: 72003
  • Checksum: AA79C3E9C6FE31AB
  • Sequence:
    • MRLPDLRPWT SLLLVDAALL WLLQGPLGTL LPQGLPGLWL EGTLRLGGLW GLLKLRGLLG 
FVGTLLLPLC LATPLTVSLR ALVAGASRAP PARVASAPWS WLLVGYGAAG LSWSLWAVLS 
PPGAQEKEQD QVNNKVLMWR LLKLSRPDLP LLVAAFFFLV LAVLGETLIP HYSGRVIDIL 
GGDFDPHAFA SAIFFMCLFS FGSSLSAGCR GGCFTYTMSR INLRIREQLF SSLLRQDLGF 
FQETKTGELN SRLSSDTTLM SNWLPLNANV LLRSLVKVVG LYGFMLSISP RLTLLSLLHM 
PFTIAAEKVY NTRHQEVLRE IQDAVARAGQ VVREAVGGLQ TVRSFGAEEH EVCRYKEALE 
QCRQLYWRRD LERALYLLVR RVLHLGVQML MLSCGLQQMQ DGELTQGSLL SFMIYQESVG 
SYVQTLVYIY GDMLSNVGAA EKVFSYMDRQ PNLPSPGTLA PTTLQGVVKF QDVSFAYPNR 
PDRPVLKGLT FTLRPGEVTA LVGPNGSGKS TVAALLQNLY QPTGGQVLLD EKPISQYEHC 
YLHSQVVSVG QEPVLFSGSV RNNIAYGLQS CEDDKVMAAA QAAHADDFIQ EMEHGIYTDV 
GEKGSQLAAG QKQRLAIARA LVRDPRVLIL DEATSALDVQ CEQAKTLWKF MIF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.