Details for: TAFAZZIN

Gene ID: 6901

Symbol: TAFAZZIN

Ensembl ID: ENSG00000102125

Description: tafazzin, phospholipid-lysophospholipid transacylase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 135.6519
    Cell Significance Index: -21.1000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 81.2755
    Cell Significance Index: -20.6200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 53.9161
    Cell Significance Index: -25.4600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 46.5021
    Cell Significance Index: -23.9200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 22.5820
    Cell Significance Index: -21.5600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.2975
    Cell Significance Index: -22.5600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.8466
    Cell Significance Index: -21.0200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.1795
    Cell Significance Index: -18.9800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.8286
    Cell Significance Index: -23.0000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.6217
    Cell Significance Index: -10.1200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.9912
    Cell Significance Index: 27.7000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8219
    Cell Significance Index: 133.6700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7965
    Cell Significance Index: 86.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7433
    Cell Significance Index: 149.1100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6495
    Cell Significance Index: 38.9900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5913
    Cell Significance Index: 38.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5773
    Cell Significance Index: 26.1700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5500
    Cell Significance Index: 16.1500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5223
    Cell Significance Index: 187.3400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4796
    Cell Significance Index: 36.8100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3789
    Cell Significance Index: 26.2000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3729
    Cell Significance Index: 23.5000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3346
    Cell Significance Index: 7.2500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3250
    Cell Significance Index: 64.5000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3094
    Cell Significance Index: 213.9700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3084
    Cell Significance Index: 30.5100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2368
    Cell Significance Index: 42.6900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2265
    Cell Significance Index: 3.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2087
    Cell Significance Index: 10.8400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1507
    Cell Significance Index: 4.0300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1463
    Cell Significance Index: 18.7500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1440
    Cell Significance Index: 78.6200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1305
    Cell Significance Index: 15.3900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1299
    Cell Significance Index: 17.8400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1284
    Cell Significance Index: 15.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1235
    Cell Significance Index: 5.8100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1149
    Cell Significance Index: 103.7100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0897
    Cell Significance Index: 4.5300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0822
    Cell Significance Index: 1.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0739
    Cell Significance Index: 32.6800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0724
    Cell Significance Index: 1.8100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0705
    Cell Significance Index: 2.0300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0691
    Cell Significance Index: 3.2200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0681
    Cell Significance Index: 128.3000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0576
    Cell Significance Index: 10.9700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0479
    Cell Significance Index: 2.1200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0470
    Cell Significance Index: 1.6500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0317
    Cell Significance Index: 20.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0299
    Cell Significance Index: 55.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0220
    Cell Significance Index: 33.9300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0087
    Cell Significance Index: 11.7900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0082
    Cell Significance Index: 3.7100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0035
    Cell Significance Index: 0.0600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0087
    Cell Significance Index: -0.3300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0203
    Cell Significance Index: -0.3000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0205
    Cell Significance Index: -15.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0205
    Cell Significance Index: -15.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0226
    Cell Significance Index: -3.2900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0274
    Cell Significance Index: -4.6800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0329
    Cell Significance Index: -24.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0343
    Cell Significance Index: -3.5000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0414
    Cell Significance Index: -25.8300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0415
    Cell Significance Index: -23.3900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0455
    Cell Significance Index: -2.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0544
    Cell Significance Index: -3.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0749
    Cell Significance Index: -9.6800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0817
    Cell Significance Index: -5.7800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0822
    Cell Significance Index: -23.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0886
    Cell Significance Index: -5.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0902
    Cell Significance Index: -1.9200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0942
    Cell Significance Index: -1.4200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1013
    Cell Significance Index: -11.6100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1098
    Cell Significance Index: -2.9900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1235
    Cell Significance Index: -26.0100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1291
    Cell Significance Index: -3.1500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1352
    Cell Significance Index: -4.3300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1384
    Cell Significance Index: -3.0300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1711
    Cell Significance Index: -2.0400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1724
    Cell Significance Index: -17.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2143
    Cell Significance Index: -15.9700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2842
    Cell Significance Index: -22.5100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2864
    Cell Significance Index: -17.5600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2943
    Cell Significance Index: -4.4100
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.3300
    Cell Significance Index: -4.4500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3333
    Cell Significance Index: -8.7700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3386
    Cell Significance Index: -8.6500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3496
    Cell Significance Index: -4.3600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3501
    Cell Significance Index: -6.4700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3560
    Cell Significance Index: -12.3700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3602
    Cell Significance Index: -7.0300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3609
    Cell Significance Index: -10.3000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3639
    Cell Significance Index: -11.5900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3851
    Cell Significance Index: -9.9000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3878
    Cell Significance Index: -8.2300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3944
    Cell Significance Index: -10.5300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3953
    Cell Significance Index: -20.5900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.4370
    Cell Significance Index: -13.8200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4377
    Cell Significance Index: -9.3600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4398
    Cell Significance Index: -14.4000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.4436
    Cell Significance Index: -7.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Phospholipid-lysophospholipid transacylase activity**: Tafazzin is a phospholipid-lysophospholipid transacylase, an enzyme that catalyzes the transfer of an acyl group from lysophospholipids to phospholipids, resulting in the formation of cardiolipin. 2. **Cardiolipin biosynthesis**: Tafazzin is essential for the biosynthesis of cardiolipin, which is critical for maintaining mitochondrial structure and function. 3. **Inner mitochondrial membrane organization**: Tafazzin plays a role in the organization of the inner mitochondrial membrane, which is essential for the proper functioning of the electron transport chain. 4. **Acyl chain remodeling**: Tafazzin is involved in the remodeling of acyl chains in cardiolipin, which is necessary for maintaining its structural integrity. **Pathways and Functions:** 1. **Cardiolipin biosynthetic process**: Tafazzin is involved in the biosynthesis of cardiolipin, which is essential for maintaining mitochondrial structure and function. 2. **Cardiolipin metabolic process**: Tafazzin plays a role in the metabolic processing of cardiolipin, which is necessary for maintaining its structural integrity. 3. **Mitochondrial atp synthesis coupled electron transport**: Tafazzin is involved in the synthesis of ATP through the electron transport chain, which is essential for maintaining cellular energy homeostasis. 4. **Cardiac muscle contraction**: Tafazzin is expressed in cardiac muscle cells and plays a role in the regulation of cardiac muscle contraction. 5. **Skeletal muscle tissue development**: Tafazzin is also expressed in skeletal muscle cells and plays a role in the development and function of skeletal muscle tissue. **Clinical Significance:** 1. **Barth syndrome**: Mutations in the tafazzin gene have been linked to Barth syndrome, a rare genetic disorder characterized by cardiac hypertrophy, skeletal muscle weakness, and neutropenia. 2. **Cardiac disorders**: Tafazzin mutations have also been associated with other cardiac disorders, including dilated cardiomyopathy and arrhythmias. 3. **Mitochondrial disorders**: Tafazzin mutations can also lead to mitochondrial disorders, including Kearns-Sayre syndrome and MERRF syndrome. 4. **Cancer**: Tafazzin has been implicated in the development of certain types of cancer, including breast cancer and lung cancer. In conclusion, the tafazzin gene plays a critical role in the phospholipid metabolism pathway, specifically involved in the remodeling of cardiolipin and the regulation of mitochondrial function and structure. Mutations in the tafazzin gene have been linked to a range of clinical disorders, including Barth syndrome, cardiac disorders, and mitochondrial disorders. Further research is necessary to fully understand the role of tafazzin in human health and disease.

Genular Protein ID: 2972175867

Symbol: TAZ_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q16635 A3KQT2 D3DWX2 Q5HY43 Q5HY44 Q5HY45 Q5HY48 Q86XQ6 Q86XQ7 Q86XQ8 Q86XQ9 Q86XR0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChEBI 28 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 19 Ensembl 4 ExpressionAtlas 1 GO 26 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 9 Pumba 1 RNAct 1 Reactome 2 RefSeq 5 Rhea 21 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8630491

Title: A novel X-linked gene, G4.5. is responsible for Barth syndrome.

PubMed ID: 8630491

DOI: 10.1038/ng0496-385

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 12930833

Title: Only one splice variant of the human TAZ gene encodes a functional protein with a role in cardiolipin metabolism.

PubMed ID: 12930833

DOI: 10.1074/jbc.m305956200

PubMed ID: 15499385

Title: Complex expression pattern of the Barth syndrome gene product tafazzin in human cell lines and murine tissues.

PubMed ID: 15499385

DOI: 10.1139/o04-055

PubMed ID: 19416660

Title: Formation of molecular species of mitochondrial cardiolipin. 1. A novel transacylation mechanism to shuttle fatty acids between sn-1 and sn-2 positions of multiple phospholipid species.

PubMed ID: 19416660

DOI: 10.1016/j.bbalip.2009.01.004

PubMed ID: 19700766

Title: Characterization of tafazzin splice variants from humans and fruit flies.

PubMed ID: 19700766

DOI: 10.1074/jbc.m109.016642

PubMed ID: 19164547

Title: Role of calcium-independent phospholipase A2 in the pathogenesis of Barth syndrome.

PubMed ID: 19164547

DOI: 10.1073/pnas.0811224106

PubMed ID: 25598000

Title: Tafazzins from Drosophila and mammalian cells assemble in large protein complexes with a short half-life.

PubMed ID: 25598000

DOI: 10.1016/j.mito.2015.01.002

PubMed ID: 26908608

Title: Defining functional classes of Barth syndrome mutation in humans.

PubMed ID: 26908608

DOI: 10.1093/hmg/ddw046

PubMed ID: 29129703

Title: Identification of novel mitochondrial localization signals in human Tafazzin, the cause of the inherited cardiomyopathic disorder Barth syndrome.

PubMed ID: 29129703

DOI: 10.1016/j.yjmcc.2017.11.005

PubMed ID: 32234310

Title: The Function of Tafazzin, a Mitochondrial Phospholipid-Lysophospholipid Acyltransferase.

PubMed ID: 32234310

DOI: 10.1016/j.jmb.2020.03.026

PubMed ID: 33096711

Title: Tafazzin Mutation Affecting Cardiolipin Leads to Increased Mitochondrial Superoxide Anions and Mitophagy Inhibition in Barth Syndrome.

PubMed ID: 33096711

DOI: 10.3390/cells9102333

PubMed ID: 25941633

Title: Structural and functional analyses of Barth syndrome-causing mutations and alternative splicing in the tafazzin acyltransferase domain.

PubMed ID: 25941633

DOI: 10.1016/j.mgene.2015.04.001

PubMed ID: 9382096

Title: The X-linked gene G4.5 is responsible for different infantile dilated cardiomyopathies.

PubMed ID: 9382096

DOI: 10.1086/514886

PubMed ID: 9382097

Title: Neonatal, lethal noncompaction of the left ventricular myocardium is allelic with Barth syndrome.

PubMed ID: 9382097

DOI: 10.1086/514879

PubMed ID: 11238270

Title: Novel gene mutations in patients with left ventricular noncompaction or Barth syndrome.

PubMed ID: 11238270

DOI: 10.1161/01.cir.103.9.1256

PubMed ID: 12032589

Title: Novel missense mutation (R94S) in the TAZ (G4.5) gene in a Japanese patient with Barth syndrome.

PubMed ID: 12032589

DOI: 10.1007/s100380200030

PubMed ID: 23409742

Title: New clinical and molecular insights on Barth syndrome.

PubMed ID: 23409742

DOI: 10.1186/1750-1172-8-27

Sequence Information:

  • Length: 262
  • Mass: 30203
  • Checksum: AE7F4EBF505C7F63
  • Sequence:
    • MPLHVKWPFP AVPPLTWTLA SSVVMGLVGT YSCFWTKYMN HLTVHNREVL YELIEKRGPA 
TPLITVSNHQ SCMDDPHLWG ILKLRHIWNL KLMRWTPAAA DICFTKELHS HFFSLGKCVP 
VCRGDGVYQK GMDFILEKLN HGDWVHIFPE GKVNMSSEFL RFKWGIGRLI AECHLNPIIL 
PLWHVGMNDV LPNSPPYFPR FGQKITVLIG KPFSALPVLE RLRAENKSAV EMRKALTDFI 
QEEFQHLKTQ AEQLHNHLQP GR

Genular Protein ID: 42280004

Symbol: A0A0S2Z4K9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z4K9

Database IDs:

ARBA 16 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 20 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 4 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 Pfam 1 RefSeq 1 Rhea 15 RuleBase 1 SMART 2 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 278
  • Mass: 31748
  • Checksum: 350624E72B677BE8
  • Sequence:
    • MPLHVKWPFP AVPPLTWTLA SSVVMGLVGT YSCFWTKYMN HLTVHNREVL YELIEKRGPA 
TPLITVSNHQ SCMDDPHLWG ILKLRHIWNL KLMRWTPAAA DICFTKELHS HFFSLGKCVP 
VCRGAEFFQA ENEGKGVLDT GRHMPGAGKR REKGDGVYQK GMDFILEKLN HGDWVHIFPE 
GIGRLIAECH LNPIILPLWH VGMNDVLPNS PPYFPRFGQK ITVLIGKPFS ALPVLERLRA 
ENKSAVEMRK ALTDFIQEEF QHLKTQAEQL HNHLQPGR

Genular Protein ID: 1385753626

Symbol: A0A0S2Z4F4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z4F4

Database IDs:

ARBA 16 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 20 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 4 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 Pfam 1 RefSeq 1 Rhea 15 RuleBase 1 SMART 2 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 248
  • Mass: 28492
  • Checksum: E23FAFFC359721CA
  • Sequence:
    • MPLHVKWPFP AVPPLTWTLA SSVVMGLVGT YSCFWTKYMN HLTVHNREVL YELIEKRGPA 
TPLITVSNHQ SCMDDPHLWG ILKLRHIWNL KLMRWTPAAA DICFTKELHS HFFSLGKCVP 
VCRGDGVYQK GMDFILEKLN HGDWVHIFPE GIGRLIAECH LNPIILPLWH VGMNDVLPNS 
PPYFPRFGQK ITVLIGKPFS ALPVLERLRA ENKSAVEMRK ALTDFIQEEF QHLKTQAEQL 
HNHLQPGR

Genular Protein ID: 4238022790

Symbol: A6XNE1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A6XNE1 A0A087X0T0

Database IDs:

ARBA 16 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 20 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 GO 4 GeneTree 1 HGNC 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 15 RuleBase 1 SMART 2 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

Sequence Information:

  • Length: 296
  • Mass: 33519
  • Checksum: F4A767B598DCF476
  • Sequence:
    • MPLHVKWPFP AVPPLTWTLA SSVVMGLVGT YSCFWTSEWA QAEAGPPGYP CPAGEYMNHL 
TVHNREVLYE LIEKRGPATP LITVSNHQSC MDDPHLWGIL KLRHIWNLKL MRWTPAAADI 
CFTKELHSHF FSLGKCVPVC RGAEFFQAEN EGKGVLDTGR HMPGAGKRRE KGDGVYQKGM 
DFILEKLNHG DWVHIFPEGI GRLIAECHLN PIILPLWHVG MNDVLPNSPP YFPRFGQKIT 
VLIGKPFSAL PVLERLRAEN KSAVEMRKAL TDFIQEEFQH LKTQAEQLHN HLQPGR

Genular Protein ID: 1232948054

Symbol: A0A0S2Z4K0_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z4K0

Database IDs:

ARBA 16 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 20 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 6 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 Pfam 1 PhylomeDB 1 RefSeq 1 Rhea 15 RuleBase 1 SMART 2 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 292
  • Mass: 33459
  • Checksum: 2805E0962DC4FE52
  • Sequence:
    • MPLHVKWPFP AVPPLTWTLA SSVVMGLVGT YSCFWTKYMN HLTVHNREVL YELIEKRGPA 
TPLITVSNHQ SCMDDPHLWG ILKLRHIWNL KLMRWTPAAA DICFTKELHS HFFSLGKCVP 
VCRGAEFFQA ENEGKGVLDT GRHMPGAGKR REKGDGVYQK GMDFILEKLN HGDWVHIFPE 
GKVNMSSEFL RFKWGIGRLI AECHLNPIIL PLWHVGMNDV LPNSPPYFPR FGQKITVLIG 
KPFSALPVLE RLRAENKSAV EMRKALTDFI QEEFQHLKTQ AEQLHNHLQP GR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.